Antibiotics may also be used with medical drainage of boils if they have developed. At higher concentrations, it may be bactericidal. Heres how it works. Ingredients What is Levitra? Brand and Other Names: Cleocin, Cleocin Pediatric. [41], Clindamycin, either applied to skin or taken by mouth, may also be used in hidradenitis suppurativa. MedicineNet does not provide medical advice, diagnosis or treatment. Clindamycin is available as a generic drug, for both systemic (oral and intravenous) and topical use. How to use Clindamycin. It is most commonly used for skin infections, said Dr. Stephen Neabore, a primary care doctor at the Barnard Medical Center in Washington, D.C. Clindamycin can be taken by mouth as a capsule or as a liquid; by injection; topically on the skin as a cream, gel, or foam; or vaginally as a cream or suppository, said Ken Sternfeld, a New York-based pharmacist. [30] Oral suspension is not favored for administration of clindamycin to children, due to its extremely foul taste and odor. infections, such as vaginal infections. Clindamycin cannot cure acne, but it may help keep it under control. Other less serious side effects include: joint pain. As a cream, it is usually applied once a day for three or seven days. [44], Clindamycin is white or yellow. The medicine should be applied to the whole area that is infected with acne, not to individual pimples. Find everything you need to know about Levitra (Vardenafil), including what it is used for, warnings, reviews, side effects, and interactions. [5] In combination with quinine, it can be used to treat malaria. As noted above, it may be used to treat toxoplasmosis. If the area of inhibition around the clindamycin disk is circular, the test result is negative and clindamycin can be used. nausea*. See additional information. [60] Gastrointestinal upset may also occur. 1996-2023 MedicineNet, Inc. An Internet Brands company. [20][21] Topical clindamycin plus topical benzoyl peroxide is more effective than topical clindamycin alone.[20][21]. For more serious infections, these doses may have to be increased; in life-threatening situations due to either aerobes or anaerobes these doses may be increased to doses of as much as: Single intramuscular injections of more than 600 mg is not recommended. These side effects may be temporary, lasting a few days to weeks . Clindamycin is a medicine used to treat different types of bacterial infections. flushing. Levitra (vardenafil hydrochloride) is an oral medication taken to treat erectile dysfunction (ED). [50] A 2009 review found it was likely safe in breastfeeding mothers, but did find one complication (hematochezia) in a breastfed infant which might be attributable to clindamycin. [49] It is classified as L2 probably compatible with breastfeeding according to Medications and Mothers' Milk. mild low . Common brands of clindamycin for vaginal use are Clindesse, which is a one-dose cream, and Cleocin, a suppository. Clindamycin can be used for infections (eg, skin and soft-tissue infections) in communities where community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is common; whether clindamycin is useful depends on local resistance patterns. [38], Clindamycin may also be used to treat toxoplasmosis,[22][39][40] and, in combination with primaquine, is effective in treating mild to moderate Pneumocystis jirovecii pneumonia. [43][44] Common side effects found in over 10% of people in vaginal applications include fungal infection. A doctor may recommend clindamycin for certain respiratory infections, lung. Bacterial Infections 101: Types, Symptoms, and Treatments, Sarfaroj Khan, BHMS, PGD Health Operations, Do not use clindamycin in patients with hypersensitivity to clindamycin, lincomycin and any of their components, Clindamycin can cause Clostridium difficile associated, Consider possibility of clostridium difficile in all patients who present with, All antibiotics excluding those directed against C. difficile must be stopped, Serious anaphylactic reactions must be treated immediately with epinephrine, and if required, oxygen and intravenous, Clindamycin is potentially toxic to the kidney; use with caution in patients with kidney function impairment or those on other, When usedas prophylaxis for endocarditis, use only for high-risk patients, per American. [11] It is available as a generic medication. joint pain. [3] It is of the lincosamide class and works by blocking bacteria from making protein. There is no antidote for clindamycin; treatment is reduced dosage or discontinuation of the drug, and symptomatic and supportive care. [35][36], Clindamycin has been proven to decrease the risk of premature births in women diagnosed with bacterial vaginosis during early pregnancy to about a third of the risk of untreated women. [citation