It works by blocking the production of certain chemical messengers that make the skin red, swollen and itchy. It is a white to almost white, crystalline powder, practically insoluble in water; slightly soluble in benzene and diethyl ether; sparingly soluble in ethanol; freely soluble in acetone, in dimethylsulfoxide, in chloroform, in methanol and in dioxane. This medicine is for use on the skin only. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Allergic contact dermatitis with corticosteroids is usually diagnosed by observing a Presence in Breast Milk, Medline Plus, Use this medication on the skin only. They are therefore also at greater risk of adrenal insufficiency during or after withdrawal of treatment. Temovate, Clobex, Olux, Impoyz, +4 more, prednisone, doxycycline, methotrexate, triamcinolone, Humira, betamethasone topical, Dupixent, Remicade, cyclosporine, Stelara. Do not double the dose to catch up. INDICATIONS AND USAGE.). Patients using topical corticosteroids should receive the following information and instructions: The following tests may be helpful in evaluating patients for HPA axis suppression: Long-term animal studies have not been performed to evaluate the carcinogenic potential of clobetasol propionate. Last updated on Jan 1, 2022. These doses are approximately 0.02 and 0.05 times, respectively, the human topical dose of Clobetasol Propionate Ointment USP. Consult your doctor before breast-feeding. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. commonly, these are "preferred" (on formulary) brand drugs. Do not bandage, wrap or cover the area.After applying the medication, wash your hands, unless you are using this medication to treat the hands. [2] Serious side effects may include adrenal suppression, allergic reactions, cellulitis, and Cushing's syndrome. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Clobetasol propionate ointment is a super-high potency topical corticosteroid; therefore, treatment should be limited to 2 consecutive weeks and amounts greater than 50 grams per week should not be used. A: Generally acceptable. This medicine may be harmful if swallowed. A different medication may be necessary in those cases.Lab and/or medical tests (such as adrenal gland function) may be done while you are using this medication, especially if you use this drug for an extended period of time or apply it over large areas of the body. It is used for many skin conditionswhich may affect the vulva and cause painand itching. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Temovate is available in generic form. Clobetasol Propionate Ointment USP is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations. Patients should report any signs of local adverse reactions to the physician. Clobetasol is used to treat certain scalp and skin conditions (such as psoriasis, dermatitis, rash ). is this? [5] It is available as a generic medication. This medication has been prescribed for your current condition only. Apply a thin film of the medication to the affected area and gently rub in as directed by your doctor, usually 2 times daily. prescription products. It is for external use only. restrictions. masso 17 May 2023. Clobetasol Propionate Ointment USP is a super-high potency topical corticosteroid; therefore, This can lead to side effects of too much corticosteroid. Cushings syndrome has been reported in infants and adults as a result of prolonged use of topical clobetasol propionate formulations. Systemic absorption of topical corticosteroids can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal from treatment. Topically applied clobetasol propionate ointment can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS). MISSED DOSE: If you miss a dose, use it as soon as you remember. 5 and a molecular weight of 466.97. ), More about getting RSS News & Updates from DailyMed, 30 g in 1 TUBE; Type 0: Not a Combination Product, 1 Teratogenic Effects: Pregnancy Category C . There are no adequate and well-controlled studies of the teratogenic potential of clobetasol propionate in pregnant women. Clobetasol Propionate Ointment USP should not be used with occlusive dressings. Apply the prescribed amount of medication to the affected area and gently rub in. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. They are therefore also at greater risk of adrenal insufficiency during or after withdrawal of treatment. This medication is not recommended for use in children younger than 18 years of age due to an increased risk of side effects. Patients receiving super-potent corticosteroids should not be treated for more than 2 weeks at a time, and only small areas should be treated at any one time due to the increased risk of HPA suppression. Download DRUG LABEL INFO: PDF XML Official Label (Printer Friendly) View All Sections SPL UNCLASSIFIED SECTION FOR TOPICAL DERMATOLOGIC USE ONLY. Clobetasol is a highly potent steroid that helps reduce inflammation in the body. [2] It is applied to the skin as a cream, ointment, or shampoo. Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 grams per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. As most of the nerveendings are just outside the vaginal opening it would not be of much use internally in any case! Clobetasol Propionate Ointment USP should not be used with occlusive dressings. You may report side effects to Health Canada at 1-866-234-2345. If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. In rabbits, clobetasol propionate was teratogenic at doses of 3 and 10 mcg/kg. Canada residents can call a provincial poison control center. It is used as first-line treatment for both acute and chronic GVHD of the skin. Manifestations of adrenal suppression in children include low plasma cortisol levels, and an absence of response to ACTH stimulation. It is also used to treat several auto-immune diseases including alopecia areata, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). Also, avoid getting the medication in your nose or mouth. If you miss a dose, use it as soon as you remember. While the number of patients is too small to permit separate analysis of efficacy and safety, the adverse reactions reported in this population were similar to those reported by younger patients. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation, For topical use only; not for oral, ophthalmic, or intravaginal use. A topical steroid is used when patches of eczema or dermatitis flare up. During pregnancy, this medication should be used only when clearly needed. Cushing's syndrome has been reported in infants and adults as a result of prolonged use of topical clobetasol propionate formulations. Clobetasol propionate was patented in 1968 and came into medical use in 1978. This drug is available at the lowest co-pay. Less frequent adverse reactions were stinging, cracking, erythema, folliculitis, numbness of fingers, skin atrophy, and telangiectasia. Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. Clobetasol propionate is a corticosteroid used to treat skin conditions such as eczema, contact dermatitis, seborrheic dermatitis, and psoriasis. Tell your doctor right away if any of the following side effects occur: unusual/extreme tiredness, weight loss, headache, swelling ankles/feet, increased thirst/urination, vision problems. We comply with the HONcode standard for trustworthy health information. Use in children under 12 years of age is not recommended. PRECAUTIONS) have been treated with clobetasol propionate ointment, safety did not differ from that in younger patients; therefore, no dosage adjustment is recommended. Patients applying a topical steroid to a large surface area or to areas under occlusion should be evaluated periodically for evidence of HPA axis suppression. Most people only need to use clobetasol 1 or 2 times a day for 1 week. A limited number of patients at or above 65 years of age have been treated with clobetasol propionate ointment (n = 101) in US and non-US clinical trials. Though it is unlikely, this medication may temporarily slow down a child's growth if used for a long time. Apply a thin layer of clobetasol propionate ointment to the affected skin areas twice daily and rub in gently and completely. Athletes foot is a fungal infection. Vhody smoothies zvisia od toho, o do nich dte. As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. Allergic contact dermatitis with corticosteroids is usually diagnosed by observing a failure to heal rather than noting a clinical exacerbation as with most topical products not containing corticosteroids. Clobetasol propionate has greater teratogenic potential than steroids that are less potent. Abnormalities seen included cleft palate and skeletal abnormalities. Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children: A Randomized Clinical Trial | Dermatology | JAMA Dermatology | JAMA Network Lenane and coauthors compare the efficacy and safety of a high- vs low-potency topical corticosteroid in pediatric patients. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity. Clobetasol propionate has not been tested for teratogenicity when applied topically; however, it is absorbed percutaneously, and when administered subcutaneously it was a significant teratogen in both the rabbit and mouse. Also, avoid getting the medication in your nose or mouth. CLOBETASOL PROPIONATE- clobetasol propionateointment If a favorable response does not occur promptly, use of clobetasol propionate ointment should be discontinued until the infection has been adequately controlled . Because many drugs are excreted in human milk, caution should be exercised when Clobetasol Propionate Ointment USP is administered to a nursing woman. Some corticosteroids have been shown to be teratogenic after dermal application to laboratory animals. Clobetasol Propionate Ointment USP, 0.05% contains clobetasol propionate USP 0.5 mg/g in a base of propylene glycol, sorbitan sesquioleate, and white petrolatum. [2] Use in pregnancy and breastfeeding is of unclear safety. Manifestations of adrenal suppression in children include low plasma cortisol levels, and an absence of response to ACTH stimulation. If you get the medication in your eyes, nose, or mouth, rinse with plenty of water.Use this medication exactly as prescribed. View the formulary and any restrictions for each plan. What is clobetasol propionate cream used for? In Canada - Call your doctor for medical advice about side effects. Occlusive dressing with hydrocortisone for up to 24 hours has not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Patients receiving super-potent corticosteroids should not be treated for more than 2 weeks at a time and only small areas should be treated at any one time due to the increased risk of HPA suppression. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: stretch marks (striae), skin thinning/discoloration, excessive hair growth, acne, small red bumps on the skin (folliculitis).Skin infections can become worse when using this medication. If no improvement occurs in 2 weeks of treatment with clobetasol, or if your condition worsens, stop using this medication and inform your doctor. You may report side effects to Health Canada at 1-866-234-2345. Avoid contact with the eyes. For information on systemic supplementation, see prescribing information for those products. If no improvement is seen within 2 weeks, reassessment of the diagnosis may be necessary. Based on available data, no adjustment of dosage of Clobetasol Propionate Ointment USP in geriatric patients is warranted. Teratogenic Effects: Pregnancy Category C. Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. This medication is to be used as directed by the physician. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, diabetes, other skin/scalp conditions (such as rosacea, perioral dermatitis), immune system problems.Do not use if there is an infection or sore in the area to be treated.Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. 30 g in 1 TUBE; Type 0: Not a Combination Product. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. 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