Limit dosages and durations to the minimum required. Effect of interaction is not clear, use caution. affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)aripiprazole and chlorpromazine both increase QTc interval. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.Serious - Use Alternative (1)oxaliplatin and chlorpromazine both increase QTc interval. Effect of interaction is not clear, use caution. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics). Comment: Increases risk of neuroleptic malignant syndrome.Serious - Use Alternative (1)chlorpromazine and amisulpride both increase QTc interval. Additive anticholinergic effects, possible hypoglycemia.Serious - Use Alternative (1)solifenacin and chlorpromazine both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)chlorpromazine and ziconotide both increase sedation. This medication may be prescribed for other uses; talk to your doctor or pharmacist for more information. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Avoid or Use Alternate Drug. Monitor Closely (1)chlorpromazine and protriptyline both increase sedation. Panobinostat is known to significantly prolong QT interval. Use Caution/Monitor. only. Monitor Closely (2)chlorpromazine, dextroamphetamine. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)clonazepam and chlorpromazine both increase sedation. Monitor Closely (1)chlorpromazine and pasireotide both decrease QTc interval. methocarbamol and chlorpromazine both increase sedation. chlorpromazine and topiramate both increase sedation. Minor/Significance Unknown. Avoid or Use Alternate Drug. Applies only to oral form of both agents. For more information, visit the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm. epinephrine racemic and chlorpromazine both increase QTc interval. Either increases effects of the other by Other (see comment). diphenoxylate hcl and chlorpromazine both increase sedation. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval. CYP2D6 inhibition decreases metabolism of tamoxifen to hydroxytamoxifen, and N-desmethyl tamoxifen to endoxifen (active metabolites with 100-fold greater affinity for estrogen receptor); decreased endoxifen levels may result in poor clinical outcome. haloperidol will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. If you become pregnant while taking chlorpromazine, call your doctor. Minor/Significance Unknown. Use Caution/Monitor.chlorpromazine increases effects of henbane by pharmacodynamic synergism. PRECAUTIONS: See also Warning section.Before using chlorpromazine, tell your doctor or pharmacist if you are allergic to it; or to other phenothiazine drugs (such as perphenazine, thioridazine); or if you have any other allergies. Use alternatives if available. Monitor Closely (1)abiraterone increases levels of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. chlorpromazine increases and dexmethylphenidate decreases sedation. Avoid or Use Alternate Drug. Use Caution/Monitor.belladonna alkaloids decreases levels of chlorpromazine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. clobazam will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. histrelin increases toxicity of chlorpromazine by QTc interval. degarelix and chlorpromazine both increase QTc interval. chlorpromazine increases effects of perindopril by unspecified interaction mechanism. Avoid or Use Alternate Drug. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties. Use Caution/Monitor. Avoid or Use Alternate Drug.Minor (1)amiodarone will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. This information is not individual medical advice and does not substitute for the advice of your health care professional. crizotinib and chlorpromazine both increase QTc interval. Several anticonvulsant agents (eg, phenytoin, valproic acid, and carbamazepine) have. Either increases toxicity of the other by pharmacodynamic synergism. QTc interval. Use Caution/Monitor. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Either increases toxicity of the other by sedation. Avoid or Use Alternate Drug. Additive anticholinergic effects, possible hypoglycemia. Avoid or Use Alternate Drug. Increased extrapyramidal symptoms. Mechanism: unknown. belladonna and opium decreases levels of chlorpromazine by pharmacodynamic antagonism. Monitor Closely (1)thalidomide increases effects of chlorpromazine by unspecified interaction mechanism. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Use Caution/Monitor. Use Caution/Monitor. desflurane and chlorpromazine both increase QTc interval. Monitor Closely (3)dicyclomine decreases levels of chlorpromazine by inhibition of GI absorption. chlorpromazine increases and arformoterol decreases sedation. Use Caution/Monitor. Monitor Closely (1)chlorpromazine increases and terbutaline decreases sedation. only. quinacrine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Comment: Phenothiazines may increase blood glucose concentrations. Use Caution/Monitor. Unless your doctor tells you otherwise, continue your normal diet. chlorpromazine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug. Comment: Amifampridine can cause seizures. Applies only to oral form of both agents. Monitor Closely (1)chlorpromazine, porfimer. voclosporin, chlorpromazine. dizziness, feeling unsteady, or having trouble keeping your balance, unusual, slowed, or uncontrollable movements of any part of the body, difficulty falling asleep or staying asleep, widening or narrowing of the pupils (black circles in the middle of the eyes), sore throat, chills, and other signs of infection, uncontrollable, rhythmic face, mouth, or jaw movements, swelling of the eyes, face, mouth, lips, tongue, throat, arms, hands, feet, ankles, or lower legs. chlorpromazine and dosulepin both increase QTc interval. amoxapine, chlorpromazine. Additive anticholinergic effects, possible hypoglycemia. chlorpromazine and thiothixene both increase sedation. Use Caution/Monitor. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. donepezil and chlorpromazine both increase QTc interval. Use Caution/Monitor.chlorpromazine, phentermine. Monitor Closely (1)alprazolam and chlorpromazine both increase sedation. Monitor Closely (1)dexchlorpheniramine and chlorpromazine both increase sedation. To use the sharing features on this page, please enable JavaScript. Chlorpromazine. tobacco use decreases levels of chlorpromazine by increasing metabolism. Use Caution/Monitor. Either increases levels of the other by decreasing metabolism. Monitor Closely (1)chlorpromazine and lenvatinib both increase QTc interval. Interaction more likely in certain predisposed pts. Minor (1)chlorpromazine increases effects of enalapril by unspecified interaction mechanism. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and droperidol both increase QTc interval. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Contraindicated (1)chlorpromazine and sotalol both increase QTc interval. Minor/Significance Unknown. unspecified interaction mechanism. Avoid or Use Alternate Drug. Use sunscreen and wear protective clothing when outdoors. escitalopram increases toxicity of chlorpromazine by QTc interval. Monitor Closely (3)chlorpromazine and paliperidone both increase QTc interval. Each drug may increase the photosensitizing effect of the other. Use Caution/Monitor. capecitabine and chlorpromazine both increase QTc interval. Consider dose reduction of either or both agents to avoid serious adverse effects. Additive photosensitizing effects. Use Caution/Monitor. Serious - Use Alternative (1)dacomitinib will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. chlorpromazine and fluconazole both increase QTc interval. smoking decreases levels of chlorpromazine by increasing metabolism. Mechanism: unknown. Use Caution/Monitor. Use Caution/Monitor. only. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)tapentadol and chlorpromazine both increase sedation. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)chlorpromazine increases levels of vortioxetine by affecting hepatic enzyme CYP2D6 metabolism. For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. It can also help you relax before a procedure. chlorpromazine increases effects of fesoterodine by pharmacodynamic synergism. Avoid or Use Alternate Drug. January 5, 2022 What is chlorpromazine? Serious - Use Alternative (1)ponesimod, chlorpromazine. chlorpromazine increases effects of dicyclomine by pharmacodynamic synergism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. STORAGE: Not applicable. Use Caution/Monitor. Serious - Use Alternative (1)givosiran will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and chlorpromazine both increase QTc interval. atropine IV/IM decreases levels of chlorpromazine by inhibition of GI absorption. Minor/Significance Unknown. Avoid or Use Alternate Drug.Minor (1)perphenazine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. chlorpromazine and erythromycin stearate both increase QTc interval. Increases risk of torsades de pointes. Limit dosages and durations to the minimum required. Avoid or Use Alternate Drug. Use Caution/Monitor. chlorpromazine and pitolisant both increase QTc interval. Use Caution/Monitor. unspecified interaction mechanism. Avoid or Use Alternate Drug.Minor (2)amitriptyline, chlorpromazine. Effect of interaction is not clear, use caution. Monitor Closely (1)ketamine and chlorpromazine both increase sedation. Monitor Closely (3)chlorpromazine and risperidone both increase QTc interval. Minor/Significance Unknown. chloroquine increases toxicity of chlorpromazine by QTc interval. You should remain lying down for at least 30 minutes after each injection.The dosage is based on your medical condition, body weight, and response to treatment.Tell your doctor if your condition lasts or gets worse. Use Caution/Monitor. Monitor Closely (1)chlorpromazine will increase the level or effect of zolpidem by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)granisetron and chlorpromazine both increase QTc interval. Mechanism: unknown. Decrease vortioxetine dose by 50% when coadministered with strong CYP2D6 inhibitors. gadobenate and chlorpromazine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. chlorpromazine increases effects of solifenacin by pharmacodynamic synergism. Modify Therapy/Monitor Closely. only. Avoid or Use Alternate Drug. Monitor Closely (2)chlorpromazine and olanzapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor.rocuronium decreases levels of chlorpromazine by pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. Additive anticholinergic effects, possible hypoglycemia.Minor (1)darifenacin will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Monitor closely for signs of respiratory depression and sedation. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor.chlorpromazine, dextroamphetamine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Use Caution/Monitor.chlorpromazine increases effects of glycopyrrolate by pharmacodynamic synergism. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.Get medical help right away if you have any very serious side effects, including: severe dizziness, fainting, slow/shallow breathing.This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Medicines. Minor (1)chlorpromazine increases effects of moexipril by unspecified interaction mechanism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Monitor Closely (2)chlorpromazine increases toxicity of glycopyrrolate by unknown mechanism. Monitor Closely (2)chlorpromazine, fenfluramine. vecuronium decreases levels of chlorpromazine by pharmacodynamic antagonism. Additive anticholinergic effects, possible hypoglycemia. chlorpromazine and trazodone both increase QTc interval. Serious - Use Alternative (1)chlorpromazine, calcium/magnesium/potassium/sodium oxybates. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. only.chlorpromazine decreases effects of epinephrine by pharmacodynamic antagonism. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate. Comment: Risk of neurotoxicity. chlorpromazine and pexidartinib both increase Other (see comment). Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. chlorpromazine increases effects of belladonna alkaloids by pharmacodynamic synergism. darifenacin decreases levels of chlorpromazine by inhibition of GI absorption. Avoid or Use Alternate Drug. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Contact the applicable plan Use Caution/Monitor. Generic alternatives may be available. hyoscyamine decreases levels of chlorpromazine by inhibition of GI absorption. Use Caution/Monitor. Minor/Significance Unknown. oxaliplatin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug. chlorpromazine increases effects of quinapril by unspecified interaction mechanism. chlorpromazine increases effects of cisatracurium by pharmacodynamic synergism. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. chlorpromazine increases and epinephrine decreases sedation. Use Caution/Monitor. Use Caution/Monitor.chlorpromazine, dopamine. Use Caution/Monitor. Monitor Closely (1)mipomersen, chlorpromazine. Serious - Use Alternative (1)inotuzumab and chlorpromazine both increase QTc interval. amitriptyline, chlorpromazine. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Either increases levels of the other by pharmacodynamic synergism. Consider predose and post-colonoscopy ECGs in patients at increased risk of serious cardiac arrhythmias. Patient should be closely observed for loss of blood glucose control; when drugs are withdrawn from a patient receiving metformin, patient should be observed closely for hypoglycemia. Avoid or Use Alternate Drug. Use Caution/Monitor. Medications that have been reported to be effective include chlorpromazine (Thorazine), 1, 2 nifedipine (Procardia), 3 haloperidol (Haldol), 1, 4 phenytoin (Dilantin), 1 metoclopramide. Modify Therapy/Monitor Closely. Monitor Closely (1)chlorpromazine and maprotiline both increase sedation. Use Caution/Monitor. chlorpromazine decreases effects of dopamine by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)chlorpromazine and imipramine both increase sedation. Use Caution/Monitor. Use Caution/Monitor.chlorpromazine, epinephrine. terbinafine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. commonly, these are "non-preferred" brand drugs or specialty chlorpromazine decreases effects of levodopa inhaled by pharmacodynamic antagonism. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. darifenacin decreases levels of chlorpromazine by pharmacodynamic antagonism. Serious - Use Alternative (1)aminolevulinic acid oral, chlorpromazine. atracurium decreases levels of chlorpromazine by pharmacodynamic antagonism. atropine decreases levels of chlorpromazine by pharmacodynamic antagonism. Excessive anticholinergic effects and/or hypoglycemia possible. Avoid or Use Alternate Drug. Contraindicated. eliglustat and chlorpromazine both increase QTc interval. chlorpromazine and pasireotide both decrease QTc interval. ECG monitoring is recommended if coadministered. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)voclosporin, chlorpromazine. diphenhydramine and chlorpromazine both increase sedation. Minor/Significance Unknown. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. . Additive anticholinergic effects. Monitor Closely (1)lumefantrine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Limit dosages and durations to the minimum required. indacaterol, inhaled, chlorpromazine. chlorzoxazone and chlorpromazine both increase sedation. Mechanism: unknown. It is also important information to carry with you in case of emergencies. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)anagrelide and chlorpromazine both increase QTc interval. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.chlorpromazine, benzphetamine. Minor/Significance Unknown. Additive anticholinergic effects, possible hypoglycemia. Applies only to oral form of both agents. chlorpromazine and posaconazole both increase QTc interval. oxybutynin topical increases toxicity of chlorpromazine by unspecified interaction mechanism. Adding plans allows you to compare formulary status to other drugs in the same class. methoxsalen, chlorpromazine. buprenorphine transdermal and chlorpromazine both increase sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Additive anticholinergic effects, possible hypoglycemia. Minor/Significance Unknown. Additive anticholinergic effects, possible hypoglycemia.Minor (1)chlorpromazine increases toxicity of atropine by unknown mechanism. Serious - Use Alternative (1)selinexor, chlorpromazine. chlorpromazine and thiothixene both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Monitor Closely (1)midazolam intranasal, chlorpromazine. Monitor Closely (1)cenobamate, chlorpromazine. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor. When chlorpromazine is used to relieve nervousness before surgery, it is usually taken 2-3 hours before surgery. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)chlorpromazine and posaconazole both increase QTc interval. ciprofloxacin and chlorpromazine both increase QTc interval. Chlorpromazine is also used in adults to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus. Minor/Significance Unknown. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor.chlorpromazine increases effects of scopolamine by pharmacodynamic synergism. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and promethazine both increase QTc interval. chlorpromazine increases and phendimetrazine decreases sedation. only. atropine decreases levels of chlorpromazine by inhibition of GI absorption. anticholinergic/sedative combos decreases levels of chlorpromazine by pharmacodynamic antagonism. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy.This medication passes into breast milk and may have undesirable effects on a nursing infant. Monitor closely for signs of respiratory depression and sedation. cyclizine and chlorpromazine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. chlorpromazine and iloperidone both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor Closely (1)chlorpromazine increases and pirbuterol decreases sedation. Comment: Phenothiazines may increase or decrease glucose levels, monitor therapy closely when these agents are concurrently administered. Monitor Closely (2)benperidol and chlorpromazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.oxybutynin topical decreases levels of chlorpromazine by pharmacodynamic antagonism. Serious - Use Alternative (1)chlorpromazine and octreotide both increase QTc interval. chlorpromazine increases and benzphetamine decreases sedation. Additive anticholinergic effects, possible hypoglycemia. Either increases levels of the other by decreasing metabolism. Either increases effects of the other by pharmacodynamic synergism. chlorpromazine and pimozide both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (3)hyoscyamine decreases levels of chlorpromazine by inhibition of GI absorption. Avoid or Use Alternate Drug. Either increases levels of the other by decreasing metabolism. Contraindicated. Use Caution/Monitor.chlorpromazine increases effects of aclidinium by pharmacodynamic synergism. chlorpromazine and fostemsavir both increase QTc interval. chlorpromazine and trazodone both increase sedation. Minor/Significance Unknown. Also tell your doctor if you have ever had to stop taking a medication for mental illness due to severe side effects or if you plan to work with organophosphorus insecticides (a type of chemical used to kill insects). Minor/Significance Unknown. Additive anticholinergic effects, possible hypoglycemia. Avoid use of chlorpromazine near the due date because it may cause low blood pressure in the mother. chlorpromazine and mirtazapine both increase sedation. QTc interval. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor. This product may contain inactive ingredients (such as sodium metabisulfite), which can cause allergic reactions or other problems. Avoid or Use Alternate Drug. 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