Atorvastatin is a substrate of the hepatic transporters, OATP1B1 and OATP1B3 transporter. Renal impairment is a risk factor for myopathy and rhabdomyolysis. Although side effects reported with all tablet strengths are the same, taking a higher dose of atorvastatin may increase your risk of these side effects. In the Collaborative Atorvastatin Diabetes Study (CARDS), the effect of atorvastatin calcium tablets on cardiovascular disease (CVD) endpoints was assessed in 2838 subjects (94% White, 2% Black, 2% South Asian, 1% other; 68% male), ages 40-75 with type 2 diabetes based on WHO criteria, without prior history of cardiovascular disease and with LDL 160 mg/dL and triglycerides (TG) 600 mg/dL. The mean LDL-C reduction in this trial was 18%. A nonstandard dosage. For additional recommendations regarding concomitant use of atorvastatin calcium tablets with other anti-viral medications, azole antifungals or macrolide antibiotics [see Drug Interactions (7.1)]. Call your doctor for medical advice about side effects. Manufactured for: Mylan Pharmaceuticals Inc., Morgantown, WV 26505 U.S.A. Vegetarian and vegan diets linked to lower levels of cholesterol, Alzheimer's risk linked to high HDL cholesterol and high blood pressure. Tell your doctor right away if you develop any symptoms of liver damage. Theyll help determine the best dosage of the drug for you. atorvastatin ( Lipitor) lovastatin (Mevacor) simvastatin (Zocor) Statins that interact less These statin medications tend to interact less with grapefruit juice: This dosage range may be anywhere from 40 mg each day to 80 mg per day. Its a place where people with certain conditions can find support and connect with others. What Atorvastatin is and what it is used for 2. Atorvastatin may cause muscle damage or muscle pain. Read this Healthline article to learn more about the differences between generic and brand-name drugs. Increases in liver enzyme tests in other patients were not associated with jaundice or other clinical signs or symptoms. The safety and effectiveness of atorvastatin calcium tablets as an adjunct to other LDL-C-lowering therapies to reduce LDL-C have been established pediatric patients 10 years of age and older with HoFH. In the latter case, theyll recommend a different treatment for your condition. The remaining 3 receptor-negative patients had a mean LDL-C reduction of 22%. believe in personal direct communication and we will inform you per direct email The recommended starting dosage of atorvastatin calcium tablets is 10 mg to 20 mg once daily. (Withdrawal symptoms are side effects that can occur when you stop taking a drug that your body has become dependent on.). Links to other websites Success: They can give you more information about the benefits and risks of using other drugs with atorvastatin. Atorvastatin is a substrate of CYP3A4 and transporters (e.g., OATP1B1/1B3, P-gp, or BCRP). What should I avoid while taking atorvastatin calcium tablets? Ankylosing Spondylitis Pain: Fact or Fiction, Atorvastatin may interact with other medications, Important considerations for taking atorvastatin, http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4d7150a0-9593-46ab-b8a2-8f6fe0e483b6, http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c6e131fe-e7df-4876-83f7-9156fc4e8228. If serious hepatic injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs, promptly discontinue atorvastatin calcium tablets. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use its online resource. Talk with your doctor if youre pregnant, planning to become pregnant, or breastfeeding. Learn more about some of the side effects atorvastatin may cause. Learn about the drugs dosages, forms, strengths, and more. If you become pregnant, stop taking LIPITOR and call your doctor right away. What are the serious side effects of atorvastatin? Like most drugs, atorvastatin oral tablets may cause mild or serious side effects. Cut III Heads for Jointers by RELIANT, Lux If you dont take atorvastatin, your cholesterol levels may not be controlled. Atorvastatin (Lipitor) is known as a moderate-to-high-intensity statin, meaning it lowers your cholesterol more so than many other statins. Files, Presentations Figure 1: Effect of Atorvastatin Calcium Tablets 10 mg/day on Cumulative Incidence of Non-Fatal Myocardial Infarction or Coronary Heart Disease Death (in ASCOT-LLA). This can cause atorvastatin to build up, raising your risk of side effects. other field (in case your order will ship per UPS or FedEx)! On the other hand, its possible to have weight loss with atorvastatin if you have certain side effects from the drug. Clinical Trials, Cmax and AUC are each 4-fold greater in patients with Childs-Pugh A disease. Persistent transaminase elevations ( 3 x ULN twice within 4-10 days) occurred in 1.3% of individuals with atorvastatin 80 mg and in 0.2% of individuals with atorvastatin 10 mg. Elevations of CK ( 10 x ULN) were higher in the high-dose atorvastatin group (0.3%) compared to the low-dose atorvastatin group (0.1%). 