Additive drowsiness or other CNS effects may occur. 4 mg PO 2 to 3 times per day. May increase if needed. Phenobarbital; Hyoscyamine; Atropine; Scopolamine: (Moderate) Additive CNS depression may occur if barbiturates are used concomitantly with cyproheptadine. Pramipexole: (Moderate) Concomitant use of pramipexole with other CNS depressants, such as sedating H1-blockers, can potentiate the sedation effects of pramipexole. It may also be used to relieve the itching of allergic skin conditions, and to treat hives, including hives caused by exposure to cold temperatures and by rubbing the skin. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. government site. Bookshelf Clinical Drug Interactions Source: Medscape from WebMD. Dosage should be reduced for patients with hepatic impairment; however, specific guidelines for dosage adjustments are not available. Pertuzumab; Trastuzumab; Hyaluronidase: (Minor) H1-blockers (antihistamines), when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Oral piperidine antihistamine (H1-blocker) that also antagonizes serotonin receptorsHas sedative and anticholinergic effectsPrimarily used to treat perennial and seasonal allergic rhinitis, vasomotor rhinitis, urticaria, and allergic conditions in adults and children as young as 2 years, Cyproheptadine/Cyproheptadine Hydrochloride Oral Sol: 2mg, 5mLCyproheptadine/Cyproheptadine Hydrochloride/Periactin Oral Tab: 4mg. 2011 Aug;49(7):681-3. doi: 10.3109/15563650.2011.602085. The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Agomelatine. The American Academy of Pediatrics considers loratadine and fexofenadine to be usually compatible with breast-feeding. Though often called "female Viagra," Addyi (flibanserin) and Vyleesi (bremelanotide) are designed to enhance sexual desire in females, but they do not affect physical performance. Glycopyrrolate; Formoterol: (Moderate) Monitor for signs or symptoms of anticholinergic toxicity during concomitant sedating H1-blocker and glycopyrrolate use. This information should not be interpreted without the help of a healthcare provider. Atropine; Edrophonium: (Moderate) Monitor for unusual drowsiness or excess sedation and for signs or symptoms of anticholinergic toxicity during concomitant sedating H1-blocker and atropine use. Concomitant use may result in additive anticholinergic adverse effects. ", Risk of potentially fatal and irreversible, Elderly patients: Avoid use in the elderly because of the high incidence of anticholinergic effects; may exacerbate existing lower urinary conditions or, Use with caution in patients with increased. Treating Underlying Causes. Selegiline: (Moderate) Monitor for excessive sedation and somnolence during coadministration of selegiline and cyproheptadine. Varied evidence of efficacy in literature. Haloperidol: (Moderate) Haloperidol can potentiate the actions of other CNS depressants such as the sedating H1-blockers. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Use antihistamines with caution in patients with asthma. Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. Concomitant use may result in additive anticholinergic adverse effects. Cyproheptadine has been shown to lower serum prolactin levels which may lead to inhibition of lactation. Utilize appropriate caution if carisoprodol is coadministered with another CNS depressant. Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. Concomitant use may result in additive CNS depression or anticholinergic adverse effects. NIDA Res Monogr. Tricyclic antidepressants: (Moderate) Additive anticholinergic and CNS effects may be seen when tricyclic antidepressants are used concomitantly with sedating H1-blockers. Cyproheptadine, a potent histamine (H 1) and 5-HT 2A receptor antagonist, is a widely used antidote for serotonin syndrome. Hydrocodone; Pseudoephedrine: (Moderate) Concomitant use of opioid agonists with cyproheptadine may cause excessive sedation and somnolence. When concurrent use cannot be avoided, monitor the patient for reduced ambenonium efficacy. Rivastigmine inhibits acetylcholinesterase, the enzyme responsible for the degradation of acetylcholine, and improves the availability of acetylcholine. Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. official website and that any information you provide is encrypted Cyproheptadine reportedly has interfered with the antidepressant and anti-bulimia actions of fluoxetine but more data are needed to confirm a direct drug-drug interaction. Unable to load your collection due to an error, Unable to load your delegates due to an error. The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Acetazolamide. 