Of the total number of subjects who received cefuroxime axetil in 20 clinical trials, 375 were aged 65 and older while 151 were aged 75 and older. 100 to 150 mg/kg/day IV or IM divided every 8 hours for 5 to 14 days. Prescribing in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria (antimicrobial resistance). 150 mg/kg/day (Max: 6 g/day) IV divided every 6 to 8 hours. 10 mg/kg/dose PO every 12 hours for 10 days. [see Carefully monitor renal function, especially during prolonged therapy or use of high aminoglycoside doses. . Skin and Subcutaneous Tissue Disorders: [28573]IV/IM formulations [49892]CrCl more than 20 mL/minute: No dosage adjustment needed.CrCl 10 to 20 mL/minute: Give a loading dose of 0.75 to 1.5 g IV/IM, followed by 750 mg IV/IM every 12 hours.CrCl less than 10 mL/minute: Give a loading dose of 0.75 to 1.5 g IV/IM, followed by 750 mg IV/IM every 24 hours. Drug Interactions (7.3)] Cefuroxime is eliminated renally, and dosages should be adjusted if renal dysfunction is present. Check the manufacturer's instructions prior to administration.Storage after reconstitution: After mixing, store suspension in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other -lactam antibacterial drugs (e.g., penicillins and . Additionally, increased monitoring of the INR, especially during initiation and upon discontinuation of the antibiotic, may be necessary. Clostridioides difficile 4O [32569]Continuous renal replacement therapyAdults: 1 g IV/IM every 12 hours. Includes Cefuroxime indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. 15 mg/kg/dose PO every 12 hours for 10 days. IV doses of 750 mg and 1.5 g produced urinary levels averaging 1,150 and 2,500 mcg/mL, respectively, during the first 8-hour period. Treat for a total duration of 2 to 3 weeks (parenteral plus oral) for uncomplicated cases. Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. Sometimes after starting treatment with antibacterials, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as 2 or more months after having taken their last dose of the antibacterial. 10 to 15 mg/kg/dose PO every 12 hours. . Treat UTIs as presumed pyelonephritis in these patients. Neonates are at risk for systemic infection and rapid change in their clinical condition. [63245] Guidelines recommend cefuroxime as an alternative oral step-down therapy for infants and children 3 months of age and older with S. pneumoniae and penicillin allergy. Guidelines recommend cefuroxime as an alternative to high-dose amoxicillin or high-dose amoxicillin; clavulanate in penicillin allergic patients. Cefuroxime axetil is in the amorphous form and has the following structural formula: Do not force thaw by immersion in water baths or by microwave.Storage: Diluted solutions are stable for 24 hours at room temperature and or 7 days under refrigeration. 1.5 g IV or IM within 30 to 60 minutes prior to the surgical incision. $67.65 medication_outlined Availability Available See GoodRx coupons What is Cefuroxime? Not recommended by guidelines. Drugs that reduce gastric acidity, such as PPIs, can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Resistance to cefuroxime axetil is primarily through hydrolysis by -lactamase, alteration of penicillin-binding proteins (PBPs), decreased permeability, and the presence of bacterial efflux pumps. Side effects Important warnings About Interactions Other warnings Dosage Take as directed Important considerations Alternatives Overview of cefuroxime Cefuroxime oral tablet is only. Chills, sleepiness, thirst. [49892]DilutionFor IV infusion, further dilute in a compatible solution to a usual concentration of 1 to 30 mg/mL.Compatible solutions include 0.9% Sodium Chloride Injection, 5% Dextrose Injection, 5% Dextrose and 0.9% Sodium Chloride Injection, 5% Dextrose and 0.45% Sodium Chloride Injection, 5% Dextrose and 0.225% Sodium Chloride Injection, 10% Dextrose Injection, 10% Invert Sugar in Water for Injection, 1/6 M Sodium Lactate Injection, Ringer's Injection, and Lactated Ringer's Injection.To prepare solution for freezing, immediately withdraw the contents of the reconstituted vials and add to a compatible container containing 50 or 100 mL of 0.9% Sodium Chloride Injection or 5% Dextrose Injection and freeze. Events, Omeprazole; Amoxicillin; Rifabutin: (Major) Avoid the concomitant use of proton pump inhibitors (PPIs) and cefuroxime. Anaphylaxis, serum sickness-like reaction, acute myocardial ischemia with or without myocardial infarction may occur as part of an allergic reaction. Although lifetime studies in animals have not been performed to evaluate carcinogenic potential, no mutagenic activity was found for cefuroxime axetil in a battery of bacterial mutation tests. 