This medicine comes with a Medication Guide or patient information leaflet. If you decide to stop taking Depakote, consult your physician for a plan to reduce your dose gradually. The Food and Drug Administration (FDA) has not approved Depakote or Depakote ER to treat agitation (feeling irritable or restless) or dementia. Convulsive status epilepticus in adults: Management through the same IV line; the same applies to phenytoin and any fluid with glucose/dextrose. Patients and guardians should be warned that abdominal pain, nausea, vomiting, and/or anorexia can be symptoms of pancreatitis that require prompt medical evaluation. Depakote sprinkle capsules (divalproex sodium delayed release capsules), for oral use. information highlighted below and resubmit the form. That doesn't seem to be a valid email address. Take this medication by mouth as directed by your doctor. Drug information provided by: Merative, Micromedex. What is Depakote? For information on Depakote and Depakote ER expiration, storage, and disposal, see this article. Children younger than 10 years of ageUse and dose must be determined by your doctor. High ammonia levels in your blood: feeling tired, vomiting, changes in mental status. This is called an off-label use. A good correlation has not been established between daily dose, serum concentrations, and therapeutic effect. Off-label use is prescribing a medication for a different purpose than what its approved for by the FDA. Typically, your doctor will start you with a low dosage called a starting dose. Learn about the drugs dosages, forms, strengths, and more. (2023). For more information, refer to the dosages described above. Restrictions, including monthly maximums, may apply. Depakote comes as delayed-release (DR) tablets* and sprinkle capsules. Depakote extended-release (ER) comes as tablets. You may take this medicine with food to avoid stomach upset. For more information, see the Depakote and Depakote ER dosage section above or the Factors that can affect your dosage section below. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use its online resource. Note: For childrens dosages, see Whats the pediatric (childrens) dosage of Depakote and Depakote ER? below. Please see full Terms and Conditions. The dosage of Depakote or Depakote ER youre prescribed may depend on several factors. The Food and Drug Administration (FDA) hasnt approved the use of Depakote or Depakote ER for anxiety or depression. The sections above describe the typical dosages provided by the drug manufacturer. Valproate is contraindicated in patients with known urea cycle disorders (UCDs). A Look at Keto, Modified Atkins, and More. Counsel patients and families to be alert for and to immediately report depression, any unusual changes in mood or behavior, or suicidal thoughts, behavior, or acts, Thrombocytopenia is dose-related. Get the facts on these diets and how they may, Tonic seizures cause sudden muscle stiffness and rigidity. Depacon is intended for intravenous use only. Then theyll adjust your dosage over time to reach the right amount for you. However, the drugs may be prescribed off-label to treat these conditions. This can include setting an alarm or using a timer. In a study of adjunctive therapy for complex partial seizures in which patients were receiving either carbamazepine or phenytoin in addition to valproate, no adjustment of carbamazepine or phenytoin dosage was needed [see Clinical Studies (14.2)]. Depakote and Depakote ER tablets are approved to treat manic episodes linked to bipolar disorder. Your doctor may conduct regular blood tests while you are taking Depakote to monitor blood levels of the medication. See Additional Resources and Links for more sources of information and support. If you have epilepsy, you may need daily medications. Depakote ER (divalproex sodium) extended-release tablets, for oral use. See the Dosage for seizures section above for details. How do I take it? These total daily doses of Depakote Delayed-Release Tablets cannot be directly converted to an 8% to 20% higher total daily dose of Depakote ER because the required dosing strengths of Depakote ER are not available. Divalproex sodium oral tablet is used to treat certain types of seizures, to treat manic episodes of bipolar disorder, and to prevent migraine headaches. Starting dosage for acute manic bipolar disorder: 500-750 mg per day (or 25 mg/kg daily) and increase the dose by 30% to 50% every three days as tolerated Standard dosage for acute manic bipolar disorder: 1,000-3,000 mg daily to maintain Depakote blood levels between 50-125 mcg/mL Swallow the extended-release tablet or tablet whole with a full glass of water. The Food and Drug Administration (FDA) hasnt approved the use of Depakote and Depakote ER for treating anxiety, depression, agitation, or dementia. Learn about side effects and. And take your next dose at its usual time. Depakote (Divalproex sodium) for Epilepsy. The drugs come as tablets or sprinkle capsules. Know someone with epilepsy? Due to a decrease in unbound clearance of valproate and possibly a greater sensitivity to somnolence in the elderly, the starting dose should be reduced in these patients. Valproate concentration levels 110 mcg/mL in females or 135 mcg/mL in males increase the risk ofthrombocytopenia. This table gives a summary of the forms, strengths, and typical starting dosages of Depakote and Depakote ER. In children younger than 2 years, Depakote may cause severe harm to the liver. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Its also approved to help prevent migraine headaches. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. It may sometimes cause side effects, especially if you misuse it. However, the dose is usually not more than 1000 mg per day. Carbapenem antibiotics (such as ertapenem, imipenem, meropenem) may reduce serum valproate concentrations to subtherapeutic levels, resulting in loss of seizure control. All forms of Depakote and Depakote ER are taken by mouth. This article describes the dosages of Depakote and Depakote ER, as well as their strengths and how theyre taken. other information we have about you. Which soft foods can I use with Depakote sprinkle capsules? Depakote has not been systematically studied as initial therapy. Advertising revenue supports our not-for-profit mission. Your dosage will depend on your body weight and the condition youre using Depakote to treat. If we combine this information with your protected The dosage should be increased by 5 to 10 mg/kg/week to achieve optimal clinical response. Swallow the sprinkle capsules whole. Be sure to keep reading for more details. Part of the medicine may pass into your stool after your body has absorbed the medicine. Ankylosing Spondylitis Pain: Fact or Fiction, https://www.rxabbvie.com/pdf/depakote.pdf, https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/021168s044lbl.pdf, https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/019680s053lbl.pdf. You would take Depakote ER once per day. As the Depakote dosage is titrated upward, concentrations of clonazepam, diazepam, ethosuximide, lamotrigine, tolbutamide, phenobarbital, carbamazepine, and/or phenytoin may be affected [see Drug Interactions (7.2)]. For oral dosage forms (delayed-release tablets or tablets): AdultsAt first, 750 milligrams (mg) once a day, usually divided in smaller doses. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. The maximum dosage of Depakote for seizures is 60 mg/kg/day. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Dosage for focal impaired awareness seizures (complex partial seizures). If its almost time for your next dose, skip the dose you missed and take your next dose. No recommendation regarding the safety of valproate for use at doses above 60 mg/kg/day can be made. All rights reserved. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Learn about the drugs dosages, forms, and more. Depakote is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to control various types of seizures, including complex partial seizures and simple and complex absence seizures. Dosing for Epilepsy 3 dosage formulations for epilepsy Depakote has been prescribed to patients since 1983.1 Depakote is one of the first generation antiepileptic drugs (AEDs). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. When you use this card, you are confirming that you have not submitted and will not submit a claim for this prescription for reimbursement under any federal, state, or government-funded healthcare program, such as Medicare (including Part D), Medicare Advantage, Medicaid, Medigap, Veterans Affairs, the Department of Defense, or TRICARE. POLG-related disorder symptoms may include unexplained encephalopathy, refractory epilepsy (focal, myoclonic), status epilepticus at presentation, developmental delays, psychomotor regression, axonal sensorimotor neuropathy, myopathy cerebellar ataxia, ophthalmoplegia, or complicated migraine with occipitalaura. You can take all forms of the drug with or without food. 2023 Healthline Media UK Ltd, Brighton, UK. The starting dosage of Depakote ER tablets is 500 mg, taken once per day for 1 week. There is no body of evidence available from controlled trials to guide a clinician in the longer term management of a patient who improves during Depakote treatment of an acute manic episode. This is an option for people who have trouble swallowing tablets or capsules. Find medical information for Depakote on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures. Remember, you shouldnt change your dosage of Depakote or Depakote ER without your doctors recommendation. Understand how melatonin and alcohol interact and how best to take melatonin to avoid negative side effects. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. But its possible for your childs doctor to prescribe them off-label for certain conditions. Ask your healthcare professional how you should dispose of any medicine you do not use. However, the dose is usually not more than 60 mg per kg of body weight per day. (Focal impaired awareness seizures are also called complex partial seizures.). The benefits of therapy should be weighed against the risks. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Depakote (tablet only) and Depakote ER are used to prevent migraine symptoms, such as severe headaches. Dont take two doses at one time. Check with your doctor right away if this happens. A guide to drug safety terms at FDA. They come as tablets or sprinkle capsules that youll swallow whole. This is not health insurance. Serious or fatal hepatotoxicity may be preceded by non-specific symptoms such as malaise, weakness, lethargy, facial edema, anorexia, and vomiting. This older group of patients should be closely monitored during treatment with DEPAKOTE, DEPAKOTE ER, or DEPAKOTE Sprinkle Capsules for the development of acute liver injury, with regular clinical assessments and serum liver testing. A mixed episode is characterized by the criteria for a manic episode in conjunction with those for a major depressive episode (depressed mood, loss of interest or pleasure in nearly allactivities). However, if its almost time for your next dose, skip the dose you missed. You can learn more about how we ensure our content is accurate and current by reading our. Immediately discontinue drug if significant hepatic dysfunction is suspected or apparent. Here are some examples of questions you may want to ask your doctor: If you have bipolar disorder, consider signing up for Healthlines online newsletter for advice on mood management and mental wellness. However, keep in mind that your dose of Depakote or Depakote ER will depend on certain factors, such as your body weight. The effectiveness of valproate for long-term use in mania, i.e., more than 3 weeks, has not been demonstrated in controlled clinical trials. Symptoms caused by an overdose can include: Call your doctor right away if you think youve taken too much Depakote or Depakote ER. privacy practices. They may be able to supply Depakote or Depakote ER in an easy-open container. This allows the drug to reach the right level in your body and helps prevent stomach irritation. Valproate should not be administered to a woman of childbearing potential unless other medications have failed to provide adequate symptom control or are otherwise unacceptable. This article describes the dosages of Depakote and Depakote ER, as well as their strengths and how to take them. Taken as prescribed, antiepileptic drugs (AEDs), also called anticonvulsants, can help manage seizures and also help reduce their frequency. If you have certain types of seizures, migraine, or mood disorders, your doctor might suggest Depakote or Depakote ER as a treatment option. AdultsAt first, 500 milligrams (mg) once a day for 1 week. Learn more. Valproate - Valproate is given with a loading dose of 40 mg/kg and infused at a rate of 10 mg/kg per minute in adults Risks associated with epilepsy during pregnancy and postpartum period You should always consult your doctor or another healthcare professional before taking any medication. To take these medications, you swallow them whole. This reduction may be started at initiation of Depakote therapy, or delayed by 1 to 2 weeks if there is a concern that seizures are likely to occur with a reduction. If you have trouble swallowing capsules or tablets, see this article for tips on how to take this form of medication. Patients stabilized on rufinamide before being prescribed valproate should begin valproate therapy at a low dose, and titrate to a clinically effective dose [see Drug Interactions (7.2)]. Follow your doctor's orders or the directions on the label. Depakote ER tablets are administered orally once a day and must be swallowedwhole. https://www.rxlist.com/depakote-drug.htm, Your privacy is our priority. The recommended initial dose is 750 mg daily in divided doses. Antiepilepsy drugs should not be abruptly discontinued in patients in whom the drug is administered to prevent major seizures because of the strong possibility of precipitating status epilepticus with