10 Things People With Depression Wish You Knew, Adults: 4 mg orally every 8 hours initially; maintenance: 4-20 mg/day, up to 32 mg/day divided every 8 hours between some patients; not to exceed 0.5 mg/kg/day, Children under 2 years old: Safety and efficacy not established, Children 2-6 years old: 2 mg orally every 8-12 hours; not to exceed 12 mg/day, Children 7-14 years old: 4 mg orally every 8-12 hours; not to exceed 16 mg/day, Alternatively, a total daily dose of 0.25 mg/kg or 8 mg/m, 2-4 mg orally every 8 hours initially; not to exceed 24 mg/day, Adults: 2 mg orally every 12 hours with or without propanol, Children under 3 years: Safety and efficacy not established, Children over 3 years and adolescents: 0.2-0.4 mg/kg/day orally divided twice daily; not to exceed 0.5 mg/kg/day, Adults: 2 mg orally every 6 hours for one week; THEN 4 mg orally every 6 hours, Children under 13 years: Safety and efficacy not established, Children over 13 years: 2 mg orally every 6 hours initially; increased to up to 8 mg every 6 hours over 3 weeks, 4-12 mg orally 1-2 hours before anticipated, 12 mg initially orally, followed by 2 mg every 2 hours or 4-8 mg orally every 6 hours as needed to control symptoms, Advanced age is associated with reduced clearance and greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity; use the lower end of dosage range (4 mg orally every 12 hours) for elderly patients, or administer less frequently, Renal impairment: Elimination is reduced in renal insufficiency; administer lower doses, and monitor closely, Hepatic impairment: Give 75% of normal dose if transaminase levels are greater than 3 times the upper limit of normal (ULN) or bilirubin is 3.1-5 mg/dL, Renal impairment: CrCl less than 10 mL/minute, give 75% of normal dose; CrCl greater than 10 mL/minute, give full dose, Disturbed coordination/loss of coordination, Restlessness or excitability (especially in children), Sedation ranging from mild drowsiness to deep sleep (most frequent), Yellowing skin and eyes (jaundice) (rare), Mental/mood changes (such as restlessness, confusion, hallucinations). Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. Metoclopramide: (Minor) Combined use of metoclopramide and other CNS depressants, such as anxiolytics, sedatives, and hypnotics, can increase possible sedation. Clinicians should keep this in mind when using antimuscarinics and other medications with anticholinergic activity in combination with olanzapine. Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. Benzodiazepines: (Moderate) Coadministration can potentiate the CNS effects (e.g., increased sedation or respiratory depression) of either agent. (Moderate) Monitor for signs or symptoms of anticholinergic toxicity during concomitant sedating H1-blocker and belladonna use. Azelastine: (Major) Avoid concomitant use of azelastine and sedating H1-blockers due to risk for additive CNS depression. For this reason, it would be prudent to monitor for drowsiness during concurrent use of desloratadine with CNS depressants such as other H1-blockers. Metaxalone: (Moderate) Concomitant administration of metaxalone with other CNS depressants can potentiate the sedative effects of either agent. Entacapone: (Moderate) COMT inhibitors should be given cautiously with other agents that cause CNS depression, including sedating H1-blockers, due to the possibility of additive sedation. Some medications exhibit additive anticholinergic effects include sedating H1-blockers. Unauthorized use of these marks is strictly prohibited. Adverse interaction of fluoxetine and cyproheptadine in two patients with bulimia nervosa. Monitor patients for sedation or respiratory depression. Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. Cyproheptadine. Eur J Pharm Sci. Improve clinical decision support with information on. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. Although H1-antagonists should be avoided during an acute asthmatic attack, these anticholinergic effects do not preclude the use of H1-antagonists in all asthmatic or COPD patients, particularly if the above respiratory symptom is not a primary component of the illness. Tramadol; Acetaminophen: (Moderate) Concomitant use of opioid agonists with cyproheptadine may cause excessive sedation and somnolence. This medication contains cyproheptadine. Drug Metab Dispos. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Esta actitud por parte del paparazzi . The https:// ensures that you are connecting to the [, Simon LV, Keenaghan M: Serotonin Syndrome . Monitor patients for sedation or respiratory depression. Batch CBD Full-Spectrum Gummies. Common interactions include agitation among females. 2 to 4 mg PO twice daily. A woman has told how she feared she'd never become a mum but gave birth to a boy at age 45 after taking Viagra to get pregnant.. Carin Rockind, 48, welcomed a "miracle" baby after trying to have a . Dosage reduction of one or both agents may be necessary. (Moderate) Monitor for unusual drowsiness or excess sedation and for signs or symptoms of anticholinergic toxicity during concomitant sedating H1-blocker and atropine use. Dosage adjustments of one or both medications may be necessary. Ropinirole: (Moderate) Concomitant use of ropinirole with other CNS depressants, such as sedating H1-blockers, can potentiate the sedation effects of ropinirole. Although cyproheptadine has only moderate anticholinergic effects, use is contraindicated in patients with bladder obstruction, stenosing peptic ulcer disease, pyloroduodenal GI obstruction, and symptomatic prostatic hypertrophy. Meperidine: (Moderate) Concomitant use of opioid agonists with cyproheptadine may cause excessive sedation and somnolence. Pentazocine: (Moderate) Use pentazocine with caution in any patient receiving medication with CNS depressant and/or anticholinergic activity. rate, decr. Concurrent use may result in additive CNS depression. Max: 16 mg/day. In addition, additive anticholinergic effects may be seen when paroxetine is used with antihistamines having anticholinergic properties such as cyproheptadine. J Clin Psychopharmacol. Alternatively, if a patient is receiving an amphetamine for treatment of narcolepsy, the combination with a sedating antihistamine may reverse the action of the amphetamine. Cyclobenzaprine: (Moderate) Cyclobenzaprine and cyproheptadine exhibit additive anticholinergic activity. Federal government websites often end in .gov or .mil. Acetaminophen; Dichloralphenazone; Isometheptene: (Moderate) Additive CNS depression may occur if dichloralphenazone is used concomitantly with any of the sedating H1 blockers. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Concomitant administration of apomorphine and cyproheptadine could result in additive depressant effects. Acetaminophen; Caffeine; Dihydrocodeine: (Moderate) Concomitant use of opioid agonists with cyproheptadine may cause excessive sedation and somnolence. Cyproheptadine is contraindicated in patients with closed-angle glaucoma. Monitor for anticholinergic-related effects such as constipation and urinary retention. Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. It is created by eHealthMe based on reports of 7 people who take Claritin and Cyproheptadine hydrochloride from the FDA, and is updated regularly. Diphenoxylate; Atropine: (Moderate) An enhanced CNS depressant effect may occur when diphenoxylate/difenoxin is combined with other CNS depressants. Max: 16 mg/day. Dexmedetomidine: (Moderate) Co-administration of dexmedetomidine with sedating antihistamines is likely to lead to an enhancement of CNS depression. Meperidine; Promethazine: (Moderate) Concomitant use of opioid agonists with cyproheptadine may cause excessive sedation and somnolence. The symptoms preceding these deaths have not been clearly defined, and there is a lack of conclusive data describing the exact cause of death. Difelikefalin: (Moderate) Monitor for dizziness, somnolence, mental status changes, and gait disturbances if concomitant use of difelikefalin with CNS depressants is necessary. Lofexidine: (Moderate) Monitor for excessive hypotension and sedation during coadministration of lofexidine and cyproheptadine. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first. The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Acetophenazine. Seizures in the newborn have been reported after use of other H1-antagonists, such as hydroxyzine, late in pregnancy. Lumateperone: (Moderate) Monitor for excessive sedation and somnolence during coadministration of lumateperone and cyproheptadine. [, FDA Approved Drug Products: Cyproheptadine hydrochloride tablets for oral use [, TGA Approved Medications: Periactin (cyproheptadine hydrochloride) tablets for oral use [, Health Canada Labelling Standard: Cyproheptadine [, Murfreesboro Pharmaceutical Nursing Supply, Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Adverse consequences of fluoxetine-MAOI combination therapy. Ziprasidone: (Moderate) Sedating H1-blockers are associated with sedation; therefore, additive effects may be seen during concurrent use with other drugs having CNS depressant properties such as antipsychotics. Patients should be advised to avoid driving or other tasks requiring mental alertness until they know how the combination affects them. Additive anticholinergic effects may occur. It is recommended that the concurrent use of MAOIs with drugs possessing anticholinergic activity, such as cyproheptadine, be avoided since their effects and those of other anticholinergic drugs are potentiated and may become severe. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. In addition, medications that decrease salivation increase the time of radiation exposure to salivary glands. Prior to concurrent use of buprenorphine in patients taking a CNS depressant, assess the level of tolerance to CNS depression that has developed, the duration of use, and the patient's overall response to treatment. Graham Head, 66, who kidnapped and tried to rape two women, was caught after one victim remembered three digits of his car registration. Mirtazapine should be administered cautiously with such agents because the CNS effects on cognitive performance and motor skills can be additive. Sedating H1-blockers may exhibit significant anticholinergic activity, thereby interfering with the therapeutic effect of donepezil. From: Drugs for Pregnant and Lactating Women (Third Edition), 2019. According to the Beers Criteria, first-generation sedating antihistamines are considered potentially inappropriate medications (PIMs) in elderly patients; avoid use as they are highly anticholinergic, there is reduced clearance in advanced age, tolerance develops when used as hypnotics, and there is a greater risk of anticholinergic effects (e.g., confusion, dry mouth, constipation) and toxicity compared to younger adults. Concomitant use may result in additive anticholinergic adverse effects. Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. Additive effects of sedation and dizziness can occur, which can impair the ability to undertake tasks requiring mental alertness. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Thalidomide: (Major) Avoid the concomitant use of thalidomide with opiate agonists; antihistamines; antipsychotics; anxiolytics, sedatives, and hypnotics; and other central nervous system depressants due to the potential for additive sedative effects. Amantadine: (Moderate) Medications with significant anticholinergic activity may potentiate the anticholinergic effects of amantadine, and may increase the risk of antimuscarinic-related side effects. Remifentanil: (Moderate) Concomitant use of opioid agonists with cyproheptadine may cause excessive sedation and somnolence. Prescribers should re-assess patients for drowsiness or sleepiness regularly throughout treatment, especially since events may occur well after the start of treatment. Cyproheptadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Use caution with this combination. Disclaimer. Alternatively, if a patient is receiving an amphetamine for treatment of narcolepsy, the combination with a sedating antihistamine may reverse the action of the amphetamine. Ziconotide: (Moderate) Sedating H1-blockers are CNS depressant medications that may increase drowsiness, dizziness, and confusion that are associated with ziconotide. Mirtazapine: (Moderate) Consistent with the CNS depressant effects of mirtazapine, additive effects may occur with other CNS depressants such as cyproheptadine. Aspirin, ASA; Carisoprodol; Codeine: (Moderate) Carisoprodol is metabolized to meprobamate, a significant CNS depressant. Combination therapy can cause additive effects of sedation and dizziness, which can impair the patient's ability to undertake tasks requiring mental alertness. midodrine. False study results are possible; thorough patient history is important in the interpretation of procedure results. cyproheptadine oral brand names and other generic formulations include: Cyprodine Oral, Cypromar Oral, Periactin Oral, Vita-Rx Oral. Limit the use of opioid pain medication with cyproheptadine to only patients for whom alternative treatment options are inadequate. 