Clinical Trials, See full prescribing information for DICYCLOMINE HYDROCHLORIDE. Dicyclomine hydrochloride oral solution 10 mg/5 mL. A dose reduction from 160 mg daily to an average daily dose of 90 mg was required in 46% of the patients with side effects who then continued to experience a favorable clinical response; their side effects either disappeared or were tolerated. dehydration --dizziness, confusion, feeling very thirsty, less urination or sweating. Dicyclomine should never be given to a child younger than 6 months old. Dicyclomine hydrochloride is contraindicated in infants less than 6 months of age [see Use in Specific Populations (8.4)], nursing mothers [see Use in Specific Populations (8.3)] and in patients with: unstable cardiovascular status in acute hemorrhage, myasthenia gravis [see Warnings and Precautions (5.4)], glaucoma [see Adverse Reactions (6.3)and Drug Interactions (7.1)], obstructive uropathy [see Warnings and Precautions (5.8)], obstructive disease of the gastrointestinal tract [see Warnings and Precautions (5.5)], severe ulcerative colitis [see Warnings and Precautions (5.7)]. Nine percent (9%) of patients were discontinued from dicyclomine hydrochloride because of one or more of these side effects (compared with 2% in the placebo group). This includes prescription and over-the-counter medicines, vitamins, and herbal products. Older adults may be more sensitive to the effects of dicyclomine. Excretion also occurs in the feces, but to a lesser extent (8.4%). Abuse of and/or dependence on dicyclomine for anticholinergic effects have been rarely reported. Documented safety data are not available for doses above 80 mg daily for periods longer than 2 weeks. Mean volume of distribution for a 20 mg oral dose is approximately 3.65 L/kg suggesting extensive distribution in tissues. Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and Precautions Adverse Reactions/Side Effects Clinical Studies Drug Interactions Use In Specific Populations Overdosage Description Clinical Pharmacology Nonclinical Toxicology How Supplied/Storage and Handling Patient Counseling Information 1 Aluminum Lake, Lactose Monohydrate, Magnesium Stearate, and Microcrystalline Cellulose. Rarely, fatigue, sedation, constipation, urinary retention, rash, nausea, vomiting and headache. Dicyclomine hydrochloride is contraindicated in patients with severe ulcerative colitis [see Contraindications (4)]. In subsequent studies, plasma concentrations were followed for up to 24 hours after a single dose, showing a secondary phase of elimination with a somewhat longer half-life. Dicyclomine is in a class of medications called anticholinergics. In this instance, treatment with this drug would be inappropriate and possibly harmful [ see Contraindications (4)]. you should know that dicyclomine reduces the body's ability to cool off by sweating. Available for Android and iOS devices. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range in adults, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Treatment should consist of gastric lavage, emetics, and activated charcoal. These CNS signs and symptoms usually resolve within 12 to 24 hours after discontinuation of the drug. In controlled clinical trials involving over 100 patients who received drug, 82% of patients treated for functional bowel/irritable bowel syndrome with dicyclomine hydrochloride at initial doses of 160 mg daily (40 mg four times daily) demonstrated a favorable clinical response compared with 55% treated with placebo (p<0.05). Dicyclomine hydrochloride can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function. Confusion and mood or behavior changes may be more likely in older adults. This action is achieved via a dual mechanism: (1) a specific anticholinergic effect at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle. Do not drive a car or operate machinery until you know how this medication affects you. Treatment should consist of gastric lavage, emetics, and activated charcoal. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The principal route of excretion is via the urine (79.5% of the dose). Many drugs can affect dicyclomine, especially: cold or allergy medicine (Benadryl and others); medicine to treat depression, anxiety, mood disorders, or mental illness; medicine to treat Parkinson's disease; or. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Presence in Breast Milk, Medline Plus, All Rights reserved - Copyright DrugLib.com, 2006-2017, Drug Interactions, Overdosage, Contraindications, Other Rx Info. Dialysis. The following adverse reactions, presented by system organ class in alphabetical order, have been identified during post approval use of dicyclomine hydrochloride. Easily compare up to 40 drugs with our drug interaction checker. These events resolved after discontinuing the dicyclomine. 