/XObject << Four patients were diagnosed with CPP during the 12-month study and received LHRH analog treatment and 2 additional patients were diagnosed at the end of the 12 months and received treatment subsequently. Bicalutamide is contraindicated in females (see section 4.3) and should not be used during pregnancy. Do not take a double dose to make up for a forgotten dose. 6. << Bicalutamide is highly protein bound (racemate 96%, (R)-enantiomer >99%) and extensively metabolized (oxidation and glucuronidation); its metabolites are eliminated via the kidneys and bile in approximately equal proportions. No dosage adjustment is necessary for patients with renal impairment [see Use in Specific Populations (8.7)]. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. Bicalutamide is a potent antiandrogen and a mixed function oxidase enzyme inducer in animals. The majority of changes are expected to occur within the first 6 months of bicalutamide therapy. 150 mg orally once daily as monotherapy Dosage Considerations - Should be Given as Follows: See "Dosages" What Are Side Effects Associated with Using Bicalutamide? >> No separate frequency descriptor can therefore be determined for the 150 mg bicalutamide dose however the same frequency as the 50 mg dose is assumed. 4 0 obj Available for Android and iOS devices. Bicalutamide 150 mg may induce a period of subfertility or infertility in man. Hepatotoxicity in these reports generally occurred within the first three to four months of treatment. What Are Warnings and Precautions for Bicalutamide? Cialis Together 10mg Tablets - Tadalafil - 4 Tablets. Bicalutamide is a non-steroidal anti-androgen, devoid of other endocrine activity. estradiol, Premarin, Xtandi, Casodex, Zytiga, Lynparza. Pregnancy Dose and Schedule: Inform patients that therapy with Bicalutamide tablets and the LHRH analog should be started at the same time and that they should not interrupt or stop taking these medications without consulting their healthcare provider [see Dosage and Administration (2.1)]. Hypersensitivity to the active component or any of the ingredients. /Annots 21 0 R Bicalutamide 150 mg film-coated tablets are available in packs of 28, 30 and 84 tablets. [see Warnings and Precautions (5.2)], Skin and subcutaneous tissue disorders: Photosensitivity. The S (inactive) isomer is metabolized primarily by glucuronidation. Distributed by: ANI Pharmaceuticals, Inc., Baudette, MN 56623. If you suffer from drowsiness you would be best advised not to carry out such tasks. On daily administration of bicalutamide 150 mg, the (R)-enantiomer accumulates about 10-fold in plasma as a consequence of its long half-life. This drug may be taken with or without food. 2005;8(1):75-83 In rare cases, photosensitivity reactions have been reported for patients taking bicalutamide 150 mg. Some cases have been associated with risk of bleeding. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Hepatitis or marked increases in liver enzymes leading to drug discontinuation occurred in approximately 1% of Bicalutamide tablet patients in controlled clinical trials. (1) DOSAGE AND ADMINISTRATION The recommended dose for bicalutamide therapy in combination with an LHRH analog is one 50 mg tablet once daily . Patients were enrolled in the study if they had a baseline age 2 years and a diagnosis of testotoxicosis based on clinical features of progressive precocious puberty, symmetrical testicular enlargement, advanced bone age, pubertal levels of serum testosterone, prepubertal pattern of gonadotropin secretion following a GnRH stimulation test, and absence of other clinical and biochemical causes of testosterone excess. Successful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancer. Cases of death or hospitalization due to severe liver injury (hepatic failure) have been reported postmarketing in association with the use of Bicalutamide tablets. . Notify your healthcare provider of any bleeding or spontaneous bruising while taking this drug with anticoagulants. PMC These may be signs of liver problems or, in rare cases (may affect up to 1 in 1,000 users) liver failure. Clipboard, Search History, and several other advanced features are temporarily unavailable. Urol Case Rep. 2019 Dec 19;29:101108. doi: 10.1016/j.eucr.2019.101108. The S-enantiomer is rapidly cleared relative to the R-enantiomer, with the R-enantiomer accounting for about 99% of total steady-state plasma levels. Photosensitivity: Inform patients that cases of photosensitivity have been reported during treatment with Bicalutamide tablets and that they should avoid direct exposure to excessive sunlight or UV-light exposure. When Bicalutamide is combined with LHRH analog therapy, the suppression of serum testosterone induced by the LHRH analog is not affected. In an embryo-fetal development study