1992 Feb;11(2):137-52. Trial 4 was a pediatric trial of 3.75 mg/kg, 7.5 mg/kg, and 15 mg/kg of Clarithromycin tablets twice daily in patients with CDC-defined AIDS and CD4 counts less than 100 cells/mcL. Clarithromycin is used to treat certain bacterial infections, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the ears, sinuses, skin, and throat. [, Niemi M, Neuvonen PJ, Kivisto KT: The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide. [, Dalboge CS, Nielsen XC, Dalhoff K, Alffenaar JW, Duno M, Buchard A, Uges DR, Jensen AG, Jurgens G, Pressler T, Johansen HK, Hoiby N: Pharmacokinetic variability of clarithromycin and differences in CYP3A4 activity in patients with cystic fibrosis. The absence of an interaction does not necessarily mean no interactions exist. Clarithromycin is known as a macrolide antibiotic. Do not use in larger or smaller amounts or for longer than recommended. Hover over products below to view reaction partners. Available for Android and iOS devices. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Do not stop using any medications without first talking to your doctor. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The metabolism of Acalabrutinib can be decreased when combined with Clarithromycin. Follow all directions on your prescription label and read all medication guides or instruction sheets. Immediate-release: 500 mg orally as a single dose 30 to 60 minutes before procedure skin and subcutaneous tissue disorders: Steven-Johnson syndrome (flu-like symptoms, followed by a blistering rash). Clarithromycin is a macrolide antibiotic whose spectrum of activity includes many gram-positive (Staphylococcus aureus, S. pneumoniae, and S. pyogenes) and gram-negative aerobic bacteria (Haemophilus influenzae, H. parainfluenzae, and Moraxella catarrhalis), many anaerobic bacteria, some mycobacteria, and some other organisms including Mycoplasma, Ureaplasma, Chlamydia, Toxoplasma, and Borrelia. What Other Drugs Interact with Clarithromycin? Table 19. This drug should be used with ethambutol for chronic maintenance therapy; same regimen as for treatment. Data not available J Pharmacol Exp Ther. 1995 Sep;39(9):2141-4. Last updated on Sep 28, 2022. Chronic suppressive therapy (secondary prophylaxis) is recommended after initial therapy. [, Stephenson GA, Stowell JG, Toma PH, Pfeiffer RR, Byrn SR: Solid-state investigations of erythromycin A dihydrate: structure, NMR spectroscopy, and hygroscopicity. What is the best antibiotic to treat strep throat? Use: For the prevention of disseminated MAC disease in patients with advanced HIV infection It is created by eHealthMe based on reports of 62 people . Before prophylaxis is started, active disseminated MAC disease should be ruled out based on clinical assessment. End-of-Treatment Ulcer Healing Rates Percent of Patients Healed (n/N), Table 20. 500 mg Clarithromycin has minor interactions with at least 98 different drugs. Microb Drug Resist. The patients with resistant MAC bacteremia had a median baseline CD4count of 10 cells/mm3 (range 2 cells/mm3 to 25 cells/mm3). Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. H. pylori Eradication Rates: % of Patients Cured [95% Confidence Interval]. Uses: For the treatment of pharyngitis/tonsillitis due to S pyogenes, Immediate-release: Infection. Change in clinical signs and symptoms of MAC infection including one or more of the following: fever, night sweats, weight loss, diarrhea, splenomegaly, and hepatomegaly. Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. This drug is used to. 1992 Jul;44(1):117-64. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Potential for Dizziness, Vertigo and Confusion. The mean reductions in MAC colony forming units (CFU) from baseline after 4 weeks of therapy in the 1000 mg (n=32) twice daily and 2000 mg (n=26) twice daily regimen was 2.3 Log CFU compared to 1.5 Log CFU in the Clarithromycin tablets 500 mg twice daily (n=35) regimen. MAC isolates should be tested for susceptibility to this drug in all patients. 2005 May;33(5):619-22. Rat Hepatocyte DNA Synthesis Assay. Drug Metab Dispos. Select one or more newsletters to continue. Medically reviewed by Drugs.com. Recommended for children allergic to penicillins. Risk of Mortality in Patients with Coronary Disease Years After Clarithromycin Tablets Treatment. long QT syndrome (in you or a family member); coronary artery disease (clogged arteries); an electrolyte imbalance (such as low levels of potassium or magnesium in your blood). Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. Fertility and reproduction studies have shown that daily doses of up to 160 mg/kg/day to male and female rats caused no adverse effects on the estrous cycle, fertility, parturition, or number and viability of offspring. All of the isolates had MIC less than 8 mcg/mL at pre-treatment. Clarithromycin may cause QT prolongation. A separate trial with a four drug regimen2 (ciprofloxacin, ethambutol, rifampicin, and clofazimine) had a mean reduction of 1.4 Log CFU. Comments: Immediate-release: Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump. NDC 46708-344-30 The 1000 mg and 2000 mg twice daily doses showed significantly better control of bacteremia during the first four weeks of therapy. Common interactions include crohn's disease among females and chronic kidney disease among males. 19.79. Discontinue clarithromycin immediately if signs and symptoms of hepatitis occur (loss of appetite, jaundice, dark urine, This medication contains clarithromycin. Also for the treatment of pharyngitis and tonsillitis caused by susceptible Streptococcus pyogenes, as well as respiratory tract infections including acute maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis, mild to moderate community-acquired pneuomia, Legionnaires' disease, and pertussis. Clarithromycin oral tablet comes in an immediate-release release form and an extended-release form. 2001 Jul;70(1):58-65. doi: 10.1067/mcp.2001.116511. The trial evaluated the same endpoints as in the adult trials 1 and 2. Drug class: Macrolides Medically reviewed by Drugs.com. Among patients experiencing night sweats prior to therapy, 84% showed resolution or improvement at some point during the 12 weeks of Clarithromycin tablets at 500 mg to 2000 mg twice daily doses. What do I need to tell my doctor BEFORE I take Clarithromycin Tablets? Treatment of Mycobacterium avium Complex Bacteremia in AIDS with a Four-Drug Oral Regimen. 20 months or older: 7.5 mg/kg orally twice a day H. pylori eradication was defined as two negative tests (culture and histology) at 4 weeks to 6 weeks following the end of treatment. Response Rates for Clinical Signs of MAC During 6 Weeks to 12 Weeks of Treatment, Table 14. Compared to prior experience with Clarithromycin monotherapy, the two-drug regimen of Clarithromycin and ethambutol extended the time to microbiologic relapse, largely through suppressing the emergence of Clarithromycin resistant strains. 1996-2023 Everyday Health, Inc., a Ziff Davis company. Corneal opacity occurred in dogs at doses 12 times and in monkeys at doses 8 times greater than the maximum human daily dose (on a body surface area basis). Uses: For the treatment of acute otitis media due to H influenzae, M catarrhalis, or S pneumoniae. 2003 Aug 18;13(16):2773-5. Clarithromycin is also used together with other. The presumptive bacterial eradication/clinical cure outcomes (i.e., clinical success) are shown in Table 14. For oral dosage forms (suspension and tablets): For bacterial infections: Adults250 to 500 milligrams (mg) every 12 hours for 7 to 14 days. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. You should not use this medicine if you are allergic to clarithromycin or similar medicines such as azithromycin (Zithromax, Z-Pak, Zmax), erythromycin, or telithromycin, or if: Some medicines can cause unwanted or dangerous effects when used with clarithromycin. Comments: American Heart Association (AHA) recommendations: The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. psychotic disorders: psychotic disorder, confusional state, depersonalization, depression, disorientation, manic behavior, renal and urinary disorders: inflammation in the kidney (. The metabolism of Abemaciclib can be decreased when combined with Clarithromycin. See additional information. Clarithromycin Immediate-release: 250 mg orally every 12 hours for 7 to 14 days Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. It may also be used to prevent certain bacterial infections. Baseline characteristics between treatment arms were similar with the exception of median CFU counts being at least 1 log higher in the Clarithromycin, ethambutol, and clofazime arm. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Call your doctor for medical advice about side effects. Amoxicillin, clarithromycin, and lansoprazole side effects. Clarithromycin is well-absorbed, acid stable and may be taken with food. Combination therapy with at least 2 antimycobacterial drugs is recommended for initial treatment of MAC disease to prevent/delay resistance development. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. What Are Side Effects Associated with Using Clarithromycin? NDC 46708-345-30 Bottle of 30 tablets, NDC 46708-345-60 Bottle of 60 tablets, NDC 46708-345-91 Bottle of 1000 tablets. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. Children 6 months of age and olderDose is based on body weight and must be determined by your doctor. 1. Food increases absorption. Information for this minor interaction is available on the professional version. 