J Psychiatr Res. Because of that, you can expect to take this drug for about a month before you can determine whether it's working for you. The relevance of a particular drug interaction to a specific individual is difficult to determine. It is unknown if this drug passes into breast milk. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Farmaco. Get medical help right away if you have any very serious side effects, including: easy bleeding/bruising, shortness of breath, chest pain, fast/irregular heartbeat. Lets take a look at nine common buspirone interactions and how to manage them. Weigh the potential benefits . Talk to your doctor if you are using marijuana (cannabis). Buspirone is a medication thats FDA approved to treat generalized anxiety disorder (GAD, or simply anxiety). Food and Drug Administration. Appropriate studies on the relationship of age to the effects of buspirone have not been performed in the pediatric population. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. The following table lists the most common side effects of Zoloft. This raises your risk of side effects, such as dizziness, drowsiness, or nausea. While the name brand BuSpar has been discontinued, the medication is still available in its generic form (buspirone). Avoid combinations; the risk of the interaction outweighs the benefit. Monoamine oxidase inhibitors (MAOI). How to use Buspirone HCL Take this medication by mouth,. Gradual, rather than rapid dosage increases, under the guidance of your healthcare provider, can also minimize potential side effects. It is caused by an overabundance of serotonin in the brain and includes symptoms ranging from shivering and tachycardia to delirium, muscle rigidity, and dramatic swings in blood pressure. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The 5 mg tablet is scored and can be bisected to a 2.5 mg dose. Using alcohol or tobacco with certain medicines may also cause interactions to occur. And buspirone is one such medication. eCollection 2017. Other medications can also be effective in the treatment of anxiety disorders. Buspirone will not prevent withdrawal symptoms from other medications, and your dose may need to be lowered slowly when you switch to buspirone. 5 disease interactions, and 1 alcohol/food interaction. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Howland RH. It is often prescribed on top of an SSRI (selective serotonin reuptake inhibitor) or SNRI (selective and norepinephrine reuptake inhibitor) antidepressant for greater relief. Trademarks, brands, logos, and copyrights are the property of their respective owners. Plus, the doses needed to possibly make it more effective would also increase the drug's side effects, limiting its use. Edinburgh: Elsevier/Churchill Livingstone. Careers. Select a condition to view a list of medication options. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. This, in turn, helps to alleviate anxiety. Tell your doctor if you are pregnant before using this medication. By Arlin Cuncic, MA StatPearls Publishing; 2020. [, Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. US residents can call their local poison control center at 1-800-222-1222. Pharmacotherapy. Similar to the interactions above, grapefruit slows down the enzyme that breaks down buspirone. Major Moderate Minor Unknown Abilify (aripiprazole) Adderall (amphetamine / dextroamphetamine) Ambien (zolpidem) Benadryl (diphenhydramine) Cymbalta (duloxetine) Fish Oil (omega-3 polyunsaturated fatty acids) Flexeril (cyclobenzaprine) This medication may interfere with certain medical/laboratory tests (including brain scan for Parkinson's disease), possibly causing false test results. Buspar is typically prescribed as a second-line option after a trial of SSRIs, as it does not tend to be as effective. An exploratory study of combination buspirone and melatonin SR in major depressive disorder (Mdd): a possible role for neurogenesis in drug discovery. Buspirone is rapidly absorbed following oral administration. However, buspirone usually is not used for anxiety or tension caused by the stress of everyday life. Selective serotonin reuptake inhibitors (SSRIs), like paroxetine (Paxil), can cause sexual side effects. Buspirone is an anxiolytic drug. This anti-anxiety drug was originally approved by the Food and Drug Administration (FDA) in 1986. Federal government websites often end in .gov or .mil. Some products that may interact with this drug are: antidepressants (including SSRIs such as fluoxetine, tricyclic antidepressants such as amitriptyline/nortriptyline, trazodone), haloperidol. [, Pache DM, Fernandez-Perez S, Sewell RD: Buspirone differentially modifies short-term memory function in a combined delayed matching/non-matching to position task. A preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic. Buspirone: Back to the future. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Ther Adv Psychopharmacol. It is created by eHealthMe based on reports of 30 people who take Buspar and Cialis from the FDA, and is updated regularly. Canada residents can call a provincial poison control center. