Queens of the Stone Age will bring Phantogram, Viagra Boys, the Armed, and Savages' Jehnny Beth on their fall North American tour. Drug interactions may change how your medications work or increase your risk for serious side effects. ARICEPT ODT tablets are available for oral administration. This is not a complete list of side effects and others may . Do not stop taking this medication without consulting your doctor. While waiting for new doctor to take over past neurologist's care, have adjusted meds myself to keep the memory help - which is astounding - and lessens side effects which includes severe muscle cramps in legs, water retention, ankle and hand swelling, back pain, increased blood pressure, heart palpitations. Adverse Reactions in Pooled Controlled Clinical Trials in Severe Alzheimers Disease Body System/Adverse Reaction Placebo (n=392) % ARICEPT (n=501) % Percent of Patients with any Adverse Reaction 73 81 Accident 12 13 Infection 9 11 Diarrhea 4 10 Anorexia 4 8 Vomiting 4 8 Nausea 2 6 Insomnia 4 5 Ecchymosis 2 5 Headache 3 4 Hypertension 2 3 Pain 2 3 Back Pain 2 3 Eczema 2 3 Hallucinations 1 3 Hostility 2 3 Increase in Creatine Phosphokinase 1 3 Nervousness 2 3 Fever 1 2 Chest Pain <1 2 Confusion 1 2 Dehydration 1 2 Depression 1 2 Dizziness 1 2 Emotional Lability 1 2 Hemorrhage 1 2 Hyperlipemia <1 2 Personality Disorder 1 2 Somnolence 1 2 Syncope 1 2 Urinary Incontinence 1 2 Moderate to Severe Alzheimers Disease (ARICEPT 23 mg/day) ARICEPT 23 mg/day has been administered to over 1300 individuals globally in clinical trials. But it can also cause trouble sleeping, headaches, and muscle cramps. You may report side effects to FDA at 1-800-FDA-1088. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of donepezil in the elderly. Common side effects of Aricept include: diarrhea, insomnia, and nausea. Swelling of the throat, lips, or face. Store at room temperature away from light and moisture. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Mayo Clinic does not endorse any of the third party products and services advertised. 10mg However, it can improve thinking ability in some patients. Follow your. Donepezil (Aricept) is approved to treat all stages of the disease. In this study, there were no important differences in the type of adverse reactions in patients taking ARICEPT with or without memantine. If your dose is different, do not change it unless your doctor tells you to do so. Our servers have detected that you are accessing this site from a restricted area. Neurology 63 (2004): 1543-4; author reply 1543-4, 14. Some people taking this medicine have improved mental function, while others may have unchanged or even worsening mental function. Pharmacy names, logos, brands, and other trademarks are the property of their respective owners. Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually 81-162 milligrams a day), should be continued. This may not be a complete list of all possible Aricept adverse effects. Towers Administrators LLC (operating as 'SingleCare Administrators') is the authorized prescription discount plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. Side effects Interactions Dosage FAQ What is Viagra? Follow all directions on your prescription label and read all medication guides or instruction sheets. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Epilepsy: There is a possibility that donepezil may increase the risk of seizures for susceptible people. The following side effects have been reported by at least 1% of people taking this medication. Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, or naproxen) that if taken together with donepezil may increase your risk for stomach/intestinal bleeding. Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. Inactive ingredients in 5 mg and 10 mg tablets are lactose monohydrate, corn starch, microcrystalline cellulose, hydroxypropyl cellulose, and magnesium stearate. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Always consult a medical provider for diagnosis and treatment. The content on Healthgrades does not provide medical advice. Data Animal Data Oral administration of donepezil to pregnant rats and rabbits during the period of organogenesis did not produce any teratogenic effects at doses up to 16 mg/kg/day (approximately 6 times the maximum recommended human dose [MRHD] of 23 mg/day on a mg/m 2 basis) and 10 mg/kg/day (approximately 7 times the MRHD on a mg/m 2 basis), respectively. You may report side effects to the FDA at 1-800-FDA-1088. It is important that this medication be taken on a regular schedule as prescribed by your doctor. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. In general, adverse reactions occurred more frequently in female patients and with advancing age. Urinary tract blockage or difficult urinationDonepezil may make these conditions worse. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. However, the dose usually is not more than 10 mg per day. Additionally, the 10 mg tablet contains ferric oxide (yellow) as a coloring agent. This is a decision you and your doctor will make. Does Aricept interact with other drugs you are taking? donepezil levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects; may decr. Vision changes are also possible. Frequency of common adverse effects may be influenced by the rate of titration. ARICEPT is available for oral administration in film-coated tablets containing 5, 10, or 23 mg of donepezil hydrochloride. This medication is an enzyme blocker that works by restoring the balance of natural substances (neurotransmitters) in the brain. Taking an overdose of this medicine may cause convulsions (seizures) or serious effects on your heart and your breathing. Approximately 1050 of these patients have been treated for at least three months and more than 950 patients have been treated for at least six months. Most Common Adverse Reactions Leading to Discontinuation in Patients with Moderate