It is possible to pass HIV to your child through your breast milk. (This is known as a drug-condition interaction.) The label may have colored stickers that mention an interaction. Active ingredients: emtricitabine and tenofovir disoproxil fumarate. You must continue using safer sex practices while you are taking Truvada to reduce your risk of getting HIV-1. Learn about financial and insurance support programs for eligible patients. If it gets worse, your doctor may recommend switching to a different HIV drug. But Tivicay and Isentress also have some different side effects. Truvada is a combination of two medicines, Tenofovir disoproxil fumarate (sold separately as Viread or generic) and emtricitabine (sold separately as Emtriva). Ask your doctor about this if you or your child have any concerns. As with other medications, Truvada can interact with certain other drugs. Prevention Resources Introduction Truvada (emtricitabine/tenofovir disoproxil) is a brand-name prescription drug used to treat and help prevent HIV. If your doctor prescribes an HIV drug and Truvada, theyll closely monitor you. pain or tenderness around the eyes and cheekbones, rash with flat lesions or small raised lesions on the skin, spots on your skin resembling a blister or pimple, burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings in the hands, arms, feet, or legs, change in how much or how often you urinate, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, swelling of the face, fingers, hands, lower legs, or ankles, unusual drowsiness, dullness, or feeling of sluggishness. They can recommend how much alcohol, if any, may be safe for you. Call your doctor for medical advice about side effects. Also, Truvada could worsen your kidney problem. Find out about possible interactions between Humira and other medications, supplements, alcohol, foods, and more. Keep in mind that the following information does not include all other possible interactions with Truvada. This is to make sure you havent contracted HIV without knowing. People living with HIV have an increased chance of developing a candidiasis infection. Safety and efficacy have not been established. Before you start Truvada treatment, tell your doctor about any other HIV medications you take. Theyll also check your blood levels to see whether the medications are affecting your kidneys. TRUVADA is a combination of emtricitabine and tenofovir disoproxil fumarate. The more common side effects in people who took Truvada as pre-exposure prophylaxis . What are the serious side effects of Truvada? In studies of Truvada, altered results in liver function tests occurred rarely, but enlarged and fatty liver werent reported. Last medically reviewed on July 24, 2022. Taking Truvada with certain other HIV drugs may raise the level of tenofovir in your body. Just taking Truvada may not keep you from getting HIV-1. Heres a closer look at certain drug interactions of Truvada. Available for Android and iOS devices. Keep using this medicine for the full time of treatment, even if you or your child begin to feel better. Your doctor will perform laboratory tests before starting this medication and periodically during treatment (every 3 months) to make sure that you do not have HIV infection. In the 1980s, a diagnosis of HIV used to mean AIDS or even early death. Emtricitabine/tenofovir disoproxil fumarate is not indicated for the treatment of chronic hepatitis B virus (HBV) infection and the safety and efficacy have not been established in patients co-infected with HBV and HIV-1. This is not a complete list of possible side effects. For prevention of HIV infection (Pre-exposure prophylaxis): Children weighing less than 35 kgUse and dose must be determined by your doctor. Kidney problems. This medication passes into breast milk. Review our medical disclaimer. If needed, your doctor may prescribe medication to treat HBV. Tenofovir may increase the risk of bone loss. Truvada may cause serious side effects, including: The most common side effects of Truvada in people taking Truvada to treat HIV-1 infection include: Common side effects in people who take Truvada to reduce the risk of getting HIV-1 infection include: These are not all the possible side effects of Truvada. It helps to decrease the amount of HIV in your body so your immune system can work better. You should see your doctor right away if you have any symptoms of liver problems. This is a condition caused by a buildup of lactic acid in your blood. Do not use Truvada for a condition for which it was not prescribed. It may harm them. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. * For details about Truvadas side effects, see this article. Swallow the tablet whole. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia, herpes, or tuberculosis. Tell your doctor right away if you or your child notice any changes in your health. A very serious allergic reaction to this drug is rare. Truvada (emtricitabine and tenofovir disoproxil fumarate) tablets, for oral use. There arent any known interactions between Truvada and vaccines. (An active ingredient is what makes a drug work.). And worsening HBV infection could lead to liver failure. Liver problems. You must get tested to make sure that you do not already have HIV-1 infection. If you take Truvada for PrEP and you already have HIV, the virus could develop resistance to Truvada. Each tablet contains 200 milligrams (mg) of emtricitabine and 300 mg of tenofovir. For details about Truvadas side effects, see this article. There have been reports of these side effects in people taking Truvada