4 UNI | 4.95 per 1UNI. Before taking atorvastatin oral tablets, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. (Keep in mind that atorvastatin is a statin.). LIPITOR is used: It is not known if LIPITOR is safe and effective in children younger than 10 years of age with HeFH or HoFH or in children with other types of hyperlipidemias (other than HeFH or HoFH). You may have the following symptoms: If you think youve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 1-800-222-1222 or through their online tool. Table 1 summarizes adverse reactions reported in 2% and at a rate greater than placebo in patients treated with atorvastatin calcium tablets (n = 8755), from seventeen placebo-controlled trials. Be sure to ask your doctor for more information about this. The film coating of the tablets contains polyvinyl alcohol, talc and titanium dioxide, and may contain polyethylene glycol or lecithin and xanthan gum. If you need to take these drugs together, your doctor may decrease your dosage of atorvastatin. This can be harmful or prevent the drug from working well. Before starting atorvastatin, ask your doctor for more information about this side effect. Possible side effects 5. Statins are known to increase risk for myopathies, or myotoxicity. Let's look deeper. In this case, your doctor can recommend the safest treatment option for you. Dose selection for an elderly patient should be cautious, recognizing the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy and the higher risk of myopathy. The mean LDL-C, TC, TG, non-HDL, and HDL cholesterol levels at 12 weeks were 73, 145, 128, 98, and 47 mg/dL during treatment with 80 mg of atorvastatin calcium tablets and 99, 177, 152, 129, and 48 mg/dL during treatment with 10 mg of atorvastatin calcium tablets. There was a higher incidence of persistent hepatic transaminase elevations ( 3 x ULN twice within 4-10 days) in the atorvastatin group (0.9%) compared to placebo (0.1%). But if your symptoms are severe, call 911 or go to the nearest emergency room right away. As a result, more of a drug stays in your body for a longer time. (2022). Monitor geriatric patients receiving atorvastatin calcium tablets for the increased risk of myopathy [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3)]. Hyderabad 500 096, India, Revised: 5/2023MX:ATOR:R17ppt/MX:PL:ATOR:R11p/MX:PL:ATOR:R11pt, Atorvastatin If youve had an allergic reaction to atorvastatin or any of its ingredients, your doctor will likely not prescribe it for you. *Each film-coated tablet containsatorvastatin calcium, USPequivalent to 20 mg of atorvastatin. Your doctor will explain how you should take atorvastatin oral tablets. Manufactured for: Individualization of drug dosage should be based on therapeutic response [see Dosage and Administration (2)]. Approximately 98% were White, and less than 1% were Black or Asian. Consider this when selecting an oral contraceptive for patients taking atorvastatin calcium tablets. Be sure to avoid doing this when the weather is very hot or very cold. If youd like to learn more about how these drugs compare, see this article. Your doctor may monitor you more closely for muscle problems. Examples of drugs that may interact with atorvastatin oral tablets include: This list does not contain all types of drugs that may interact with atorvastatin oral tablets. Atorvastatin only comes in the form of a tablet you take by mouth. If your co-pay or out-of-pocket costs are no more than $150, you pay $4. Renal disease has no influence on the plasma concentrations or LDL-C reduction of atorvastatin [see Use in Specific Populations (8.6)]. your muscle problems. It belongs to a group of drugs . Plasma concentrations of atorvastatin in women differ from those in men (approximately 20% higher for Cmax and 10% lower for AUC); however, there is no clinically significant difference in LDL-C reduction with atorvastatin calcium tablets between men and women. muscle problems that do not go away after your doctor has told you to stop taking LIPITOR. Examples of these drugs include: Taking rifampin with atorvastatin may lower the amount of atorvastatin in your body. Specifically, your risk may be higher if you: If you have muscle pain while youre taking atorvastatin, call your doctor right away. Lactation: Advise patients that breastfeeding is not recommended during treatment with atorvastatin calcium tablets [see Use in Specific Populations (8.2)]. LIPITOR may harm your unborn baby. What are the possible side effects of atorvastatin calcium tablets? Alternatively, consider the ongoing therapeutic needs of the individual patient. Thus, if your co-pay or out-of-pocket cost is more than $150, you will save $150 off of your co-pay or total out-of-pocket costs. Increases in HbA1c and fasting serum glucose levels have been reported with statins, including atorvastatin calcium tablets. For women who are breastfeeding: Atorvastatin should not be used during breastfeeding. In animal reproduction studies, no adverse developmental effects were observed in pregnant rats or rabbits orally administered atorvastatin at doses that resulted in up to 30 and 20 times, respectively, the human exposure at the maximum recommended human dose (MRHD) of 80 mg, based on body surface area (mg/m2). You should not use this Savings Offer if your insurer or health plan prohibits use of manufacturer Savings Offers, This Savings Offer is not valid (i) for Massachusetts residents or (ii) for California residents whose prescriptions are covered, in whole or in part, by third-party insurance, This Savings Offer is not valid where prohibited by law, This Savings Offer is not valid for purchases of prescriptions discounted under the 340B drug pricing program, This Savings Offer cannot be combined with any other rebate/coupon, free trial, or similar offer for the specified prescription, This Savings Offer may not be redeemed more than once per month per patient, This Savings Offer is good only in the U.S. and Puerto Rico, This Savings Offer is limited to 1 per person during this offering period and is not transferable, This Savings Offer may not be redeemed more than once per 30 days per patient, Data related to your redemption of this Savings Offer may be collected, analyzed, and shared with VIATRIS, Viatris reserves the right to rescind, revoke, or amend the program without notice, No membership fees. 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