A consultation with a primary care physician was pursued followed by a COVID-19 reverse transcriptase-polymerase chain reaction (RT-PCR) test via nasopharyngeal swab performed on the patient. Balmforth found that SARS-CoV-2 infection confirmed by serology was 71% lower with xylitol compared to placebo [36 cases (13.1%) Vs 97 cases (34.5%); p < 0.0001]. This . Repeat testing of COVID-19 RT-PCR was also done on day 8 which also showed non-reactive results (Appendices). protection can significantly reduce the risks of infection and may The only . Being a novel virus, several treatments have been explored against COVID-19. An official website of the United States government. A follow-up was done on day 14 and the patient reported no symptoms with a return to baseline health. Xylitol also has cleansing benefits; it almost acts like soap for your nose. On day 4, the patient's CRP and d-dimerwere tested and were unremarkable(Appendices). See product label for more information. A commercially available nasal 38 spray (Xlear) combining xylitol and GSE has been available for years, but the antiviral effects of 39 this solution have not been documented. The tooth would also receive calcium and minerals, as xylitol is a carrier for calcium. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. Xlear Sinus Care Nasal Spray 1.5 FL Oz (pack of 4) BRAND. Xlear Nasal Spray is a combination of xylitol and saline spray that has shown to be effective in soothing and moisturizing the sinuses and nasal passages. The testing, conducted in separate studies at Utah State University and the University of Geneva in Switzerland found the grapefruit seed extract used in Xlear Nasal Spray has potent virucidal activity against the virus. Releasing a small dose of nitric oxide, a natural nanomolecule with We have been working with Xlear for a number of months now and are impressed with the antiviral and virucidal data generated at world-class research institutions against SARS-CoV-2, Farrar said. antiviral (it blocks the adhesion of the virus to the nasal membrane, which is how most people get sick from COVID-19); antibacterial against streptococcus bacteria, which is the leading cause of bacterial pneumonia (a COVID-19 complication linked to morbidity); and. (27) $13.89 New. BPA-free. and for the following two weeks according to instructions, and just The patient demonstrated stable vital signs and oxygenation and reported that he has regained his sense of smell and his sense of taste. Health related and label information change frequently, and while every attempt has been made to ensure that the content on this site is accurate, product infomation changes are subject to change without notice. The patient was instructed to use the Xlear nasal spray four times a day every six hours for seven days, which was an adjuvant to his self-medication. Please Note: Professional Supplement Center assumes no risk or liability for your use or misuse of information contained on this website. iota-carrageenan may potentially lower the risk of getting Terry Graedon, PhD, is a medical anthropologist and co-host of The Peoples Pharmacy radio show, co-author of The Peoples Pharmacy syndicated newspaper columns and numerous books, and co-founder of The Peoples Pharmacy website. Jia HP, Look DC, Shi L, et al. The average time to negativization was found to be approximately an average of 14 days[18]. Erectile dysfunction (ED) is often a symptom . Using xylitol can suppress the acid and suppress the germs. The patient also reported taking self-medication for two days with warm water and tea, which did not help alleviate the symptoms. The .gov means its official. Xlear pronounced "clear" Sinus Care saline nasal spray is a non-addictive, all-natural saline solution that reduces congestion and promotes upper respiratory health by cleansing and moisturizing the nasal passages. On day 2, the patient was noted to have tiredness and productive cough, with awakenings at night time due to coughing episodes. Normal saline nasal sprays can dry out the nasal passage, actually leaving it more irritated and susceptible to external contaminants. Copyright 2023. Reach the BBB at 800-222-8754. Remove the safety clip on the bottle. Professor Yaakov Naparstek, the scientific director of the Meuhedet The patient had a past medical history of leukemia, which was diagnosed in 2012. Another study is looking to analyze iota-carrageenans ability to When the air gets dry in the winter, my husband uses a neti pot to rinse his nasal passages. (See graph on side panel). Product Code: nasal-spray-xylitol-XLR-1_5-oz. Natural saline spray helps relieve congestion, Added xylitol cleanses and moisturizes inside of nose and nasal passages to prevent dryness, Cleanses to prevent bacteria and other pollutants from sticking to nasal tissues, Pump spray bottle allows for easy application. It may take you a few tries to get used to the process, but its well worth the effort!. A high-fat meal might keep it from absorbing as quickly. This formula uses Xylitol to help moisten and refresh nasal passages while promoting pH and bacterial balance with sea salt and sodium bicarbonate. https://www.researchgate.net/publication/347176706_A_Nasal_Spray_Solution_of_Grapefruit_Se.. https://www.precisionvaccinations.com/nasal-spray-may-eliminate-sars-cov-2-virus, Nebulised Hydroxychloroquine for COVID-19, Fenbendazole Joe Tippens Protocol: A Simple Step-by-Step Guide (2023), Find a Doctor who will prescribe Early Outpatient Treatments for COVID-19 (USA), 12 Natural Alternatives to Oral Ivermectin (2023) - Evidence based Review, 10 Natural Alternatives to Ozempic (Semaglutide) 2023, 12 Uses of PRP (Platelet-Rich Plasma) in various Gynaecological Problems, 10 Most Studied Treatments for COVID 19 (updated January 2021), Hydroxychloroquine vs Ivermectin vs Quercetin: What's the Difference? This nasal spray is not habit-forming. Reduces both the duration and severity of illness when used to treat COVID-19 patients. Cureus. A 38-year-old Hispanic male tested positive for COVID-19 on September 26, 2020. If the item details above arent accurate or complete, we want to know about it. The use of this container by more than one person may spread infection. Interim Order. These results join earlier results from the University of Tennessee whose data showed