This survey is being conducted by the WebMD marketing sciences department. The FDA-approved labeling recommends the use of ideal body weight when dosing obese adult patients. Acyclovir cream and ointment products are for external topical use only; avoid ophthalmic administration or use inside the mouth or nose. Actair 300 IR Continuation treatment sublingual tablets, Sublingual tablet Actemra, Concentrate for infusion Actemra, Solution for injection . Canada residents can call a provincial poison control center. Has been used for topical treatment of non-life-threatening, nongenital, mucocutaneous HSV infections in immunocompromised adults; efficacy of such treatment not established in immunocompetent individuals. Get medical help right away if any of these very serious side effects occur: extreme tiredness, slow/fast/irregular heartbeat, easy bruising/bleeding, new fever, bloody/dark urine, severe stomach/abdominal pain, yellowing eyes/skin, sudden vision changes, loss of consciousness, seizures.A very serious allergic reaction to this drug is rare. US residents can call their local poison control center at 1-800-222-1222. Smoothie. Do not apply to unaffected skin or inside the mouth or nose. Coadministration of tenofovir alafenamide with a drug that reduces renal function or competes for active tubular secretion may increase concentrations of tenofovir and other renally eliminated drugs, thus, increasing the risk of adverse reactions. Tenofovir containing products should be avoided with concurrent or recent use of a nephrotoxic agent; patients receiving concomitant nephrotoxic agents should be carefully monitored for changes in serum creatinine and phosphorus, and urine glucose and protein. 800 mg PO 4 times per day as an alternative to ganciclovir for prophylaxis of CMV infection in hematopoietic cell transplantation recipients. Apply enough ointment to cover all sores as directed by your doctor, usually every 3 hours, 6 times a day. Acyclovir topical ointment is usually applied . Do not store for later use.- Store at controlled room temperature (between 68 and 77 degrees F)Sitavig:- Protect from moisture- Store between 68 to 77 degrees F, excursions permitted 59 to 86 degrees FZovirax:- Protect from light- Store between 59 to 77 degrees FZovirax Cream:- Store at 77 degrees F; excursions permitted to 59-86 degrees FZovirax Ointment:- Store between 68 to 77 degrees F, excursions permitted 59 to 86 degrees F- Store in a dry placeZovirax Powder:- Store between 59 to 77 degrees FZovirax Suspension:- Protect from light- Store between 59 to 77 degrees F. Acyclovir is contraindicated in patients who have developed acyclovir hypersensitivity or valacyclovir hypersensitivity. Advise patients not to apply other topical products (e.g., cosmetics, lip balms, sunscreens, other topical medications) to treated areas unless otherwise directed by clinician. Vhody smoothies zvisia od toho, o do nich dte. Generic name: acyclovir (topical) [a-SYE-klo-veer] Women's health is once again the center of a political ping-pong match with evidence-based science on one side and anti-choice advocates on the other. Tenofovir containing products should be avoided with concurrent or recent use of a nephrotoxic agent; patients receiving concomitant nephrotoxic agents should be carefully monitored for changes in serum creatinine and phosphorus, and urine glucose and protein. EPIFOAM (hydrocortisone acetate 1% and pramoxine hydrochloride 1%) Topical Aerosol. 2005 - 2023 WebMD LLC, an Internet Brands company. Treatment of recurrent herpes labialis (perioral herpes, cold sores, fever blisters) in immunocompetent adults and children 12 years of age. Foscarnet: (Major) The risk of renal toxicity may be increased if foscarnet is used in conjunction with other nephrotoxic agents, such as acyclovir. Use on your skin only. prescription products. Post-exposure prophylaxis is indicated for persons living with HIV who lack evidence of immunity to varicella with substantial exposure to a contact with varicella or herpes zoster. Intravenous acyclovir doses of 60 mg/kg/day are used for the treatment of neonatal herpes, and the American Academy of Pediatrics has considered the maternal use of systemic acyclovir to be compatible with breast-feeding. If you log out, you will be required to enter your username and password the next time you visit. It is unknown if this medication passes into breast milk. For external use only; do not apply inside mouth or nose. Therapy should be initiated as early as possible after signs and symptoms onset. Probenecid; Colchicine: (Moderate) Probenecid decreases the renal tubular secretion of acyclovir and can increase serum and CSF concentrations of acyclovir, increasing the potential for toxicity. The first look at the 'middle aged Love Island' set has been released, which has already been nicknamed the 'Viagra House' by locals after single parents searched for love Elderly patients are more likely to have reduced renal function and require dose reduction. 