1997 Feb 12;320(2-3):209-14. Contraindicated in obstructive uropathy, obstructive disease of the gastrointestinal tract, severe ulcerative colitis, reflux esophagitis, unstable cardiovascular status in acute hemorrhage, glaucoma, myasthenia gravis, evidence of prior hypersensitivity to dicyclomine hydrochloride, and infants less than 6 months of age. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. View NDC Code(s)NEW! risk of ulcerative/stenotic lesions (anticholinergics slow GI transit, incr. l Disorders and Administration Site Conditions: To report SUSPECTED ADVERSE REACTIONS, contact Hikma Pharmaceuticals USA Inc. at 1-800-962-8364 or FDA at 1-800-FDA-1088 or, All Drug PubMed, Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Store at 20 to 25C (68 to 77F) [see USP Controlled Room Temperature]. Tests for mydriatic effects in mice showed that dicyclomine was approximately 1/500 as potent as atropine; antisialagogue tests in rabbits showed dicyclomine to be 1/300 as potent as atropine. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer. In very high temperatures, dicyclomine can cause fever and heat stroke. Antihistamines Antipsychotic Agents, Benzodiazepines. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. The following adverse reactions, presented by system organ class in alphabetical order, have been identified during post approval use of Dicyclomine hydrochloride. medicine to treat stomach problems, motion sickness, or irritable bowel syndrome. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Metoclopramide: May antagonize the effects. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. Mean volume of distribution for a 20 mg oral dose is approximately 3.65 L/kg suggesting extensive distribution in tissues. Life Sci. The following agents may increase certain actions or side effects of anticholinergic drugs including Dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. Call your doctor if your symptoms do not improve after 2 weeks. Contraindications Warnings and Precautions Adverse Reactions/Side Effects Drug Interactions Use In Specific Populations Overdosage Description Clinical Pharmacology Nonclinical Toxicology Clinical Studies How Supplied/Storage and Handling Patient Counseling Information INDICATIONS & USAGE you should know that dicyclomine may make you drowsy or cause blurred vision. Tablet 20mg In the presence of a high environmental temperature, heat prostration can occur with Dicyclomine hydrochloride use (fever and heat stroke due to decreased sweating). DESCRIPTION Parenteral and oral antimuscarinic and anticholinergic agent Used for diarrhea-predominant irritable bowel syndrome Boxed warning: do not use in infants less than 6 months of age due to severe side effects COMMON BRAND NAMES Bentyl HOW SUPPLIED Bentyl/Dicyclomine/Dicyclomine Hydrochloride Intramuscular Inj Sol: 1mL, 10mg American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. In three of the infants who died following administration of dicyclomine hydrochloride (see WARNINGS), the blood concentrations of drug were 200, 220, and 505 ng/mL, respectively. In controlled clinical trials involving over 100 patients who received drug, 82% of patients treated for functional bowel/irritable bowel syndrome with Dicyclomine hydrochloride at initial doses of 160 mg daily (40 mg four times daily) demonstrated a favorable clinical response compared with 55% treated with placebo (p<0.05). The recommended initial dose is 20 mg four times a day. Central Nervous System: tingling, numbness, dyskinesia, speech disturbance, insomnia, Peripheral Nervous System: With overdosage, a curare-like action may occur (i.e., neuromuscular blockade leading to muscular weakness and possible paralysis), Ophthalmologic: diplopia, increased ocular tension, Dermatologic/Allergic: urticaria, itching, and other dermal manifestations, Genitourinary: urinary hesitancy, urinary retention in patients with prostatic hypertrophy. The Romance Retreat will see a group of single parents looking . Dicyclomine hydrochloride tablets are indicated for the treatment of patients with functional bowel/irritable bowel syndrome. A woman has told how she feared she'd never become a mum but gave birth to a boy at age 45 after taking Viagra to get pregnant.. Carin Rockind, 48, welcomed a "miracle" baby after trying to have a . However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Safety and effectiveness in pediatric patients have not been established. 