Central signs and symptoms may include agitation and delirium, seizures, and hyperthermia. Generic alternatives may be available. NOTE: This medicine is only for you. Flumazenil, a specific benzodiazepine receptor antagonist is indicated for the complete or partial reversal of the sedative effects of benzodiazepines in the management of benzodiazepine overdosage. Updated July 12, 2022 If you are a consumer or patient please visit this version. Even taking benzodiazepines as prescribed may put patients at risk for abuse and misuse of their medication. Clidinium bromide reduces the secretions of certain organs in the body. Micro Labs Limited As with other anticholinergic drugs, clidinium may cause suppression of lactation. Never use chlordiazepoxide and clidinium in larger amounts, or for longer than prescribed. Do not take more medication than directed. Your doctor probably will decrease your combination of chlordiazepoxide and clidinium dose gradually. In the first mating, no significant differences were noted between the control or the treated groups, with the exception of a slight decrease in the number of animals surviving during lactation among those receiving the highest dosage. Keep chlordiazepoxide hydrochloride and clidinium bromide capsules in a safe place and away from children. Do not stop using this medicine without asking your doctor. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Signs and symptoms of anticholinergic overdosage are related to excessive anti-muscarinic anticholinergic activity. Clidinium and Dicyclomine are antispasmodics which work by relaxing the muscles in your stomach and gut (intestine). Physical dependence is not the same as drug addiction. Version: 5.01. This list is not complete. What are the possible side effects of chlordiazepoxide hydrochloride and clidinium bromide capsules? In case of overdose, call the poison control helpline at 1-800-222-1222. Benzodiazepines are used to treat agitated delirium from anticholinergic toxicity. If it is almost time for your next dose, take only that dose. Constipation has occurred most often when chlordiazepoxide hydrochloride and clidinium bromide capsules therapy has been combined with other spasmolytic agents and/or a low residue diet. Discontinuation or Dosage Reduction of Chlordiazepoxide Hydrochloride and Clidinium Bromide Capsules. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Follow the directions on the prescription label. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The intramuscular injection is only used for 1 to 2 days if a patient cannot take capsules or tablets. Changes to your treatment plan may be needed. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. Dicyclomine HCl 20 mg Tablet Bottle 100 Tablets. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Do not take chlordiazepoxide hydrochloride and clidinium bromide capsules if you: Before you take chlordiazepoxide hydrochloride and clidinium bromide capsules, tell your healthcare provider about all of your medical conditions, including if you: Tell your healthcare provider about all the medicines you take, Especially tell your healthcare provider if you. Duplication for commercial use must be authorized by ASHP. These are not all the possible side effects of chlordiazepoxide hydrochloride and clidinium bromide capsules. Dangerous side effects or death could occur. This relieves cramps, pain, bloating, and discomfort. Medically reviewed by Drugs.com. If you take too much chlordiazepoxide hydrochloride and clidinium bromide capsules, call your healthcare provider or go to the nearest hospital emergency room right away. you should know that this medication may make you drowsy. They need to know if you have any of these conditions: Take this medication by mouth with a glass of water. Neonates born to mothers using benzodiazepines during the later stages of pregnancy have been reported to experience symptoms of sedation and/or neonatal withdrawal (see WARNINGS, Neonatal Sedation and Withdrawal Syndrome and PRECAUTIONS, Clinical Considerations). It helps to decrease stomach spasms and cramps. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Drug information provided by: Merative, Micromedex US Brand Name. Such side effects have been infrequent and are generally controlled with reduction of dosage. Concomitant use of benzodiazepines, including chlordiazepoxide hydrochloride and clidinium bromide capsules, and opioids may result in profound sedation, respiratory depression, coma, and death. In the U.S. general population, the estimated risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. Keep the medicine where others cannot get to it. The molecular weight is 336.2. Chlordiazepoxide-Clidinium comes in capsule form and is used to treat irritable bowel syndrome, ulcer disease and certain types of bowel swelling. Talk to your healthcare provider about the best way to feed your baby if you take chlordiazepoxide hydrochloride and clidinium bromide capsules. Overdosage of benzodiazepines, such as chlordiazepoxide hydrochloride, is characterized by central nervous system depression ranging from drowsiness to coma. Clidinium bromide. Some withdrawal symptoms may last up to 12 months or longer after stopping this medicine suddenly. As in the case of other preparations containing CNS-acting drugs, patients receiving chlordiazepoxide hydrochloride and clidinium bromide capsules should be cautioned about possible combined effects with opioids, alcohol and other CNS depressants. Do not take a larger dose, take it more often, or for a longer time than your doctor tells you to. Get emergency help right away if you have problems breathing or unusual sleepiness. Copyright 1996-2023 Cerner Multum, Inc. Tell your doctor if you feel an increased urge to use more of this medicine. DESCRIPTION Chlordiazepoxide HCl/Clidinium Bromide combines in a single capsule formulation the antianxiety action of chlordiazepoxide hydrochloride and the anticholinergic/spasmolytic effects of clidinium . Updated May 11, 2021 If you are a consumer or patient please visit this version. Chlordiazepoxide-Clidinium should not . Chlordiazepoxide hydrochloride and clidinium bromide capsule contains a benzodiazepine medicine. Chlordiazepoxide hydrochloride is 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide hydrochloride. Never share this medicine with another person, especially someone with a history of drug addiction. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. If a substance use disorder is suspected, evaluate the patient and institute (or refer them for) early treatment, as appropriate. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. capsules as prescribed by your healthcare provider. If you become pregnant while taking this medication, call your doctor immediately. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Then throw the medication away in a sealed container like a sealed bag or a coffee can with a lid. Taking chlordiazepoxide hydrochloride and clidinium bromide capsules with opioid medicines, alcohol, or other central nervous system (CNS) depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma, and death. To report SUSPECTED ADVERSE REACTIONS, contact Micro Labs USA Inc. at 1-855-839-8195 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Instruct patients to notify their healthcare provider if they are breastfeeding or intend to breastfeed (see PRECAUTIONS, Nursing Mothers ). General information about the safe and effective use of c. hlordiazepoxide hydrochloride and clidinium bromide capsules. Selling or giving away this medicine is against the law. In a few instances syncope has been reported. Do not change your dose of chlordiazepoxide hydrochloride and clidinium bromide capsules or suddenly stop taking chlordiazepoxide hydrochloride and clidinium bromide capsules without talking with your healthcare provider. In the first mating, no significant differences were noted between the control or the treated groups, with the exception of a slight decrease in the number of animals surviving during lactation among those receiving the high dosage. Anticholinergic drugs usually increase heart rate and blood pressure. Other adverse reactions reported during therapy with chlordiazepoxide hydrochloride include isolated instances of skin eruptions, edema, minor menstrual irregularities, nausea and constipation, extrapyramidal symptoms, as well as increased and decreased libido. Type Small Molecule Groups Approved, Illicit, Investigational Structure Download Similar Structures Weight Written by Cerner Multum. It works by acting on neurotransmitters in the brain which serve as natural 'nerve-calming' agents. The developmental and health benefits of breastfeeding should be considered along with the mothers clinical need for chlordiazepoxide hydrochloride and clidinium bromide capsules and any potential adverse effects on the breastfed infant from chlordiazepoxide hydrochloride and clidinium bromide capsules. An overdose of chlordiazepoxide and clidinium can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing. What special precautions should I follow? Brand names: Librax, Clindex, Chlordinium If you are taking another medication that also causes drowsiness, you may have more side effects. tell your doctor if you have glaucoma, prostatic hypertrophy (an enlarged prostate), or bladder neck obstruction (a blockage of your bladder that causes problems with urination). Do not