Predictions about the interaction can be made based on the metabolic pathways of both drugs. For patients receiving combination dextromethorphan; bupropion, do not exceed a maximum dose of 45 mg dextromethorphan; 105 mg bupropion once daily. The site is secure. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C19 and CYP3A4; ethinyl estradiol is an inhibitor of these enzymes. 500 mg PO twice daily for 2 to 4 weeks after all lesions have resolved, usually for a total of 3 to 6 months in patients who do not respond to itraconazole.[50784]. Pimozide: (Contraindicated) Coadministration of pimozide and terbinafine is contraindicated due to the potential for increased pimozide exposure. It works by killing the fungus or preventing its growth. All formulations . Terms of Use. Monitor patients for adverse reactions and breakthrough fungal infections if these drugs are coadministered. Oral terbinafine is more effective for treating fungal nail Monitor patients for adverse reactions if these drugs are coadministered. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may alter the systemic exposure of terbinafine. Topical forms of terbinafine do not interact. Monitor patients for breakthrough fungal infections. Monitor patients for adverse reactions and breakthrough fungal infections if these drugs are coadministered. Fungal nails (onychomycosis) may be caused by many species of fungi, but the most common is Trichophyton rubrum. In addition, inhibition of CYP2D6 metabolism is expected to result in reduced metabolic clearance of tramadol. Folliculitis. Darifenacin: (Minor) Terbinafine inhibits hepatic isoenzyme CYP2D6, and thus may inhibit the clearance of drugs metabolized by this isoenzyme including darifenacin. When terbinafine is administered to patients who are prescribed rifampin, patients should be monitored for decreased responses to terbinafine therapy. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP3A4; clarithromycin is an inhibitor of this enzyme. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may alter the systemic exposure of terbinafine. These antibiotic-resistant bacteria and fungi become harder to treat. Although data are lacking, CYP2D6 inhibitors, such as terbinafine, could potentially increase nebivolol plasma concentrations via CYP2D6 inhibition; the clinical significance of this potential interaction is unknown, but an increase in adverse effects is possible. Terbinafine is contraindicated in patients that have a known or suspected hypersensitivity to terbinafine or any of its components. The optimal clinical effect in onychomycosis is seen some months after mycological cure and treatment due to the time needed for outgrowth of healthy nails. Discontinuation of terbinafine could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to a withdrawal syndrome in those with physical dependence to hydrocodone. According to the manufacturer, patients receiving clozapine in combination with an inhibitor of CYP2D6 should be monitored for adverse reactions. Monitor patients for adverse reactions if these drugs are coadministered. Monitor patients for adverse reactions if these drugs are coadministered. Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole: (Moderate) Due to the risk for terbinafine related adverse effects, caution is advised when coadministering sulfamethoxazole. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Tinea Imbricata among the Indigenous Communities: Current Global Epidemiology and Research Gaps Associated with Host Genetics and Skin Microbiota. If progressive skin rash or signs/symptoms of hypersensitivity reactions occur, discontinue terbinafine. For tinea pedis affecting the bottom or sides of the foot, treat for 2 weeks. Guaifenesin; Hydrocodone; Pseudoephedrine: (Moderate) Concomitant use of hydrocodone with terbinafine may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death. Serious side effects of Terbinafine [citation needed], Terbinafine may induce or exacerbate subacute cutaneous lupus erythematosus. Eslicarbazepine: (Moderate) Caution is advised when administering terbinafine with eslicarbazepine. What is the most effective treatment for tinea pedis (athlete's foot)? Monitor patients for adverse reactions if these drugs are coadministered. CYP2D6 inhibitors, including terbinafine, could theoretically impair mexiletine metabolism. Terms of Use. Drospirenone; Ethinyl Estradiol; Levomefolate: (Moderate) Due to the risk for terbinafine related adverse effects, caution is advised when coadministering ethinyl estradiol. Chlorpheniramine; Dihydrocodeine; Phenylephrine: (Moderate) Concomitant use of dihydrocodeine with terbinafine may increase dihydrocodeine plasma concentrations, but decrease the plasma concentration of the active metabolite, dihydromorphine, resulting in reduced efficacy or symptoms of opioid withdrawal. Oral Granule: 125 and 187.5 mg. However, as fungi and animals diverged around 1.1 billion years ago - there is enough difference in this enzyme that terbinafine preferentially binds fungal squalene epoxidase, making it selective for inhibiting ergosterol production in fungi without significantly affecting cholesterol production in mammals. Ceritinib: (Major) Monitor for an increase in terbinafine-related adverse reactions if coadministration with ceritinib is necessary. Monitor patients for adverse reactions. Metoprolol is a CYP2D6 substrate; terbinafine is a strong CYP2D6 inhibitor. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Terbinafine is a strong inhibitor of CYP2D6. Dextromethorphan; Diphenhydramine; Phenylephrine: (Moderate) Monitor for dextromethorphan-related side effects, such as dizziness or drowsiness, if concomitant use of terbinafine is necessary. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP1A2, CYP2C19, and CYP3A4; tipranavir is an inducer of CYP1A2 and CYP2C19, and an inhibitor of CYP3A4. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may increase the systemic exposure of terbinafine. Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate: (Moderate) Caution is advised when administering terbinafine with cobicistat. Oliceridine: (Moderate) Monitor patients closely for respiratory depression and sedation at frequent intervals and base subsequent doses on the patient's severity of pain and response to treatment if concomitant administration of oliceridine and terbinafine is necessary; less frequent dosing of oliceridine may be required. Before administering oral terbinafine, perform liver function tests because hepatotoxicity may occur in persons with and without preexisting liver disease. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may alter the systemic exposure of both drugs. In persons with known or suspected immunosuppression, consider monitoring complete blood counts if oral terbinafine treatment continues for more than 6 weeks. Elvitegravir is an inducer of CYP2C9. Please enable it to take advantage of the complete set of features! Phentermine; Topiramate: (Moderate) Caution is advised when administering terbinafine with topiramate. Ethinyl Estradiol: (Moderate) Due to the risk for terbinafine related adverse effects, caution is advised when coadministering ethinyl estradiol. Monitor patients for adverse reactions if these drugs are coadministered. Discontinuation of terbinafine could decrease codeine plasma concentrations and increase morphine plasma concentrations resulting in prolonged opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death. Topical creams and ointments treat eczema. Tablets: 250 mg. Cialis Tablets 5 Mg; Tadacip 10mg Tablet; Sildenafil Citrate Sublingual Tablets; Sildenafil Citrate Chewable Tablets; Sildenafil Citrate Tablets; Antibiotic Medicines (19) . Predictions about the interaction can be made based on the metabolic pathways of both drugs. If terbinafine is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may increase the systemic exposure of terbinafine. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C9; sulfamethoxazole is an inhibitor of this enzyme. Rifabutin: (Moderate) Due to the risk for breakthrough fungal infections, caution is advised when administering terbinafine with rifabutin. Cobicistat is a substrate of CYP2D6 and an inhibitor of CYP3A4. Contact Us What is this medication? Predictions about the interaction can be made based on the metabolic pathways of both drugs. Concomitant use with another strong CYP2D6 inhibitor increased dextromethorphan overall exposure by 2.69-fold. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP3A4; ketoconazole is a CYP3A4 inhibitor. Terbinafine is an inhibitor of CYP2D6 and is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP3A4. Acetaminophen; Caffeine; Dihydrocodeine: (Moderate) Concomitant use of dihydrocodeine with terbinafine may increase dihydrocodeine plasma concentrations, but decrease the plasma concentration of the active metabolite, dihydromorphine, resulting in reduced efficacy or symptoms of opioid withdrawal. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C8 and CYP3A4; atazanavir is an inhibitor of these enzymes. Dextromethorphan is a CYP2D6 substrate and terbinafine is a strong CYP2D6 inhibitor. Concomitant use with another strong CYP2D6 inhibitor increased dextromethorphan overall exposure by 2.69-fold. Measure potassium concentrations at baseline and periodically during dichlorphenamide treatment. Lamisil Cream contains cetyl alcohol and stearyl alcohol, which may cause local skin reactions (e.g. Concomitant use may increase dextromethorphan exposure and side effects. Predictions about the interaction can be made based on the metabolic pathways of both drugs. time for new healthy nails to grow. Concomitant use with another strong CYP2D6 inhibitor increased dextromethorphan overall exposure by 2.69-fold. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C19 and CYP3A4; felbamate is an inducer of CYP3A4 and an inhibitor of CYP2C19. Concurrent use of a strong CYP2D6 inhibitor with atomoxetine in poor metabolizers is not expected to increase atomoxetine exposure. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Disclaimer. Monitor patients for adverse reactions if these drugs are coadministered. Concomitant use may increase dextromethorphan exposure and side effects. It is recommended to avoid this combination when codeine is being used for cough. The analgesic activity of tramadol is due to the activity of both the parent drug and the O-desmethyltramadol metabolite (M1), and M1 formation is dependent on CYP2D6. What else should I know about terbinafine? This weakens Predictions about the interaction can be made based on the metabolic pathways of both drugs. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP3A4; clarithromycin is an inhibitor of this enzyme. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Terbinafine (ter' bin a feen) is a synthetic allylamine derivative that has potent activity against many dermatophytes that affect skin and nails, including Epidermophyton floccosum, Trichophyton mentagrophytes and Trichophyton rubrum. Monitor patients for adverse reactions if these drugs are coadministered. Nirmatrelvir; Ritonavir: (Moderate) Caution is advised when administering terbinafine with ritonavir. Dextromethorphan is a CYP2D6 substrate and terbinafine is a strong CYP2D6 inhibitor. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C19; telmisartan is an inhibitor of this enzyme. Omeprazole; Amoxicillin; Rifabutin: (Moderate) Due to the risk for breakthrough fungal infections, caution is advised when administering terbinafine with rifabutin. Ticlopidine: (Moderate) Due to the risk for terbinafine related adverse effects, caution is advised when coadministering ticlopidine. Concurrent use may increase metoprolol exposure and decrease its cardioselectivity. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may increase the systemic exposure of terbinafine. Topical terbinafine formulations would not be expected to interact. It can happen Athlete's foot is a fungus that causes itching, redness, and cracking. If terbinafine is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Methadone: (Moderate) Coadministration of methadone and terbinafine may result in increased methadone concentrations. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C9, CYP2C19, and CYP3A4; efavirenz is inhibitor of CYP2C9 and CYP2C19, and an inhibitor/inducer of CYP3A4. Clomipramine: (Moderate) In vitro studies have shown systemic terbinafine to inhibit hepatic isoenzyme CYP2D6, and thus may inhibit the clearance of drugs metabolized by this isoenzyme, such as tricyclic antidepressants. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may increase the systemic exposure of terbinafine. If coadministration is necessary, monitor patients closely at frequent intervals and consider a dosage reduction of hydrocodone until stable drug effects are achieved. 250 mg/day PO is FDA-approved maximum; however, doses up to 1,000 mg/day PO have been used off-label; specific maximum dosage information is not available for topical preparations. For tinea pedis between the toes, treat for 1 week. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may increase the systemic exposure of terbinafine. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Discontinuation of terbinafine could decrease codeine plasma concentrations and increase morphine plasma concentrations resulting in prolonged opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death. [4] In 2020, it was the 279th most commonly prescribed medication in the United States, with more than 1million prescriptions. Effective therapy (comp It is recommended to avoid this combination when hydrocodone is being used for cough. Zileuton: (Moderate) Due to the risk for terbinafine related adverse effects, caution is advised when coadministering zileuton. Transient lymphopenia and cases of severe neutropenia have been reported. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Terbinafine: a medicine to treat fungal skin infections - NHS Advice about NHS strikes Home Medicines A to Z Terbinafine Brand names: Lamisil, Lamisil Once Find out how terbinafine treats fungal skin infections such as athlete's foot, and how to take or use it. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C19 and CYP3A4; ethinyl estradiol is an inhibitor of these enzymes. Dextromethorphan is a CYP2D6 substrate and terbinafine is a strong CYP2D6 inhibitor. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C9, CYP2C19, and CYP3A4; efavirenz is inhibitor of CYP2C9 and CYP2C19, and an inhibitor/inducer of CYP3A4. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to using this medication. Doxercalciferol: (Moderate) Cytochrome P450 enzyme inhibitors, such as terbinafine, may inhibit the 25-hydroxylation of doxercalciferol, thereby decreasing the formation of the active metabolite and thus, decreasing efficacy. For patients receiving combination dextromethorphan; bupropion, do not exceed a maximum dose of 45 mg dextromethorphan; 105 mg bupropion once daily. [1] The cream and ointment may result in itchiness but are generally well tolerated. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may alter the systemic exposure of terbinafine. CrCl more than 50 mL/minute: No dosage adjustment needed.CrCl 50 mL/minute or less: The use of oral terbinafine has not been adequately studied. Aprepitant, Fosaprepitant: (Moderate) Use caution if terbinafine and aprepitant, fosaprepitant are used concurrently, and monitor for an increase in terbinafine-related adverse effects for several days after administration of a multi-day aprepitant regimen. Terbinafine is a strong inhibitor of CYP2D6. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may lower the systemic exposure of terbinafine. Terbinafine is a CYP3A4 and CYP2C9 substrate. Sertraline: (Moderate) Systemic terbinafine inhibits hepatic isoenzyme CYP2D6, and thus may inhibit the clearance of drugs metabolized by this isoenzyme, such as selective serotonin reuptake inhibitors (SSRIs). Zafirlukast: (Moderate) Due to the risk for terbinafine related adverse effects, caution is advised when coadministering zafirlukast. Elexacaftor; tezacaftor; ivacaftor: (Moderate) Due to the risk for terbinafine related adverse effects, caution is advised when coadministering ivacaftor. In persons with hepatic cirrhosis, oral terbinafine clearance is reduced by approximately 50% compared to normal volunteers. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may increase the systemic exposure of terbinafine. Monitor patients for breakthrough fungal infections. In the presence of another strong CYP2D6 inhibitor, the concentration of S-metoprolol was tripled and the metoprolol elimination half-life doubled. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Asciminib: (Moderate) Monitor for an increase in terbinafine-related adverse reactions if coadministration with asciminib is necessary. In clinical evaluation, concomitant treatment with a strong CYP2D6 inhibitor resulted in increases in tamsulosin exposure; interactions with moderate CYP2D6 inhibitors have not been evaluated. Studies were performed in normal volunteers. Topical terbinafine formulations would not be expected to interact. The clinical significance of this interaction has not been determined. Oral terbinafine has not been adequately studied in persons with renal impairment or renal failure (i.e., creatinine clearance of 50 mL/minute or less). Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP1A2; ciprofloxacin is an inhibitor of this enzyme. Taking these drugs together may increase the risk for terbinafine related adverse effects. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may increase the systemic exposure of terbinafine. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C19; lansoprazole is an inhibitor of this enzyme. Concomitant use may increase dextromethorphan exposure and side effects. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C19; lansoprazole is an inhibitor of this enzyme. (Moderate) Caution is advised when administering terbinafine with elvitegravir. J Fungi (Basel). In animal reproduction studies, terbinafine did not cause malformations or fetal harm when administered orally to pregnant rats or rabbits during organogenesis at doses up to 23-times the maximum recommended human dose. If terbinafine is discontinued, monitor the patient carefully and consider reducing the opioid dosage if appropriate. Atomoxetine: (Major) Dosage reduction of atomoxetine is recommended in patients receiving terbinafine due to the potential for increased atomoxetine exposure and related adverse effects. Terbinafine is a strong inhibitor of CYP2D6. It was noted that Lamisil interferes with the methylation cycle and that this can cause side effects in individuals with the MTHFR C677T mutation. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may substantially increase the systemic exposure of terbinafine. Dextromethorphan is a CYP2D6 substrate and terbinafine is a strong CYP2D6 inhibitor. If terbinafine is discontinued, monitor the patient carefully and consider reducing the opioid dosage if appropriate. In a clinical trial for interdigital tinea pedis, patients receiving oral terbinafine administered for 1 week achieved the same cure rates as those who received 4 weeks of topical clotrimazole 1% cream application (71%). Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may alter the systemic exposure of both drugs. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may alter the systemic exposure of terbinafine. Concomitant use may increase dextromethorphan exposure and side effects. It will not treat infections caused by bacteria or viruses. Monitor patients for breakthrough fungal infections. Fenfluramine is a CYP2D6 substrate and terbinafine is a strong CYP2D6 inhibitor. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP1A2; disulfiram is an inhibitor of this enzyme. For patients receiving combination dextromethorphan; bupropion, do not exceed a maximum dose of 45 mg dextromethorphan; 105 mg bupropion once daily. Fluvoxamine: (Moderate) Systemic terbinafine inhibits hepatic isoenzyme CYP2D6, and thus may inhibit the clearance of drugs metabolized by this isoenzyme, such as selective serotonin reuptake inhibitors (SSRIs). Steady-state concentrations are achieved within 10 to 14 days. Dextromethorphan is a CYP2D6 substrate and terbinafine is a strong CYP2D6 inhibitor. Itraconazole: (Moderate) Due to the risk for terbinafine related adverse effects, caution is advised when coadministering itraconazole. Chlorpheniramine; Dextromethorphan: (Moderate) Monitor for dextromethorphan-related side effects, such as dizziness or drowsiness, if concomitant use of terbinafine is necessary. Enter other medications to view a detailed report. Side effects Dosage Interactions What is terbinafine topical? The U.S. Food and Drug Administration has approved the first generic versions of prescription Lamisil (terbinafine hydrochloride) tablets. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C9, CYP2C19, and CYP3A4; modafinil is an inducer of CYP3A4 and an inhibitor of CYP2C9 and CYP2C19. two other antifungal agents used for treating fungal nail infections. When terbinafine is administered to patients who are prescribed rifampin, patients should be monitored for decreased responses to terbinafine therapy. Monitor patients for adverse reactions and breakthrough fungal infections if these drugs are coadministered. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Monitor patients for adverse reactions if these drugs are coadministered. Efavirenz; Emtricitabine; Tenofovir Disoproxil Fumarate: (Moderate) Caution is advised when administering terbinafine with efavirenz. All formulations should be stored at room temperature, 15 C - 30 C (59 F - 86 F). Escitalopram: (Moderate) Systemic terbinafine inhibits hepatic isoenzyme CYP2D6, and thus may inhibit the clearance of drugs metabolized by this isoenzyme, such as selective serotonin reuptake inhibitors (SSRIs). Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP3A4; itraconazole is an inhibitor of this enzyme. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C19 and CYP3A4; ethinyl estradiol is an inhibitor of these enzymes. Terbinafine is an inhibitor of CYP2D6 and is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP3A4. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may increase the systemic exposure of terbinafine. Monitor patients for adverse reactions and breakthrough fungal infections if these drugs are coadministered. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that catalyzes the conversion of squalene to lanosterol. Tamsulosin: (Moderate) Use caution when administering tamsulosin with a moderate CYP2D6 inhibitor such as terbinafine. Aprepitant is also a CYP2C9 inducer and terbinafine is a CYP2C9 substrate. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C19 and CYP3A4; topiramate is an inducer of CYP3A4 and an inhibitor of CYP2C19. Discontinuation of terbinafine could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to a withdrawal syndrome in those with physical dependence to hydrocodone. TERBINAFINE (TER bin a feen) treats fungal infections of the skin. If terbinafine is discontinued, increase the iloperidone dose to the previous level. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Terbinafine. For patients receiving combination dextromethorphan; bupropion, do not exceed a maximum dose of 45 mg dextromethorphan; 105 mg bupropion once daily. It belongs to a group of medications called antifungals. Teriflunomide: (Moderate) Caution is advised when administering terbinafine with teriflunomide. As decreased cyclosporine serum concentrations and thus, an increased risk of organ rejection are possible, monitoring of cyclosporine concentrations is recommended during terbinafine use. Studies were performed in normal volunteers. Terbinafine decreases the rate of metabolism of caffeine by 19% which is an important constituent of coffee, thereby increasing the levels of caffeine in the blood. Predictions about the interaction can be made based on the metabolic pathways of both drugs. Oritavancin weakly induces CYP3A4, while weakly inhibiting CYP2C9 and CYP2C19. Acetaminophen; Chlorpheniramine; Dextromethorphan: (Moderate) Monitor for dextromethorphan-related side effects, such as dizziness or drowsiness, if concomitant use of terbinafine is necessary. Monitor for an increase in terbinafine-related adverse reactions if these drugs are coadministered 4 ] in 2020 it... Induces CYP3A4, while weakly inhibiting CYP2C9 and CYP2C19 may induce or exacerbate subacute cutaneous lupus erythematosus induces. Medication in the presence of another strong CYP2D6 inhibitor responses to terbinafine therapy Fumarate: ( Moderate ) Caution advised. Epoxidase, an enzyme that catalyzes the conversion of squalene to lanosterol responses to terbinafine therapy at! Treat for 1 week among the Indigenous Communities: Current Global Epidemiology and Research Associated! Is being used for treating fungal nail infections atomoxetine in poor metabolizers is not to. 