29 (TCA or TCAs).tw. We will search the World Health Organization International Trials Registry (apps.who.int/trialsearch/Default.aspx) and the ClinicalTrials.gov registry (www.clinicaltrials.gov) for ongoing and registered trials. (2015). Antidepressant medications arent prescribed for weight loss for several reasons: If youve been diagnosed with depression, your doctor will discuss the best medication option for you based on your specific needs. 21 (Venlafaxine or Effexor or Desvenlafaxine).tw. Kupperman Menopausal Index: a numerical index that scores 11 menopausal symptoms: hot flushes, paraesthesia, insomnia, nervousness, melancholia, vertigo, weakness, arthralgia or myalgia, headache, palpitations, and formication. Weight loss medications (anti-obesity medications). Its difficult to say how a medication will affect your weight. Antidepressants offer an alternative treatment option, often with fewer side effects than hormonal therapy. bupropion (Wellbutrin) fluoxetine (Prozac) duolexetine (Cymbalta) Research published in 2014 suggests that bupropion (Wellbutrin) can lead to weight loss. Find out whether its a concern for people taking Celexa, a type of SSRI. May be taken with or without food. 21 (Venlafaxine or Effexor or Desvenlafaxine).tw. If your doctor feels you would benefit from this medication over other antidepressants, theyll discuss this with you. Antidepressant utilisation and incidence of weight gain during 10 years follow-up: Population based cohort study. The majority of the studies are on SNRIs and SSRIs, with a few studies on type A MAOI (moclobemide), NDRI (bupropion) and NaSSa (mirtazapine). 2a. We will resolve any disagreement through discussion. A few antidepressants have had reports of causing weight loss: SSRIs may cause weight loss with short-term use, but taking them for 6 months or more can lead to an increase in weight. Because of the concerns regarding the safety of menopausal hormonal therapy, antidepressant drugs seem to be an attractive alternative because of their wide use and favourable safety profile in women who have contraindications for hormonal treatment or who wish to avoid hormones because of concerns about adverse effects. 5. Over the years, the use of antidepressants has been observed to result in numerous side effects. We plan to conduct sensitivity analyses for the primary outcomes to determine whether the conclusions are robust to arbitrary decisions made regarding eligibility and analysis. Bethesda, MD 20894, Web Policies 2. Freedman RR, Lopez JF, In women with underlying depression, and with vasomotor disturbances and depression due to menopause, antidepressants might improve their ability to cope with their hot flushes along with depression (Shanafelt 2002). Ankylosing Spondylitis Pain: Fact or Fiction. Coping with this common side effect from antidepressants. People can also snack on nuts, peanut butter toast, yogurt, or fruit between meals. 24 MAO B inhibitor*.tw. This will help with weight maintenance. Weight gain is a common side effect of antidepressants, but a few medications may cause weight loss instead. 5 exp Hot Flashes/ 6 (hot flash* or hot flush*).tw. 2. We will combine the MEDLINE search with the Cochrane Highly Sensitive Search strategy for identifying RCTs, as described in the Cochrane Handbook for Systematic Reviews of Interventions (Version 5.0.2; Chapter 6, 6.4.11) (Higgins 2011). Limacher M, Thus agents that increase oestrogen, serotonin, and endorphin levels or that decrease central norepinephrine release would be expected to reduce hot flushes. 3 climacter*.tw. For continuous data (e.g. The results showed the most acceptable antidepressants were agomelatine, citalopram, escitalopram, fluoxetine, sertraline, and vortioxetine; least acceptable (ones with the highest dropout rates). Akl E, SNRI, NDRI, NaSSa, MAOI) and subgrouped by mode of administration and dose in premenopausal and postmenopausal women. 33 Noradrenaline Reuptake Inhibitor*.tw. SSRIantidepressantuse potentiatesweightgain in the context of unhealthy lifestyles: Results from a 4-year Australian follow-up study. Antidepressants for Weight Loss While some antidepressants are linked to weight gain, others are associated with weight loss. They largely improve symptoms of depression by altering neurotransmitters such as serotonin, norepinephrine, and dopamine. Norton D, While antidepressants do carry an array of side effects, they may be a potential treatment option for menopausal women who have difficulty getting their symptoms under control. Below, check out the tour dates, as well as a weird tour . The premium product BATCH gummies is full-spectrum, vegan-friendly, and made with solely natural components. Weight changes can be a concern with antidepressants. 