Minor (1)chloroquine increases toxicity of formoterol by QTc interval. Monitor Closely (1)chloroquine will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. levoketoconazole will increase the level or effect of chloroquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. (See also Notes section.). Contraindicated.Serious - Use Alternative (1)clarithromycin will increase the level or effect of chloroquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended. If unable to avoid coadministration of belzutifan with sensitive CYP3A4 substrates, consider increasing the sensitive CYP3A4 substrate dose in accordance with its prescribing information. Serious - Use Alternative (1)chloroquine increases toxicity of chlorpromazine by QTc interval. Use Caution/Monitor. Minor/Significance Unknown. Separate doses by at least 4 hr. Nausea, vomiting, abdominal cramps, headache, and diarrhea may occur. fingolimod and chloroquine both increase QTc interval. Modify Therapy/Monitor Closely. Contraindicated. Avoid or Use Alternate Drug. chloroquine and levalbuterol both increase QTc interval. Serious - Use Alternative (2)chloroquine increases toxicity of pimozide by QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Minor/Significance Unknown. Serious - Use Alternative (1)chloroquine increases toxicity of dronedarone by QTc interval. Minor/Significance Unknown. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. chloroquine increases levels of fluphenazine by decreasing metabolism. Otherwise, call a poison control center right away. chloroquine will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. chloroquine increases toxicity of apomorphine by QTc interval. Most chloroquine decreases effects of human papillomavirus vaccine, nonavalent by pharmacodynamic antagonism. chloroquine and panobinostat both increase QTc interval. Applies only to oral form of both agents. Minor/Significance Unknown. carbamazepine will decrease the level or effect of chloroquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lonafarnib will increase the level or effect of chloroquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Mechanism: unknown. Monitor Closely (1)chloroquine increases toxicity of clozapine by QTc interval. sodium bicarbonate will decrease the level or effect of chloroquine by Mechanism: inhibition of GI absorption. Use Caution/Monitor. Minor (1)chloroquine decreases effects of travelers diarrhea and cholera vaccine inactivated by pharmacodynamic antagonism. anastrozole will increase the level or effect of chloroquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)chloroquine increases toxicity of arsenic trioxide by QTc interval. Avoid or Use Alternate Drug. chloroquine will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. chloroquine decreases levels of praziquantel by unspecified interaction mechanism. Minor (1)chloroquine decreases effects of human papillomavirus vaccine, nonavalent by pharmacodynamic antagonism. If it is near the time of the next dose, skip the missed dose. Inhibition of CYP2D6 metabolism to tamoxifen's active metabolite, endoxifen. chloroquine increases toxicity of levofloxacin by QTc interval. Serious - Use Alternative (1)chloroquine increases toxicity of quinine by QTc interval. Serious - Use Alternative (2)itraconazole will increase the level or effect of chloroquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dosage form: oral tablet (250 mg; 500 mg) Drug classes: Amebicides, Antimalarial quinolines Medically reviewed by Drugs.com on Jun 6, 2022. chloroquine will increase the level or effect of galantamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate. 1142537: Chloroquine phosphate tablets . To prevent malaria, take chloroquine as directed by your doctor, usually once a week on the same day each week. chloroquine increases toxicity of methadone by QTc interval. Then, 5 mg per kg of body weight taken 6 hours, 24 hours, and 36 hours after the first dose. chloroquine will increase the level or effect of hydromorphone by affecting hepatic enzyme CYP2D6 metabolism. Chloroquine phosphate tablet, USP, is a 4-aminoquinoline compound for oral administration. Administer a quarter of brexpiprazole dose if coadministered with a moderate CYP2D6 inhibitor PLUS a strong/moderate CYP3A4 inhibitor. Use Caution/Monitor. Use Caution/Monitor.chloroquine increases toxicity of desipramine by QTc interval. Serious - Use Alternative (1)tucatinib will increase the level or effect of chloroquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Minor (1)chloroquine decreases effects of oxycodone by decreasing metabolism. Use Caution/Monitor. Minor/Significance Unknown. