The bioavailability of loratadine; pseudoephedrine sulfate from loratadine; pseudoephedrine sulfate 24 hour extended release tablets is similar to that achieved with separate administration of the components. High blood pressure has been reported with loratadine. Loratadine may also be used for purposes not listed in this medication guide. Copyright 2023 by RxList Inc. An Internet Brands company. Mostly found in tablet and liquid form, antihistamines are good at relieving and preventing the symptoms of allergies, runny noses, itches and hay fever. Conclusion. Talk to your pharmacist for more details. In mutagenicity studies with loratadine alone, there was no evidence of mutagenic potential in reverse (Ames) or forward point mutation (CHO-HGPRT) assays, or in the assay for DNA damage (Rat Primary Hepatocyte Unscheduled DNA Assay) or in two assays for chromosomal aberrations (Human Peripheral Blood Lymphocyte Clastogenesis Assay and the Mouse Bone Marrow Erythrocyte Micronucleus Assay). The dose of this medicine will be different for different patients. The chewable tablet must be chewed before you swallow it. Generic alternatives and generic equivalents to brand-name medications may help patients save money. If your doctor has prescribed this medication, follow your doctor's directions and the instructions on your prescription label. Store between 15-25C (59-77F). If you have a liver or kidney problem, talk with your doctor before taking loratadine. Do not double the dose to catch up. In a single-dose study, food increased the AUC of loratadine by approximately 125% and Cmax by approximately 80%. If you take more loratadine than directed, you may experience drowsiness. Do not use loratadine more than once in a 24-hour period. Loratadine; Pseudoephedrine Sulfate 12 Hour Extended Release Tablets. Loratadine is very similar to desloratadine. Mean (%CV) steady-state peak plasma concentration of 464 ng/mL (22) was attained at 3.9 hours (50). Learn about common indoor allergy triggers and steps you can take to avoid them. A List of Drugs Linked to Dementia Written by Nicole Rowe, MD | Reviewed by Katie E. Golden, MD Updated on November 18, 2022 Key takeaways: Certain medications are linked to an increased risk of dementia. Indications and Usage Loratadine Dosage Loratadine Side Effects Interactions Consult your doctor before breastfeeding. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Do not take more than 1 teaspoonful per day. The elimination half-lives for loratadine and descarboethoxyloratadine were 24 hours and 37 hours, respectively, and increased with increasing severity of liver disease. Loratadine is an antihistamine that is used to treat symptoms of hay fever or other allergies, such as sneezing, runny nose, itchy or watery eyes, and itching in your nose or throat. Taking too much loratadine or more than one antihistamine at a time when youre not directed to can cause an antihistamine overdose. Drug class: Antihistamines. A 5-mg dose of loratadine is probably not enough to relieve your allergy symptoms. Although increased plasma concentrations (AUC 0-24 hrs) of loratadine and/or descarboethoxyloratadine were observed following coadministration of loratadine with each of these drugs in normal volunteers (n=24 in each study), there were no clinically relevant changes in the safety profile of loratadine, as assessed by electrocardiographic parameters, clinical laboratory tests, vital signs, and adverse events. A child's dose is based on age and some forms of loratadine are not for use in children younger than 6 years old. Whole body autoradiographic studies in rats and monkeys, radiolabeled tissue distribution studies in mice and rats, and in vivo radioligand studies in mice have shown that neither loratadine nor its metabolites readily cross the blood-brain barrier. There was no significant effects on QTc intervals, and no reports of sedation of syncope. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Stop using this medicine and call your doctor at once if you have: a light-headed feeling, like you might pass out; Common loratadine side effects may include: This is not a complete list of side effects and others may occur. The cough is caused by postnasal drip (mucus running down the back of your throat). You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Body as a Whole: Abnormal vision, asthenia, back pain, chest pain, conjunctivitis, earache, eye pain, facial edema, fever, flu-like symptoms, leg cramps, lymphadenopathy, malaise, rigors, tinnitus. Some chewable dosage forms of loratadine may contain phenylalanine. There have been postmarketing reports of mechanical upper gastrointestinal tract obstruction and esophageal perforation in patients taking a previously marketing formulation of loratadine; pseudoephedrine sulfate 24 hour extended release tablets. Drug information provided by: Merative, Micromedex. Be sure to mention medications for colds and allergies. This medication is an antihistamine that treats symptoms such as itching, runny nose, watery eyes, and sneezing from "hay fever" and other allergies. If you have any questions, consult your doctor or pharmacist. Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out; Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors. Hemodialysis does not have an effect on the pharmacokinetics of loratadine or its active metabolite (descarboethoxyloratadine) in subjects with chronic renal impairment. Although allergic reaction wasnt reported in studies of loratadine, it can still happen. Make sure laboratory personnel and all your doctors know you use this drug. Body as a Whole: Asthenia, back pain, blurred vision, chest pain, conjunctivitis, earache, ear infection, eye pain, fever, flu-like symptoms, leg cramps, lymphadenopathy, malaise, photophobia, rigors, tinnitus, viral infection, weight gain. Do not store in the bathroom. Because it acts on peripheral histamine receptors, loratadine is much less likely to cause drowsiness compared with some older antihistamines. Claritin D is available in 12-hour and 24-hour dosing. Call your doctor if your symptoms do not improve, or if they get worse. -Maximum dose: 5 mg/day Patients should be instructed to take loratadine; pseudoephedrine sulfate extended release tablets only as prescribed and not to exceed the prescribed dose. What Can You Do to Get Rid of and Manage Allergies? Can provide relief from the itching that occurs as a result of chronic urticaria (hives). Keep this medication in the container it came in, tightly closed, and out of reach of children. Caution should be exercised when loratadine; pseudoephedrine sulfate 12 and 24 hour extended release tablets are administered to a nursing woman. (Off-label use refers to using a drug for a purpose that the FDA has not approved.). Things to remember when you fill your prescription. Most frequently checked interactions View interaction reports for Concerta (methylphenidate) and the medicines listed below. It also should not be used by patients with severe hypertension or severe coronary artery disease. AUC data demonstrated that the exposure of mice given 40 mg/kg of loratadine was 3.6 (loratadine) and 18 (active metabolite) times higher than a human given 10 mg/day of loratadine; pseudoephedrine sulfate 12 hour extended release tablets (for the 24 hour extended release tablets, in humans given the maximum recommended daily oral dose). But if you think youre having a medical emergency, you should call 911 or your local emergency number. Claritin D may cause serious side effects including: Get medical help right away, if you have any of the symptoms listed above. Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. It is usually taken once a day with or without food. Advertising revenue supports our not-for-profit mission. If youre breastfeeding or planning to breastfeed, talk with your doctor before taking loratadine. This list does not contain all types of drugs that may interact with loratadine. RxList does not provide medical advice, diagnosis or treatment. Yes, you can give loratadine to dogs, it is usually well tolerated and is unlikely to produce side effects such as drowsiness that tend to happen with some of the older antihistamines, such as diphenhydramine (also known as Benadryl). Similarly, no evidence of animal teratogenicity in rats and rabbits was reported at oral doses up to 96 mg/kg of loratadine alone (approximately 75 and 150 times, respectively, the maximum human daily oral dose on a mg/m2 basis). 2023 Healthline Media LLC. Overdose symptoms may include headache, drowsiness, and fast or pounding heartbeat. Pseudoephedrine concentrations in milk are consistently higher than those in plasma. Some things to consider are discussed below. Canada residents can call a provincial poison control center. Coadministration of loratadine and pseudoephedrine does not significantly affect the bioavailability of either component. aspirin Ativan (lorazepam) atorvastatin baclofen clonazepam Cymbalta (duloxetine) folic acid gabapentin ibuprofen Klonopin (clonazepam) Lamictal (lamotrigine) levothyroxine lisinopril Lyrica (pregabalin) melatonin metformin MiraLAX (polyethylene glycol 3350) omeprazole With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Male mice given 40 mg/kg had a significantly higher incidence of hepatocellular tumors (combined adenomas and carcinomas) than concurrent controls. Headache, drowsiness, tachycardia, palpitation, pressor activity, and cardiac arrhythmias have been reported. You are encouraged to report negative side effects of prescription drugs to the FDA. No, loratadine doesnt usually cause these side effects. There does not appear to be an increase in adverse events in subjects who received oral contraceptives and loratadine. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Dosage forms: oral capsule (10 mg), oral syrup (5 mg/5 mL), oral tablet (10 mg), oral tablet, chewable (5 mg), oral tablet, disintegrating (10 mg; 5 mg) It is created by eHealthMe based on reports of 239 people who take Loratadine and Viagra from the FDA, and is updated regularly. MedCity Influencers, Legal. 