49 or/4048 50 exp animals/ not humans.sh. For example, the addition of the antidepressant bupropion may ease sexual side effects caused by another antidepressant. 10 or/19 11 exp Antidepressive Agents/ 12 (antidepressant* or antidepressant*).tw. change in hot flushes) we will calculate the standardised mean difference (SMD). Most impact a type of chemical called a neurotransmitter. 6 Nocturnal diaphoresis.tw. 1. Ory M, Menopausespecific quality of life (MENQOL): 29 questions covering four domains: vasomotor, psychosocial, physical, and sexual. Menopause can also be induced by surgery, radiation or chemotherapy. In addition, mental health symptoms can affect a persons eating habits and activity levels, and treating the underlying condition may lessen or stop these effects. We will resolve discrepancies through discussion. Bupropion: A systematic review and meta-analysis of effectiveness as an antidepressant. Doctors commonly prescribe antidepressants to treat mental health conditions such as depression and anxiety. . 27 (TCA or TCAs).tw. In this article we briefly discuss the types of antidepressants and their side effects, and outline the benefits and risks of using antidepressants for the treatment of menopause. If you live with depression, you know that your symptoms can range from mild to serious and include physical symptoms like pain and fatigue, as well as emotions like hopelessness, sadness, and anxiety. We will also search OpenGrey (www.opengrey.eu) for grey literature. Side Effects of Antidepressants for Menopause Allocation concealment (checking for possible selection bias). Could a new blood biomarker help predict Alzheimer's risk? SNRIs can potentially elevate blood pressure and regular monitoring of blood pressure is needed (Watts 2012). In general, citalopram is less likely to cause drug interactions due to enzyme inhibition than fluoxetine or paroxetine. 33 Noradrenaline Reuptake Inhibitor*.tw. Women's Health Questionnaire (WHQ): contains menopausespecific quality of life subscales enabling a detailed assessment of dimensions of emotional and physical health, such as depression, anxiety, sleep problems, and somatic symptoms, with optional subscales for menstrual problems and sexual difficulties. 3 exp Climacteric/ 4 climacter*.tw. (2016). 26 (Phenelzine or Tranylcypromine or Moclobemide or Isocarboxazid or Selegeline).tw. Whatever the cause, we've got tips to, Some of the common drugs for depression and autoimmune diseases, like Zoloft, prednisone, and other antidepressants or corticosteroids, have less-than-, Sexual side effects, like erectile dysfunction, are common complaints of taking antidepressants. We will evaluate the overall quality of the body of evidence for the review outcomes (hot flushes (with and without night sweats): i.e. Associations of hormones and menopausal status with depressed mood in women with no history of depression. Bonfill X. There are various types of antidepressants that can be used to treat menopause. We will search the following databases from inception to present; the Cochrane Gynaecology and Fertility Group specialised register (Appendix 1), the Cochrane Central Register of Controlled Trials (via CENTRAL CRSO) (Appendix 2), MEDLINE (Appendix 3), Embase (Appendix 4), PsycINFO (Appendix 5) and CINAHL Plus (Appendix 5). We will present 95% confidence intervals for all outcomes. Examples include additive sedation with CNS depressants and serotonin syndrome with other serotonergic drugs. This review shall be updated every two years, or earlier if any new RCTs become available. We will describe for each included study, and for each outcome or class of outcomes, the completeness of data including attrition and exclusions from the analysis. 10 or/19 11 exp Antidepressive Agents/ 12 (antidepressant* or antidepressant*).tw. Oxman AD, 'Summary of findings' tables will be generated using GRADEpro software and Cochrane methods (GRADEpro GDT). 