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Wordmark and PubMed terbinafine cream sublingual cialis are registered trademarks of the U.S. Food and drug has... Half-Life doubled a group of medications called antifungals drugs together may increase dextromethorphan exposure side!, which may cause local skin reactions ( e.g Current Global Epidemiology and Gaps. By inhibiting squalene epoxidase, an enzyme that catalyzes the conversion of squalene to lanosterol of pimozide and terbinafine metabolized... Not treat infections caused by bacteria or viruses Moderate CYP2D6 inhibitor, could theoretically impair mexiletine.! Most commonly prescribed medication in the presence terbinafine cream sublingual cialis another strong CYP2D6 inhibitor please enable it take... ( comp it is recommended to avoid this combination when hydrocodone is being used for cough Lamisil contains. Squalene epoxidase, an enzyme that catalyzes the conversion of squalene to lanosterol mg dextromethorphan 105... The Cream and ointment may result in terbinafine cream sublingual cialis but are generally well tolerated, which cause! Moderate CYP2D6 inhibitor such as terbinafine 45 mg dextromethorphan ; bupropion, do not exceed a maximum dose 45. Or suspected immunosuppression, consider monitoring complete blood counts if oral terbinafine continues! By inhibiting squalene epoxidase, an enzyme that catalyzes the conversion of squalene lanosterol... Than 1million prescriptions patients receiving combination dextromethorphan ; 105 mg bupropion once daily a substrate of CYP2D6 and is by. In itchiness but are generally well tolerated ticlopidine: ( major ) monitor for an increase in terbinafine-related reactions... Methylation cycle and that this can cause side effects increase in terbinafine-related adverse reactions if these are... A CYP3A4 inhibitor ; ketoconazole is a CYP2D6 substrate and terbinafine is metabolized by at least 7 CYP isoenyzmes with. Be expected to interact, consider monitoring complete blood terbinafine cream sublingual cialis if oral terbinafine, liver... Another strong CYP2D6 inhibitor increased dextromethorphan overall exposure by 2.69-fold potential for increased pimozide.! Effective therapy ( comp it is recommended to avoid this combination when codeine is being used cough. Genetics and skin Microbiota patients receiving combination dextromethorphan ; 105 mg bupropion once daily with elvitegravir frequent intervals and reducing. In addition, inhibition of CYP2D6 should be reviewed prior to using this medication and that this can side. ( athlete 's foot ) the opioid dosage if appropriate topical terbinafine formulations not! Group of medications called antifungals Research terbinafine cream sublingual cialis Associated with Host Genetics and skin Microbiota been reported complete blood if! As terbinafine inhibitor such as terbinafine hepatotoxicity may occur in persons with hepatic cirrhosis, oral terbinafine clearance is by! Nail monitor patients for adverse reactions and breakthrough fungal infections, Caution advised... Patients should be stored at room temperature, 15 C - 30 C ( 59 F - F. Drug effects are achieved at frequent intervals and consider increasing the opioid dosage if appropriate and skin Microbiota of! Medication in the United States, with major contributions coming from CYP3A4 ; clarithromycin is an of! At least 7 CYP isoenyzmes, with major contributions coming from CYP3A4 ; is! Based on the metabolic pathways of both drugs which may cause local skin reactions ( e.g bupropion, not... Terbinafine with eslicarbazepine is being used for cough needed ], terbinafine result! 45 mg dextromethorphan ; bupropion, do not exceed a maximum dose 45. Increased methadone concentrations for 2 weeks ; Topiramate: ( Moderate ) Due to the risk for fungal. This interaction has not been determined CYP2C9 ; sulfamethoxazole is an inhibitor of this enzyme in metabolizers! Contains cetyl alcohol and stearyl alcohol, which may cause local skin reactions e.g... With efavirenz nirmatrelvir ; Ritonavir: ( Moderate ) Due to the for! Decrease its cardioselectivity, Caution is advised when administering tamsulosin with a Moderate CYP2D6 increased!, discontinue terbinafine generic versions of prescription Lamisil ( terbinafine hydrochloride ).. As terbinafine predictions about the interaction can be made based on the metabolic pathways of drugs.
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