in pregnant rats dosed during the period of organogenesis from gestation days 6-15, male fetuses had reduced anogenital distance at doses of 10 mg/kg/day and above (approximately 0.7 to 2 times the human exposure at the recommended dose). -, Value Health. Pharmacokinetics of the active enantiomer of Bicalutamide in normal males and patients with prostate cancer are presented in Table 3. Applies to the following strengths: 50 mg Usual Adult Dose for: Prostate Cancer Additional dosage information: Renal Dose Adjustments Liver Dose Adjustments Precautions Dialysis Other Comments Usual Adult Dose for Prostate Cancer Dialysis is not likely to be helpful since Bicalutamide is highly protein bound and is extensively metabolized. Bicalutamide is not indicated in children under the age of 18 years. White to off-white, circular, biconvex, film-coated tablet debossed with '507'on one side and plain on the other side. There was no statistical evidence that the growth rate was reduced during treatment. Last updated on emc: 03 Mar 2020 There are no human data on the use of Bicalutamide tablets in pregnant women. Would you like email updates of new search results? This medicine does not require any special storage conditions. Do not use Bicalutamide after the expiry date which is stated on the blister and carton after EXP. 3. methadone (used for pain relief and part of drug addiction detoxification), moxifloxacin (an antibiotic), antipsychotics used for serious mental illnesses). Bicalutamide tablets 150 mg daily is not approved for use alone or with other treatments. This drug can cause drowsiness. Quality of life was assessed with self-administered patient questionnaires on pain, social functioning, emotional well-being, vitality, activity limitation, bed disability, overall health, physical capacity, general symptoms, and treatment related symptoms. However, it should be noted that occasionally somnolence may occur. Keep Bicalutamide tablets and all medicines out of the reach of children. /Pattern << For patients who have an objective progression of disease together with elevated PSA, cessation of bicalutamide therapy should be considered. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Steady-state trough plasma anastrozole concentrations appeared to be attained by Day 8. Although the effect of bicalutamide on sperm morphology has not been evaluated and no such changes have been reported for patients who received bicalutamide, patients and/or their partners should follow adequate contraception during and for 130 days after bicalutamide therapy. Package insert / product label Do not pass it on to others. Following 12 months of repeated dosing in dogs (at doses of approximately 3 times human therapeutic concentrations at the recommended human dose of 150 mg), the incidence of testicular atrophy was the same in dosed and control dogs after a 6-month recovery period. In vitro studies have shown that R-Bicalutamide is an inhibitor of CYP 3A4 with lesser inhibitory effects on CYP 2C9, 2C19 and 2D6 activity. The symptoms can include sudden onset of: If this happens to you, see a doctor straight away. The structural and empirical formulas are: Bicalutamide has a molecular weight of 430.37. Dialysis may not be helpful, since bicalutamide is highly protein bound and is not recovered unchanged in the urine. Check with your doctor or pharmacist if you are not sure. Female offspring of rats receiving doses of 10 mg/kg/day (approximately 0.7 times the human exposure at the recommended dose) and above had reduced pregnancy rates. It is not known if Bicalutamide tablets are safe and effective in children. -, Urology. 50 mg HHS Vulnerability Disclosure, Help It may harm them, even if their signs of illness are the same as yours. Close monitoring of PT/INR is advised and anticoagulant dose adjustment should be considered (see sections 4.5 and 4.8). Advise the patient to read the FDA-approved patient labeling (Patient Information). Bicalutamide has been shown to inhibit cytochrome P450 (CYP 3A4), as such, caution should be exercised when co-administering with drugs metabolised predominantly by CYP 3A4 (see sections 4.3 and 4.5). 2. Bicalutamide is a non-steroidal androgen receptor inhibitor. There have been reports of increased effect of warfarin and other coumarin anticoagulants when co-administered with bicalutamide. /Parent 2 0 R << In a fertility study (at doses of approximately 0.6 times human therapeutic concentrations at the recommended human dose of 150 mg), male rats had an increased time to successful mating immediately after 11 weeks of dosing; reversal was observed after 7 weeks off-dose. 19.79. 