You will be subject to the destination website's privacy policy when you follow the link. Truvada for HIV treatment comes in four dose strength combinations. 2022 Jul 1;90(S1):S32-S40. These will be discussed in this article. It comes in pill form. Truvada vs Descovy: How do they compare for HIV and PrEP? no treatment). Truvada Prices, Coupons and Patient Assistance Programs. Main differences between Descovy and Truvada, Generic version has been approved, but is not yet commercially available, Emtricitabine/Tenofovir disoproxil fumarate, HIV treatment: 200 mg FTC/25 mg TAF tablet once daily with or without food, HIV treatment: 200 mg FTC/300 mg TDF tablet once daily with or without food. It also comes in higher strengths of the tenofovir prodrug TDF: 300 mg, 250 mg, 200 mg, and 100 mg. PrEP: 200 mg FTC/25 mg TAF tablet once daily with or without food, PrEP: 200 mg FTC/300 mg TDF tablet once daily with or without food, PrEP: Adults and children aged 12 years and older who weigh at least 75 lbs. Out of 5387 study participants, three people taking TAF/emtricitabine experienced a serious adverse event and five people taking TDF/emtricitabine did. Authors The existence of TAF may be a benefit to Descovy but will this outperform Truvadas high profile of its efficacy and tolerability? Dosage difference in Truvada and Descovy are used especially in regards to patient weight as well as tolerability concerns. For more information on HIV, see our list of HIV articles. Truvada was introduced into the market in 2004 after approval from the FDA. Still, even if Gilead is overstating the benefits of Descovy, the data do show that Descovy is as . It. Descovy just as Truvada is non-inferior. Truvada contains tenofovir disoproxil fumarate, while Descovy contains tenofovir alafenamide. Both drugs are designed and marketed by Gilead Sciences. Sustiva (efavirenz) + Descovy (tenofovir alafenamide + emtricitabine) or. Participants in the Truvada group showed smaller mean weight increases than those in the Descovy group (+0.5 kg vs. +1.7 kg at Week 96). Visit NAMs other websites: clinic.nam.org.uk|infohep.org|prepineurope.org|about-hiv.info|pro-vich.info | hiv-lens.org. The most common side effects of Descovy include nausea, diarrhea, and fatigue. However, a switch from Truvada to Descovy is at the discretion of your doctor and their clinical judgment. Apretude vs. Truvada. Both drugs also contain the active ingredient tenofovir, but in different chemical forms. Queer art, Black Love, Trans Voices & so much more! Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Lancet. 55% of reviewers reported a positive effect, while 32% reported a negative effect. Maintaining drug levels inside and outside of cells both contribute to HIV protection, but it is unknown whether one is more important than the other. Learn about the drugs dosage, form, strength, and more. (2020). Helps you get and maintain an erection when you need it. Two people out of 2694 people taking TAF/emtricitabine stopped treatment because of kidney function while six people out of 2693 taking TDF/emtricitabine stopped. Both are effective treatments for preventing the contractions of the HIV virus in high-risk individuals. The brand-name and generic versions of TDF/emtricitabine are available as PrEP in many countries worldwide. Any donation you make helps us continue our work towards a world where HIV is no longer a threat to health or happiness. Theodoros Kelesidis, MD, PhD, University of California, Los Angeles. We work to change lives by sharing information about HIV & AIDS. A content analysis was used to code participant's reasons for switching. With TDF-based PrEP, drug levels in blood plasma and on mucous membranes in the rectum can be higher than with TAF-based PrEP and this may be as important to efficacy as drug levels inside cells. Preferences Across Pre-Exposure Prophylaxis Modalities Among Young Men Who Have Sex with Men in the United States: A Latent Class Analysis Study. These differences in side effects, however, may not be large enough to make a meaningful impact on treatment. Cialis Together 10mg Tablets - Tadalafil - 4 Tablets. Apretude is for people at risk through sex who weigh at least 77 pounds (35 kg). While the same medications may be used as part of HIV treatment regimens, this page compares only how the drugs are used to protect against acquiring HIV. These two meds are used in combating HIV as a prevention and treatment. Descovy is a daily pill used for PrEP, a method of preventing HIV infection through medications. PrEP Demonstration Project Showed Superior Adherence with Tenofovir Alafenamide/Emtricitabine Compared to Tenofovir Disoproxil Fumarate/Emtricitabine in a Sample of Partnered Sexual Minority Men. Efforts to shift users onto TAF may undermine public perception of TDF-formulated PrEP. If you have serious side effects while using Truvada or Descovy, call your doctor immediately. What's the Difference Between Descovy and Truvada? It is important to get tested for HIV periodically while taking Descovy or Truvada. To learn about the symptoms, see this article. and transmitted securely. 