Expert panel recommendations. Linezolid may increase serotonin as a result of MAO-A inhibition. Microbiota oral contains bacterial spores. Either increases toxicity of the other by serotonin levels. Minor/Significance Unknown. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Contraindicated. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. If urgent opioid treatment needed, use test doses and frequent titration of small doses to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression. swelling of the face, ankles, or hands. The administration of a lower dose suggested by the algorithm was predicted to rapidly allow for the achievement of a linezolid trough concentration that was safe and effective (Fig. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. Mechanism: pharmacodynamic synergism. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation, Practical therapeutic drug management in HIV-infected patients: use of population pharmacokinetic models supplemented by individualized Bayesian dose optimization. Serious - Use Alternative (2)sumatriptan intranasal and linezolid both increase serotonin levels. Monitor Closely (1)linezolid, oliceridine. Serious - Use Alternative (1)linezolid increases toxicity of hydromorphone by unknown mechanism. linezolid increases effects of dopamine by pharmacodynamic synergism. (Score: 9.25) Reason linezolid increases toxicity of levorphanol by unknown mechanism. Avoid or Use Alternate Drug. However, it has to be considered that a much lower cutoff point (a trough concentration of linezolid of 0.19mg/liter) has been associated with a 50% maximal mitochondrial toxicity in an in vitro hollow-fiber infection model system (33). Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Avoid use and monitor patients receiving the combination for effects of excessive myelosuppression. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. linezolid increases levels of desflurane by pharmacodynamic synergism. The performance of the model was first tested by visually comparing the observed versus last predicted concentrations of each individual patient. Avoid or Use Alternate Drug. Applies only to oral forms of hormone. Deutetrabenazine should not be used in combination with an MAOI, or within 14 days of discontinuing therapy with an MAOI. unspecified interaction mechanism. Linezolid may increase serotonin as a result of MAO-A inhibition. Monitor Closely (1)linezolid will decrease the level or effect of bazedoxifene/conjugated estrogens by altering intestinal flora. Mechanism: pharmacodynamic synergism. Regimen planning should be performed by an experienced clinician with due consideration for factors with spurious results (e.g., suboptimal compliance and medication errors). Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Tyramine containing foods include cheese, red wine, caviar, herring, canned figs, fermented meats, fava beans, yeast extracts, miso, avocado. metoclopramide intranasal increases toxicity of linezolid by Other (see comment). Contraindicated. linezolid increases effects of diethylpropion by pharmacodynamic synergism. Monitor Closely (1)linezolid increases effects of insulin detemir by unknown mechanism. linezolid increases effects of pseudoephedrine by pharmacodynamic synergism. Serious - Use Alternative (1)linezolid and escitalopram both increase serotonin levels. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Avoid or Use Alternate Drug. Contraindicated (1)linezolid increases effects of phendimetrazine by pharmacodynamic synergism. Serious - Use Alternative (1)linezolid and St John's Wort both increase serotonin levels. This limitation provides the principal justification for considering dosage individualization to achieve drug exposures of linezolid that are safe and effective. Applies only to oral forms of hormone. Contraindicated. Linezolid may increase serotonin as a result of MAO-A inhibition. Morata L, De la Calle C, Gmez-Cerquera JM, Manzanedo L, Casals G, Brunet M, Cobos-Trigueros N, Martnez JA, Mensa J, Soriano A. Use Caution/Monitor. linezolid increases effects of fenfluramine by pharmacodynamic synergism. Contraindicated (1)linezolid increases effects of methylenedioxymethamphetamine by pharmacodynamic synergism. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Low risk of contraceptive failure. Risk of acute hypertensive episode. Serious - Use Alternative (1)linezolid and protriptyline both increase serotonin levels. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. linezolid increases levels of naratriptan by decreasing metabolism. Minor/Significance Unknown. Risk of acute hypertensive episode. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. linezolid increases effects of phenylephrine ophthalmic by pharmacodynamic synergism. Risk of acute hypertensive episode. National Library of Medicine The final model was also evaluated graphically and statistically by visual predictive checks (VPCs) and normalized prediction distribution errors (NPDE) (see Fig. Use Caution/Monitor. Linezolid may increase serotonin as a result of MAO-A inhibition. Linezolid may increase serotonin as a result of MAO-A inhibition. Use Caution/Monitor. linezolid and isoniazid both increase serotonin levels. The combined individual patient observed-versus-predicted concentrations of linezolid from all 10 patients are shown in Fig. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Comment: Myelosuppressive agents can produce additive myelosuppression. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)linezolid, perphenazine. of metrizamide. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. linezolid increases effects of dextroamphetamine transdermal by decreasing metabolism. As a library, NLM provides access to scientific literature. Avoid or Use Alternate Drug. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Contraindicated. Serious - Use Alternative (1)linezolid, valbenazine. The potential utility of the controller is illustrated in Fig. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. linezolid increases toxicity of buprenorphine by unknown mechanism. Antibacterial agents may decrease efficacy if coadministered. Linezolid (lin ayz' oh lid) is a synthetic antibiotic that belongs to the oxazolidinone class. Risk factors for a low linezolid trough plasma concentration in acute infections. The dose can be reduced to 600 mg daily and further to 300 mg daily Linezolid may increase serotonin as a result of MAO-A inhibition. Clinical population pharmacokinetics and toxicodynamics of linezolid. linezolid will decrease the level or effect of conjugated estrogens by altering intestinal flora. Linezolid may increase serotonin as a result of MAO-A inhibition. linezolid increases toxicity of opium tincture by unknown mechanism. INTRODUCTION. Risk of acute hypertensive episode. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Population pharmacokinetics and pharmacodynamics of linezolid-induced thrombocytopenia in hospitalized patients. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. linezolid increases effects of dobutamine by pharmacodynamic synergism. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. Either increases toxicity of the other by serotonin levels. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). commonly, these are generic drugs. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. 2001. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Use Caution/Monitor. This drug is available at a middle level co-pay. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d. methylene blue and linezolid both increase serotonin levels. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. Applies only to oral form of both agents. Avoid use of deferiprone with other drugs known to be associated with neutropenia or agranulocytosis; if an alternative is not possible, monitor absolute neutrophil count more frequently. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Microbiota oral contains bacterial spores. Monitor Closely (1)linezolid, olanzapine. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. unspecified interaction mechanism. Serious - Use Alternative (1)deferiprone, linezolid. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Minor/Significance Unknown. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Contraindicated. Linezolid may increase serotonin as a result of MAO-A inhibition. Use Caution/Monitor. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. Please confirm that you would like to log out of Medscape. Either increases toxicity of the other by serotonin levels. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Linezolid should not be used with any of these medications. Was 21.99. Use Caution/Monitor. Linezolid may increase serotonin as a result of MAO-A inhibition. Serious - Use Alternative (1)linezolid decreases effects of microbiota oral by pharmacodynamic antagonism. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Linezolid may increase serotonin as a result of MAO-A inhibition. linezolid increases toxicity of morphine by unknown mechanism. Avoid or Use Alternate Drug. Serious - Use Alternative (1)linezolid and milnacipran both increase serotonin levels. If you miss a dose of this medicine, take it as soon as possible. Monitor Closely (1)linezolid, clozapine. Do not administer cholera vaccine to patients who have received oral or parenteral antibiotics within 14 days prior to vaccination. Avoid or Use Alternate Drug. SIDE EFFECTS: Diarrhea, headache, nausea, vomiting, or dizziness may occur. Properly discard this product when it is expired or no longer needed. Avoid or Use Alternate Drug. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d. Contraindicated (1)linezolid increases effects of caffeine by pharmacodynamic synergism. Write a review. Avoid or Use Alternate Drug. Applies only to oral forms of hormone. Contraindicated. Avoid or Use Alternate Drug. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, blood/bone marrow problems (such as low red/white blood cells and platelets), kidney problems, liver problems, certain tumor conditions (such as pheochromocytoma, carcinoid syndrome), overactive thyroid, seizures.This drug may make you dizzy. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea. 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