to Severe Alzheimers Disease Adverse Reaction 23 mg/day ARICEPT (n=963) % 10 mg/day ARICEPT (n=471) % Vomiting 3 0 Diarrhea 2 0 Nausea 2 0 Dizziness 1 0 The majority of discontinuations due to adverse reactions in the 23 mg group occurred during the first month of treatment. Onofrj M, Thomas A "Severe worsening of parkinsonism in Lewy body dementia due to donepezil." Controlled and uncontrolled trials in the United States included approximately 900 patients. Canada residents can call a provincial poison control center. confusion, disorientation, appetite loss, weight loss, daytime somnolence, vestibular dysfunction (loss of hearing and balance), daily nightmares, general malaise/sense of not feeling well, could not recognize family members, spikes in blood pressure. It can be harmful for people to take this medication if their doctor has not prescribed it. Drug information provided by: Merative, Micromedex. Read the Patient Information Leaflet if available from your pharmacist before you start taking donepezil and each time you get a refill. This is NOT insurance nor a Medicare prescription drug plan. 2 Lactation Risk Summary There are no data on the presence of donepezil or its metabolites in human milk, the effects on the breastfed infant, or on milk production. How does Aricept/Donezepil work? [T]hey can get erections at other times, but they get anxious, particularly in new situations, new relationships, or if they're . Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.Towers Administrators LLC (operating as 'SingleCare Administrators') is the authorized prescription discount plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Selected from data included with permission and copyrighted by First Databank, Inc. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. For senior women with a low body weight, it is recommended that the dose of donepezil not exceed 5mg daily. This medicine is available only with your doctor's prescription. stop taking one of the medications. In the U.S. general population, the estimated background risks of major birth defects and miscarriage in clinically recognized pregnancies are 2% to 4% and 15% to 20%, respectively. Its produced by EISAI. Donepezil hydrochloride is commonly referred to in the pharmacological literature as E2020. The rate of discontinuation of patients who received 7-day escalations from 5 mg/day to 10 mg/day was higher at 13%. Ann Pharmacother 34 (2000): 1347, 10. burning, prickling, or tingling sensations, increased urge to urinate during the night. Inactive ingredients are carrageenan, mannitol, colloidal silicon dioxide, and polyvinyl alcohol. Applies to donepezil: oral tablet, oral tablet disintegrating. These may be symptoms of stomach or bowel bleeding. Your pharmacist may be able to advise you on managing side effects. Donepezil is used to treat dementia (memory loss and mental changes) associated with mild, moderate, or severe Alzheimer's disease. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. If you think you or someone else may have overdosed on: If someone collapses or isn't breathing after taking. Donepezil hydrochloride is a white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile, and practically insoluble in ethyl acetate and in n-hexane. Follow your doctor's instructions carefully. It is approved to treat Alzheimer's disease, dementia with Lewy bodies, Down syndrome and Parkinson's disease. Most Common Adverse Reactions The most common adverse reactions, defined as those occurring at a frequency of at least 5% in patients receiving ARICEPT and at twice or more the placebo rate, are largely predicted by ARICEPTs cholinomimetic effects. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Liver disease or Low body weight (below 50 kilograms or 110 pounds)Higher blood levels of donepezil may result and increase the chance of side effects. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. Nausea and vomiting. This medication may be available under multiple brand names and/or in several different forms. Make sure you tell your doctor if you have any other medical problems, especially: Take this medicine exactly as directed by your doctor in order to improve your condition as much as possible. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. feeling tired. This is a prescription discount plan. O 0, 3. If you think that you or someone else may have taken an overdose of this medicine, get emergency help at once. change one of the medications to another, change how you are taking one or both of the medications, or. Pregnancy: Based on animal data, may cause fetal harm ( 8.1 ) 8.1 Pregnancy Risk Summary There are no adequate data on the developmental risks associated with the use of ARICEPT in pregnant women. Comparison of Rates of Adverse Reactions in Mild to M oderate Patients Titrated to 10 mg/day over 1 and 6 Weeks No titration One week titration Six week titration Adverse Reaction Placebo (n=315) % 5 mg/day (n=311) % 10 mg/day (n=315) % 10 mg/day (n=269) % Nausea 6 5 19 6 Diarrhea 5 8 15 9 Insomnia 6 6 14 6 Fatigue 3 4 8 3 Vomiting 3 3 8 5 Muscle cramps 2 6 8 3 Anorexia 2 3 7 3 Table 3 lists adverse reactions that occurred in at least 2% of patients in pooled placebo-controlled trials who received either ARICEPT 5 mg or 10 mg and for which the rate of occurrence was greater for patients treated with ARICEPT than with placebo. Consult your doctor before breast-feeding. Donepezil most commonly causes stomach-related side effects, such as nausea, diarrhea, and appetite changes. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. 8.4 Pediatric Use The safety and effectiveness in pediatric patients have not been established. Select a condition to view a list of medication options. down the sink or in the toilet) or in household garbage. If you are a breast-feeding mother and are taking this medication, it may affect your baby. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Overdose symptoms may include severe nausea, vomiting, drooling, sweating, blurred vision, feeling light-headed, slow heartbeat, shallow breathing, muscle weakness, fainting, or seizure (convulsions). Copyright: Merative US L.P. 1973, 2023. For non-prescription products, read the label or package ingredients carefully. Properly discard this product when it is expired or no longer needed. Aricept (donepezil) +. Aricept; Descriptions. Do not give this medication to anyone else, even if they have the same symptoms as you do. You can also report other adverse reactions of Aricept to the FDA at 1-800-FDA-1088. Speak to your doctor about how any drug interactions are being managed or should be managed. Take your next dose at the regular time. Common side effects of Aricept include headache, generalized pain, fatigue, dizziness, nausea, vomiting, diarrhea, loss of appetite, weight loss, muscle cramping, joint pain, insomnia, and increased urinary frequency. If you have a history of ulcers or are at increased risk of developing stomach ulcers, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Abdominal pain, agitation, aggression, cholecystitis, confusion, convulsions, hallucinations, heart block (all types), hemolytic anemia, hepatitis, hyponatremia, neuroleptic malignant syndrome, pancreatitis, rash, rhabdomyolysis, QTc prolongation, and torsade de pointes. It is unknown if this drug passes into breast milk. Check with your doctor if you notice any symptom that worries you while you are taking this medication. Runny nose . This document does not contain all possible drug interactions. Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Suitable management of donepezil overdose should include donepezil discontinuation and supportive care. Talk to your doctor if you are using marijuana (cannabis). If you do not take donepezil for 7 or more days in row, talk with your doctor before starting again. The contents herein are for informational purposes only. You should not stop using donepezil without your doctor's advice. You may report side effects to Health Canada at 1-866-234-2345. If you notice any other effects, check with your healthcare professional. The developmental and health benefits of breastfeeding should be considered along with the mothers clinical need for ARICEPT and any potential adverse effects on the breastfed infant from ARICEPT or from the underlying maternal condition. Ask your healthcare professional how you should dispose of any medicine you do not use. Donepezil does not cure Alzheimer's disease. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Uncommon (0.1% to 1%): Bradycardia, angina pectoris, postural hypotension, myocardial infarction, AV block (first degree), congestive heart failure, arteritis, peripheral vascular disease, supraventricular tachycardia, deep vein thrombosis. Some of these side effects may require emergency medical help. These include diarrhea, anorexia, vomiting, nausea, and ecchymosis. The rates of common adverse reactions were lower than those seen in patients titrated to 10 mg/day over one week in the controlled clinical trials and were comparable to those seen in patients on 5 mg/day. Other dosage forms: Along with its needed effects, donepezil (the active ingredient contained in Aricept) may cause some unwanted effects. 10 mg. 12/8/2016. Your doctor may increase your dose as needed. Place the tablet in your mouth and allow it to dissolve, without chewing. The following serious adverse reactions are described below and elsewhere in the labeling: Cardiovascular Conditions [see Warnings and Precautions ( 5.2 )] Nausea and Vomiting [see Warnings and Precautions ( 5.3 )] Peptic Ulcer Disease and GI Bleeding [see Warnings and Precautions ( 5.4 )] Weight Loss [see Warnings and Precautions ( 5.5 )] Genitourinary Conditions [see Warnings and Precautions ( 5.6 )] Neurological Conditions: Seizures [see Warnings and Precautions ( 5.7 )] Pulmonary Conditions [see Warnings and Precautions ( 5.8 )] Most common adverse reactions in clinical studies of ARICEPT are nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, and anorexia ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Eisai Inc. at 1-888-274-2378 (fax 1-201-746-3207) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. From Web advertising help support our mission 1543-4 ; author reply 1543-4,.. Causing side effects to FDA at 1-800-FDA-1088 without memantine, Thomas a Severe... 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Swelling of the third party products and services advertised from heat, moisture and... Schedule as prescribed by your doctor may change how your medications work increase. Consult a medical provider for diagnosis and treatment approvals, alerts and updates 5 mg/day to 10 mg/day higher! Not stop taking this medication, it can be harmful for people to take medication... Or instruction sheets unwanted effects is an enzyme blocker that works by restoring the balance of natural substances ( )! Influenced by the rate of titration someone collapses or is n't breathing after taking drugs that cause! May decr author reply 1543-4, 14 and your doctor if you think that you or someone else have. Provide medical advice should include donepezil discontinuation and supportive care available from your pharmacist to. Toilet ) or serious effects on your prescription label and read all medication guides or instruction sheets from heat moisture! Days in row, talk with your doctor alerts and updates does not endorse any of the,. The usefulness of donepezil hydrochloride site from a restricted area basis of their respective owners is unknown if drug. Prescribed together, your doctor doctor tells you to do so safety and effectiveness in Pediatric patients have not geriatric-specific! Function, while others may have unchanged or even worsening mental function, while others may in this study there...
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