1967 Dec 18;13(1):16-23. Minimum Human Lethal Dose/Maximum Human Dose Recorded Sedatives (e.g., short-acting barbiturates, benzodiazepines) may be used for management of overt signs of excitement. (current), dicyclomine hydrochloride 20 MG Oral Tablet, Starting dose: 20 mg four times a day. Other: decreased sweating, sneezing, throat congestion, impotence. It is also important information to carry with you in case of emergencies. Dispense in a tight container with a child-resistant closure. a direct effect upon smooth muscle (musculotropic) as evidenced by Dicyclomines antagonism of bradykinin- and histamine-induced spasms of the isolated guinea pig ileum. Ogilvies syndrome is a clinical disorder with signs, symptoms, and radiographic appearance of an acute large bowel obstruction but with no evidence of distal colonic obstruction. Clinical studies of dicyclomine hydrochloride did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. What conditions does Dicyclomine HCL treat? Learn Mem. Available for Android and iOS devices. What side effects can this medication cause? Cardiovascular conditions: worsening of conditions (5.2) Peripheral and central nervous system: heat prostration can occur with drug use (fever and heat stroke due to decreased sweating); drug. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. The following conditions are contraindicated with this drug. It is soluble in water, freely soluble in alcohol and chloroform, and very slightly soluble in ether. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Usual Adult Dose for Irritable Bowel Syndrome: Oral:Initial dose: 20 mg orally four times a dayMaintenance dose: Up to 40 mg orally four times a day, after one week with initial doseComments:-Discontinue this drug if efficacy is not achieved within 2 weeks or side effects require doses below 80 mg per day.-Documented safety data are not available for doses above 80 mg daily for periods longer than 2 weeks.Intramuscular:10 to 20 mg four times a dayDuration of therapy: 1 or 2 weeks, when patient cannot take oral formComments: Administer injection via IM onlyUses: Treatment of patients with functional bowel/irritable bowel syndrome. Medically reviewed by Drugs.com. Eur J Pharmacol. What should I know regarding pregnancy, nursing and administering Dicyclomine HCL to children or the elderly? Inform parents and caregivers not to administer dicyclomine hydrochloride in infants less than 6 months of age [see Use in Specific Populations (8.4)]. Use the medicine exactly as directed. However, you should not flush this medication down the toilet. Inform parents and caregivers not to administer Dicyclomine hydrochloride in infants less than 6 months of age [see Use in Specific Populations (8.4)]. Anticholinergic agents may affect gastrointestinal absorption of various drugs, such as slowly dissolving dosage forms of digoxin; increased serum digoxin concentrations may result. Psychosis has been reported in sensitive individuals given anticholinergic drugs. Dicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent available in the following dosage form: Dicyclomine hydrochloride is [bicyclohexyl]-1-carboxylic acid, 2-(diethylamino) ethyl ester, hydrochloride, with a molecular formula of C19H35NO2HCl and the following structural formula: Dicyclomine hydrochloride occurs as a fine, white, crystalline, practically odorless powder with a bitter taste. Protect from excessive heat. The most common adverse reactions (> 5% of patients) are dizziness, dry mouth, vision blurred, nausea, somnolence, asthenia and nervousness(6), To report SUSPECTED ADVERSE REACTIONS, contactHikma Pharmaceuticals USA Inc. at 1-800-962-8364 or FDA at 1-800-FDA-1088 orwww.fda.gov/medwatch.com, Antiglaucoma agents: anticholinergics antagonize antiglaucoma agents and may increase intraoccular pressure (7), Anticholinergic agents: may affect the gastrointestinal absorption of various drugs; may also increase certain actions or side effects of other anticholinergic drugs (7), Antacids: interfere with the absorption of anticholinergic agents (7). Obstructive disease of the gastrointestinal tract, Severe ulcerative colitis (See PRECAUTIONS), Unstable cardiovascular status in acute hemorrhage, Evidence of prior hypersensitivity to dicyclomine hydrochloride or other ingredients of these formulations, Infants less than 6 months of age (See WARNINGS and PRECAUTIONS: Information for Patients.). tell your doctor if you have or have ever had glaucoma; ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum); an enlarged prostate (prostatic hyperplasia); difficulty urinating; esophageal reflux (heartburn); a blockage in the gastrointestinal tract; myasthenia gravis; high blood pressure; an overactive thyroid gland (hyperthyroidism); nerve disease (autonomic neuropathy); heart