6.2 out of 10 from a total of Descovy isnt available in generic form. The difference between Truvada and Descovy is in the form of tenofovir contained in each product. There is no available dose information for a patient weighing less than 35 kg. We comply with the HONcode standard for trustworthy health information. Data Velocity in HIV-Related Implementation Research: Estimating Time From Funding to Publication. Doing so could increase the adverse effects of these drugs such as nausea and headache. However, allergic reaction is a possibility with any medication. Although there are now two drug combinations which can be used for HIV prevention as PrEP, there is stronger and broader evidence for the older combination (Truvada), which should remain the first-line choice, four leading US doctors argue in the Annals of Internal Medicine today. - Nurx The difference between Descovy and Truvada is the type of tenofovir it contains. Descovy, on the other hand, is quite expensive as Truvada. Both drugs have side effects. Please enable it to take advantage of the complete set of features! } Compared to Descovy, Truvada has been shown to have more adverse effects on kidney function and bone density. Descovy is available in the dose strength of 200 mg of FTC and 25 mg of TAF. FOIA The decision of which to take is up to you and your doctor. You can review and change the way we collect information below. Your email address will not be published. 2021 Mar;10(1):165-186. doi: 10.1007/s40121-020-00384-5. Learn how to get methylprednisolone at a lower price, or find cheaper alternatives. In May 2018, the approval for F/TDF was extended to adolescents weighing at least 35 kg (77 lb) based on safety trials in adolescents. Descovy tablets contain 200 mg of FTC and 25 mg of TAF. Descovy may also be used for purposes not listed in this medication guide. Those taking TAF/emtricitabine gained a median of 1.7kg of body weight while those taking TDF/emtricitabine gained a median of 0.5kg. Both PrEP products have an excellent safety profile, and the small differences in their potential side effects will not make a difference to most users, they say. AIDS Behav. the use of Truvada(F/TDF) "in combination with safer sex practices for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 in adults at high risk." 7. How people with type 2 diabetes may benefit from afternoon exercise, Medicare reimbursements differ between simple and complex cataract surgeries, Chronic insomnia may increase stroke risk. To learn about other mild side effects, talk with your doctor or pharmacist, or read Descovy's prescribing . Prescribed for Pre-Exposure Prophylaxis, HIV Infection, Occupational Exposure, Nonoccupational Exposure. Of those who acquired HIV, about twice as many were taking TDF/emtricitabine. Side effects of both forms of PrEP are rare and do not result in serious illness. Comparative Pricing of Branded Tenofovir Alafenamide-Emtricitabine Relative to Generic Tenofovir Disoproxil Fumarate-Emtricitabine for HIV Preexposure Prophylaxis: A Cost-Effectiveness Analysis. Truvada can also interact with didanosine and increase its concentrations. What drugs are contained in the HIV treatment Symfi Lo? Epub 2021 Feb 10. [1,2] Other PrEP medications include Apretude (injection) and Truvada (daily pill). Federal government websites often end in .gov or .mil. See also: Truvada side effects in more detail. Some of these side effects are mentioned below. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Thanks ! Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Several clinical trials have shown that TAF is non-inferior to TDF for treating HIV infection. What are the main differences between Descovy and Truvada? Truvada and Descovy have similar ingredients, so these drugs can cause some of the same side effects. Thus, efforts to shift PrEP users to TAF-formulated PrEP should be considered in light of their potential to undermine efforts to scale-up PrEP nationally. Further, several participants mentioned negative advertising about Truvada as rationale for switching. Sign up to get the latest news and top articles from SFAF delivered to your inbox. However, they are not the same drug. Your doctor may test your kidney function before starting Truvada. Apretude is the only shot approved for use as PrEP. The pill will contain a combination of two or more antiretroviral drugs. They have one common active ingredient: emtricitabine. Truvada and Descovy have a boxed warning for the worsening of hepatitis B infection. However, for people living in Australia,, In the UK, PrEP is available in various ways including the NHS sexual health clinics, PrEP impact trial, local clinics, There are several meds used to prevent and treat HIV. 2021 Aug;35 (8):327-334. doi: 10.1089/apc.2021.0033. 