1. "Vitamn C njdete v ovoc, ako s pomarane a jahody, a vitamn E v . Some antidepressants may affect appetite, leading to weight changes. Melaka Manipal Medical College, Department of Obstetrics and Gynaecology, Bukit Baru, Jalan BatuHampar, MelakaMalaysia, 75150, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) (Institution of National Importance Under Ministry of Health and Family Welfare, Government of India), Department of Medical Biometrics & Informatics (Biostatistics), 4th Floor, Administrative Block, Dhanvantri NagarIndia, 605006. The tour begins on Aug. 3 in Sterling . Nausea. They work in the body in different ways and are also administered differently . People under the age of 25 years are most at risk of suicidal thoughts when they first begin taking antidepressants. Two review authors (KLK and NC) will independently assess risk of bias for each study using the criteria outlined in the Cochrane Handbook for Systematic Reviews of Interventions (Higgins 2011). Antidepressants together with symptoms of mood disorders, poor diet, a sedentary lifestyle, and smoking can all contribute to weight gain. We avoid using tertiary references. Addressing the side effects of contemporary antidepressant drugs: A comprehensive review. Examples of SSRIs include the most popular one, fluoxetine, as well as paroxetine, sertraline and citalopram. hot flushes), if all studies report exactly the same outcomes we will calculate mean difference (MDs) between treatment groups. Gabapentin and pregabalin can cause dizziness, so should be titrated from a lower dosage. Lean. Keywords CONTAINS "menopausal" or "Menopause" or "menopausal symptoms" or "menopausal index" or "menopausal transition" or "menopause rating scale" or "Menopause Specific Quality of Life" or "menopausesurgical" or "perimenopausal" or "perimenopausal depression" or "perimenopause" or "Postmenopausal" or "postmenopause" or "PostmenopausalSymptoms" or "climacteric" or "climacteric symptomspsychological" or "climacteric depression" or "hot flash" or "Hot flashes" or "Hot Flush" or "hot flushes" or "hot flushes frequency" or "hot flushes severity" or "night sweats" or "night time awakenings" or Title CONTAINS "menopausal" or "Menopause" or "menopausal symptoms" or "menopausal index" or "menopausal transition" or "menopause rating scale" or "Menopause Specific Quality of Life" or "menopausesurgical" or "perimenopausal" or "perimenopausal depression" or "perimenopause" or "Postmenopausal" or "postmenopause", Keywords CONTAINS "antidepressants" or "antidepressants" or "selective serotonin reuptake inhibitor" or "SSRI" or "SSRIs" or "serotoninnorepinephrine reuptake inhibitor" or "serotonin reuptake inhibitor" or "SNRI" or "Sertraline" or "SSRI" or "SSRIs" or "Citalopram" or "paroxetin" or "paroxetine" or "fluoxetine" or "fluoxetine hydrochloride" or "escitalopram" or "Prozac" or "SNRI" or "venlafaxine" or "desvenlafaxine" or "phenelzine" or "amitriptyline" or "imipramine "or "reboxetine" or "bupropion" or Title CONTAINS "antidepressants" or "antidepressants" or "selective serotonin reuptake inhibitor" or "SSRI" or "SSRIs" or "serotoninnorepinephrine reuptake inhibitor" or "serotonin reuptake inhibitor" or "SNRI" or "Sertraline" or "SSRI" or "SSRIs" or "Citalopram" or "paroxetin" or "paroxetine" or "fluoxetine" or "fluoxetine hydrochloride" or "escitalopram" or "Prozac" or "SNRI" or "venlafaxine" or "desvenlafaxine" or "phenelzine" or "amitriptyline" or "imipramine" or "reboxetine" or "bupropion", #1 MESH DESCRIPTOR Menopause EXPLODE ALL TREES, #2 (menopaus* or perimenopaus* or postmenopaus*):TI,AB,KY, #4 MESH DESCRIPTOR Hot Flashes EXPLODE ALL TREES, #9 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8, #10 MESH DESCRIPTOR Antidepressive Agents EXPLODE ALL TREES, #11 (antidepressant* or antidepressant*):TI,AB,KY, #12 MESH DESCRIPTOR Serotonin Uptake Inhibitors EXPLODE ALL TREES, #15 (citalopram or paroxetine or sertraline or fluoxetine or fluvoxamine or escitalopram):TI,AB,KY, #16 (Celexa or Lexapro or Prozac or Luvox or Paxil or Zoloft):TI,AB,KY, #17 (Serotonin adj2 Noradrenaline Reuptake Inhibitor*):TI,AB,KY, #18 MESH DESCRIPTOR Serotonin and Noradrenaline Reuptake Inhibitors EXPLODE ALL TREES, #19 (serotonin norepinephrine reuptake inhibitor*):TI,AB,KY, #21 (Venlafaxine or Effexor or Desvenlafaxine):TI,AB,KY, #22 MESH DESCRIPTOR Monoamine Oxidase Inhibitors EXPLODE ALL TREES, #26 (Phenelzine or Tranylcypromine or Moclobemide or Isocarboxazid or Selegeline):TI,AB,KY, #27 (Amitryptyline or Imipramine or Dothiepin or Trazodone or Clomipramine or Desipramine or Dosulepin or Doxepine or Lofepramine or Nortriptyline or Protriptyline or Trimipramine):TI,AB,KY, #30 (Noradrenergic adj1 Specific Serotonergic):TI,AB,KY, #32 (Noradrenaline Reuptake Inhibitor*):TI,AB,KY, #35 (norepinephrine dopamine reuptake inhibitor*):TI,AB,KY, #38 #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37, 1 exp Menopause/ 2 (menopaus* or perimenopaus* or postmenopaus*).tw. 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