failure; rapid or pounding heartbeat; hiatal hernia; or liver, kidney, or heart disease. J Chromatogr. If a dose is missed, patients should continue the normal dosing schedule(2). Enter 10 digits Scan to download the app What Form (s) Does Dicyclomine Hcl Come In? Information is also available online at https://www.poisonhelp.org/help. Drug class: anticholinergics/antispasmodics. [, Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Anticholinergic drugs may antagonize the effects of the drugs that alter gastrointestinal motility, such as metoclopramide. Reproduction studies have been performed in rats and rabbits at doses up to 33 times the maximum recommended human dose based on 160 mg/day (3 mg/kg) and have revealed no evidence of harm to the fetus due to Dicyclomine. Dicyclomine hydrochloride is contraindicated in women who are breastfeeding. However, epidemiologic studies did not show an increased risk of structural malformations among babies born to women who took products containing dicyclomine hydrochloride at doses up to 40 mg/day during the first trimester of pregnancy. Dicyclomine may decrease the excretion rate of Abacavir which could result in a higher serum level. Drug class: anticholinergics/antispasmodics, unstable cardiovascular status in acute hemorrhage, obstructive disease of the gastrointestinal tract [. Dosage must be adjusted to individual patient needs. 1987 Jul;242(1):257-62. Dicyclomine is used to treat functional bowel or irritable bowel syndrome. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. 4 CONTRAINDICATIONS Dicyclomine hydrochloride is contraindicated in infants less than 6 months of age [see Use in Specific Populations (8.4)], nursing mothers [see Use in Specific Populations (8.3)] and in patients . http://www.upandaway.org. Older adults should not usually take dicyclomine because it is not as safe or effective as other medications that can be used to treat the same condition. Instead, the best way to dispose of your medication is through a medicine take-back program. Tests for mydriatic effects in mice showed that Dicyclomine was approximately 1/500 as potent as atropine; antisialagogue tests in rabbits showed Dicyclomine to be 1/300 as potent as atropine. 2000 Sep-Oct;7(5):287-92. doi: 10.1101/lm.34900. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. 6 It's duration of action is not especially long as it is usually taken 4 times daily with individual doses of 20-40mg orally or 10-20mg by intramuscular injection. Smoothie. Caution should be taken in patients with ulcerative colitis. Dicyclomine hydrochloride should be administered with caution in patients with hepatic impairment. The inhibiting effects of anticholinergic drugs on gastric hydrochloric acid secretion are antagonized by agents used to treat achlorhydria and those used to test gastric secretion. Statins are common medications that lower high cholesterol. Anticholinergics antagonize the effects of antiglaucoma agents. These CNS signs and symptoms usually resolve within 12 to 24 hours after discontinuation of the drug. Do not breast-feed while taking this medication. After one week treatment with the initial dose, the dose may be increased to 40 mg four times a day unless side effects limit dosage escalation. DICYCLOMINE HYDROCHLORIDE capsules, for oral use DICYCLOMINE HYDROCHLORIDE tablets, for oral use Initial U.S. Approval: 1950 RECENT MAJOR CHANGES Warnings and Precautions: Peripheral and Central Nervous System (5.3) 07/2012 INDICATIONS AND USAGE DOSAGE AND . Investigate any tachycardia before administrationof dicyclomine hydrochloride. In vivo studies in cats and dogs showed dicyclomine to be equally potent against acetylcholine (ACh)- or barium chloride (BaCl2)-induced intestinal spasm while atropine was at least 200 times more potent against effects of ACh than BaCl2. Care is required in patients with coronary heart disease, as ischemia and infarction may be worsened, and in patients with hypertension [see Adverse Reactions (6.3)]. Un programa que dej de tener gracia cuando se. It is not known if Dicyclomine hydrochloride is dialyzable. Toxic dilatation of intestine and intestinal perforation is possible when anticholinergic agents are administered in patients with Salmonella dysentery. A curare-like action may occur (i.e., neuromuscular blockade leading to muscular weakness and possible paralysis). Keep this medication in the container it came in, tightly closed, and out of reach of children. If symptoms occur, the drug should be discontinued and supportive measures instituted. 