5 WARNINGS AND PRECAUTIONS Replace cap securely after each opening. The FDA-approved dose is 250 mg PO every 12 hours for 10 days. Skipping doses or not completing the full course of therapy may: (1) decrease the effectiveness of the immediate treatment, and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by cefuroxime axetil or other antibacterial drugs in the future. 500 mg PO every 12 hours for 14 to 21 days for patients with mild disease not requiring hospitalization (i.e., first degree AV block with PR interval less than 300 milliseconds) or as appropriate oral stepdown treatment after IV therapy in hospitalized patients with severe disease (i.e., symptomatic, first degree AV block with PR interval 300 milliseconds or greater, second or third degree AV block). Children (who cannot swallow the tablets)Use is not recommended. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. R)-7-[2-(2-furyl)glyoxyl-amido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2-carboxylate, 7 generic Patient Education Add to Interaction Check Dosing Calculator Adult Dosing . Drugs that reduce gastric acidity, such as PPIs, can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Gastrointestinal Disorders: In infants (from the age of 3 months) and children with a body mass of less than 40 kg, it may be preferable to adjust dosage according to weight or age. Careful medical history is necessary as pseudomembranous colitis has been reported to occur over 2 months after the administration of antibacterial agents. There is a maximum proportion of PBPs that can be acylated; therefore, once maximum acylation has occurred, killing rates cannot increase. The percentage of subjects treated with cefuroxime axetil who discontinued study drug because of adverse reactions was similar at daily doses of 1,000, 500, and 250 mg (2.3%, 2.1%, and 2.2%, respectively). . The majority of reported cases involve the combination of aminoglycosides and cephalothin or cephaloridine, which are associated with dose-related nephrotoxicity as singular agents. Add the total amount of water, invert the bottle and vigorously rock the bottle from side to side so that water rises through the powder. Limited but conflicting data with other cephalosporins have been noted. 60 to 100 mg/kg/day (Max: 3 g/day) PO divided every 8 hours as step-down therapy after initial parenteral therapy. Investigations: Inform patients that cefuroxime axetil is a cephalosporin that can cause allergic reactions in some individuals To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefuroxime axetil tablets and other antibacterial drugs, cefuroxime axetil tabletsshould be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. 50 mg/kg IV or IM as a single dose (Max: 1.5 g/dose) within 60 minutes prior to the surgical incision. Lansoprazole; Naproxen: (Major) Avoid the concomitant use of proton pump inhibitors (PPIs) and cefuroxime. To treat gonorrhea, cefuroxime is taken as a single dose, and to treat Lyme disease, cefuroxime is taken every 12 hours for 20 days. Approximately 89% of a dose of cefuroxime is excreted by the kidneys over an 8-hour period, resulting in high urinary concentrations. US-based MDs, DOs, NPs and PAs in full-time patient practice can register for free on PDR.net. in vitro and in clinical infections Drugs that reduce gastric acidity, such as PPIs, can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Cefuroxime axetil tabletsare a cephalosporin antibacterial drug indicated for the treatment of the following infections due to susceptible bacteria: ( We do not record any personal information entered above. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. Cefuroxime Axetil Tablets USP, 500 mg of cefuroxime (as cefuroxime axetil), are white to off-white, film-coated, capsule shaped tablets with A34 debossed on one side and plain on the other side. You should confirm the information on the PDR.net site through independent sources and seek other professional guidance in all treatment and diagnosis decisions. The first look at the 'middle aged Love Island' set has been released, which has already been nicknamed the 'Viagra House' by locals after single parents searched for love 60 to 100 mg/kg/day (Max: 3 g/day) PO divided every 8 hours as step-down therapy after initial parenteral therapy. Antibiotics are non-selective and may result in the eradication of beneficial microorganisms while promoting the emergence of undesired ones, causing secondary infections such as oral thrush, colitis, or vaginitis. in vitro minimum inhibitory concentration (MIC) less than or equal to the susceptible breakpoint for cefuroxime against isolates of similar genus or organism group. To compensate for the prolonged elimination half-life, dosing frequency of the oral formulations should be reduced in patients with CrCl less than 30 mL/minute. This trial randomized 317 adult subjects, 132 subjects in the U.S. and 185 subjects in South America. Drug Interaction Studies Streptococcus pyogenes. Revised: 04/2021, Report Adverse Not recommended by guidelines. 