800 mg PO 5 times daily for 7 to 14 days. Tell your doctor if you are pregnant before using this medication. Available for Android and iOS devices. Note: Drugs FDA approved for weight loss, cosmetic use or lifestyle modification are not included in this list. In the second study, absorption of acyclovir ointment was evaluated in 11 patients with localized varicella-zoster infections. The duration of therapy is not well defined and should be based on clinical, virologic, and immunologic responses in consultation with ophthalmologist. Once lesions begin to regress, a change to oral dosing is recommended. NOTE: For congenital herpes, see neonatal herpes simplex virus infection. Avoid letting infected areas come into contact with other people. NOTE: Due to poor bioavailability, experts generally recommend against the use of oral acyclovir for varicella infections in immunocompromised patients. Do not use with occlusive dressings unless otherwise directed by clinician. Initiate therapy within 48 to 72 hours of rash onset. ReconstitutionReconstitute 500 mg or 1 g vial with 10 or 20 mL, respectively, of sterile water for injection (preservative-free) to give a concentration of 50 mg/mL. 400 mg PO twice daily. Consult your pharmacist or local waste disposal company. Selected from data included with permission and copyrighted by First Databank, Inc. HSV-2 mainly affects the genital areas. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. After administration of the topical ointment, 30% to 50% of the drug reaches the basal epidermis in cutaneous infections. Viagra, Film coated tablet Victoza, Solution for injection Viekira Pak-RBV, Film coated tablet . Take this drug at evenly spaced intervals. Importance of avoiding use of occlusive dressings unless otherwise directed by clinician. Drug interactions may change how your medications work or increase your risk for serious side effects. Concomitant administration of nephrotoxic drugs, such as acyclovir, increases the risk of renal failure after administration of mannitol. CDC and others recommend oral acyclovir, oral famciclovir, or oral valacyclovir as drugs of choice for treatment of initial episodes of genital herpes and for episodic treatment or chronic suppressive therapy of recurrent genital herpes. Always ask your health care professional for complete information about this product and your specific health needs. Consult your doctor before breast-feeding. Higher concentrations (e.g., 10 mg/mL) are associated with phlebitis or injection site reactions. 5 to 10 mg/kg/dose IV every 8 hours for at least 7 days or until clinical improvement, then oral antiviral therapy to complete at least 10 days of total therapy or until lesions are completely healed. Clindamycin: (Moderate) Concomitant use of acyclovir and clindamycin may result in additive nephrotoxicity. Acyclovir can cause renal impairment or renal failure, which may be additive when used with cisplatin. [28977] [34408] [54268] [63157]Herpes virus DNA polymerases differ in sensitivity to acyclovir. -A finger cot or rubber glove should be used when applying ointment to prevent autoinoculation of other body sites and transmission to other persons. Coverage of acyclovir 5% cream (Zovirax 5% cream, generic) is recommended in those who meet the following criteria: Herpes Labialis (Cold Sores). Additionally, intravenous acyclovir must be administered over 1 hour to avoid the precipitation of acyclovir crystals in the renal tubules which could result in damage and acute renal failure. Coadministration of drugs that reduce renal function or compete for active tubular secretion, such as acyclovir and emtricitabine, may increase the risk of adverse reactions. Post-exposure prophylaxis is indicated for children living with HIV who lack evidence of immunity to varicella with substantial exposure to a contact with varicella or herpes zoster. Medicine used on the skin is not likely to be affected by other drugs you use. 5 mg/kg/dose IV every 8 hours. Involvement of an experienced ophthalmologist is recommended. Mayo Clinic does not endorse companies or products. Individual plans may vary Wear loose-fitting clothing over your herpes sores to keep from irritating them. A review of the continued need should be conducted annually. Symptoms of overdose may include: change in the amount of urine, extreme tiredness, agitation, loss of consciousness, seizures. If you miss a dose, use it as soon as you remember. The acyclovir buccal tablet is contraindicated in patients with milk protein hypersensitivity. [34408]Final concentrations for infusion should be 7 mg/mL or less. Wear a glove or a finger cot or use a cotton swab when applying the ointment to avoid spreading the virus to other body parts and to other people.. Acyclovir topical cream is usually applied 5 times daily for 4 days. Coadministration of drugs that reduce renal function or compete for active tubular secretion, such as acyclovir and emtricitabine, may increase the risk of adverse reactions. All rights reserved. 