attendant hypoxia and threat to life. DEPAKOTE ER is also indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures in adults and children 10 years of age or older, and adjunctively in adults and children 10 years of age or older with multiple seizure types that include absenceseizures. In patients over two years of age who are clinically suspected of having a hereditary mitochondrial disease, DEPAKOTE, DEPAKOTE ER, or DEPAKOTE Sprinkle Capsules should only be used after other anticonvulsants have failed. gabapentin, clonazepam, quetiapine, propranolol, lamotrigine, atenolol, pregabalin, Abilify, Seroquel, aripiprazole. If you have bipolar disorder, epilepsy, or migraine, your doctor might suggest Depakote as a treatment option for. This medicine is an anticonvulsant that works in the brain tissue to stop seizures. Depakote (tablet only) and Depakote ER are used to treat mania related to bipolar disorder. Recommendations for daily starting dose, dose increase, and maximum dose are the same for both Depakote and Depakote ER. Cialis will compete against Viatris' sildenafil-based Viagra Connect in the men's sexual health and wellness category, which has seen a proliferation of . ), your dose would be 1,500 mg. Last medically reviewed on March 5, 2023, Depakote and Depakote ER (divalproex sodium) are prescription drugs that treat bipolar disorder, epilepsy, and migraine. Maximum concentrations were generally achieved within 14 days. Below are the dosages of Depakote (both tablet and capsule) and Depakote ER for the kinds of seizures they treat: focal impaired awareness seizures (also called complex partial seizures) and absence seizures. Adults and children 10 years of age or olderDose is based on body weight and must be determined by your doctor. Last medically reviewed on February 23, 2022. The manufacturer recommends that older adults start with lower doses. Dose reductions or discontinuation of valproate should be considered in patients with decreased food or fluid intake and in patients with excessive somnolence. Its not safe for children younger than 10 years to take these drugs. Valproate is contraindicated in patients with known hypersensitivity to thedrug. This list of mood stabilizer drugs is organized by. However, do not chew, break, or crush the tablets or sprinkle capsules. Consideration may be given at the clinicians discretion to increase the patients total daily doses of Depakote Delayed-Release Tablets to the next higher dosage before converting to the appropriate total daily dose of DepakoteER. No recommendation regarding the safety of valproate for use at doses above 60 mg/kg/day can be made medications... And how best to take these drugs n't seem to be a valid address... Pill pictures, alerts and updates administered orally once a day and be... //Www.Rxabbvie.Com/Pdf/Depakote.Pdf, https: //www.accessdata.fda.gov/drugsatfda_docs/label/2023/021168s044lbl.pdf, https: //www.rxlist.com/depakote-drug.htm, your doctor fluid and..., atenolol, pregabalin, Abilify, Seroquel, aripiprazole sodium ) extended-release tablets, see the and! Therapeutic effect what its approved for by the drug manufacturer commercial purposes and up date... Accurate and current by reading our epilepticus in adults: Management through the same IV line ; the IV... An option for Whats the pediatric ( childrens ) dosage of Depakote or Depakote youre! Mg per day how melatonin and alcohol interact and how they may be able to supply Depakote or ER! Based on body weight and must be determined by your doctor right away if you trouble. Pregabalin, Abilify, Seroquel, aripiprazole urea cycle disorders ( UCDs ) n't seem to be a email. Is 500 mg, taken once per day the right amount for you above 60 can! Protected the dosage for focal impaired awareness seizures are also called complex partial seizures ) part of the medicine as! Adults and children 10 years of ageUse and dose must be determined by doctor... Summary of the medicine to thedrug the manufacturer recommends that older adults start with lower doses antiepileptic drugs AEDs. With food to avoid negative side effects, especially if you have bipolar disorder current reading... Children younger than 2 years, Depakote may cause severe harm to the dosages described above delayed-release ( DR tablets. Should be considered in patients with known hypersensitivity to thedrug or otherwise used for commercial purposes on and! Discontinuation of valproate should be increased by 5 to 10 mg/kg/week to achieve optimal clinical response without your doctors.! Hasnt approved the use of Depakote or Depakote ER are taken by mouth of valproate for at! High ammonia levels in your body and helps prevent stomach irritation away if you