It is important to get each dose of this medication as scheduled. Report any side effects you experience to your health care . The five-day cardiovascular mortality observed in these studies ranged from 20 to 400 per million azithromycin treatment courses. Azithromycin (azithromycin)." ZITHROMAX for injection consists of azithromycin dihydrate and the following inactive ingredients: citric acid and sodium hydroxide. If it happens, it may be a sign of something more serious, like liver damage or a Clostridium difficile ("C. diff") infection. You may report side effects to the FDA at 1-800-FDA-1088. Approximately 17 hrafter dosing, azithromycin concentrations were 2.7 mcg/g in ovarian tissue, 3.5 mcg/g in uterine tissue, and 3.3 mcg/g in salpinx. Decreased viability and delayed development were observed in the offspring of pregnant rats administered azithromycin from day 6 of pregnancy through weaning ata dose equivalent to 4 times an adult human daily dose of 500 mg based on body surface area (see Data). RxList does not provide medical advice, diagnosis or treatment. Interactions with digoxin, colchicine or phenytoin have not been reported in clinical trials with azithromycin. Breast milk samples collected on days 3 and 6 postpartum as well as 2 and 4 weeks postpartum revealed the presence of azithromycin in breastmilk up to 4 weeks after dosing. ZITHROMAX is contraindicated in patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior use of azithromycin. Azithromycin monohydrate [package insert]. Common azithromycin side effects include diarrhea, nausea, and stomach pain. ZITHROMAX for injection contains the active ingredient azithromycin, an azalide, a subclass of macrolide antibacterial drug, for intravenous injection. Rare but serious side effects include severe skin problems, liver damage, and heart rhythm problems. Indicated for treatment of acute bacterial exacerbations of chronic bronchitis due to Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae. Serious side effects Other side effects Professional info FAQ Note: This document contains side effect information about azithromycin. Adverse reactions reported with azithromycin during the post marketing period in adult and/or pediatric patients for which a causal relationship may not be established include: Allergic: Arthralgia, edema, urticaria and angioedema. Visit the FDA MedWatch website or call 1-800-FDA-1088. During pregnancy, this medication should be used only when clearly needed. [see WARNINGS AND PRECAUTIONS]. Some observational studies have shown an approximately two-fold increased short-term potential risk of acute cardiovascular death in adults exposed to azithromycin relative to other antibacterial drugs, including amoxicillin. What is the best antibiotic to treat strep throat? This medication is an antibiotic used to treat certain bacterial infections. Consult your doctor before breast-feeding. This medication contains sodium. Aspire Pharma Ltd (2022): 7. The clinical outcome rates, i.e., cure, improved, and success (cure + improved) among the 84 patients seen at 10 to 14 days post-therapy were as follows: Microbiological determinations in both trials were made at the pre-treatment visit and, where applicable, were reassessed at latervisits. For the best effect, use this antibiotic at evenly spaced times. Effects in the offspring were noted at 200 mg/kg/day during the postnatal development period (decreased viability, delayed developmental landmarks). Check with your physician for additional information about side effects. Although a dose adjustment of azithromycin is not recommended when administered in combination with nelfinavir, close monitoring for known adverse reactions of azithromycin, such as liver enzyme abnormalities and hearing impairment, is warranted. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Less than 1% of study participants reported vomiting as a side effect of azithromycin, but its still possible. See additional information. Was azithromycin in my system long enough to treat chlamydia after throwing up? Discuss the risks and benefits with your doctor. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Check with your doctor or nurse immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Prothrombin times should be carefully monitored while patients are receiving azithromycin and oral anticoagulants concomitantly. QTc interval prolongation was studied in a randomized, placebo-controlled parallel trial in 116 healthy subjects who received either chloroquine (1,000 mg) alone or in combination with oral azithromycin (500 mg, 1,000 mg, and 1,500 mg once daily). Approximately 12% of patients experienced a side effect related to the intravenous infusion; most common were pain at the injection site (6.5%) and local inflammation (3.1%). You can unsubscribe at any time. It belongs to a group of medications called macrolide antibiotics, and its a helpful option for several bacterial infections. patients with ongoing proarrhythmic conditions such as uncorrected. Be sure to let your healthcare provider know if you have a history of liver problems before starting azithromycin. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Now, youll enjoy a streamlined experience created specifically for healthcare providers. Since the mean Cmax of azithromycin following a 500 mg IV dose given over 1 hr is higher than the mean Cmax of azithromycin following the administration of a 1,500 mg oral dose, it is possible that QTc may be prolonged to a greater extent with IV azithromycin at close proximity to a one hour infusion of 500 mg. A generic formulation of Zithromax is available. Since ZITHROMAX for injection is supplied under vacuum, it is recommended that a standard 5 mL (non-automated) syringe be used to ensure that the exact amount of 4.8 mL of Sterile Water is dispensed. Similarly, severe allergic reactions to azithromycin are rare, but possible. 2005 - 2023 WebMD LLC, an Internet Brands company. (n.d.). MedlinePlus. Although not all of these side effects may occur, if they do occur they may need medical attention. Clostridioides difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including ZITHROMAX (azithromycin for injection), and may range in severity from mild diarrhea to fatal colitis. Copyright: Merative US L.P. 1973, 2023. [see CONTRAINDICATIONS]. Sinus Infection and Sinusitis Medications. There are also many OTC nausea relief medications that you can try if needed. Azithromycin (Zithromax), commonly referred to as a Z-Pak, is one antibiotic that youve likely heard of. If either is present, do not use the liquid. Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Some side effects may not be reported. If you notice other effects not listed above, contact your doctor or pharmacist. Introductory Offer: Save 10 percent on Cialis Together 4 pack - online only. Cialis Together 10mg Tablets - Tadalafil - 4 Tablets. Ratio (with/without azithromycin) of Coadministered Drug Pharmacokinetic Parameters, 200 mg/day for 2 days, then 200 mg twice a day for 18 days, 500 mg orally on day 7, then 250 mg/day on days 8-11, 500 mg orally on day 7, 250 mg/day on days 8-11, 500 mg orally on day 6, then 250 mg/day on days 7-10, 500 mg orally on day 1, then 250 mg/day on day 2, Ratio (with/without co-administered drug) of Azithromycin Pharmacokinetic Parameters (90% CI); No Effect = 1, * Nineteen of twenty-four patients (79%) with positive blood cultures for. AziTHROMYCIN (Mylan) (aziTHROMYCIN)." Co-administration of azithromycin increased the QTc interval in a dose- and concentration- dependent manner. Prescribing azithromycin. Clinical adverse reactions leading to discontinuations from these studies were gastrointestinal (abdominal pain, nausea, vomiting,diarrhea), and rashes; laboratory side effects leading to discontinuation were increases in transaminase levels and/or alkaline phosphatase levels. Until further data are developed regarding drug interactions when digoxin, colchicine or phenytoin areused with azithromycin careful monitoring of patients is advised. But if you have symptoms of serious side effects, you should contact your healthcare provider right away. Side effects, particularly stomach side effects, are more likely to happen when you receive higher doses over a shorter period of time. If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. This condition may occur during treatment or weeks to months after treatment has stopped. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Azithromycin acts by binding to the 23S rRNA of the 50S ribosomal subunit of susceptible microorganisms inhibiting bacterial protein synthesis and impeding the assembly of the 50S ribosomal subunit. The recommended dose of ZITHROMAX for injection for the treatment of adult patients with pelvic inflammatory disease due to the indicated organisms is 500 mg as a single daily dose by the intravenous route for one or two days. Continue reading for a comprehensive list of adverse effects. This is more common in people with low blood levels of potassium or magnesium, people taking medications that control heart rhythm (antiarrhythmics), and older adults. Association of Community Cancer Centers. Based on the pharmacokinetic data, phospholipidosis has been seen in the rat (50 mg/kg/day dose) at the observed maximal plasma concentration of 1.3 mcg/mL (1.6 times the observed Cmax of 0.821 mcg /mL at the adult doseof 2 g.) Similarly, it has been shown in the dog (10 mg/kg/day dose) at the observed maximal serum concentration of 1 mcg /mL (1.2times the observed Cmax of 0.821 mcg /mL at the adult dose of 2 g). The phase IV clinical study analyzes what interactions people who take Azithromycin and Xarelto have. Some dosage forms listed on this page may not apply to the brand name Zithromax. Tell your health care professional that you are using azithromycin before having any immunizations/vaccinations. Pharmacokinetic studies with intravenous azithromycin have not been performed in older volunteers. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Common (1% to 10%): Increased AST, increased ALT, increased GGT, increased blood bilirubin, Uncommon (0.1% to 1%): Hepatitis, abnormal liver function tests, Rare (0.01% to 0.1%): Abnormal hepatic function, cholestatic jaundice, Frequency not reported: Liver enzyme abnormalities, increased transaminase levels, jaundice, Postmarketing reports: Hepatic failure, fulminant hepatitis, hepatic necrosis, Postmarketing reports: Anaphylactic reaction/anaphylaxis (e.g., anaphylactic shock), allergic reactions. Azithromycin may cause a condition that affects the heart rhythm (QT prolongation). As a precaution, if you develop any new skin rashes while taking azithromycin, its recommended to contact your healthcare provider as soon as you can to make sure it's not a sign of something more serious. This is not a complete list of possible side effects. Common side effects of Zithromax include: diarrhea or loose stools, nausea, abdominal or stomach pain, vomiting, and. Direct parents and caregivers to contact their physician if vomiting or irritability with feeding occurs. Diarrhea: Inform patients that diarrhea is a common problem caused by antibacterial drugs which usually ends when the antibacterial is discontinued. Ribosomal modifications can determine crossresistance to other macrolides, lincosamides and streptogramin B (MLSB phenotype). Call your doctor for medical advice about side effects. McMullan, B. J., et al. Tissue concentrations have not been obtained following intravenous infusions of azithromycin, but following oral administration inhumans azithromycin has been shown to penetrate into tissues, including skin, lung, tonsil, and cervix. All rights reserved. Bryant Ranch Prepack. This side effect happened to between 2% and 3% of people taking azithromycin in clinical studies. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Severe diarrhea (watery or bloody stools) and stomach cramps occurring up to two months or more after treatment. But there are ways to help control diarrhea. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Babies (especially younger than 6 weeks) may be at higher risk for a certain serious stomach problem. Canada residents can call a provincial poison control center. A very serious allergic reaction to this drug is rare. To help you remember, use this medication at the same time(s) every day. Check with your doctor immediately if any of the following side effects occur while taking azithromycin: Some side effects of azithromycin may occur that usually do not need medical attention. Azithromycin (azithromycin as powder for solution for infusion) should be reconstituted and diluted according to the instructions and should be administered as an intravenous infusion over at least 60 minutes. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our. If you notice any other effects, check with your healthcare professional. In the event of overdosage, general symptomatic and supportive measures are indicated as required. This minimal effect on pregnancy rate (approximately 12% reduction compared to concurrent controls) did not become more pronounced when the dose was increased from 20 to 30 mg/kg/day (approximately 0.4 to0.6 times the adult daily dose of 500 mg based on body surface area) and it was not observed when only one animal in the mated pair was treated. "Product Information. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. This medicine is a colorless, clear, vial, Select a condition to view a list of medication options. There were no effects on any other reproductive parameters, and there were no effects on fertility at 10 mg/kg/day. Before using, check this product visually for particles or discoloration. In clinical trials, liver function tests (blood tests that evaluate your liver health) slightly worsened in a little more than 1% of people. The UK is the first country to allow OTC access to Sanofi's tadalafil-based erectile dysfunction drug Cialis following a successful switch. To help prevent and control these risks, make sure your healthcare provider knows your full medical history and all the medications and supplements you take. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Azithromycin has been shown to be active against the following microorganisms, both in vitro and in clinical infections. I would also like to sign up for a free GoodRx account, Written by Jennifer Gershman, PharmD, CPh, PACS, Written by Tegan Smedley, PharmD, BCPS, APh, Written by Jennifer Clements, MD, MSEd, NBHWC, Written by Ross Phan, PharmD, BCACP, BCGP, BCPS. When azithromycin wasco-administered with metronidazole in these trials, a higher proportion of women experienced adverse reactions of nausea (10.3%),abdominal pain (3.7%), vomiting (2.8%), infusion site reaction, stomatitis, dizziness, or dyspnea (all at 1.9%). Reconstituted solution is stable for 24 hr when stored below 30C (86F). What antibiotics kill Covid-19 (coronavirus)? zithromax injection (azithromycin) drug. This side effect is usually reversible once you stop the medication. pain or redness at the injection site. In the US - Call your doctor for medical advice about side effects. Parenteral drug products should be inspected visually for particulate matter prior to administration. 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