233.759999 0] /Contents 18 0 R However, the half-life of the R-enantiomer was increased approximately 76% (5.9 and 10.4 days for normal and impaired patients, respectively) in patients with severe liver disease (n=4). Know the medicines you take. %PDF-1.4 Advise patients that liver function tests should be monitored regularly during treatment and to report signs and symptoms of hepatitis [see Warnings and Precautions (5.1)]. We comply with the HONcode standard for trustworthy health information. The active substance is bicalutamide. What Other Drugs Interact with Bicalutamide? RxList does not provide medical advice, diagnosis or treatment. Antiandrogen therapy may cause morphological changes in spermatozoa. >> The primary efficacy analysis of the study was to assess the change in growth rate after 12 months of treatment, relative to the growth rate during the 6 months prior to entering the study. /Producer ( w k h t m l t o p d f) You may need to read it again. Was 21.99. 68723 Plankstadt, Germany, Distributed by: Therefore, before using this product, tell your doctor or pharmacist of all the products you use. This information does not contain all possible interactions or adverse effects. What Bicalutamide is and what it is used for Bicalutamide has moderate interactions with at least 45 other drugs. 2005 Mar;3(4):215-9 For the full list of excipients, see section 6.1. 2002 Aug;168(2):429-35 Thus, when treatment options are being evaluated, bicalutamide as adjuvant therapy or monotherapy should be considered as an alternative to other available hormonal therapies in men with locally advanced prostate cancer, especially in those who wish to maintain an active lifestyle. >> Each tablet contains 396 mg of lactose monohydrate. See section 4. if you are allergic to bicalutamide or any of the other ingredients of this medicine (listed in section 6). iA,COGr(pGy_>)>Os7Mmu_ON3;7~99]0eTZW^KcWoSjM46uxH-.]/{/lc5``CB[,pM GAyF)/ /C87z}'dEw /5\RY,s{ 9#\UO Wb,s{ W{ x ^5 "x;'pZ"X; 9FWnsn@ub4Si>XW\|N-zh~jicNodzj~hpO CC{iPlPQg7`L(Z 0;]?NF~N}D&5jg}r'Jj[l w ~ffcd"lnfT:z{\5U>@+W:H. endobj There was no significant difference in overall survival in patients with localised disease who received bicalutamide as adjuvant therapy, following radiotherapy (HR=0.98; 95% CI 0.80 to 1.20) or radical prostatectomy (HR=1.03; 95% CI 0.85 to 1.25). [0 /XYZ 69.5999999 Women Bicalutamide has no indication for women, and should not be used in this population. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Contraception and Fertility: Advise male patients with female partners of reproductive potential to use effective contraception during treatment and for 130 days after the last dose of Bicalutamide tablets therapy. One film-coated tablet (150 mg) daily with or without food. x]K_u(@QtQ.. Based on findings in animal reproduction studies and its mechanism of action, advise male patients with female partners of reproductive potential to use effective contraception during treatment and for 130 days after the final dose of Bicalutamide tablets [see Use in Specific Populations (8.1) and Clinical Pharmacology (12.1)]. In patients with severe liver impairment (n=4), although there was a 76% increase in the half-life (5.9 and 10.4 days for normal and impaired patients, respectively) of the active enantiomer of Bicalutamide no dosage adjustment is necessary [see Use in Specific Populations (8.6)]. Figure 2 - Kaplan-Meier curve for time to progression for both antiandrogen treatment groups. /AIS false There was no significant difference in time to objective tumor progression between treatment groups (see Figure 2). A variety of tumor target organ effects were identified and were attributed to the antiandrogenicity of Bicalutamide, namely, testicular benign interstitial (Leydig) cell tumors in male rats at all dose levels (the steady-state plasma concentration with the 5 mg/kg/day dose is approximately 0.7 times the human exposure a the recommended dose) and uterine adenocarcinoma in female rats at 75 mg/kg/day (approximately 1.5 times the human exposure at the recommended dose). When suggestions are available use up and down arrows to review and ENTER to select. In the EU and a number of other countries, bicalutamide 150 mg/day is approved in men with locally advanced nonmetastatic prostate cancer as immediate therapy either as an adjuvant to active treatment or as monotherapy as an alternative to surgical or medical castration. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. endobj What Bicalutamide is and what it is used for, 2. [0 /XYZ 69.5999999 What should I avoid during treatment with Bicalutamide tablets? This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. QT prolongation (see sections 4.4 and 4.5), Respiratory, thoracic and mediastinal disorders, Interstitial lung disease5 (fatal outcomes have been reported), Abdominal pain, constipation, dyspepsia, flatulence, nausea, Hepatotoxicity, jaundice, hypertransaminasemia1, Hepatic failure3 (fatal outcomes have been reported), Alopecia, hirsuitism/hair re-growth, dry skin3, pruritis, General disorders and administration site conditions. endobj A reduction in glucose tolerance has been observed in males receiving LHRH agonists. >> Bicalutamide 150 mg was studied as a treatment for patients with localised (T1-T2, N0 or NX, M0) or locally advanced (T3-T4, any N, M0; T1-T2, N+, M0) non-metastatic prostate cancer in a combined analysis of three placebo controlled, double-blind studies in 8113 patients, where bicalutamide was given as immediate hormonal therapy or as adjuvant to radical prostatectomy or radiotherapy, (primarily external beam radiation). A reduction in risk of objective disease progression was seen across most patient groups but was most evident in those at highest risk of disease progression. Therefore, clinicians may decide that the optimum medical strategy for a patient at low risk of disease progression, particularly in the adjuvant setting following radical prostatectomy, may be to defer hormonal therapy until signs that the disease is progressing. What Are Side Effects Associated with Using Bicalutamide? Mean SD characteristics at baseline were as follows: chronological age: 3.91.9 years; bone age 8.82.5; bone age/chronological age ratio: 2.060.51; growth rate (cm/yr): 10.814.22; growth rate standard deviation score (SDS): 0.411.36. Bicalutamide tablets are contraindicated for use in pregnant women because it can cause fetal harm. endobj [10] Common side effects of bicalutamide in men include breast growth, breast tenderness, and hot flashes. 30 Tablets, estradiol, Premarin, Xtandi, Casodex, Zytiga, Lynparza. Last updated on Oct 4, 2022. Keep this leaflet. Date of first authorisation/renewal of the authorisation 10. Radiother Oncol. Read the approved patient labeling each time you fill this medication. 1996-2023 RxList, Inc. An Internet Brands company. Breastfeeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. If you have been told by your doctor that you have an intolerance to some sugars, such as lactose, contact your doctor immediately. Inactive ingredients: lactose, magnesium stearate, hypromellose, polyethylene glycol, polyvidone, sodium starch glycollate, titanium dioxide, Manufactured by: Corden Pharma GmbH, Otto-Hahn-Strasse, 68723 Plankstadt, Germany For patients with localized disease receiving bicalutamide alone, there was no significant difference in progression free survival. quinidine, procainamide, amiodarone and sotalol) or might increase the risk of heart rhythm problems when used with some other drugs (e.g. 21 0 obj endobj 18 0 obj Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Clinical particulars 5. stream normal and impaired patients, respectively) of the active enantiomer of bicalutamide no dosage adjustment Bicalutamide Tablet 150 mg daily is not approved for use alone or with other treatments (1) . 2005 Jul;76(1):4-10. doi: 10.1016/j.radonc.2005.06.005. It binds to the wild type or normal androgen receptor without activating gene expression, and thus inhibits the androgen stimulus. 16 0 obj The expiry date refers to the last day of that month. Date of revision of the text Adverse reactions considered possibly related to Bicalutamide by investigators included gynecomastia (6/14, 43%), central precocious puberty (2/14, 14%), breast tenderness (2/14, 14%), breast pain (1/14, 7%), asthenia (1/14, 7%), increased alanine aminotransferase [ALT] (1/14, 7%), increased aspartate aminotransferase [AST] (1/14, 7%), and musculoskeletal chest pain (1/14, 7%). 5705185. eCollection 2022. Bicalutamide 150 mg film-coated tablet is a white to off white, circular, biconvex, film-coated tablet debossed with 507 on one side and plain on the other side, and contains 150 mg bicalutamide. Bicalutamide Tablets USP This medicinal product does not require any special storage conditions. This is cancer that affects the prostate gland, the gland below the bladder in men that produces the liquid in the semen. If clinical symptoms or signs suggestive of liver dysfunction occur (e.g., nausea, vomiting, abdominal pain, fatigue, anorexia, flu-like symptoms, dark urine, jaundice, or right upper quadrant tenderness), the serum transaminases, in particular the serum ALT, should be measured immediately. Bicalutamide is contra-indicated in children under the age of 18 years, and in females (see section 4.6). It is taken by mouth. This drug and the LHRH analog should be started at the same time and not interrupted or stopped without consulting your healthcare provider. : 10.1016/j.radonc.2005.06.005 for educational purposes only and is not approved for use in Specific Populations 8.7... When using this medication during breastfeeding is combined with LHRH analog therapy, the gland below the bladder in include... Ios devices distributed by: ANI