8 are major, 308 are moderate, and 2 are minor. Apomorphine: (Moderate) Apomorphine causes significant somnolence. Dantrolene: (Moderate) Because sedating H1-blockers cause sedation, an enhanced CNS depressant effect (e.g., drowsiness) may occur when dantrolene is combined with other CNS depressants. Patients should avoid activities requiring full alertness (e.g., operating machinery or driving) until at least 6 hours after each dose and until they know how flibanserin affects them. Concomitant use may result in additive anticholinergic adverse effects. Alternatively, if a patient is receiving an amphetamine for treatment of narcolepsy, the combination with a sedating antihistamine may reverse the action of the amphetamine. Oxybutynin: (Moderate) Monitor for signs or symptoms of anticholinergic toxicity during concomitant sedating H1-blocker and oxybutynin use. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. Concomitant use may result in additive CNS depression or anticholinergic adverse effects. Most frequently checked interactions View interaction reports for cyproheptadine and the medicines listed below. Guaifenesin; Hydrocodone; Pseudoephedrine: (Moderate) Concomitant use of opioid agonists with cyproheptadine may cause excessive sedation and somnolence. Cyproheptadine is contraindicated in older, debilitated adult patients. Sodium Iodide: (Moderate) Antihistamines may alter sodium iodide I-131 pharmacokinetics and dynamics for up to 1 week after administration. Venlafaxine: (Moderate) Cyproheptadine is a serotonin and histamine antagonist. Smoothie. The FDA recommends that if parents and caregivers use cough and cold products in children greater than 2 years, labels should be read carefully, caution should be used when administering multiple products, and only measuring devices specifically designed for use with medications should be used. Flavoxate: (Moderate) Monitor for signs or symptoms of anticholinergic toxicity during concomitant sedating H1-blocker and flavoxate use. Concomitant use may result in additive anticholinergic adverse effects. Aspirin, ASA; Butalbital; Caffeine: (Moderate) Additive CNS depression may occur if barbiturates are used concomitantly with cyproheptadine. Nefazodone: (Moderate) An enhanced CNS depressant effect may occur when sedating H1-blockers are combined with other CNS depressants including nefazodone. Female Humans Middle Aged Paroxetine / adverse effects* Paroxetine / pharmacology Psychoses, Substance-Induced / etiology Substances Cyproheptadine Paroxetine In January 2008, the FDA issued a Public Health Advisory recommending that OTC cough and cold products not be used in infants and children less than 2 years. Olanzapine may also cause additive sedation with many of these drugs. Careful monitoring is recommended during combined use. For the second half of the tour, QOTSA will join forces with likeminded spirits Viagra Boys and with former Savages leader Jehnny Beth. 4 mg PO 3 times per day. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. Consider discontinuing sedating H1-blockers prior to sodium iodide I-131 administration. J Pharmacol Sci. Concomitant use may result in additive anticholinergic adverse effects. Female | On medication for less than 1 month | Caregiver . Glycopyrrolate: (Moderate) Monitor for signs or symptoms of anticholinergic toxicity during concomitant sedating H1-blocker and glycopyrrolate use. Belladonna; Opium: (Moderate) Concomitant use of opioid agonists with cyproheptadine may cause excessive sedation and somnolence. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Use cyproheptadine with caution in children because a paradoxical CNS stimulation and/or respiratory depression can occur. Copyright 2023 by RxList Inc. An Internet Brands company. There is 1 alcohol/food interaction with cyproheptadine. Drug Interactions Female Fluoxetine / administration & dosage* Humans Migraine Disorders / complications Migraine Disorders / prevention & control* Serotonin Antagonists / administration & dosage* Serotonin Uptake Inhibitors / administration & dosage* Substances Serotonin Antagonists Serotonin Uptake Inhibitors Fluoxetine Cyproheptadine Cyproheptadine is extensively metabolized in the liver. Although these cardiovascular effects are uncommon, H1-antagonists should be used conservatively in patients with cardiac disease. Levocetirizine: (Moderate) Monitor for unusual drowsiness and sedation, urinary retention, and reduced gastric motility during coadministration of cetirizine and sedating H1-blockers. Healthcare provider for additive CNS depression can be increased when cyproheptadine is combined with Acetazolamide and sedation during of. ; Scopolamine: ( Moderate ) an enhanced CNS depressant desloratadine with CNS depressants therapy can cause additive effects sedation... 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