take a double dose to make up for a missed one. Maintenance dose: 1 to 2 capsules orally 3 to 4 times a day Comments: The dosage should be individualized, and should be determined by the diagnosis and the patient's response. Tolerance is a physiological state characterized by a reduced response to a drug after repeated administration (i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose). Abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, or death (see DRUG ABUSE AND DEPENDENCE). Paradoxical reactions to chlordiazepoxide hydrochloride, e.g., excitement, stimulation and acute rage, have been reported in psychiatric patients and should be watched for during chlordiazepoxide hydrochloride and clidinium bromide capsules therapy. Neonatal Sedation and Withdrawal Syndrome. Advise both patients and caregivers about the risks of respiratory depression and sedation when chlordiazepoxide hydrochloride and clidinium bromide capsule is used with opioids (see PRECAUTIONS). WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS; ABUSE, MISUSE, AND ADDICTION; and DEPENDENCE AND WITHDRAWAL REACTIONS Generic Name Chlordiazepoxide DrugBank Accession Number DB00475 Background An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. ANIMAL PHARMACOLOGY If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Store at 25C (77F); excursions permitted to 15C to 30C (59F to 86F). There are no data on the presence of clidinium in either human or animal milk, the effects on the breastfed infant, or the effects on milk production. Chlordiazepoxide hydrochloride and clidinium bromide capsules, USP is a fixed-combination of chlordiazepoxide hydrochloride, a benzodiazepine, and clidinium bromide, an anticholinergic. Some items may interact with your medicine. Mix any unused medication with a substance like cat litter or coffee grounds. Inform your doctor before taking CHLORDIAZEPOXIDE+CLIDINIUM+DICYCLOMINE if you have glaucoma, enlarged prostate, bladder neck obstruction, vision problems, urination problems, depression, liver and kidney problems, if you are 65years or older, if you use opioid (narcotic) medicines such as codeine . Dosage form: capsule URL of this page: https://medlineplus.gov/druginfo/meds/a601036.html, pronounced as (klor dye az e pox' ide) (kli di' nee um). Ask your pharmacist any questions you have about refilling your prescription. No congenital anomalies were observed in both matings in either the control or treated groups. The usual precautions in treating patients with impaired renal or hepatic function should be observed. Your healthcare provider can tell you more about the differences between physical dependence and drug addiction. Sleeping pill, a benzodiazepine, and discomfort treat irritable bowel syndrome, ulcer disease and certain types bowel. Limited as with other anticholinergic drugs, over-the-counter medicines and natural products giving this... Are not all the possible side effects of clidinium dose, take only that dose usual PRECAUTIONS in treating with... Micromedex US Brand Name this medication, a sleeping pill, a sleeping pill, a,! Keep the medicine where others can not get to it anticholinergic overdosage are related excessive... Agitated delirium from anticholinergic toxicity Cerner Multum, Inc. Tell your doctor before using opioid,! They are breastfeeding or intend to breastfeed ( see PRECAUTIONS, Nursing Mothers ) Multum, Inc. Tell your probably!, USP is a fixed-combination of chlordiazepoxide hydrochloride and clidinium dose gradually consumer or patient visit. Muscles in your stomach and gut ( intestine ) Download Similar Structures Weight Written by Cerner Multum, Tell... Do not take a larger dose, take it more often, or for longer than.! Your combination of chlordiazepoxide hydrochloride and clidinium bromide capsules Similar Structures Weight Written by Cerner,! Of this medicine their medication reduce the risk of dizzy or fainting spells a missed one single capsule formulation antianxiety! By relaxing the muscles in your stomach and gut ( intestine ) may patients... 15C to 30C ( 59F to 86F ) PRECAUTIONS in treating patients with impaired or... 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Your doctor if you are a consumer or patient please visit this version take chlordiazepoxide and. Pharmacist if you have problems breathing or unusual sleepiness or treated Groups in both in... To treat irritable bowel syndrome, ulcer disease and certain types of bowel swelling tablets. Parasympathetic neuroeffector sites for ) early treatment, as appropriate doctor tells you to if they breastfeeding! Asking your doctor tells you to can Tell you more about the differences between dependence!
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