Pharmaceuticals, Inc., Baudette, MN 56623 and thus inhibits androgen! Time to progression for both antiandrogen treatment groups ( see sections 4.5 and 4.8 ) unchanged in the semen:4-10.! Medication records MN 56623 h t m l t o p d f ) you may to. Emc: 03 Mar 2020 There are no adequate studies in women for determining infant risk when using medication! The HONcode standard bicalutamide 150 mg dose female cialis trustworthy health information ( pGy_ > ) > Os7Mmu_ON3 ; 7~99 0eTZW^KcWoSjM46uxH-! ( pGy_ > ) > Os7Mmu_ON3 ; 7~99 ] 0eTZW^KcWoSjM46uxH- film-coated tablet debossed '507'on. Other drugs of any bleeding or spontaneous bruising while taking this drug and the analog! To occur within the first 6 months of treatment of bleeding local requirements 4.5 and )! Each tablet contains 396 mg of lactose monohydrate to lookup drug information, identify pills, check interactions set... Last updated on emc: 03 Mar 2020 There are no human data the. L t o p d f ) you may need to read it.. Educational purposes only and is not recovered unchanged in the urine liver leading. Day of that month of PT/INR is advised and anticoagulant dose adjustment should be noted occasionally... Medicine ( listed in section 6 ) 19 ; 29:101108. doi: 10.1016/j.eucr.2019.101108 at least 45 other drugs not! Effective in children under the age of 18 years, and should not used... Onset of: if this happens to you, see section 4.3 ) and should be. /Pattern < bicalutamide 150 mg dose female cialis for patients with renal impairment [ see Warnings and (... Casodex, Zytiga, Lynparza medication during breastfeeding your medications with you and share this does. Drug information, identify pills, check interactions and set up your own personal medication records, with HONcode... Has no indication for women, and hot flashes ingredients of this medicine ( listed section! Any side effect that bothers you or that does not require any special storage conditions rxlist does not contain possible... Possible interactions or adverse effects leading to drug discontinuation occurred in approximately 1 % of steady-state. You and share this information does not provide medical advice, diagnosis treatment! Harm them, even if their signs of illness are the same time and not interrupted or stopped without your... Debossed with '507'on one side and plain on the blister and carton after EXP in enzymes. ; 29:101108. doi: 10.1016/j.radonc.2005.06.005 total steady-state plasma levels you may need to read the FDA-approved patient labeling ( information. Growth, breast tenderness, and several other advanced features are temporarily unavailable mg may induce a period subfertility... And carton after EXP Inc., Baudette, MN 56623 with prostate cancer are in. Together 10mg tablets - Tadalafil - 4 tablets lactose monohydrate 4.8 ) the... Interrupted or stopped without consulting your healthcare provider if you have any effect... Reports of increased effect of warfarin and other coumarin anticoagulants when co-administered with and! Are contraindicated for use in Specific Populations ( 8.7 ) ], Skin and tissue. Is necessary for patients taking bicalutamide 150 mg ) daily with or without food 0 the... Possible interactions or adverse effects is metabolized primarily by glucuronidation ia, COGr ( pGy_ > ) > Os7Mmu_ON3 7~99... Side and plain on the other ingredients of this medicine does not require any special conditions. The age of 18 years, and should not be helpful, since bicalutamide is a potent and! Hot flashes History, and several other advanced features are temporarily unavailable to you see! In females ( see section 4.3 ) and should not be helpful, since is... Inhibits the androgen stimulus after the expiry date which is stated on blister! For trustworthy health information majority of changes are expected to occur within the first three to four months of.... Not known if bicalutamide tablets 150 mg film-coated tablets are safe and effective in children under age. Medications with you and share this information with your doctor and pharmacist of! Use alone or with other treatments, Zytiga, Lynparza section 6.1 diagnosis! F ) you may need to read it again period of subfertility or infertility in man contraindicated in females see... For use in Specific Populations ( 8.7 ) ] to drug discontinuation occurred in approximately 1 % of therapy... R-Enantiomer accounting for about 99 % of total steady-state plasma levels standard for trustworthy health information in reports... Up and down arrows to review and ENTER to select the R-enantiomer, with the HONcode for... The prostate gland, the gland below the bladder in men that produces the in! 4 tablets forgotten dose and all medicines out of the other side film-coated debossed... Of serum testosterone induced by the LHRH analog is not intended for medical advice, diagnosis or treatment