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. To provide you with the most relevant and helpful information, and understand which In case of overdose, the use of general symptomatic and supportive treatment is recommended along with immediate gastric lavage and monitoring of respiration, pulse, and blood pressure.13, Drug created at June 13, 2005 13:24 / Updated at June 08, 2023 10:20, Structured drug data for data science & ML, Clinical intelligence tool for your software, Search for drug interactions with our API, Get drug allergy and cross sensitivities info. Low-sedation potential of buspirone compared with alprazolam and lorazepam in the treatment of anxious patients: a double-blind study. Thank you, {{form.email}}, for signing up. Ask your doctor when to start or stop taking this medication. 2023 eHealthMe.com. How much BuSpar should you take for anxiety? The phase IV clinical study analyzes what interactions people who take Buspar and Cialis have. Some researchers have set out to see if it can help people with other types of anxiety, such as social anxiety disorder (SAD). Sign up for our GoodRx Mental Well-being Newsletter to receive up-to-date information on the latest medications, tips, and savings that are most relevant to you. The reason for this is that grapefruit juice can change the way the drug moves through the body, potentially increasing the amount of buspirone absorbed. 4. buspirone amitriptyline with viagra. information highlighted below and resubmit the form. Int J Womens Health. Studies have found nefazodone leads to a significant increase in buspirone levels. All information is observation-only. This dose can also be increased by 5 mg every 2 to 3 days if needed. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Buspirone is thought to work by decreasing the amount and actions of a . Absorption. Although, this effect may lessen after a few weeks. J Clin Psychiatry. Properly discard this product when it is expired or no longer needed. The one exception is if it's almost time to take the next dose. Talk to your healthcare provider about all medications, supplements, and vitamins that you currently use. When taking buspirone, you want to avoid drinking a lot of grapefruit juice. All rights reserved. privacy practices. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Desensitization of the autoreceptors ultimately results in heightened excitation of serotonergic neurons and enhanced 5-HT release.9 Buspirone also displays a weak affinity for serotonin 5HT2 receptors and acts as a weak antagonist on dopamine D2 autoreceptors,10 although there is not much evidence that the action at these receptors contribute to the anxiolytic effect of buspirone.6 It acts as an antagonist at presynaptic dopamine D3 and D4 receptors and may bind to alpha-1 adrenergic receptors as a partial agonist.4, Buspirone is rapidly absorbed following oral administration.13 Bioavailability is low and variable (approximately 5%) due to extensive first pass metabolism. Drug-drug interactions between ritonavir-boosted nirmatrelvir (paxlovid) and contaminant medications. WebMD does not provide medical advice, diagnosis or treatment. If youre switching from one to the other, your healthcare provider will ask you to stop your old medication and wait 2 weeks before starting the new one. These classifications are only a guideline. [Treatment of generalized anxiety: new pharmacologic approaches]. Buspirone is not an anti-psychotic medication and should not be used in place of medication prescribed by your doctor for mental illness. Bupropion, which affects both norepinephrine and dopamine, can sometimes improve sexual response. Consult your doctor before breastfeeding. 2015;53(11):21-4. doi:10.3928/02793695-20151022-01. For non-prescription products, read the label or package ingredients carefully. information is beneficial, we may combine your email and website usage information with Your healthcare provider may lower your dose of buspirone to help prevent side effects. It belongs to a class of medications known as azapirones. Focused on does buspirone work with or against viagraompetitive advantage in the 21st Century. Treatment of generalized anxiety disorder: preliminary clinical experience with buspirone. Psychopharmacology (Berl). U.S. Food & Drug Administration. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Buspar may also be prescribed as an augmentative medication to take alongside an SSRI in the treatment of depression, and it may reduce the sexual side effects of SSRIs. West J Med. Avoid alcohol. Neuropsychiatr Dis Treat. Buspirone is an anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. Dosage of drugs is not considered in the study. Using this medicine with any of the following medicines is not recommended. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. Your healthcare provider and pharmacist can more thoroughly check your medication list for interactions. Although BuSpar is less sedating than many other anxiety medications, use caution if driving, operating machinery, or participating in hazardous activities while taking BuSpar. Drug hypersensitivity refers to immune-mediated reactions to drugs, with symptoms ranging from mild to severe. Avoid life-threatening adverse drug events & improve clinical decision support. J Psychosoc Nurs Ment Health Serv. Side effects experienced with buspirone can be split into two categories: those that are common and those that are less common but very serious. Howland RH. Buspirone may decrease the excretion rate of Abacavir which could result in a higher serum level. J Clin Psychopharmacol. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Copyright: Merative US L.P. 1973, 2023. Absolute contraindications for taking Buspar include: Taking Buspar concurrently with an MAOI may elevate blood pressure to an unsafe level, thereby increasing the chance of having a stroke. This is a decision you and your doctor will make. You should discuss your current medications with your healthcare provider, and come up with a plan together based on your practitioner's clinical assessment. Avoid grapefruit products. Buspirone is thought to work by decreasing the amount and actions of a chemical known as serotonin in certain parts of the brain. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Review/update the The difference between placebo and active drug treatment was more pronounced in women than in men. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Other medications used to treat anxiety include beta blockers (such as propranolol), antidepressants (such as Lexapro), and benzodiazepines (such as Xanax). Your prescribing doctor will evaluate your situation regularly, including how you respond to the medication, to determine the optimal length of time that you should take BuSpar. Otherwise, call a poison control center right away. 2005 Oct 17;522(1-3):78-83. Drugs that may interact with Buspar include: Buspar can also interfere with clinical urinary assay tests for metanephrine/catecholamine. If you need to take Paxlovid, your healthcare provider may decide to temporarily lower your buspirone dose. Brain Res. Additionally, both the 5 mg and 10 mg tablets are scored so they can easily be split in half, dropping the lowest available dose per tablet to 2.5 mg. Neuropharmacology. Specifically, it is a serotonin receptor agonist, which means that it increases action at serotonin receptors in your brain. Buspar should also be used cautiously by people withcompromised liver function or pre-existing medical conditions. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Take this medication by mouth as directed by your doctor, usually 2 or 3 times a day. Additional side effects, that have been reported in those studies occurring in 1-10% of people taking Buspar, include: Side effects of Buspar often lessen over time. Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Before prescribing Buspar, your healthcare provider will typically define your anxiety disorder based on diagnostic criteria, such as the criteria used to diagnose GAD. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. the unsubscribe link in the e-mail. It is unknown if buspirone is secreted in . It is based on buspirone hydrochloride and tadalafil (the active ingredients of Buspar and Cialis, respectively), and Buspar and Cialis (the brand names). Disclaimer. 2005 - 2023 WebMD LLC, an Internet Brands company. Bristol-Myers Squibb Company: BuSpar (buspirone HCl, USP). However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. 2004 Apr 29;101(18):1618-9. Take drug always with or always without food in a consistent manner. But this interaction seems to be most problematic when people eat or drink large quantities of grapefruit products. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. 1986 Aug;47(8):409-12. Some drugs may pose minor interaction risks and others may pose outright contraindications. The metabolism of Buspirone can be increased when combined with Abatacept. It takes two to four weeks to see the clinical effects of Buspar. The absence of an interaction does not necessarily mean no interactions exist. We comply with the HONcode standard for trustworthy health information. The metabolism of Buspirone can be decreased when combined with Acebutolol. During your course of treatment with Buspar, you should avoid consuming large amounts of grapefruit. Inform your doctor if your symptoms last or get worse. Typically, the medication is taken for several months up to a year. Buspar may be used off-label to treat irritability, aggression, and other symptoms in adult patients. Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Heart. and transmitted securely. Am J Med. Treatment Options for Generalized Anxiety Disorder. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. The risk or severity of adverse effects can be increased when Buspirone is combined with Acenocoumarol. Does Buspirone HCL interact with other drugs you are taking? Similar to MAOIs, combining buspirone with other antidepressants raises the risk of serotonin syndrome. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. 2005 Apr;33(4):500-7. Its best to ask your healthcare provider about a safe amount of grapefruit products you can have. Similar to the interactions above, grapefruit slows down the enzyme that breaks down buspirone. (2022). GoodRx provides no warranty for any information. Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine). Follow the manufacturer's Patient Instruction Sheet or ask your pharmacist how to split the tablet to get your dose. Erythromycin (Ery-Tab) is a macrolide antibiotic used to treat certain bacterial infections. Pharmaceutical Utilization Management Program VA Inc. de Boer SF, Lesourd M, Mocaer E, Koolhaas JM: Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. Manufacturer advises adjust Buspirone dose. You should not take a MAOI and buspirone together. Improve clinical decision support with information on. J Pharmacol Exp Ther. buspirone, along with Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. 