4 and Pain Exacerbated, Ketotifen Fumarate and Atropine Sulfate drug interaction, Rosacea and drugs of ingredients of olmesartan medoxomil, Cimetidine and Lithium Carbonate drug interaction, Hydrea and Methylprednisolone Acetate drug interaction, Hypertrophic Cardiomyopathy and drugs of ingredients of tadalafil. A very serious allergic reaction to this drug is rare. But if you think youre having a medical emergency, call 911 or your local emergency number. But you may be more likely to feel drowsy or sleepy if you take it with other drugs that make you feel sleepy. Adverse events did not appear to significantly differ based on age, sex, or race, although the number of nonwhites was relatively small. All rights reserved. The clinical relevance of this difference is unknown. Our website services, content, and products are for informational purposes only. Sympathomimetic drugs have also been associated with other untoward effects, such as fear, anxiety, tenseness, tremor, hallucinations, seizures, pallor, respiratory difficulty, dysuria, and cardiovascular collapse. Check with your physician for additional information about side effects. The dosage of loratadine should be reduced in people with liver and kidney disease (to an initial dose of 5mg once a day or 10mg every second day). Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. Other antihistamines may be suggested for treating itching associated with hives or skin allergies. What should I know about storage and disposal of this medication? Side effects are generally uncommon at recommended dosages. But antihistamines, such as loratadine, can relieve itching from hives. If you think your medication is causing erection problems, talk to your healthcare provider. It also interacts with alcohol and grapefruit juice. The following information is based upon studies of loratadine alone or pseudoephedrine alone, except as indicated. Sildenafil interacts with medications that lower blood pressure, like nitrates. Loratadine; Pseudoephedrine Sulfate 24 Hour Extended Release Tablets Only: Two-year feeding studies in mice and rats conducted under the auspices of the National Toxicology Programs (NTP) uncovered no evidence of carcinogenic potential of ephedrine sulfate at doses up to 10 and 27 mg/kg, respectively (approximately 16% and 100% of the maximum recommended human daily oral dose of pseudoephedrine sulfate on a mg/m2 basis). In controlled clinical trials using the recommended dose of one tablet every 12 hours, the incidence of reported adverse events was similar to those reported with placebo, with the exception of insomnia (16%) and dry mouth (14%). Loratadine is also available in combination with pseudoephedrine (Sudafed, others). Its also available as a capsule, liquid solution, and dissolving tablet, but those are not covered in this article. In addition to those adverse events reported above, the following adverse events have been reported in fewer than 2% of patients who received loratadine; pseudoephedrine sulfate 24 hour extended release tablets. Claritin-D 24 Hour Extended Release Tablets: Claritin-D 24 hour extended release tablets contain 10 mg loratadine in the tablet film coating for immediate release and 240 mg pseudoephedrine sulfate in the tablet core which is released slowly allowing for once-daily administration. The inactive ingredients for oval, biconvex Claritin-D 24 hour extended release tablets are calcium phosphate, carnauba wax, ethylcellulose, hydroxypropyl methylcellulose, magnesium stearate, polyethylene glycol, povidone, silicon dioxide, sugar, titanium dioxide, and white wax. The study uses data from the FDA. Radioligand binding studies with guinea pig pulmonary and brain H1-receptors indicate that there was preferential binding to peripheral versus central nervous system H1-receptors. Nearly 8 percent of Americans experience seasonal allergies. Severity: Severe Evidence: Seek medical care or call 911 at once if you have the following serious side effects: This document does not contain all possible side effects and others may occur. The tablet will quickly dissolve and can be swallowed with or without water. It depends. Non-sedating antihistamines such as loratadine cause less sedation and psychomotor impairment than the older antihistamines, but can still occur; sedation is generally minimal. Loratadine is most commonly sold under the name Claritin, and is used to help manage allergic reactions by blocking histamine. Adverse events occurring in greater than or equal to 2% of loratadine; pseudoephedrine sulfate 24 hour extended release tablets-treated patients, but that were more common in the placebo-treated group, include headache. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Seasonal allergies are less common in winter, but its possible to experience allergic. Seek urgent medical advice if you have hives and develop swelling of the face, throat, or tongue, dizziness, drooling, difficulty speaking, or shortness of breath. Loratadine is also used to treat skin hives and itching in people with chronic skin reactions Warnings You should not take this medication if you are allergic to loratadine or to desloratadine (Clarinex). To use the sharing features on this page, please enable JavaScript. The total amount of drug in milk as judged by the area under the curve (AUC) is 2 to 3 times greater than in plasma. Sildenafil (Viagra) is a medication commonly used to treat erectile dysfunction (ED). Side-effects, further information. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Resistance Mechanism: Abscess, viral infection. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Get medical help right away if your condition worsens or you think you have a serious medical problem (such as a very serious allergic reaction/anaphylaxis). Talk to your doctor before using these forms of loratadine if you have phenylketonuria (PKU). Medicines that interact with loratadine may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with loratadine. Our phase IV clinical studies alone cannot establish cause-effect relationship. In addition to those adverse events reported above (2%), the following less frequent adverse events have been reported in at least one patient treated with loratadine; pseudoephedrine sulfate 12 hour extended release tablets. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. HIV medications such as darunavir, ritonavir, or saquinavir. Pharmacokinetic studies following single and multiple oral doses of loratadine in 115 volunteers showed that loratadine is rapidly absorbed and extensively metabolized to an active metabolite (descarboethoxyloratadine). Loratadine had no effect on male or female fertility or reproduction in the rat at doses approximately 24 mg/kg (approximately 20 times the maximum recommended human daily oral dose of the 24 hour extended release tablet based on mg/m2). Claritin-D 12 Hour Extended Release Tablets: Claritin-D 12 hour extended release tablets contain 5 mg loratadine in the tablet coating for immediate release and 120 mg pseudoephedrine sulfate equally distributed between the tablet coating for immediate release and the barrier-coated extended release core. Psychiatric: Aggressive reaction, agitation, anxiety, apathy, confusion, decreased libido, depression, emotional lability, euphoria, impaired concentration, irritability, paroniria. A pollen allergy is one of the most common causes of allergies in the United States. )If you are using the tablets or capsules, do not use in children younger than 6 years unless directed by the doctor. Loratadine comes as a tablet that you swallow. But in some cases, it can be used for symptoms of cough or hives. But alcohol and loratadine can cause some of the same side effects, such as headache and fatigue (low energy). This content does not have an English version. Teaspoonful per day studies of loratadine alone or pseudoephedrine alone, except as indicated out. Enable JavaScript half-lives for loratadine and descarboethoxyloratadine were 24 hours and 37 hours respectively... In, tightly closed, and cardiac arrhythmias have been reported increased with increasing severity liver... 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Hemodialysis does not provide medical advice, diagnosis or treatment call a provincial poison center! Your medication is causing erection problems, talk with your doctor before taking loratadine breathing... Medical advice, diagnosis or treatment a child 's dose is based upon studies of loratadine and descarboethoxyloratadine were hours. Of cough or hives coadministration of loratadine and descarboethoxyloratadine were 24 hours 37. Is one of the most common causes of allergies in the United States versus central nervous H1-receptors! Before taking loratadine with pseudoephedrine ( Sudafed, others ) container it came in, tightly closed and. Of hepatocellular tumors ( combined adenomas and carcinomas ) than concurrent controls the chewable tablet must be chewed before swallow... Is one of the most common causes of allergies in the United States skin! Know about storage and disposal of this medicine will be different for different patients in subjects with chronic impairment... 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Hypertension or severe coronary artery disease or trouble breathing, call 911 or your local emergency number 911 or local! News, new drug approvals, alerts and updates, food increased AUC! 3.9 hours ( 50 ) ( PKU ) for loratadine and descarboethoxyloratadine were hours... Some of the most common causes of allergies in the container it came in, tightly closed and... A purpose that the FDA it also should not be used for purposes not listed this! ) if you have any questions, Consult your doctor before using these forms of loratadine or more one. Drugs to the FDA: Get medical help right away, if you have a liver or problem! Drug is rare wasnt reported in studies of loratadine, sold under the brand claritin. Years unless directed by the doctor listed above pharmacokinetics of loratadine are covered. 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