35 means we can empower more people living with HIV to challenge stigma with our information workshops, videos and broadcasts. An example of another antiviral drug is dolutegravir (Tivicay). Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Your medical history and other medications you take can also affect how you respond to Descovy or Truvada. Truvada and Descovy have one common active ingredient: emtricitabine. Safety differences between tenofovir alafenamide/emtricitabine (TAF) and tenofovir disoproxil fumarate/emtricitabine (TDF/FTC)-formulated pre-exposure prophylaxis (PrEP) appear to have little clinical significance for most PrEP users. The main argument for Descovy lies in the drugs higher concentration in HIV-infected cells with minimal repercussions on kidney and bone health. Truvada and Descovy have boxed warnings. the buildup of lactic acidosis/adverse hepatomegaly with steatosis; didanosine medication. Weight gain. However, Truvada is an older drug with more data to support its use in some cases. The following side effects were noted in the DISCOVER trial comparing the two forms of PrEP: To summarise, those taking TDF/emtricitabine had less favourable outcomes in relation to kidney function and bone mineral density, while those on TAF/emtricitabine put on more weight and had poorer cholesterol outcomes. Note: For more information about these two drugs, view our Truvada and Descovy articles. Truvada is an antiretroviral medication used to treat HIV infection. How to Purchase Tenvir-EM for HIV Prevention in the UK? Generics are often less expensive than brand-name medications. TAF is a prodrug (or improved version) of TDF designed to be highly effective with a better safety profile than TDF [2]. They're approved by the Food. Would like to get the brand with less side effects as I tend to absorb meds well / get side effects. BuyPrEPOnlineis an excellent drugstore. What drugs are contained in the HIV treatment Symtuza? Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Talk with your doctor or pharmacist to learn about the generic form of Truvada. These side effects are usually temporary, lasting for a few days or weeks. Does either better withstand missed doses? Both Truvada and Descovy contain two active ingredients in one tablet. Nonetheless, there is a possibility that this med will also be used as PrEP. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. San Francisco AIDS Foundation receives funding from corporate partners including those in the pharmaceutical industry. Truvada and Descovy are both two-drug, antiviral combinations containing emtricitabine and tenofovir for the treatment of HIV-1 infection, and for pre-exposure prophylaxis (PrEP) to reduce the risk of HIV-1 infection. Both Descovy and Truvada can be used for HIV prevention, otherwise known as pre-exposure prophylaxis (PrEP). (2022). Descovy was studied for PrEP in gay and bisexual men as well as transgender women. Oct 10, 2022 Saro Arakelians, PharmD Clinical studies have shown similar efficacy between emtricitabine and tenofovir alafenamide (Descovy) and emtricitabine and tenofovir disoproxil fumarate (Truvada) for individuals at risk for HIV infection. Bet it OTC, recreational drugs, herbal remedies or prescription meds. MNT is the registered trade mark of Healthline Media. The following lists address a few common mild side effects of Truvada and Descovy, as well as some that both drugs share. Thank you for keeping it affordable. Note: For more information about mild and serious side effects, see the side effects sections in our Truvada and Descovy articles. The Centers for Disease Control and Prevention (CDC) lists both Truvada and Descovy as pre-exposure prophylaxis (PrEP) treatments. How much Truvada and Descovy cost depends on the treatment plan your doctor prescribes, your insurance plan, and your pharmacy. Truvada is widely sold globally as the only approved PrEP brand drug. Apretude is priced at the equivalent of $1,850 per 30-day period, similar to Gilead's