xylitol to have antiviral properties. articles published within Cureus should not be deemed a suitable substitute for the advice of a qualified health care professional . The product is authorized as a medical device targeting COVID-19 in India, Preprints were available in November 2020 Over 90% of all infection-causing bacteria enter through the nose. Currently, the management and therapeutic options for COVID-19 are limited, including self-quarantine and supportive care, usually indicated for mild cases. The patient also noted that he was now able to start smelling strong substances. I use neti salt, now, but began with table salt. Accordingly, taking into consideration the current COVID-19 pandemic situation and the antimicrobial and virucidal effects of xylitol and GSE, we hereby present a case series of three COVID-19 positive patients who were prescribed the commercially available Xlearnasal spray, which contains xylitol and GSE, for a duration of seven days. Gustavo Ferrer- research grants from Xlear and work on research and development with Xlear. Properties of GSE were evaluated in vitro with several viruses such as the avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bursal disease virus (IBDV) and it showed activity against enveloped viruses such as the AIV and NVD but resistance with non-enveloped viruses namely IBDV[6]. Other IngredientsPurified Water, Xylitol, Saline, and Grapefruit Seed Extract as a preservative . Biocidin Botanicals (formerly Bio-Botanical Research), Dynamic Nutritional Associates (DNA Labs), Ten times more Xylitol than any other nasal spray, Soothes and moisturizes dry, irritated nasal passages due to low humidity, pollutants, overuse of nasal decongestants and other nasal irritations, Helps wash away pollutants, pollens, irritants and other airborne contaminants, Refreshes and hydrates to alleviate dry air, No side effects, non-habit forming, safe for all ages, The metered nasal pump sprayer provides a precise amount of soothing spray in a fine mist, Purified Water, Xylitol, USP Sodium Chloride, Grapefruit Seed Extract. Please Note: Professional Supplement Center assumes no risk or liability for your use or misuse of information contained on this website. So far, one study of about 400 healthcare workers suggested that Lastly, the time to negativization is important to note. The patient also noted increasing tiredness. please contact your licensed healthcare professional for advice or answers. Ahead of the approaching holiday, characterized by mass gatherings at On day 1, the patient complained of a runny and stuffy nose, tiredness, productive cough, nasal congestion, diarrhea, with oxygen saturation at 94%, and afebrile. Studies on Effects of Nasal Hygiene on COVID-19, Ear, Nose & Throat journal in August 2022, https://www.carragelose.com/en/portfolio/launched-products, https://www.carragelose.com/en/publications, https://www.dovepress.com/efficacy-of-a-nasal-spray-containing-iota-carrageenan-in-the-postexpos-peer-reviewed-fulltext-article-IJGM, https://www.marinomed.com/en/news/marinomed-biotech-ag-shares-positive-clinical-trial-results-for-iota-carrageenan-nasal-spray-in-the-prevention-of-covid-19-1, FDA approved its use in treating a rare blood clotting disorder in (2023 Edition), Quercetin and Zinc: Dr Zelenko Prevention and Treatment Protocol (2023). The results of the aforementioned preliminary studies seem to point towardthe conclusion that thecomponents exerta significant virucidal effect. The SARS-CoV-2 virus has created an unprecedented impact on healthcare globally. Biocidin Botanicals (formerly Bio-Botanical Research), Dynamic Nutritional Associates (DNA Labs). This is not to "push" a product but so that patient's are introduced to a purely xylitol product that will offer therapeutic benefits. Justice in Ongoing Lawsuit; More Clinical Data Than FDA Clear nozzle after each use and replace the cap. The site is secure. Xylitol is the ingredient that sets Xlear products apart from all of the other products. Preliminary studiesconducted by our group at two different laboratories have tested the individual components xylitol and GSE of commercially available intranasal spray (Xlear Nasal Spray; Xlear, Inc., American Fork, USA). Xylitol nasal sprays help alleviate sinusitis, dryness, rhinitis, sinus pressure, symptoms from flu and cold, and nasal congestion in a natural way. thyroid disease . is expected to wrap up by. A total of 83 worshipers used the spray before Rosh Hashanah prayers Made with all natural ingredients Salome and xylitol. Is there any evidence to support claims about a treatment or cure? The patient was then prescribed withXlear nasal spray and was instructed to spray twice per nostril four times a day every six hours for seven days, as an adjuvant to his ongoing previously mentioned treatment. In short, a xylitol nasal spray makes it difficult for the viral attachment mechanisms to work (figure 2). The present cases highlight the potential efficacy of intranasal xylitol and GSE, as a therapeutic aid for the management and treatment of COVID-19. They are committed to providing consumers with the health benefits of xylitol, erythritol, and other natural sweeteners by manufacturing natural, health-enhancing xylitol products based on these incredible sweeteners found in wood, fruits, vegetables, and other natural sources. The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. The patient had a past surgical history of arthroscopy 20 years ago and was currently taking n-acetyl glucosamine, vitamin C, and vitamin D daily. If allergies are troublesome, you could do worse than to try Xlear nose spray or a sinus rinse. A person who uses a medicine like cetirizine for a long period of time may experience itching if he or she stops taking the drug suddenly, however. The. This was recommended by my ent. 1 In their systematic review, Gengler et al. co-authored the study said that the fact that Taffix was able to Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. The Xlear Nasal Spray line contains xylitol, purified water, salt, and grapefruit seed extract as a preservative. On day 7, the patient reported symptoms of tiredness, ageusia, and anosmia with a 70-80% improvement of the ability to smell. Hurrah for the neti pot.. 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