in any particular circumstances. [1] The medication has also been used in the treatment of endometriosis. You may feel sick or nauseated, especially during the first few months that you take this medicine. [, Schrager S, Paddock E, Dalby J, Knudsen L: Contraception in Wisconsin: a review. Check with your doctor right away if you have pain in the chest, groin, or legs, especially the calves, difficulty with breathing, a sudden, severe headache, slurred speech, a sudden, unexplained shortness of breath, a sudden unexplained shortness of breath, a sudden loss of coordination, or vision changes while using this medicine. Appropriate studies on the relationship of age to the effects of desogestrel and ethinyl estradiol combination have not been performed in the geriatric population. The manufacturer states desogestrel may be used safely when breastfeeding. Desogestrel is available alone in the form of 75 g oral tablets and at a dose of 150 g in combination with 20 or 30 g ethinylestradiol in oral tablets. These formulations are all indicated specifically for contraceptive purposes. Desogestrel is not indicated for use in pregnancy. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ). If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. For an implant or progestogen-releasing IUD, tablet taking should start on the day of removal. WebIndications and dose For desogestrel Contraception for desogestrel By mouth. [4], No serious harmful effects have been reported with overdose of desogestrel. The management of AMD with single- and ; US. These visits will usually be every 6 to 12 months, but some doctors require them more often. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. [11] Peak concentrations of etonogestrel occur about 1.5hours after a dose while concentrations of desogestrel are very low and have disappeared by 3hours after a dose. Revised April 2013. [58] Medications containing desogestrel as the only active ingredient (as opposed to being used in conjunction with ethinylestradiol, like in combined oral contraceptives) do not show an increased thrombosis risk and are therefore safer than second-generation birth-control pills in regards to thrombosis. 2002 Jan 1;30(1):412-5. [42][43] It is unclear if these findings may explain the different risks of breast cancer observed with progesterone and progestins in clinical studies. medical history of particular patients or groups of patients and so It therefore [, Juchem M, Pollow K: Binding of oral contraceptive progestogens to serum proteins and cytoplasmic receptor. [4], Desogestrel is a prodrug of etonogestrel (3-ketodesogestrel), and, via this active metabolite, it has progestogenic activity, antigonadotropic effects, very weak androgenic activity, very weak glucocorticoid activity, and no other hormonal activity. This usually occurs when you first start taking this medicine, or after starting birth control pills after not using them for a month or more. Using this medicine may increase your risk of having blood clotting problems. [34] Upon cessation of treatment, levels of LH, FSH, and testosterone all recovered to baseline values within 4weeks. [45][46][24], Desogestrel is marketed under a variety of brand names throughout the world including Alenvona, Apri, Azalia, Azurette, Bekyree, Caziant, Cerazette,[4] Cerelle, Cesia, Cyclessa, Cyred, Denise, Desogen, Desirett, Diamilla, Emoquette, Enskyce, Feanolla, Gedarel, Gracial, Hana,[5] Isibloom, Juleber, Kalliga, Kariva, Laurina, Linessa, Lovima, Marvelon,[2] Mercilon,[3] Mircette, Mirvala, Novynette, Ortho-Cept, Pimtrea, Reclipsen, Regulon, Simliya, Solia, Velivet, Viorele, and Volnea among others. [18][19][20] Desogestrel is sometimes referred to as a "third-generation" progestin. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. WebView desogestrel information, including dose, uses, side-effects, pregnancy, breast feeding and contra-indications. Discuss your options for birth control with your doctor. Hum Reprod. WebSymptoms of ED include. [1][14][32] Hence, etonogestrel is exclusively responsible for the effects of desogestrel. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. Consilient Health Ltd. Revised March 2019. in any particular circumstances. Sunday start: Continue taking one pill a day until Sunday, then throw out the rest of the pack and start a new pack that same day. [, McClamrock HD, Adashi EY: Pharmacokinetics of desogestrel. However, infrequent cases of decrease in breast milk production have been reported. Mayo Clinic does not endorse any of the third party products and services advertised. In the UK, in July 2021, some Desogestrel pills were made available to purchase over the counter,[57] without requiring a prescription from a doctor beforehand. [35] Clinical studies with norethisterone even at very high dosages (e.g., 10 to 60mg/day) have observed only mild androgenic effects in a minority of women including acne, increased sebum production, hirsutism, and slight virilization of female fetuses. patient's history is different, and even the most exhaustive sources of [4], Inducers of liver enzymes can increase the metabolism of desogestrel and etonogestrel and reduce their circulating levels. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. being able to get an erection sometimes, but not every time you want to have sex. Check with your doctor right away if you miss a menstrual period. For most patients, the recommended starting dose of LEVITRA is 10 mg, taken orally, as needed, approximately 60 minutes before sexual Do not eat grapefruit or drink grapefruit juice while you are using this medicine. This medicine does not prevent HIV infection or other sexually transmitted diseases. [1] It is an inactive prodrug of etonogestrel with essentially no affinity for the PR itself (about 1% of that of promegestone). Desogestrel And Ethinyl Estradiol (Oral Route), https://www.mayoclinic.org/drugs-supplements/desogestrel-and-ethinyl-estradiol-oral-route/side-effects/drg-20061362, Advertising and sponsorship opportunities, Blood clots (eg, deep vein thrombosis, pulmonary embolism), or history of or, Blood disorders (eg, hypercoagulopathy), acquired or inherited or, Diabetes with kidney, eye, nerve, or blood vessel damage or, Heart or blood vessel disease (eg, coronary artery disease, heart valve problems), or history of or, Hypertension (high blood pressure), uncontrolled or, Jaundice during pregnancy or from using hormonal therapy in the past or, Liver disease, including tumors or cancer or, Major surgery with prolonged periods of immobilization or. [33] Desogestrel and etonogestrel are among the most potent progestogens available, along with gestodene and levonorgestrel (which have effective ovulation-inhibiting dosages 40g/day and 60g/day, respectively). Contraception after delivery or second-trimester childbirthTablet taking can start 21 to 28 days after delivery or second-trimester abortion. Applies to the following strengths: 0.15 mg-0.03 mg; biphasic; triphasic 25 mcg. These conditions may increase risk for more serious side effects. If you miss two light orange or white pills in week 1 or 2: Take the two pills as soon as possible and the next two pills the next day. To use oral contraceptives as safe and reliable as possible, you should understand how and when to take them and what effects may be expected. Lupin Healthcare (UK) Ltd. Revised January 2019. The metabolism of Abacavir can be increased when combined with Desogestrel. professionals should bear in mind): Register or Login to access the full drug monographs and more. [14][30][40] Hence, desogestrel and etonogestrel have weak glucocorticoid activity. The increased risk has been reported to be related to the duration of use. If you smoke while using birth control pills, you increase your risk of having a blood clot, heart attack, or stroke. basis, healthcare professionals should ensure that they are satisfied Available at: https://www.drugs-porphyria.orgLast accessed: 06 August 2021, Medscape UK | Univadis prescription drug monographs & interactions are While FDB Multilex use reputable sources of information, such as published [, Kloosterboer HJ, Vonk-Noordegraaf CA, Turpijn EW: Selectivity in progesterone and androgen receptor binding of progestagens used in oral contraceptives. The risk or severity of adverse effects can be increased when Desogestrel is combined with Acenocoumarol. [59] Most of those second-generation medications have been on the market longer and have been shown to be as effective in preventing unwanted pregnancy, but with a lower risk of blood clots. Talk with your doctor about this risk. [14] One study found that 150g/day and 300g/day desogestrel alone in healthy young men suppressed luteinizing hormone (LH) levels by about 35% and 42%, respectively; follicle-stimulating hormone (FSH) levels by about 47% and 55%, respectively; and testosterone levels by about 59% and 68%, respectively. For non-prescription products, read the label or package ingredients carefully. J Fam Plann Reprod Health Care. Summary of Product Characteristics: Moonia 75 microgram film-coated tablets. Can Fam Physician. Desogestrel main therapeutic effect due to its mechanism of action is known to be related to the inhibition of the ovulation in 97% of the cycles. This result indicated that desogestrel is more efficient when compared to other progestogen-only pills.6 All the therapeutic effect is produced by a transformation of the endometrium followed by an inhibition of the ovulation due to the suppression of other hormones.10, Desogestrel has been widely confirmed to be related to an increase in the risk of venous thromboembolism due to the driven increased in blood coagulation factors, leading to a pronounced prothrombotic state.1 However, the effects of desogestrel are known to not impact significantly the level of total cholesterol remaining in the range of change of 10% which allows it to be a molecule that presents a favorable lipid profile.4, Desogestrel enters the cell passively and acts by binding selectively to the progesterone receptor and generating low androgenic activity.8 Its binding produces an effect like a transcription factor and thus, it produces modifications in the mRNA synthesis.9, The active metabolite of desogestrel, etonogestrel, presents a combination of high progestational activity with minimal intrinsic androgenicity.Label, After oral administration, desogestrel is rapidly absorbed and it reaches a peak concentration of 2 ng/ml after 1.5 hours. 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