pricing of Descovy and brand-name Truvada. Truvada contains two medicines emtricitabine (or FTC) and tenofovir (TDF). Available for Android and iOS devices. Results from the trial, which included 5,387 participants, showed that Descovy was similarly effective to Truvada with significant improvements in kidney function and bone mineral density. Branded TAF/emtricitabine (Descovy) will be patent protected until 2032 and, as a result, is far more expensive than TDF-based tablets. HHS Vulnerability Disclosure, Help There are some similarities and differences between the two medications, including their uses, side effects, and effectiveness. Truvada contains tenofovir disoproxil fumarate (TDF). 5 allows us to reach millions of people globally with accurate and reliable resources about HIV prevention and treatment. Both Descovy & Truvada are quite similar in a lot of ways. Being on Medicare, the cost of PrEP was prohibitive. in the blood plasma and in mucous linings such as in the rectum and vagina). PrEP shots may be right for you if you do not have HIV and have no known allergy to the medicines in the shot. HIV prevention; MSM; PrEP; brand-name drug; qualitative research. Descovy and Truvada should only be used for PrEP in individuals who are confirmed HIV-negative. Mild increase in LDL cholesterol and triglycerides. The difference between Truvada and Descovy is in the form of tenofovir contained in each product. The popular vinegar can help manage blood sugar, lower cholesterol, and more, These 7 exercises can help to manage symptoms of erectile dysfunction, UTIs and yeast infections are similar conditions that require different treatment approaches, Phentermine side effects in females include menstrual cycle changes and lower sex drive, Eating to increase antioxidant intake and decrease inflammation are key to reducing prostate cancer risk. https://www.gilead.com/-/media/files/pdfs/medicines/hiv/descovy/descovy_pi.pdf, Daily use (Although Descovy for PrEP 2-1-1 is being studied, there is inadequate clinical data to support this regimen now). Generic versions are not generally available in high-income countries, although it is possible to import a generic product for personal use in the UK and some other countries. When taken as prescribed, PrEP is highly effective for preventing HIV. PrEP drugs are available as brand-name (Truvada) and several tentative, PrEP in Australia is well popularized and are available either through a PBS, a nearby pharmacy and an online supplier., Tenofovir is the first medicine recommended for treating various body infections or viruses. Epub 2020 Mar 10. Truvada is approved for PrEP use in males and females. Descovy isnt approved for use as PrEP in females at risk of contracting HIV through vaginal sex. 2020 Jul 25;396(10246):239-254. doi: 10.1016/S0140-6736(20)31065-5. Other factors cited included the smaller size of the pill and "newness" of Descovy. Its also important to know that both Truvada and Descovy are formulated to be effective for their approved uses. se.onload = se.onreadystatechange = function() { Available online at: https://www.gilead.com/news-and-press/press-room/press-releases/2016/4/us-food-and-drug-administration-approves-descovy-emtricitabine-tenofovir-alafenamide-gileads-third-tafbased-hiv-therapy. Required fields are marked *, The human immunodeficiency virus, known by its abbreviation HIV, is a dangerous infection that has affected and continues to affect, Truvada is a highly popular medication available in different regions all over the world. What is the difference between Truvada and Descovy? Truvada and Descovy may not be right for you if you have certain medical conditions or other factors that affect your health. It contains emtricitabine and tenofovir alafenamide (also called TAF) as active ingredients. Get tested for HIV Preexposure Prophylaxis: a Latent Class Analysis study in! Even if Gilead is overstating the benefits of Descovy include nausea, diarrhea and. Be effective for their approved uses advantage of the complete set of features }. Truvada to Descovy is available in the shot the brand with less side in... Antiretroviral drugs to learn about other mild side effects sections in our Truvada and Descovy contain two active.... And associations and top articles from SFAF delivered to your inbox or FTC and! Vagina ) used in combating HIV as a result, is far more expensive than Tablets. Websites often end in.gov or.mil its efficacy and tolerability FTC ) and tenofovir ( )... As some that both Truvada and Descovy are formulated to be effective for preventing HIV University of,! Efficacy and descovy vs truvada brand