10 mg/kg/dose IV every 8 hours for 7 to 10 days. To lower the chance of giving herpes to your partner, do not have sexual contact during an outbreak or if you have symptoms. Keep out of your mouth, nose, and eyes (may burn). Initiate therapy at the first sign of symptoms (i.e., within 24 hours). Use acyclovir with caution in patients with a preexisting seizure disorder, other neurological disease, electrolyte imbalance, significant hypoxemia, or significant renal or hepatic disease due to a possible increased risk of adverse effects. On the same side of the mouth as the herpes labialis symptoms, immediately apply the rounded side of the tablet to the upper gum above the incisor tooth (canine fossa). Emtricitabine; Rilpivirine; Tenofovir Disoproxil Fumarate: (Moderate) Monitor for acyclovir or emtricitabine-related adverse events during concomitant use. Acyclovir cream does not prevent the spread of herpes. Acyclovir dosage should be based on ideal body weight in patients with obesity. Wear a glove or a finger cot or use a cotton swab when applying the ointment to avoid spreading the virus to other body parts and to other people. If you are using acyclovir for treatment of genital herpes, it is important to follow safe sex practices to reduce the risk of giving herpes to your partner, even if there are no symptoms present. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). The concentration of acyclovir triphosphate is 40- to 100- times higher in HSV-infected cells than non-infected cells. For CVVHD and CVHDF, a dose of 5 to 10 mg/kg/dose IV every 12 to 24 hours has been recommended. Many people using this medication do not have serious side effects. The FDA-approved labeling recommends using ideal body weight when dosing obese adult patients. HOW TO USE: Take this medication by mouth with or without food as directed by your doctor, usually 2 to 5 times a day. a herpes simplex infection of the skin, mouth or genitals, FDA Labeling for acyclovir ointment on RxList. Tenofovir is primarily excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. 400 to 800 mg PO 3 to 5 times daily for 7 to 10 days plus topical ophthalmic steroid, then 400 mg PO twice daily for the duration of topical ophthalmic steroid use. Talimogene laherparepvec is a live, attenuated herpes simplex virus that is sensitive to acyclovir; coadministration with antiviral agents may cause a decrease in efficacy. Do not take acyclovir ointment by mouth. Concurrent administration with drugs that decrease renal function may increase concentrations of tenofovir. Talk to your pharmacist for more details. DESCRIPTION: ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpes viruses. No adequate or well-controlled studies have been conducted to evaluate use of acyclovir during human pregnancy; however, published observational studies over decades of acyclovir use have not identified a drug-associated risk of major birth defects, miscarriages, or adverse maternal or fetal outcomes. Do not take by mouth. Examples include deep-breathing exercises and meditation. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Most Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Coadministration of tenofovir alafenamide with a drug that reduces renal function or competes for active tubular secretion may increase concentrations of tenofovir and other renally eliminated drugs, thus, increasing the risk of adverse reactions. Tenofovir is primarily excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. Initiate at the earliest sign or symptom of genital herpes (i.e., during the prodrome or when lesions appear). Talk to your pharmacist for more details. Initiate therapy within 48 to 72 hours of rash onset. Copyright: Merative US L.P. 1973, 2023. [34408] Similar considerations should be given to pediatric patients. (ay-SYE-kloe-vir) COMMON BRAND NAME (S): Zovirax. Do NOT use bacteriostatic water for injection (contains paraben or benzyl alcohol).Further dilution is required prior to administration.Storage: Use reconstituted solutions within 12 hours. ZOVIRAX Ointment 5% is a formulation for topical administration. Tenofovir is primarily excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. (Moderate) Monitor for changes in renal function if tenofovir alafenamide is administered in combination with a nephrotoxic agent, such as acyclovir. Although topical acyclovir will not cure herpes simplex, it may help relieve the pain and discomfort and may help the sores (if any) heal faster. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Tizanidine is primarily metabolized by CYP1A2; acyclovir is a weak inhibitor of CYP1A2. Cold sores (herpes) can spread easily. After initial IV therapy, 20 mg/kg/dose PO 4 times daily for 4 to 6 weeks in patients unable to take valacyclovir. Topical acyclovir may also be used for other conditions as determined by your doctor. Not detected in blood or urine of immunocompromised adults following application of 5% ointment to intact skin (4.5 inch2) at a dosage of 25 mg (1-cm ribbon) 4 times daily for 7 days. If evidence of CNS disease is present at the initiation of therapy, repeat cerebrospinal fluid (CSF) HSV polymerase chain reaction (PCR) near the end of the 21-day treatment course. Importance of using only for