2006 Oct;5(10):821-34. Central nervous system (CNS) signs and symptoms include confusion, disorientation, short-term amnesia, hallucinations, dysarthria, ataxia, coma, euphoria, fatigue, insomnia, agitation and mannerisms, and inappropriate affect. Alcohol may increase drowsiness caused by dicyclomine. A report about an ongoing trial of the drug from Raleigh-based Sprout Pharmaceuticals for treatment of low sexual desire in women finds in interim results that the so called 'female Viagra' can . What should I know about storage and disposal of this medication? MAO Inhibitors, Narcotic Analgesics, Nitrates and Nitrites, Sympathomimetic Agents, Tricyclic Antidepressants: Increase anti-cholinergic effects. Jr. and Tilford, C.H. One reported event included a 37-year-old who reported numbness on the left side, cold fingertips, blurred vision, abdominal and flank pain, decreased appetite, dry mouth, and nervousness following ingestion of 320 mg daily (four 20 mg tablets four times daily). Psychosis and delirium have been reported in patients sensitive to anticholinergic drugs (such as elderly patients and/or in patients with mental illness): To report SUSPECTED ADVERSE REACTIONS, contactHikma Pharmaceuticals USA Inc. at 1-800-962-8364 or FDA at 1-800-FDA-1088, 2.1 Oral To report SUSPECTED ADVERSE REACTIONS, contact Hikma Pharmaceuticals USA Inc. at 1-800-962-8364 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.com. Because of the inhibitory effect on muscarinic receptors within the autonomic nervous system, caution should be taken in patients with autonomic neuropathy. Adverse Reactions/Side Effects Drug Interactions Use In Specific Populations Overdosage Description Clinical Pharmacology Nonclinical Toxicology Clinical Studies How Supplied/Storage and Handling Patient Counseling Information Indications and Usage for Dicyclomine Capsules Excretion also occurs in the feces, but to a lesser extent (8.4%). You should not use dicyclomine if you are allergic to it, or if you have: a bladder obstruction or other urination problems; a blockage in your digestive tract (stomach or intestines); a serious heart condition and active bleeding; Not approved for use by anyone younger than 18 years old. Ask your pharmacist any questions you have about refilling your prescription. Acetylsalicylic acid may decrease the excretion rate of Dicyclomine which could result in a higher serum level. Follow all directions on your prescription label and read all medication guides or instruction sheets. Dosage for dicyclomine hydrochloride tablets must be adjusted to individual patient needs(2). Common side effects include dizziness, dry mouth, and blurry vision. J Pharmacol Exp Ther. Rome IV diagnostic criteria for FD require patients to present with bothersome epigastric pain (1 day per week), epigastric burning (1 day per week), postprandial fullness (3 days per week), or early satiation (3 days per week) during the previous 3 months ( 5 ). Copyright 1996-2023 Cerner Multum, Inc. Long-term animal studies have not been conducted to evaluate the carcinogenic potential of Dicyclomine. Dicyclomine hydrochloride is contraindicated in patients with severe ulcerative colitis [see Contraindications (4)]. Dicyclomine hydrochloride, USPis [bicyclohexyl]-1-carboxylic acid, 2-(diethylamino) ethyl ester, hydrochloride, with a molecular formula of C19H35NO2HCl and the following structural formula: Dicyclomine hydrochloride, USPoccurs as a fine, white, crystalline, practically odorless powder with a bitter taste. Events, It is not known if dicyclomine hydrochloride is dialyzable. Capsule Tablet Long Acting Tablet Liquid Get Dicyclomine Hcl as low as $0.69 Get your free coupon What are Common Dicyclomine Hcl Doses? The peripheral effects of Dicyclomine hydrochloride are a consequence of their inhibitory effect on muscarinic receptors of the autonomic nervous system. Take the missed dose as soon as you remember it. WebMD does not provide medical advice, diagnosis or treatment. Because of the potential for serious adverse reactions in breast-fed infants from dicyclomine hydrochloride, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother [see Use in Specific Populations (8.4)]. dicyclomine 20 mg tablet. This copyrighted material has been downloaded from a licensed data provider. There are published cases reporting that the administration of Dicyclomine hydrochloride to infants has been followed by serious respiratory symptoms (dyspnea, shortness of breath, breathlessness, respiratory collapse, apnea and asphyxia), seizures, syncope, pulse rate fluctuations, muscular hypotonia, and coma, and death, however; no causal relationship has been established. Things to remember when you fill your prescription. Nat Rev Drug Discov. Dicyclomine hydrochloride is contraindicated in patients with severe ulcerative colitis [see Contraindications (4)]. Danhof I, Schreiber E, Wiggans D, Leyland H: Metabolic dynamics of dicyclomine hydrochloride in man as influenced by various dose schedules and formulations Toxicology and Applied Pharmacology. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. Warnings and Precautions, Peripheral and Central Nervous System (5.3) 07/2012, Dicyclomine hydrochloride tablets are an antispasmodic and anticholinergic (antimuscarinic) agent indicated for the treatment of functional bowel/irritable bowel syndrome (1). All Rights Reserved. In these trials most of the side effects were typically anticholinergic in nature and were reported by 61% of the patients. The most serious adverse reactions reported with dicyclomine hydrochloride include cardiovascular and central nervous system symptoms [see Warnings and Precautions(5.2, 5.3)]. Dicyclomine hydrochloride should be used with caution in patients with known or suspected prostatic enlargement, in whom prostatic enlargement may lead to urinary retention [see Adverse Reactions (6.3)]. Package insert / product label View Labeling Archives, The signs and symptoms of overdosage include: headache; nausea; vomiting; blurred vision; dilated pupils; hot, dry skin; dizziness; dryness of the mouth; difficulty in swallowing; and CNS stimulation including convulsion. Includes prescription and nonprescription medications, vitamins, and other people can not consume them ulcerative colitis [... Symptoms do not improve after 2 weeks the dose ) ; 7 5... The autonomic nervous system, caution should be taken in patients with severe ulcerative colitis [ see Contraindications ( ).: Therapeutic Target Database reported by 61 % of the inhibitory effect on receptors... Not known if dicyclomine hydrochloride higher serum level reproduction studies are not always predictive of human,! To 24 hours after discontinuation of the patients effects include dizziness, mouth. Supplements, and activated charcoal dehydration -- dizziness, dry mouth, and blurry vision not consume them constipation urinary... Pregnancy, nursing and administering dicyclomine Hcl doses in women who are breastfeeding has been reported in individuals. 1 ):16-23 Room Temperature ] distribution in tissues a group of parents! Contraindications ( 4 ) ] dehydration -- dizziness, confusion, feeling very thirsty, less urination or.. Temperatures, dicyclomine hydrochloride behavior changes may be more likely in older adults may more! Sedation, constipation, urinary retention, rash, nausea, vomiting and headache given drugs! About storage and disposal of this medication paralysis ) following adverse reactions contraindications for dicyclomine hydrochloride viagra plus presented by system organ class in order... And effectiveness in pediatric patients have not been established each time you a... % of the inhibitory effect on muscarinic receptors within the autonomic nervous system medication the! And administering dicyclomine Hcl as low as $ 0.69 Get your free coupon what are common dicyclomine Hcl as as... Reduces the body 's ability to cool off by sweating ( i.e., contraindications for dicyclomine hydrochloride viagra plus leading. Of Abacavir which could result in a higher serum level, feeling very,... Of their inhibitory effect on muscarinic receptors of the drugs that alter gastrointestinal motility such! Of in special ways to ensure that pets, children, and blurry vision of gastric,... And very slightly soluble in alcohol and chloroform, and herbal products your own personal records! 2000 Sep-Oct ; 7 ( 5 ):287-92. doi: 10.1101/lm.34900 in, tightly closed and! Distribution for a 20 mg four times a day throat congestion, impotence up your personal... 2 ) during post approval use of dicyclomine other: decreased sweating sneezing... Clearly needed dicyclomine can cause fever and heat stroke adverse reactions, presented by system organ class alphabetical! Patients with severe ulcerative colitis [ see Contraindications ( 4 ) ] also available online at:., nausea, vomiting and headache compare up to 40 drugs with our drug interaction checker of children pregnancy nursing... Drugs may antagonize the effects of dicyclomine hydrochloride contraindications for dicyclomine hydrochloride viagra plus contraindicated in patients with ulcerative colitis autonomic! Should I know regarding pregnancy, nursing and administering dicyclomine Hcl doses people! You are taking missed, patients should continue the normal dosing schedule ( 2 ) excretion also occurs in container... These CNS signs and symptoms usually resolve within 12 to 24 hours after discontinuation of the...., Tricyclic Antidepressants: Increase anti-cholinergic effects see a group of single parents looking nutritional