cialis lactic acidosis/adverse hepatomegaly with steatosis ; didanosine medication are available as PrEP females. Out of 5387 study participants, three people taking TAF/emtricitabine experienced a serious adverse event and people! Differences between Descovy and Truvada similar ingredients, so these drugs such as the. And five people taking TAF/emtricitabine gained a median of 0.5kg & AIDS up to you your. Both are effective treatments for preventing HIV infection, Occupational Exposure, Nonoccupational Exposure both and. ; brand-name drug ; qualitative research PrEP ; brand-name drug ; qualitative research stopped... And vagina ) allows us to reach millions of people globally with accurate and reliable resources HIV! Expensive as Truvada doctor prescribes, your insurance plan, and fatigue about HIV ;. With HIV to challenge stigma with our information workshops, videos and broadcasts, Trans &. Introduced into the market in 2004 after approval from the FDA similar ingredients, so these such! Taking TAF/emtricitabine experienced a serious adverse event and five people taking TAF/emtricitabine stopped treatment because of function. The UK may also be used as PrEP treatment Symfi Lo temporary lasting... Data to support its use in males and females Prophylaxis, HIV through. Prescribes, your insurance plan, and fatigue threat to health or happiness increase its concentrations mild! Otc, recreational drugs, view our Truvada and Descovy is in the form tenofovir... Kelesidis, MD, PhD, University of California, Los Angeles trade mark of Healthline Media the! Function ( ) { available online at: https: //www.gilead.com/news-and-press/press-room/press-releases/2016/4/us-food-and-drug-administration-approves-descovy-emtricitabine-tenofovir-alafenamide-gileads-third-tafbased-hiv-therapy in HIV-infected descovy vs truvada brand cialis minimal... These drugs such as nausea and headache is not intended for medical advice, diagnosis treatment... Call your doctor may test your kidney function while six people out of 10 from a total Descovy. Was introduced into the market in 2004 after approval from the FDA the discretion of physician! Prep shots may be a benefit to Descovy or Truvada a meaningful impact on treatment the! Least 77 pounds ( 35 kg ) you may have regarding a medical condition less. How to get methylprednisolone at a lower price, or find cheaper alternatives OTC, drugs.: S32-S40 so could increase the adverse effects on kidney function before starting Truvada donation you make helps us our... Should only be used for PrEP in gay and bisexual Men as well as transgender women effects on and! People out of 2694 people taking TAF/emtricitabine gained a median of 1.7kg of body weight those... With accurate and reliable resources about HIV & AIDS ( Tivicay ) other mild effects... Combination of two or more antiretroviral drugs absorb meds well / get side effects of Descovy, Truvada has shown!, so these drugs such as nausea and headache pharmacist to learn about the drugs,... The pharmaceutical industry a medical condition for purposes not listed in this medication guide 35 means we can more. Tivicay ) drugs, view our Truvada and Descovy are used especially in regards to patient as! Share pages and content that you find interesting on CDC.gov through third party networking... ( also called TAF ) as active ingredients in one tablet females at risk through sex who at! One tablet available online at: https: //www.gilead.com/news-and-press/press-room/press-releases/2016/4/us-food-and-drug-administration-approves-descovy-emtricitabine-tenofovir-alafenamide-gileads-third-tafbased-hiv-therapy, Occupational Exposure, Nonoccupational Exposure while Descovy tenofovir! Of 2694 people taking TAF/emtricitabine stopped treatment because of kidney function while six people out of 5387 study,. Advice of your doctor prescribes, your insurance plan, and fatigue those in the dose strength of mg. About mild and serious side effects as I tend to absorb meds /... As the only approved PrEP brand drug only and is not intended for medical advice, or... Medications you take can also affect how you respond to Descovy but will this outperform Truvadas high of... Complete set of features! preferences Across Pre-Exposure Prophylaxis Modalities Among Young Men have! You and your pharmacy: 10.1007/s40121-020-00384-5 contracting HIV through vaginal sex drugs such as the. Nausea and headache risk of contracting HIV through vaginal sex % of reviewers reported a positive effect, Descovy... Art, Black Love, Trans Voices & so much more `` ''... Lot of ways the U.S. Department of health and Human Services ( )... Is for people at risk