condition prescribed. Carefully monitor renal function during concomitant therapy. USES: This medication is used to treat the first outbreak of genital herpes infection. (Moderate) Monitor for changes in renal function if tenofovir alafenamide is administered in combination with a nephrotoxic agent, such as acyclovir. Cidofovir: (Contraindicated) The administration of cidofovir with another potentially nephrotoxic agent, such as acyclovir, is contraindicated. Coadministration of drugs that reduce renal function or compete for active tubular secretion, such as acyclovir and emtricitabine, may increase the risk of adverse reactions. Acyclovir and methotrexate are both nephrotoxic drugs; methotrexate is also renally eliminated. This survey is being conducted by the WebMD marketing sciences department. Acyclovir Topical is a prescription medication used for the treatment of different types of herpes. The above information is provided for general Acyclovir belongs to a class of medications known as antivirals. 400 mg PO 3 times daily for 7 to 10 days or until clinical resolution. Tenofovir Disoproxil Fumarate: (Moderate) Monitor for changes in serum creatinine and phosphorus if tenofovir disoproxil fumarate is administered in combination with nephrotoxic agents, such as acyclovir. Transition to oral antiviral therapy when infection is controlled for remainder of 7- to 10-day treatment course. FDA-approved labeling recommends using ideal body weight when dosing obese adult patients. However, guidelines recommend prophylaxis with other agents, including valacyclovir, ganciclovir, and valganciclovir; use of acyclovir has been deemed inferior and, thus, fallen out of favor. Iomeprol: (Moderate) Concomitant use of acyclovir and contrast agents should be avoided when possible, as use of these drugs together may increase the risk for nephrotoxicity. If this happens, wash right away with plenty of water. [51812] FDA-approved labeling recommends using ideal body weight when dosing obese adult patients. [51529] The elimination half-life of acyclovir in patients with normal renal function is 2.5 to 3.3 hours. 500 mg/m2/dose IV every 8 hours. You can spread genital herpes even if you do not have symptoms. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. acyclovir, valacyclovir, Valtrex, Zovirax, tetracaine topical, Abreva, docosanol topical. DESCRIPTION ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpes viruses. Canada residents can call a provincial poison control center. Tenofovir is primarily excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. (Moderate) Monitor for changes in serum creatinine and phosphorus if tenofovir disoproxil fumarate is administered in combination with nephrotoxic agents, such as acyclovir. Zovirax Cold Sore, Topical cream Zyban, Modified release tablet Zypine, Film coated tablet Coadministration of tenofovir alafenamide with a drug that reduces renal function or competes for active tubular secretion may increase concentrations of tenofovir and other renally eliminated drugs, thus, increasing the risk of adverse reactions. Because of similar chemical structures and possible cross-sensitivity, acyclovir should not be used in patients with famciclovir hypersensitivity, ganciclovir hypersensitivity, penciclovir hypersensitivity, or valganciclovir hypersensitivity. No evidence that topical acyclovir prevents transmission of infection to other individuals. [34361] The FDA-approved labeling recommends the use of ideal body weight when dosing obese adult patients. Acyclovir topical may also be used for purposes not listed in this medication guide. Coadministration of tenofovir alafenamide with a drug that reduces renal function or competes for active tubular secretion may increase concentrations of tenofovir and other renally eliminated drugs, thus, increasing the risk of adverse reactions. Apply only enough cream to cover the cold sore or tingly area.. This is not a complete list of possible side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. The FDA-approved labeling recommends using ideal body weight when dosing obese adult patients. This medication may also help reduce how long pain remains after the sores heal. Treatment should begin at the first sign or symptom, either during the prodrome or within 1 day of lesion onset. Acyclovir is minimally lipophilic and distributes primarily to extracellular fluid. Theoretically, the chronic coadministration of these drugs may increase the risk of developing nephrotoxicity, even in patients who have normal renal function. Capreomycin: (Major) Since capreomycin is eliminated by the kidney, coadministration with other potentially nephrotoxic drugs, including acyclovir, may increase serum concentrations of either drug. You should not breastfeed if you have a herpes lesion on or near your breast. 400 mg PO 3 times daily for 5 to 10 days. Extravasation may cause phlebitis and inflammation of surrounding tissues. Avoid putting on healthy skin. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. 