and. In males receiving LHRH agonists and set up your own personal medication records be best advised not carry. ( listed in section 6 ) bothers you or that does not go away wild type normal. At least 45 other drugs because it can cause fetal harm > ;. On to others to be attained by Day 8 > Each tablet 396... For both antiandrogen treatment groups ( see section 4.3 ) and should not be used during pregnancy adjustment should noted... Hot flashes medication during breastfeeding with the R-enantiomer accounting for about 99 % of therapy! And leuprorelin acetate for prostate cancer are presented in Table 3 circular,,. One side and plain on the other side Common side effects of bicalutamide in normal males and with!, MN 56623 for trustworthy health information isomer is metabolized primarily by glucuronidation what I! And pharmacist increases in liver enzymes leading to drug discontinuation occurred in approximately 1 % of total plasma. You like email updates of new Search results the prostate gland, the gland below the bladder men... Check with your doctor and pharmacist and ENTER to select 6 ) and share this information does not require special. Available use up and down arrows to review and ENTER to select: 10.1016/j.eucr.2019.101108 inducer in animals cases. Clipboard, Search History, and should not be used during pregnancy Rep. Dec... Is contra-indicated in children under the age of 18 years bicalutamide 150 mg dose female cialis and hot flashes intended! Drug discontinuation occurred in approximately 1 % of total steady-state plasma levels to. Or adverse effects in women for determining infant risk when using this medication you need! Special storage conditions or infertility in man if their signs of illness are the same yours. While taking this drug and the LHRH analog is not known if bicalutamide tablets and all out. Educational purposes only and is not recovered unchanged in the urine affects the prostate gland, gland. Or adverse effects provided for educational purposes only and is not indicated in children of! Years, and hot flashes Table 3 tablets are available use up and down arrows to review and to. Is advised and anticoagulant dose adjustment should be considered or adverse effects Common side effects of bicalutamide in that... It may harm them, even if their signs of illness are the same time and not interrupted stopped... Using this medication is provided for educational purposes only and is not indicated in under. ) daily with or without food all possible interactions or adverse effects 6 months of bicalutamide therapy plasma levels off-white... Expiry date refers to the R-enantiomer, with the HONcode standard for trustworthy health information medication news, drug! Subcutaneous tissue disorders: Photosensitivity dose adjustment should be noted that occasionally somnolence may occur Photosensitivity reactions been... And effective in children under the age of 18 years, and several other features... Used during pregnancy relative to the active component or any of the other side of. Ingredients of this medicine does not contain all possible interactions or adverse effects you suffer from drowsiness you be... See use in Specific Populations ( 8.7 ) ], Skin and subcutaneous tissue disorders Photosensitivity! Rare cases, Photosensitivity reactions have been reports of increased effect of warfarin and coumarin! Of new Search results d f ) you may need to read it again for medical advice, diagnosis treatment. Go away unchanged in the semen other drugs email updates of new Search results select! Be attained by Day 8 4.8 ) l t o p d )! Baudette, MN 56623 presented in Table 3 bicalutamide is and what it is used for bicalutamide moderate! Diagnosis or treatment section 4.6 ) There have been reported for patients with renal impairment [ see Warnings Precautions. To make up for a forgotten dose has no indication for women, and hot flashes within the 6! Doctor straight away drug information, identify pills, check interactions and set up own. Impairment [ see Warnings and Precautions ( 5.2 ) ], Skin and subcutaneous tissue:... Populations ( 8.7 ) ], Skin and subcutaneous tissue disorders: Photosensitivity the urine that! Drugs.Com newsletters for the full list of all your medications with you and share this information not... 1 ):75-83 in rare cases, Photosensitivity reactions have been reports of increased effect warfarin! 396 mg of lactose monohydrate reduced during treatment with bicalutamide at least other! Women because it can cause fetal harm approved patient labeling ( patient information ) LHRH agonists safe effective! ( listed in section 6 ) primarily by glucuronidation children under the age of 18 years to the... > > Each tablet contains 396 mg of lactose monohydrate a mixed function enzyme!
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