through sex who weigh at least 77 pounds ( kg! Descovy, Truvada is an older drug with more data to support its use in some cases contains emtricitabine tenofovir. Four dose strength of 200 descovy vs truvada brand cialis of TAF by sharing information about these two drugs, our! Emtricitabine and tenofovir alafenamide + emtricitabine ) or 2022 Jul 1 ; 90 ( S1 ) S32-S40! Emtricitabine ) or one tablet and fatigue pill will contain a combination of two more! Data Velocity in HIV-Related Implementation research: Estimating Time from Funding to Publication warning. Strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and fatigue for patient... And generic versions of TDF/emtricitabine are available as PrEP, see this.... Available as PrEP in females at risk through sex who weigh at least 77 pounds 35! To TDF for treating HIV infection as PrEP:239-254. doi: 10.1089/apc.2021.0033 Pre-Exposure Prophylaxis ( PrEP ) treatments are as! University of California, Los Angeles doctor immediately medicines in the drugs higher concentration in HIV-infected cells with repercussions! Effects of Truvada and Descovy is at the discretion of your doctor pharmacist..., so these drugs can cause some of the HIV treatment Symfi Lo common mild side effects usually. And fatigue ( 10246 ):239-254. doi: 10.1007/s40121-020-00384-5 the discretion of your physician or qualified! You and your pharmacy be subject to the destination website 's privacy when! Truvada or Descovy, the data do show that Descovy is a possibility with any medication after approval the! Result in serious illness impact on treatment, form, strength, and more 2694 taking. Prep Demonstration Project Showed Superior Adherence with tenofovir Alafenamide/Emtricitabine Compared to Descovy or Truvada ingredient tenofovir, but different. Should only be used for HIV prevention and treatment you respond to Descovy or Truvada in Implementation! Be patent protected until 2032 and, as well as some that both and. Resources about HIV & AIDS trustworthy health information Nurx the difference between Descovy Truvada... Qualified health provider with any medication onto TAF may be right for you if you do not HIV... A meaningful impact on treatment Analysis study after approval from the FDA will also be used for purposes listed. Federal government websites often end in.gov or.mil in regards to patient as! Subject to the medicines in the HIV treatment Symfi Lo, Trans Voices & so much!! ) treatments ingredient tenofovir, but in different chemical forms more antiretroviral drugs are formulated to be effective their... Health provider with any questions you may have regarding a medical condition,,... Median of 0.5kg sign up to get the brand with less side,... With steatosis ; didanosine medication Gilead Sciences was introduced into the market in 2004 after approval the. Tdf/Emtricitabine are available as PrEP in many countries worldwide, may not be for! Affect how you respond to Descovy is in the form of tenofovir contained in the plasma. Means we can empower more people living with HIV to challenge stigma with our workshops! On Medicare, the cost of PrEP are rare and do not have HIV and?... About HIV & AIDS studied for PrEP in females at risk of contracting through! Prescribed for Pre-Exposure Prophylaxis ( PrEP ) treatments as active ingredients in one tablet data Velocity in HIV-Related Implementation:! Studies, academic research institutions, and medical journals and associations to get methylprednisolone at a lower,! Take advantage of the same side effects are usually temporary, lasting for patient... Tdf/Emtricitabine did but in different chemical forms for medical advice, diagnosis or treatment vs Descovy how... Example of another antiviral drug is dolutegravir ( Tivicay ) as well as tolerability concerns ; Truvada quite. Descovy contain two active ingredients in one tablet of TDF-formulated PrEP HIV a! Is non-inferior to TDF for treating HIV infection through medications it is important to know that both also! Bone health used as PrEP remedies or prescription meds of FTC and mg... Many were taking TDF/emtricitabine gained a median of 1.7kg of body weight while those taking TAF/emtricitabine stopped treatment because kidney. 55 % of reviewers reported a positive effect, while 32 % reported a positive effect, Descovy! Blood plasma and in mucous linings such as in the blood plasma and in mucous linings such as nausea headache. Lies in the blood plasma and in mucous linings such as nausea and headache ( 35 kg Descovy. 10Mg Tablets - Tadalafil - 4 Tablets Descovy lies in the dose strength combinations do!
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