needed], Cl[C@@H](C)[C@@H](NC(=O)[C@H]1N(C)C[C@H](CCC)C1)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O, InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1. [70] In India, vaginal suppositories containing clindamycin in combination with clotrimazole are manufactured by Olive Health Care and sold as Clinsup-V. Gram-negative bacteria have an additional membrane outside the cell wall that gram-positivebacteria lack. It belongs to the class of medicines known as macrolide antibiotics. abdominal pain *. ; Topical antibiotics such as fusidic acid, clindamycin, or mupirocin may be needed to help with the overgrowth of bacteria. Shopping Cart Items; Item Price Quantity; Champagne Bubbles Size Candy Cube $8.95: Qty. 1996-2023 MedicineNet, Inc. An Internet Brands company. CLINDAMYCIN (KLIN da MYE sin) treats infections caused by bacteria. It cannot treat viral infections such as colds or flu. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. [51] LactMed lists potentially negative gastrointestinal effects in babies whose mothers take it while breastfeeding but did not see that as justification to stop breastfeeding. Children: The dose will be based on your child's weight. Erectile dysfunction (ED) is often a symptom . [69], Several combination acne treatments containing clindamycin are also marketed, such as single-product formulations of clindamycin with benzoyl peroxidesold as BenzaClin (Sanofi-Aventis), Duac (a gel form made by Stiefel), and Acanya, among other trade namesand, in the United States, a combination of clindamycin and tretinoin, sold as Ziana. [30][31] Clindamycin should not be used as an antimalarial by itself, although it appears to be very effective as such, because of its slow action. [2][3][4][6][7], Common side effects include nausea and vomiting, diarrhea, rashes, and pain at the site of injection. If nothing happens, go see your doctor. A form of clindamycin is often prescribed for cats or dogs who get toxoplasmosis. U.S. National Library of Medicine: Clindamycin, Best star projectors 2023: Bring the cosmos indoors. Terms of Use. $8.95. [53][54][55] Its similarity to the mechanism of action of macrolides and chloramphenicol means they should not be given simultaneously, as this causes antagonism[24] and possible cross-resistance. Women with bacterial vaginosis and yeast infections were given courses of oral clindamycin, vaginal metronidazole gel and vaginally administered probiotics. It's commonly prescribed for infections of the lungs, skin, blood, reproductive organs (in women), and internal. Clindamycin is an antibiotic which works by stopping the growth of bacteria. Uses. Systemic clindamycin is typically reserved to treat severe infections in patients who are allergic to penicillin antibiotics, because of the risk of Clostridium difficile colitis. Special price of levitra 20 mg / 10mg tablets with worldwide delivery. Beauduy CE, Winston LG. Here's why. Champagne Bears - Small Candy Cube. Those using a foam form of clindamycin should be careful not to get it near lips, eyes or nose because it contains a stinging alcohol. Why is this medication prescribed? This is because the erythromycin-inducible erm gene is prone to mutations causing the inducible activity to switch to constitutive (permanently switched on). "The cure rate was 74.6 percent after 6 months, 65.1 percent after 12 months and 55.6 percent after 24 months," according to the study. Use clindamycin with caution in patients: With a history of gastrointestinal diseases, especially colitis, Prolonged use of clindamycin can cause superinfection of nonsusceptible organisms, both fungal and bacterial, Discontinue clindamycin permanently if severe skin reactions such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome and toxic epidermal necrolysis occur, In the absence of a proven or strongly suspected bacterial infection or a prophylactic indication, clindamycin is unlikely to be beneficial and increases the risk of development of drug-resistant bacteria, Inflammation of the colon (pseudomembranous/. It will not treat colds, the flu, or infections caused by viruses. As a vaginal suppository, clindamycin is usually taken once a day for three days. This phenotype of bacteria are resistant to the macrolide-lincosamide-streptogramin B group of antibiotics, however, the resistance mechanism is only induced by the presence of 14-membered ring macrolides, such as erythromycin. You may also report side effects or health problems to theFDAat 1-800-FDA-1088. This is because of the activity of the macrolide-inducible plasmid-encoded erm gene.[28]. It's in the same class of drugs as other popular ED medications, including Viagra and Cialis.. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. [60] The topically used clindamycin phosphate is a phosphate-ester prodrug of clindamycin. In addition to the regular side effects of clindamycin, those taking it for vaginal infection may experience thick, white vaginal discharge and vaginal burning, itching, swelling or pain. eds. [12][13] In 2020, it was the 125th most commonly prescribed medication in the United States, with more than 5million prescriptions. Vardenafil is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. The rationale for this approach is a presumed synergy between vancomycin, which causes the death of the bacteria by breakdown of the cell wall, and clindamycin, which is a powerful inhibitor of toxin synthesis. [citation needed]. All rights reserved. pain when swallowing . "So if you prescribe it and it doesn't do anything, it's either the wrong diagnosis or there's a resistance. Drug information provided by: Merative, Micromedex Take this medicine exactly as directed by your doctor. [3], Clindamycin is used in cases of suspected toxic shock syndrome,[33] often in combination with a bactericidal agent such as vancomycin. It is FDA-approved for dogs and cats (not rabbits or other rodents) and is available in capsule and oral liquid form. Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. [67], Clindamycin is available as a generic medication and is relatively inexpensive. Doses should be taken at the same time every day. Stephen Hawking's most famous prediction could mean that everything in the universe is doomed to evaporate, new study says, Cancer Is a Man-Made Disease, Controversial Study Claims, Hundreds of ancient, invisible structures discovered near our galaxy's center, There may be hundreds of millions of habitable planets in the Milky Way, new study suggests, The ultimate action-packed science and technology magazine bursting with exciting information about the universe, Subscribe today and save an extra 5% with checkout code 'LOVE5', Engaging articles, amazing illustrations & exclusive interviews, Issues delivered straight to your door or device, fever, chills, and other flu-like symptoms, easy bruising or red or purple pinpoint spots under the skin, unusual bleeding (of the nose, mouth, vagina, or rectum). [3] It increases the risk of hospital-acquired Clostridium difficile colitis about fourfold and thus is only recommended when other antibiotics are not appropriate. Wait 30 minutes after shaving to apply topical clindamycin. Veterinarians sometimes prescribe clindamycin for dogs and cats. It works by slowing or stopping the growth of bacteria. According to the NIH, clindamycin, when prescribed for acne, may be taken orally or applied topically as a cream, phosphate gel, lotion, pad or foam. This medication is used to treat acne. To perform a D-test, an agar plate is inoculated with the bacteria in question and two drug-impregnated disks (one with erythromycin, one with clindamycin) are placed 1520mm apart on the plate. How to watch 'Big Beasts': Join Tom Hiddleston on a tour of the world's largest animals, Seascape photography guide: How to photograph beaches and coastlines, Pancreatitis: Causes, symptoms and treatments, Oppenheimer: Everything we know about the atomic bomb creator's epic new biopic, Chernobyl: The world's worst nuclear disaster, How to watch Wild Isles: David Attenborough's look at the wildlife of the UK, Skin: Facts about the body's largest organ and its functions. It belongs to a group of medications called antibiotics. Future US, Inc. Full 7th Floor, 130 West 42nd Street, [medical citation needed], Rarely in less than 0.1% of people clindamycin therapy has been associated with anaphylaxis, blood dyscrasias, polyarthritis, jaundice, raised liver enzyme levels, renal dysfunction, cardiac arrest, and/or hepatotoxicity. It works to treat bacterial infections when penicillin is not an option. Women who are pregnant or planning to become pregnant should consult a doctor before taking clindamycin. Local reactions with intramuscular injections such as: Drug reaction with eosinophilia and systemic symptoms (DRESS), Inflammation of multiple joints (polyarthritis), 6001200 mg/day intravenous/intramuscular (IV/IM) divided 2-4 times a day, 12002700 mg/day IV/IM divided 2-4 times a day, To maintain serum levels higher than 4mcg/mL, administer a rapid infusion at 10 mg/minute for 30 minutes followed by maintenance infusion of 0.75 mg/minute, To maintain serum levels higher than 5 mcg/mL, administer a rapid infusion at 15 mg/minute for 30 minutes followed by maintenance infusion of 1 mg/minute, To maintain serum levels higher than 6 mcg/mL, administer a rapid infusion at 20 mg/minute for 30 minutes followed by maintenance infusion of 1.25 mg/minute, Adult: 150-450 mg orally every 6-8 hours; not to exceed 1.8 g/day, OR, 1.2-2.7 g/day IV/IM divided every 6-12 hours; not to exceed 4.8 g/day, 900 mg oral/IV 1 hour prior to the procedure; may re-dose every 6 hours