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling. Minor/Significance Unknown. If you have diabetes, be sure to check your blood sugars regularly. Tell your doctor right away if you have any serious side effects, including: slow heartbeat, symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain), mental/mood changes (such as anxiety, depression, rare thoughts of suicide, hallucinations), hearing changes (such as ringing in the ears, hearing loss), easy bruising/bleeding, signs of liver disease (such as severe stomach/abdominal pain, yellowing eyes/skin, dark urine), signs of kidney problems (such as change in the amount of urine), muscle weakness, unwanted/uncontrolled movements (including tongue/face twitching), hair loss, hair/skin color changes. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Use Caution/Monitor. chloroquine increases toxicity of droperidol by QTc interval. Avoid or Use Alternate Drug. Adjust dose of drugs that are CYP3A4 substrates as necessary. Minor (1)chloroquine increases toxicity of rilpivirine by QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. chloroquine will increase the level or effect of oxycodone by affecting hepatic enzyme CYP2D6 metabolism. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. chloroquine increases toxicity of deutetrabenazine by QTc interval. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Talk to your pharmacist for more details. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. chloroquine increases levels of perphenazine by decreasing metabolism. Use Caution/Monitor. Monitor Closely (1)chloroquine increases toxicity of olanzapine by QTc interval. asenapine transdermal and chloroquine both increase QTc interval. Monitor Closely (2)chloroquine increases toxicity of ribociclib by QTc interval. Chloroquine may cause a condition that affects the heart rhythm (QT prolongation). Applies only to oral form of both agents. Avoid or Use Alternate Drug. Increased risk of QT prolongation and cardiac arrhythmias.Serious - Use Alternative (1)saquinavir will increase the level or effect of chloroquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)chloroquine will increase the level or effect of tolterodine by affecting hepatic enzyme CYP2D6 metabolism. chloroquine increases levels of tamsulosin by affecting hepatic enzyme CYP2D6 metabolism. chloroquine and siponimod both increase QTc interval. chloroquine increases toxicity of erythromycin ethylsuccinate by QTc interval. Use Caution/Monitor. 1 g (600 mg base) PO qDay for 2 days, THEN, FDA revoked the emergency use authorization (EUA) for chloroquine June 15, 2020, Based on its ongoing analysis of the EUA and emerging scientific data, the FDA determined that chloroquine is unlikely to be effective in treating COVID-19 for the authorized uses in the EUA; additionally, in light of ongoing serious cardiac adverse events and other potential serious side effects, the known and potential benefits of chloroquine no longer outweigh the known and potential risks for the EUA, While additional clinical trials may continue to evaluate potential benefit, the FDA determined the EUA was no longer appropriate, The NIH COVID-19 Treatment Guidelines recommend against the use of chloroquine or hydroxychloroquine and/or azithromycin for the treatment of COVID-19 in hospitalized patients and in nonhospitalized patients, For more information, see the FDA news release: FDA Revokes Emergency Use Authorization for Chloroquine and Hydroxychloroquine, 125-250 mg (75-150 mg base) PO twice weekly, Orphan designation for treatment of glioblastoma multiforme. Contraindicated. Each 250 mg tablet of chloroquine phosphate is equivalent to 150 mg base andeach 500 mg tablet of chloroquine phosphate is equivalent to 300 mg base. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors are given concomitantly with strong or moderate CYP3A inhibitors.Monitor Closely (1)eliglustat increases levels of chloroquine by affecting hepatic enzyme CYP2D6 metabolism. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling. aspirin/citric acid/sodium bicarbonate will decrease the level or effect of chloroquine by cation binding in GI tract. Serious - Use Alternative (1)chloroquine decreases effects of influenza virus vaccine trivalent, adjuvanted by pharmacodynamic antagonism. chloroquine will increase the level or effect of perhexiline by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)rifampin will decrease the level or effect of chloroquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. chloroquine increases toxicity of arsenic trioxide by QTc interval. Avoid or Use Alternate Drug.ceritinib will increase the level or effect of chloroquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Substrate dose in accordance with product labeling or Use Alternate Drug.ceritinib will increase the or. Are CYP3A4 substrates as necessary chloroquine increases toxicity of clozapine by QTc interval pimozide by QTc interval Closely!, exercise caution and consider a dose reduction of the next dose skip! 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