6.1) How should this medicine be used? Ask your doctor or pharmacist for more information. A dosage interval adjustment is required for patients whose creatinine clearance is less than 30 mL/min, as listed in Table 4 below, because cefuroxime is eliminated primarily by the kidney Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. For life-threatening infections or infections due to less susceptible organisms, 1.5 g IV every 6 hours may be required. 100 to 150 mg/kg/day IV or IM divided every 6 to 8 hours (Max: 6 g/day) for 5 to 14 days. Cefuroxime and dextrose injection is available in generic form. It is distributed into most body tissues and fluids including gallbladder; liver; kidney; bone; uterus; ovary; sputum; bile; and peritoneal, pleural, and synovial fluids. A longer course (several months) may be needed for severe or complicated infections. MedCity Influencers, Legal. Gentamicin: (Minor) Cefuroxime's product label states that cephalosporins may potentiate the adverse renal effects of nephrotoxic agents, such as aminoglycosides and loop diuretics. Geriatric Patients: In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. All Drug 1 g IV every 12 hours plus an anaerobic agent. Neonates are at risk for systemic infection and rapid change in their clinical condition. Concomitant administration of probenecid with cefuroxime axetil tablets increases the cefuroxime area under the serum concentration versus time curve and maximum serum concentration by 50% and 21%, respectively [28573], Cefuroxime is excreted in human breast milk. 50 to 100 mg/kg/day (Max: 2.25 g/day) IV or IM divided every 6 to 8 hours. Clinical Pharmacology (12.3)]. However, because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Ibuprofen; Famotidine: (Major) Avoid the concomitant use of H2-blockers and cefuroxime. Staphylococcus aureus (including Overdosage of cephalosporins can cause cerebral irritation leading to convulsions or encephalopathy. Cefuroxime should be used cautiously in patients with hypersensitivity to penicillin. The chemical name of cefuroxime axetil (1-(acetyloxy) ethyl ester of cefuroxime) is ( ReconstitutionReconstitute 750 mg or 1.5 g vial with 8.3 or 16 mL, respectively, of Sterile Water for Injection to yield a concentration of approximately 90 mg/mL.Storage: Reconstituted solutions are stable for 24 hours at room temperature or 48 hours under refrigeration (5 degrees C). Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients on -lactam antibacterials, including cefuroxime axetil The FDA-approved dosage is 1 g PO as a single dose. Calcium Carbonate; Magnesium Hydroxide; Simethicone: (Moderate) Antacids can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. The Infectious Diseases Society of America (IDSA) does not recommend cefuroxime for empiric use. The following adverse reactions occurred in less than 1% but greater than 0.1% of subjects (n = 1,061) treated with a single dose of cefuroxime axetil 1,000 mg for uncomplicated gonorrhea in U.S. clinical trials. [see Proton pump inhibitors: (Major) Avoid the concomitant use of proton pump inhibitors (PPIs) and cefuroxime. Additionally, certain cephalosporins (cefotetan, cefoperazone, cefamandole) are associated with prolongation of the prothrombin time due to the methylthiotetrazole (MTT) side chain at the R2 position, which disturbs the synthesis of vitamin K-dependent clotting factors in the liver. Urinary concentrations following IM dosing averaged 1,300 mcg/mL during the first 8 hours. 15 mg/kg/dose (Max: 500 mg/dose) PO every 12 hours for 28 days. Limited but conflicting data with other cephalosporins have been noted. The Clinical and Laboratory Standards Institute (CLSI) and the FDA differ on MIC interpretation for Enterobacterales. Cefuroxime is largely excreted unchanged into the urine via glomerular filtration and tubular secretion. Streptococcus pyogenes. [27500] [30584]. The most common drug-related adverse experiences were diarrhea (10.6%), Jarisch-Herxheimer reaction (5.6%), and vaginitis (5.4%). Drugs that reduce gastric acidity, such as H2-blockers, can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Besides the medical condition it is advised for, the route of administration also plays an important role in determining the correct drug . Patients with hypersensitivity to penicillin: 1.5 g/dose ) within 60 minutes prior to the surgical incision advised. Organisms, 1.5 g produced urinary levels averaging 1,150 and 2,500 mcg/mL, respectively, during the first hours!, acute myocardial ischemia with or without myocardial infarction may occur as part an! 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