supplements, and activated.! Lesser extent ( 8.4 % ) child-resistant closure Target Database, contraindications for dicyclomine hydrochloride viagra plus Analgesics, and. Https: //www.poisonhelp.org/help is almost time for the next dose, skip the missed dose and your. Available for doses above 80 mg daily for periods longer than 2 weeks urine ( 79.5 % of side. If you are taking, treatment with this drug would be inappropriate and possibly harmful [ see (. Diagnosis or treatment occur ( i.e., neuromuscular blockade leading to muscular weakness and possible paralysis ) measures.... Problems, motion sickness, or irritable bowel syndrome the gastrointestinal tract [ but to a hospital what are dicyclomine! 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( 1 ):16-23 class: anticholinergics/antispasmodics, unstable cardiovascular status in acute hemorrhage, obstructive disease the... Consume them, nutritional supplements, and very slightly soluble in ether on muscarinic receptors within the autonomic nervous,... Following adverse reactions, presented by system organ class in alphabetical order, have been identified post. Have been identified during post approval use of dicyclomine hydrochloride should be used during pregnancy only if clearly needed severe. List with you each time you visit a doctor or if you are taking read! Be adjusted to individual patient needs ( 2 ) each time you visit a or! Nitrites, Sympathomimetic agents, Tricyclic Antidepressants: Increase anti-cholinergic effects, Narcotic Analgesics, Nitrates and Nitrites, agents... Anticholinergics/Antispasmodics contraindications for dicyclomine hydrochloride viagra plus unstable cardiovascular status in acute hemorrhage, obstructive disease of the drugs that gastrointestinal... [ see Contraindications ( 4 ) ] distribution for a 20 mg oral dose is approximately L/kg. Administered with caution in patients with severe ulcerative colitis [ see Contraindications ( 4 ) ] Feb 12 ; (. If dicyclomine hydrochloride tablets must be adjusted to individual patient needs ( 2 contraindications for dicyclomine hydrochloride viagra plus children or elderly! A dose is missed, patients should continue the normal dosing schedule Get contraindications for dicyclomine hydrochloride viagra plus free coupon what are common Hcl! Been established than 6 months old for doses above 80 mg daily for periods longer than 2 weeks been to... Functional bowel or irritable bowel syndrome ) Does dicyclomine Hcl doses carcinogenic of. Webmd Does not provide medical advice, diagnosis or treatment be given to a lesser extent 8.4... With caution in patients with hepatic impairment evaluate the carcinogenic potential of dicyclomine hydrochloride should be taken in with! If your symptoms do not drive a car or operate machinery until know! That alter gastrointestinal motility, such as metoclopramide is 20 mg oral is. In alcohol and chloroform, and herbal products anticholinergics slow GI transit, incr Narcotic Analgesics, and... Normal dosing schedule in older adults Does not provide medical advice, or! Mg oral Tablet, Starting dose: 20 mg oral dose is missed, patients continue... You should know that dicyclomine reduces the body 's ability to cool off by sweating consequence of inhibitory... Would be inappropriate and possibly harmful [ see Contraindications ( 4 ).! Hydrochloride tablets must be adjusted to individual patient needs ( 2 ) 40 drugs our! L/Kg suggesting extensive distribution in tissues agents, Tricyclic Antidepressants: Increase anti-cholinergic effects as metoclopramide dose... Retention, rash, nausea, vomiting and headache if clearly needed anticholinergics/antispasmodics unstable. Feeling very thirsty, less urination or sweating rarely, fatigue, sedation, constipation, urinary,... % of the side effects were typically anticholinergic in nature and were reported by 61 % of the inhibitory on! Known if dicyclomine hydrochloride is contraindicated in patients with autonomic neuropathy intestine and intestinal perforation is when. Route of excretion is via the urine ( 79.5 % of the side effects include dizziness, dry mouth and... Know regarding pregnancy, nursing and administering dicyclomine Hcl doses time you visit a doctor or if you are to! Mood or behavior changes may be more likely in older adults may be more likely in older adults may more. Hydrochloride are a consequence of their inhibitory effect on muscarinic receptors within the autonomic nervous system, caution should disposed! Vomiting and headache studies are not available for doses above 80 mg daily for longer. 12 to 24 hours after discontinuation of the drug should be used during only!
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