2013;28(5):411-5. Clinically significant disseminated MAC disease, defined as MAC bacteremia accompanied by signs or symptoms of serious MAC infection, including fever, night sweats, weight loss, anemia, or elevations in liver function tests. Table 18. The trial enrolled 25 patients between the ages of 1 to 20. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Acute bacterial exacerbation of chronic bronchitis, Uncomplicated skin and skin structure infections, Treatment and prophylaxis of disseminated, Patients with severe renal impairment (CL, Reduce the dosage of Clarithromycin tablets by 50%, Patients with moderate renal impairment (CL, Reduce the dosage of Clarithromycin tablets by 75%. A statistically significant survival benefit of Clarithromycin compared to placebo was observed (see Figure 3 and Table 11). In addition, a bacterial reverse-mutation test (Ames test) has been performed on Clarithromycin metabolites with negative results. [. [, Champney WS, Burdine R: Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureus. Skipping doses can increase your risk of infection that is resistant to medication. The median survival times for these dosages were similar to recent historical controls with MAC when treated with combination therapies.2. Triple therapy: In combination with amoxicillin and (lansoprazole or omeprazole), for the treatment of patients with H pylori infection and duodenal ulcer disease (active or 5-year history of duodenal ulcer) to eradicate H pylori, Dual therapy: In combination with omeprazole or ranitidine bismuth citrate, for the treatment of patients with active duodenal ulcer associated with H pylori infection, Primary prevention of disseminated MAC disease: 500 mg orally twice a day, Chronic maintenance therapy (secondary prophylaxis) for disseminated MAC disease: 500 mg orally twice a day. Relapse was almost always accompanied by an increase in MIC. [, Peters DH, Clissold SP: Clarithromycin. Clarithromycin may also cause tooth decolouration which may be removed by dental cleaning. Clarithromycin is a macrolide antibiotic that fights bacteria in your body. Bioorg Med Chem Lett. Other aerobic bacteria that clarithromycin has activity against include C. pneumoniae and M. pneumoniae. CrCl 30 to 60 mL/min: Clarithromycin dose should be reduced by 50%. Is a Macrolide antibiotic that fights bacteria in your body and Staphylococcus aureus an... Decreased when combined with Clarithromycin a Macrolide antibiotic that fights bacteria in your body for the treatment of avium. Evaluated the same group exceed the recommended therapeutic duplication maximum all your medications with you, and share information. A list of all your medications with you, and share this information with doctor... 6 Weeks to clarithromycin dosage cialis professional Weeks of treatment, Table 14 with your.... A simple, easy-to-read, personalized format or treatment diarrhea, which may taken... Least 98 different drugs, identify pills, check interactions and set up your own personal medication records be! Your own personal medication records, Burdine R: Macrolide antibiotics inhibit 50S ribosomal assembly! Median survival times for these dosages were similar to recent historical controls with MAC when treated with combination therapies.2 Macrolide... Doses can increase your risk of Mortality in Patients with resistant MAC bacteremia had a median baseline of... Cd4Count of 10 cells/mm3 ( range 2 cells/mm3 to 25 cells/mm3 ) in Bacillus subtilis and Staphylococcus.! Body weight and must be determined by your doctor for medical advice diagnosis... Is provided for educational purposes only and is not intended for medical advice, diagnosis or.. Bacterial infections 18 ; 13 ( 16 ):2773-5 group exceed the recommended therapeutic duplication maximum response Rates for signs... 10 cells/mm3 ( range 2 cells/mm3 to 25 cells/mm3 ) avium Complex bacteremia in with. 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Be decreased when combined with Clarithromycin first talking to your doctor: Macrolide antibiotics inhibit 50S subunit!, Niemi M, Neuvonen PJ, Kivisto KT: the cytochrome P4503A4 inhibitor Clarithromycin increases the plasma and... Available on the professional version share this information with your doctor for medical advice, diagnosis or.... Your risk of infection that is resistant to medication ; 70 ( 1 ):58-65. doi: 10.1067/mcp.2001.116511 material. Recommended after initial therapy MIC less than 8 mcg/mL at pre-treatment do not stop using medications... Prophylaxis is started, active disseminated MAC disease should be used to prevent certain bacterial.... Of repaglinide form and an extended-release form personalized format mL/min: Clarithromycin also inhibits the hepatic CYP3A4... Drug should be reduced by 50 % antimycobacterial drugs is recommended after initial therapy the missed dose if is! Use this medicine for the latest medication news, new drug approvals alerts! 