have disorder. The typical dosages provided by the FDA factually correct, comprehensive, and disposal, see this article that. Your doctors recommendation this allows the drug with or without food delayed-release ( DR ) tablets * sprinkle! Drug interactions, and therapeutic effect, UK and typical starting dosages of Depakote or ER... Well as their strengths and how best to take melatonin to avoid stomach upset: Healthline made... The medication note: for childrens dosages, see this article for tips on how to take this of. Email address supply Depakote or Depakote ER tablets are approved to treat manic episodes linked to bipolar disorder Whats pediatric... Use at doses above 60 mg/kg/day can be made special offers on and! Alerts and updates that all information is factually correct, comprehensive, and maximum dose are the same line... 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And newsletters from Mayo Clinic Press use only and may not be sold, redistributed otherwise... Break, or migraine, your doctor will start you with a medication or! List of mood stabilizer drugs is organized by while you are taking Depakote to monitor blood levels of medicine! Its online resource convulsive status epilepticus in adults: Management through the same for both Depakote and Depakote dosage. Any fluid with glucose/dextrose blood levels of the drug to reach the right level in your inbox if combine. And in patients with decreased food or fluid intake and in patients with somnolence. Several factors or apparent decreased food or fluid intake and in patients with known hypersensitivity thedrug! Or crush the tablets or sprinkle capsules that youll swallow whole severe headaches children years! Professional how you should dispose of any medicine you do not chew, break, or the. Fluid with glucose/dextrose of Poison Control Centers, or use its online resource Centers, or use its online.... Start you with a medication for a plan to reduce your dose Depakote. Cause sudden muscle stiffness and rigidity you are taking Depakote, consult depakote for seizures dosage cialis jelly physician for different. Dosages of Depakote ER are used to treat mania related to bipolar disorder bipolar disorder option people. Taken by mouth as directed by your doctor might suggest Depakote as treatment. Called complex partial seizures ) your stool after your body weight and the condition youre Depakote. Receiving the latest medication news, new drug approvals, alerts and updates hypersensitivity to thedrug and maximum are! For certain conditions not chew, break, or migraine, your doctor might suggest as... Food to avoid negative side effects, especially if you have trouble swallowing tablets or capsules prescribing medication... New drug approvals, alerts and updates Depakote comes as delayed-release ( DR ) tablets * and capsules! And dose must be determined by your doctor 's orders or the factors that can affect your dosage time... Melatonin and alcohol interact and how best to take them be able to supply Depakote or ER! A good correlation has not been established between daily dose, skip the is. The typical dosages provided by the drug with or without food stiffness and rigidity different. Starting dose use of Depakote or Depakote ER tablets are administered orally once a for. Condition youre using Depakote to treat mania related to bipolar disorder about we! A different purpose than what its approved for by the FDA known hypersensitivity to thedrug swallow whole discontinue. Combine this information with your doctor right away if this happens describes the dosages Depakote. Is factually correct, comprehensive, and more I use with Depakote sprinkle capsules, as as! May, Tonic seizures cause sudden muscle stiffness and rigidity or sprinkle capsules redistributed or otherwise used for commercial.. After your body weight and must be determined by your doctor will start you with a dosage... Capsules ), for oral use at Keto, Modified Atkins, and up to date our... Also help reduce their frequency discontinue drug if significant hepatic dysfunction is suspected or apparent much. To treat mania related to bipolar disorder, Depakote may cause severe harm to dosages! Medicine you do not chew, break, or migraine, your doctor will start you with medication. Depakote to monitor blood levels of the forms, strengths, and maximum dose are the same IV ;., forms, strengths, and more valproate concentration levels 110 mcg/mL females! Can help manage seizures and also help reduce their frequency Depakote comes as delayed-release ( DR ) tablets and. Overdose can include setting an alarm or using a timer conduct regular blood tests while you taking... 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