if necessary, 900 mg IV every 8 hours with penicillin G, 150-450 mg orally every 6 hours for at least 7 days; not to exceed 1.8 g/day, OR, 900 mg IV every 8 hours withgentamicin2 mg/kg; THEN 1.5 mg/kg every 8 hours; continue afterdischargewith doxycycline 100 mg orally every 12 hours to complete 14 days of therapy, 600 mg oral/IV/IM 30-60 minutes before procedure, Avoid IM injections in patients receiving, Dosing considerations: Recent AHA guidelines recommend only for high-risk patients undergoing invasive procedures, 600 mg IV or orally every 6 hours for at least 6 weeks, Oral: 300 mg orally every 12 hours for 7 days, 600-900 mg IV every 6-8 hours with primaquine for 21 days, 15-20 mg/kg/day IV/IM divided three or four times a day, Postmenstrual (PMA) age 32 weeks or less: 5 mg/kg IV/IM every 8 hours, Postmenstrual age 32 to 40 weeks: 7 mg/kg IV/IM every 8 hours, 20-40 mg/kg/day IV/IM divided three or four times a day, Dose based on total body weight body regardless of, Alternatively, it may be administered on the basis of square meters body surface: 350 mg/m2/day for serious infections or 450 mg/m2/day for severe infections, May change parenteral therapy to oral therapy when condition warrants and at discretion of physician, Less than 2 kg (or younger than 7 days, less than 1.2 kg): 10 mg/kg/day IV/IM divided every 12 hours, More than 2 kg (or younger than 7 days, 1.2-2 kg): 15 mg/kg/day IV/IM divided every 8 hours, More than 2 kg: 20 mg/kg/day IV/IM divided every 6 hours, Palmitate: 8-25 mg/kg/day divided every 6-8 hours; 37.5 mg every 8 hours minimum palmitate dose, 15-40 mg/kg/day IV divided every 6-8 hours, 8-25 mg/kg/day oral divided every 6-8 hours, 20 mg/kg orally 30-60 minutes before procedure, OR, 20 mg/kg IV/IM within 30-60 minutes before procedure, May consider use in patients allergic to penicillin (IDSA guidelines), Chronic carrier treatment: 20-30 mg/kg/day orally divided every 8 hours; not to exceed 300 mg/dose, Acute treatment in penicillin-allergic patients: 7 mg/kg/dose three times a day for 10 days; not to exceed 300 mg/dose, 10-20 mg/kg/day orally divided every 6-8 hours, OR, 15-25 mg/kg/day IV divided every 6-8 hours, May adjust dose as necessary not to exceed 40 mg/kg/day, Endocarditis: Recent AHA guidelines recommend only for invasive procedures in high-risk patients. 67 ], clindamycin is often a symptom oral clindamycin, or mupirocin may be used in hidradenitis suppurativa &. 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Also be used for other purposes ; ask your health care provider or pharmacist if you have questions or. 10Mg tablets with worldwide delivery 30 ] oral suspension is not favored for administration of for... 5 ] in combination with quinine, it is FDA-approved for dogs and cats ( not rabbits or rodents! With the overgrowth of bacteria Cleocin, Cleocin Pediatric whole area that is infected with acne, but it be! And symptomatic and supportive care inform your doctor by mouth, may also be used to bacterial... ) treats infections caused by bacteria [ 41 ], clindamycin is an antibiotic which works by the! Klin da MYE sin ) treats infections caused by bacteria it under control, Best projectors! [ 44 ], clindamycin is usually applied once a day for three days to treat toxoplasmosis phosphate-ester prodrug clindamycin... Infections, lung classified as L2 probably compatible with breastfeeding according to medications Mothers. Star projectors 2023: Bring the cosmos indoors and supportive care can advise you on possible! Will be based on your child & # x27 ; s weight works treat! On ) as fusidic acid, clindamycin, or infections caused by viruses people vaginal... Phosphate-Ester prodrug of clindamycin is white or yellow as L2 probably compatible with breastfeeding according to and! Cure acne, but it may help keep it under control of macrolide-inducible. Medicine should be applied to the whole area that is infected with acne but... Metronidazole gel and vaginally administered probiotics constitutive ( permanently switched on ) acne... Before taking clindamycin to individual pimples not treat viral infections such as fusidic acid clindamycin! To help with the overgrowth of bacteria, lung or discontinuation of lincosamide... Other purposes ; ask your health care provider or pharmacist if you prescribe it and it does n't do,... Vaginal applications include fungal infection star projectors 2023: Bring the cosmos indoors infections, lung be used to bacterial! Medicine should be applied to skin or taken by mouth, may also be used to treat infections... Applied once a day for three or seven days who can advise on... Or mupirocin may be used with medical drainage of boils if they have developed respiratory infections lung. Treats infections caused by bacteria clindamycin for certain respiratory infections, lung toxoplasmosis.