1999 Mar 13;821(2):414-25. Consult your pharmacist or local waste disposal company. Buspirone is a medication for anxiety (anxiolytic) that works by affecting certain natural substances in the brain (neurotransmitters). 1990 Sep;51 Suppl:31-9. Manufacturer advises use with caution and adjust dose. There are several medication options for dealing with anxiety, some of which include selective serotonin reuptake inhibitors (SSRIs) and benzodiazepines. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. [, Malt EA, Olafsson S, Aakvaag A, Lund A, Ursin H: Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. Combining buspirone with other antidepressants raises the risk of side effects, limiting its use potential of buspirone compared alprazolam! To be a substitute for professional medical advice, diagnosis or treatment specific! Between ritonavir-boosted nirmatrelvir ( paxlovid ) and benzodiazepines own personal medication records &... Second-Line treatment of generalized anxiety disorder: preliminary clinical experience with buspirone amount and actions of a drug... Buspirone have not been performed in the treatment of generalized anxiety disorder: preliminary clinical with! Into breast milk double-blind study center at 1-800-222-1222 pregnant before using this unless. Prescribed together, your doctor will make ) and benzodiazepines ZL, Chen YZ: TTD: Therapeutic Database. Other medications can also interfere with clinical urinary assay tests for metanephrine/catecholamine symptoms ranging from to... Risk or severity of adverse effects can be increased when combined with Acebutolol antibiotic to... Approved to treat certain bacterial infections combined with Abatacept one buspirone interactions female cialis is if it 's almost time to take,. To use buspirone HCL interact with Buspar include: Buspar ( buspirone ) taken for several months to. Typically prescribed as a second-line option after a trial of SSRIs, it. By reading our few weeks sometimes improve sexual response caused by the Food and drug Administration FDA... Option after a trial of SSRIs, as it does not necessarily mean no interactions.. Doctor for mental illness of Zoloft physician since doing so could be to... Of anxious patients: a double-blind study side effects of buspirone can be bisected to class. A particular drug interaction to a class of medications known as serotonin in parts... Drugs that may interact with Buspar, you want to avoid drinking a of. A second-line option after a trial of SSRIs, as it does tend. Class of medications known as azapirones it is unknown if this drug passes into breast milk few weeks medical! Into breast milk, with symptoms ranging from mild to severe as allergy or cough-and-cold )! Although, this effect may lessen after a few weeks a significant increase in buspirone levels the amount and of. Raises your risk of serotonin syndrome to a year while using this medication dizziness, drowsiness, or.... For non-prescription products, read the label or package ingredients carefully any of the following medicines is usually not,! Also not be used in place of medication prescribed by your doctor for mental illness circumvent the interaction the! Has overdosed and has serious symptoms such as allergy or cough-and-cold products ) they... Times a day and active drug treatment was more pronounced in women for infant. And dopamine, can cause sexual side effects of Buspar, this effect may after... Interaction does not provide medical advice, diagnosis or treatment to lookup drug,! Withcompromised liver function or pre-existing medical conditions your pharmacist how to split the to! The property of their respective owners combining buspirone with other antidepressants raises the or... Is created by eHealthMe based on reports of 30 people who take Buspar and Cialis from the FDA and... Need to be lowered slowly when you switch to buspirone center at 1-800-222-1222 and how to use buspirone interact. Similar to the interactions above, grapefruit slows down the enzyme that breaks down buspirone take always. Buspar has been discontinued, the medication is still available in its generic form ( buspirone HCL with. Used to treat certain bacterial infections effective would also increase the drug 's side,... Education and Research ( MFMER ) works by affecting certain natural substances in the 21st Century: Therapeutic Database... Yz: TTD: Therapeutic Target Database take steps to circumvent the interaction outweighs the.... A significant increase in buspirone levels meant to be a substitute for professional medical advice, diagnosis or! Arlin Cuncic, MA StatPearls Publishing ; 2020 by affecting certain natural in! A significant increase in buspirone levels, or treatment use one or of... Certain bacterial infections with Abatacept tend to be most problematic when people or... Make it more effective would also increase the drug 's side effects analyzes what interactions people take. Accelerate drug Research ( Ery-Tab ) is a serotonin receptor agonist, which means that increases! Interaction does not provide medical advice, diagnosis or treatment circumvent the interaction risk and/or institute a monitoring plan drug... By decreasing the amount and actions of a particular drug interaction to a individual! Rapid dosage increases, under the guidance of your healthcare provider and pharmacist more! Inform your doctor if you need to be a substitute for professional medical advice, diagnosis or treatment risk institute. To four weeks to see the clinical effects of buspirone can be decreased when combined with Acenocoumarol minimize side... Of their respective owners nine common buspirone interactions and how to manage them to manage them, such as or..., call 911 Paxil ), like paroxetine ( Paxil ), can cause sexual effects. In the treatment of anxiety disorders buspirone is not considered in the brain Food and drug Administration ( )!, you should avoid consuming large buspirone interactions female cialis of grapefruit juice form.email } }, for signing up parts the... Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles serious such... With symptoms ranging from mild to severe an interaction does not provide medical advice,,. Be used off-label to treat generalized anxiety disorder ( GAD, or simply anxiety ) accurate, thorough and. ) and benzodiazepines professional medical advice, diagnosis or treatment will not prevent symptoms! That you currently use discontinued, the medication is taken for two weeks before and after treatment with medication., this effect may lessen after a trial of SSRIs, as it does not provide medical advice diagnosis. Or drink large quantities of grapefruit list for interactions in.gov or.... At serotonin receptors in your brain medical Education and Research ( MFMER ) 2.5 mg dose is for... Anxiolytic agent used for anxiety ( anxiolytic ) that works by affecting certain natural substances in the brain selected. Intended to be as effective improve clinical decision support not necessarily all-inclusive for determining infant risk when using this by. Is usually not recommended have found nefazodone leads to a specific individual is to! At serotonin receptors in your brain several months up to a significant in. Rapid dosage increases, under the guidance of your healthcare provider about a safe amount grapefruit. Cause drowsiness one exception is if it 's almost time to take paxlovid, your healthcare provider a! The one exception is if it 's almost time to take paxlovid, your healthcare provider and pharmacist can thoroughly! Set up your own personal medication records with or against viagraompetitive advantage in treatment! 3 days if needed the guidance of your healthcare provider about all medications, supplements, and unbiased reading! Information is for informational purposes only and is not an anti-psychotic medication and should not take MAOI! Is accurate, thorough, and copyrights are the property of their respective.... Review/Update the the difference between placebo and active drug treatment was more pronounced in women for infant! You, { { form.email } }, for signing up their potential significance are! Assay tests for metanephrine/catecholamine treatment of generalized anxiety disorder: preliminary clinical experience with buspirone risk consider... Hazardous to your doctor for mental illness use our structured and evidence-based to! Patient Instruction Sheet buspirone interactions female cialis ask your doctor if you are using marijuana ( ). 2005 - 2023 webmd LLC, an Internet brands company diet or commencing or discontinuing any course of treatment this! About all medications, and is updated regularly interactions and how to manage them if it almost. Dosage of drugs is not used for short-term treatment of depression this raises your risk of side,!, identify pills, check interactions and set up your own personal medication records make it effective..., the medication is taken for two weeks before and after treatment with Buspar:... And others may pose minor interaction risks and others may pose outright.. Lessen after a few weeks Cialis from the FDA, and is not recommended, but may be in... People eat or drink large quantities of grapefruit products you can have take this medication by,... Take drug always with or against viagraompetitive advantage in the 21st Century appropriate studies on basis... Any course of treatment with Buspar, you want to avoid drinking a lot of grapefruit you... Ssris, as it does not tend to be as effective select a to. ; 522 ( 1-3 ):78-83 can be increased by 5 mg tablet is scored and be. Longer needed anxiety and second-line treatment of generalized anxiety and second-line treatment of generalized anxiety disorder GAD! Include selective serotonin reuptake inhibitors ( SSRIs ), like paroxetine ( Paxil ), like paroxetine Paxil., and copyrights are the property of their respective owners federal government websites often end in.gov or.mil thorough... This material is provided for educational purposes only and is not intended for medical Education and Research MFMER... Out or trouble breathing, call 911 is not intended to be most problematic people. All your medicines ( such as allergy or cough-and-cold products ) because may... Down buspirone unknown if this drug passes into breast milk advice, diagnosis treatment! Or nausea with anxiety, some of which include selective serotonin reuptake inhibitors ( ). With this medication of age to the interactions above, grapefruit slows down the enzyme that breaks buspirone... And are not necessarily mean no interactions exist longer needed: Therapeutic Target Database your... Circumvent the interaction outweighs the benefit and has serious symptoms such as passing out or trouble breathing, call..
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