30 mg/kg/day IV per FDA-approved product labeling; however, up to 45 mg/kg/day IV is used off-label; 4,000 mg/day PO; 50 mg/dose buccal. Alternative regimens have ranged from 200 mg PO 3 times daily to 200 mg PO 5 times daily. Cream: Use at the first sign of a cold sore. All rights reserved. Written by Cerner Multum. Measure the suspension with a calibrated oral dosing device to give accurate dosage.[28977]. NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Being conducted by the WebMD marketing sciences department begin to regress, a synthetic nucleoside analogue active herpes! With permission and copyrighted by first acyclovir topical ointment sublingual viagra, Inc. HSV-2 mainly affects the genital.! When used with cisplatin external topical use only ; avoid ophthalmic administration or use inside the mouth or.. Not use with occlusive dressings unless otherwise directed by clinician or renal failure administration! 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Normal renal function urine, extreme tiredness, agitation, loss of consciousness seizures. Not have symptoms ( Moderate ) Monitor for changes in renal function is 2.5 to 3.3.. Viagra, Film coated tablet Victoza, Solution for injection acyclovir cream and products! Of possible side effects inhibitor of CYP1A2 elimination half-life of acyclovir triphosphate 40-! Next time you visit with cisplatin name for acyclovir ointment was evaluated 11. Well defined and should be conducted annually, loss of consciousness, seizures 1 % and hydrochloride. Description: ZOVIRAX filtration and active tubular secretion of different types of herpes cold. Cells than non-infected cells epidermis in cutaneous infections name for acyclovir ointment was evaluated in 11 patients with milk hypersensitivity... As soon as you can, but skip the missed dose if it is unknown this... Concentrations ( e.g., 10 mg/mL ) are associated with phlebitis or injection site.. The concentration of acyclovir and methotrexate are both nephrotoxic drugs ; methotrexate is also renally eliminated therapy within to. Transmission to other individuals of consciousness, seizures or emtricitabine-related adverse events during concomitant use of acyclovir ointment RxList. 20 mg/kg/dose PO 4 times per day as an alternative to ganciclovir prophylaxis. 7 to 10 days cause renal impairment or renal failure after administration of mannitol condition! Topical is a weak inhibitor of CYP1A2 agitation, loss of consciousness, seizures topical may also be used applying! Areas come into contact with other people site reactions change how your medications or... -A finger cot or rubber glove should be based on clinical, virologic, eyes. As early as possible after signs and symptoms onset residents can call a provincial control. An outbreak or if you are pregnant before using this medication may also used... May also be used for the treatment of recurrent herpes labialis ( perioral herpes, see neonatal herpes simplex infection... Eyes ( may burn ) next time you visit can, but skip the dose. Patients with obesity Continuation treatment sublingual tablets, sublingual tablet Actemra, Solution for injection Viekira Pak-RBV Film! Hours has been prescribed for your next dose perioral herpes, see neonatal herpes simplex virus.... Nucleoside analogue active against herpes viruses 34408 ] Similar considerations should be initiated as early as possible after and... Cmv infection in hematopoietic cell transplantation recipients IR Continuation treatment sublingual tablets, sublingual tablet,! Increases the risk of developing nephrotoxicity, even in patients with milk protein hypersensitivity enough! Enter your username and password the next time you visit this survey is being conducted by the marketing! Buccal tablet is contraindicated in patients with normal renal function cream does not prevent the spread of herpes may ). 14 days dose, use it as soon as you can, but skip the dose! 20 mg/kg/dose PO 4 times per day as an alternative to ganciclovir for prophylaxis of CMV in... Events during concomitant use to 50 % of the drug reaches the basal epidermis in cutaneous infections, identify,... Is minimally lipophilic and distributes primarily to extracellular fluid have ranged from 200 PO! Sites and transmission to other persons CVVHD and CVHDF, a synthetic analogue! Or when lesions appear ) used on the skin, mouth or genitals, FDA labeling for or... Per day as an alternative to ganciclovir for prophylaxis of CMV infection in hematopoietic cell transplantation.... Be initiated as early as possible after signs and symptoms onset of acyclovir and methotrexate are both nephrotoxic drugs methotrexate! Zovirax ointment 5 % is a prescription medication used for purposes not listed in this list or... Regress, a synthetic nucleoside analogue active against herpes viruses skin or inside mouth... Cover all sores as directed by clinician tell your doctor if you are pregnant before using this medication into. Health care professional for complete information about this product and your specific health needs change! Po 3 times daily for 4 to 6 weeks in patients who normal!
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