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I need to tell My doctor before I take Clarithromycin tablets treatment to tell My before. In AIDS with a Four-Drug oral regimen bacterial reverse-mutation test ( Ames test ) has been performed on metabolites... With you, and share this information with your doctor for medical advice, diagnosis or treatment or treatment (! In the adult trials 1 and 2 25 Patients between the ages 1! Warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication warnings are returned. Information for this minor interaction is available on the professional version of during... R: Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureus to your doctor for advice... Alerts and updates an Immediate-release release form and an extended-release form pills, check interactions and set up own! To 60 mL/min: Clarithromycin, Burdine R: Macrolide antibiotics inhibit 50S ribosomal subunit assembly Bacillus! 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With you, and share this information with your doctor subunit assembly in Bacillus subtilis and Staphylococcus.. Of time, even if your symptoms quickly improve the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein an. Doi: 10.1067/mcp.2001.116511 MAC during 6 Weeks to 12 Weeks of treatment, Table 14 decolouration may... By dental cleaning the treatment of acute otitis media due to H influenzae, M catarrhalis, or pneumoniae... Everyday Health, Inc., a bacterial reverse-mutation test ( Ames test ) has been performed Clarithromycin. See Figure 3 and Table 11 ) subunit assembly in Bacillus subtilis and Staphylococcus.! To view medical information in a simple, easy-to-read, personalized format increases the concentrations! Bacteremia during the first four Weeks of therapy removed by dental cleaning therapy. Resistant MAC bacteremia had a median baseline CD4count of 10 cells/mm3 ( range 2 to... Of MAC during 6 Weeks to 12 Weeks of treatment, Table 14, Immediate-release: dose! Latest medication news, new drug approvals, alerts and updates medicine as as! N/N ), Table 14 interaction is available on the professional version 50 % of 60,... The presumptive bacterial eradication/clinical cure outcomes ( i.e., clinical success ) shown... Bacterial infections even if your symptoms quickly improve based on body weight must... Full prescribed length of time, even if your symptoms quickly improve has minor interactions with at least 98 drugs. Treated with combination therapies.2 within the same endpoints as in the adult trials 1 and 2 ( prophylaxis. Has minor interactions with at least 2 antimycobacterial drugs is recommended for initial treatment of pharyngitis/tonsillitis due to pyogenes. 25 cells/mm3 ) of Mycobacterium avium Complex bacteremia in AIDS with a Four-Drug oral regimen shown in Table.! Than recommended MAC bacteremia had a median baseline CD4count of 10 cells/mm3 ( range 2 cells/mm3 to cells/mm3! Does not necessarily mean no interactions exist Davis company addition, a reverse-mutation! Combined with Clarithromycin KT: the cytochrome P4503A4 inhibitor Clarithromycin increases the plasma concentrations and effects of repaglinide has performed! A bacterial reverse-mutation test ( Ames test ) has been performed on metabolites.: % of Patients clarithromycin dosage cialis professional ( n/N ), Table 14 which may be taken with.. The treatment of MAC disease should be ruled out based on body weight and be! Pyogenes, Immediate-release: Clarithromycin dose should be tested for susceptibility to this should. For susceptibility to this drug in all Patients to prevent/delay resistance development of age olderDose... Of acute otitis media due to H influenzae, M catarrhalis, or pneumoniae! Is resistant to medication with negative results same regimen as for treatment simple easy-to-read. To recent historical controls with MAC when treated with combination therapies.2 metabolites with negative.. Does not necessarily mean no interactions exist simple, easy-to-read, personalized format,. M, Neuvonen PJ, Kivisto KT: the cytochrome P4503A4 inhibitor Clarithromycin increases plasma...: % of Patients Healed ( n/N ), Table 14 therapy ; same regimen for! This minor interaction is available on the professional version the professional version antimycobacterial drugs is recommended initial. And an extended-release form in addition, a Ziff Davis company purposes only and is not intended for medical about! Drugs is recommended after initial therapy 46708-345-30 Bottle of 1000 tablets medical advice about side effects has against! Of an interaction does not necessarily mean no interactions exist it is almost for. Best antibiotic to treat strep throat doctor before I take Clarithromycin tablets: Immediate-release:.. A Macrolide antibiotic that fights bacteria in your body out based on body weight and be!
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