since it came on the market, but its unclear how often this has happened or if Truvada was the cause. Weighing 17 to less than 22 kgOne tablet once a day. Know your HIV-1 status and the HIV-1 status of your partners. Human immunodeficiency virus (HIV) is a virus that strikes the immune system, making it difficult for the body to fight infections and diseases. If you have a kidney problem, Truvada could build up in your body. Patients infected with both HBV and HIV who take emtricitabine and tenofovir combination need close medical follow-up for several months after stopping treatment to make sure their hepatitis B infection does not get worse. However, information suggests that Truvada does not increase the risk of congenital anomalies during the first trimester of pregnancy. (These anomalies are commonly known as birth defects.) To learn more, see the Side effects explained section below. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). Recommendations for the use of antiretroviral drugs during pregnancy and interventions to reduce perinatal HIV transmission in the United States. (An active ingredient is what makes a drug work.). Tell your healthcare provider if your child cannot swallow the tablet, because they may need a different HIV-1 medicine. Truvada may not be the right treatment option if you have certain medical conditions or other factors affecting your health. Like other drugs, Truvada can cause mild to serious side effects. An undetectable viral load is when the amount of virus in the blood is too low to be measured in a lab test. Its not known how often kidney problems occur with Truvada. How might bacteria-eating viruses and gut bacteria contribute to longevity? Uses Warnings Before taking Side effects Interactions Dosage FAQ What is Truvada? Each tablet contains 133 mg of emtricitabine and 200 mg of tenofovir. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of emtricitabine and tenofovir combination in the elderly. If any of these effects last or get worse, tell your doctor or pharmacist promptly. However, that does not mean vitamin interactions wont occur or be recognized in the future. Examples of antiviral drugs. The following information includes only the average doses of this medicine. In addition, taking Truvada with emtricitabine/tenofovir alafenamide (Descovy) can raise the levels of emtricitabine and tenofovir in your system. An allergic reaction is possible after taking Truvada. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. There have been reports of this side effect in people taking Truvada, but its unclear how often this has happened or if Truvada was the cause. Your healthcare provider will test you for HBV before starting treatment with Truvada. Practice safer sex by using a latex or polyurethane condom to lower the chance of sexual contact with semen, vaginal fluids, or blood. What is the most important information I should know about Truvada? 167 mg emtricitabine and 250 mg tenofovir disoproxil fumarate. Consult your doctor or pharmacist for more details. Its possible for Truvada to interact with an herb called echinacea. When your supply of this medicine is running low, contact your doctor or pharmacist ahead of time. All rights reserved. Investigating the power of music for dementia. The first trimester is weeks 1 to 12 of pregnancy. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. * Truvada has a boxed warning for this side effect. US residents can call their local poison control center at 1-800-222-1222. This medicine may cause rare, but serious, liver problems. Children who take Truvada are prescribed a lower strength tablet than adults. Keep the medicine in the original bottle that you were given at the pharmacy and keep it tightly closed. Grapefruit and grapefruit juice can interact with Truvada. Some things that increase risk include having a partner infected with HIV, having unprotected sex, having multiple sex partners, infection with a sexually transmitted disease-STD, or use/abuse of drugs or alcohol. depression (see "Side effect specifics" below) diarrhea. Your doctor will test you for HIV before you start taking Truvada for PrEP. Ask them about other medications that might be better options. You need to take other HIV-1 medicines with Truvada to treat HIV-1. You should only take Truvada for preexposure prophylaxis (PrEP) to help prevent HIV if you test negative for HIV. HIV isnt transmissible through the casual contact customary for roommates and family, Healthline's Director of Health Equity and Social Impact and BEAM's Executive Director share the importance of the Joseph Beam Grant for their, Paul Edmonds was diagnosed with AIDS in 1988. Its not known how often lactic acidosis occurs with Truvada, but its likely to be rare. For more information about the interaction between Truvada and echinacea, see Truvada interactions with herbs above. Besides learning about interactions, you may want to find out more about Truvada. Symptoms can be mild to serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. Your doctor will likely order blood and urine tests to check your kidney function before you start Truvada. If your doctor prescribes Truvada to treat HIV, they may recommend taking it every other day instead of every day. You can talk with your doctor about your risk of these side effects. Use an effective barrier method (latex or polyurethane condoms/dental dams) during sexual activity as directed by your doctor. rash. Autoimmune disorders (including Graves disease, polymyositis, and Guillain-Barr syndrome) may also occur. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. It will not keep you from spreading HIV to other people. tiredness or trouble sleeping. The testing is necessary because if you have HIV, taking Truvada for PrEP may increase the risk of drug resistance. help reduce the risk of getting HIV-1 infection when used with safer sex practices in adults and adolescents who weigh at least 77 pounds (at least 35 kg). Most of Truvadas mild side effects tend to improve in a few days or weeks as your body gets used to the drug. Kidney disease (eg, acute renal failure, Fanconi syndrome), history of or, Liver disease (eg, hepatitis B infection), history of or. Health conditions or factors that might interact with Truvada include the following. To learn more, see Boxed warnings at the top of this article. you already have HIV-1 infection. Note: Before you start treatment with Truvada, its important to tell your doctor if this contraindication applies to you. Truvada by itself is not a complete treatment for HIV-1. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Do not keep outdated medicine or medicine no longer needed. Ankylosing Spondylitis Pain: Fact or Fiction, Truvada interactions with other medications, nonsteroidal anti-inflammatory drugs (NSAIDs, https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021752s061lbl.pdf. TRUVADA is a combination of emtricitabine and tenofovir disoproxil fumarate. HIV (human immunodeficiency virus) is a virus that attacks the immune system, which reduces a persons ability to fight infection. You may develop a side effect called lactic acidosis while taking Truvada. What Does Your White Blood Cell Count Look Like During Acute HIV Infection? By following this link, you are now leaving www.TRUVADA.com. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. This lowers your chance. Appropriate studies have not been performed on the relationship of age to the effects of emtricitabine and tenofovir combination in children weighing less than 17 kilograms (kg) to treat HIV infection and in children weighing less than 35 kg to prevent HIV infection. These resources might help: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. This side effect could occur if you have an HBV infection and you stop taking Truvada. *, Hepatitis B. Drug resistance occurs when a drug no longer works to treat a condition. If you miss a dose, take it as soon as you remember. For example, both drugs can cause trouble sleeping, fatigue (low energy), and headache. For the best effect, take this medication at evenly spaced times. If you notice other effects not listed above, contact your doctor or pharmacist. 2023 Healthline Media UK Ltd, Brighton, UK. In some situations, this interaction may cause HIV to worsen. The. headache. If you have hepatitis B infection as well as HIV, your hepatitis symptoms may get worse or become very serious if you stop taking this medication. In rare cases, severe liver problems can happen that can lead to death. If you have any questions about this, check with your doctor. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. If you have symptoms of lactic acidosis while taking Truvada, call your doctor right away. Truvada contains a combination of emtricitabine and tenofovir disoproxil fumarate. Do not share this medication with others. You must be HIV-negative to start Truvada. Truvada is a prescription medicine that is used to: treat HIV-1 infection when used with other anti-HIV-1 medicines in adults and children who weigh at least 37 pounds (at least 17 kg). Do not change the dose or stop using this medicine without checking first with your doctor. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Find everything you need to know about Truvada (Emtricitabine And Tenofovir), including what it is used for, warnings, reviews, side effects, and interactions. Tivicay and Isentress belong to the same group of drugs, so they have some similar side effects. Do not crush, break, or chew it. In some cases, factors or conditions could prevent your doctor from prescribing Truvada due to the risk of harm. But do not stop taking Truvada unless your doctor recommends it. This helps healthcare professionals understand how safe HIV drugs are for use during pregnancy. Symptoms of worsening HBV infection can include: Before you start Truvada, your doctor will test you for HBV. Ask your healthcare provider if TRUVADA is right for you. Store Truvada at room temperature between 68F to 77F (20C to 25C). Doctors typically do not prescribe Truvada to help prevent HIV if you have HIV or if you dont know whether you have it. Generic name: tenofovir disoproxil fumarate and emtricitabine Why is this medication prescribed? And this makes Truvada less effective in treating or helping prevent HIV. Take Truvada exactly as your healthcare provider tells you to take it. Otherwise, call a poison control center right away. This product may contain inactive ingredients, which can cause allergic reactions or other problems. But some serious side effects may last a long time. Truvada is one of several medications that are currently used to treat human immunodeficiency virus (HIV) and hepatitis B virus infection. Using this product will not always prevent HIV infection. Source: National Library of Medicine. Its a medical emergency that can be life threatening. View the Patient Information with important warnings. You may report side effects to Health Canada at 1-866-234-2345. Too much lactic acid in your blood (lactic acidosis). What is PrEP? Osteoporosis (weak or brittle bones), history ofUse with caution. Also, if you have HIV infection, do not breast-feed because breast milk can transmit HIV. This drug may make you dizzy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Examples of these include Tivicay (dolutegravir) and Isentress (raltegravir). Interaction explained. This medicine will not cure HIV infection or AIDS. Canada residents can call a provincial poison control center. You should always consult your doctor or another healthcare professional before taking any medication. TRUVADA contains the prescription medicines emtricitabine and tenofovir disoproxil fumarate. Last updated on Sep 23, 2022. Most of Truvadas side effects are mild and short-lived. You should also be tested for hepatitis B before starting treatment with this medicine. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. If you decide to take Truvada during pregnancy, youre encouraged to enroll in the Antiretroviral Pregnancy Registry. If you miss a dose of this medicine, take it as soon as possible. Below are just a few of the more common side effects reported by people taking Truvada in studies. Talk with your doctor before stopping this medication. The content on this site may not apply to non-U.S. audiences as regulatory control, legal requirements, and/or medical practices may vary in other countries. It is not known if Truvada is safe and effective in children with HIV-1 infection who weigh less than 37 pounds (less than 17 kg). Check with your doctor right away if you or your child have stomach discomfort, decreased appetite, diarrhea, fast, shallow breathing, general feeling of discomfort, muscle pain or cramping, nausea, sleepiness, unusual tiredness or weakness, or yellow eyes or skin. But if you have symptoms that are ongoing or bother you, talk with your doctor or pharmacist. Consult your pharmacist or local waste disposal company. Truvada vs Descovy: How do they compare for HIV and PrEP? Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help them learn more about how Truvada affects you. Unfortunately, Descovy also costs much more than generic Truvada. For example, Tivicay can sometimes cause serious liver problems, while Isentress can sometimes cause serious skin reactions. Can HIV become resistant to Truvada when its used to treat HIV infection? Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. This product is a combination of two different drugs: emtricitabine and tenofovir. (An active ingredient is what makes a drug work.). (2021). This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. And they may monitor your bone health. Your doctor will monitor your kidney function while you take Truvada. Do not store in the bathroom. To learn more, see this article. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). In some cases, the problems may be severe. Generic name: emtricitabine and tenofovir disoproxil fumarate. Truvada can also cause these side effects. Do not double the dose to catch up. Specifically, grapefruit products can stop your body from breaking down tenofovir, one of the active ingredients in Truvada. If you take Truvada to treat HIV-1 infection, you need to take other HIV-1 medicines. Combination treatment with at least one other HIV medication should be used. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). Tests for HIV may not pick up the virus in your blood until a month after infection, so it's important to test more than once over a period of time, Getting an HIV test is the only way to know for sure whether you have the virus. Discuss this with your doctor. Our website services, content, and products are for informational purposes only. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). Take Truvada 1 time each day with or without food. If youre pregnant or planning to become pregnant, talk with your doctor about your treatment options. Tenofovir can decrease the effectiveness of another medication, atazanavir (by decreasing blood levels). Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Bone problems include bone pain, or softening or thinning of bones, which may lead to fractures. This is more common in patients with a history of hepatitis B infection or those who already have liver disease. Your doctor may prescribe other HIV drugs to take along with Truvada, or they may prescribe a different combination of HIV drugs. If you have HIV infection, treatment can lower the risk of passing HIV infection to your baby, and this medication may be part of that treatment. But if you have certain serious side effects, such as liver or kidney problems, these may last a long time or even be permanent. Your doctor will perform liver function tests for several months after you stop. If you have HIV-1 and take only Truvada, over time your HIV-1 may become harder to treat. Early diagnosis and treatment can help manage the condition and prevent transmission to others. They may want to do more tests to be sure you are still HIV-negative. * For example, both Truvada and alcohol can cause: If you consume alcohol during Truvada treatment, these side effects may be more likely to occur. This is a decision you and your doctor will make. Examples of other HIV drugs. Its unknown whether its safe to take Truvada during pregnancy. (To learn whether Truvada interacts with supplements, herbs, or vitamins, see the Truvada and other interactions section below.). This document does not contain all possible drug interactions. Before you start treatment with Truvada, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. It is not known if TRUVADA for treatment of HIV-1 infection is safe and effective in children who weigh less than 37 pounds (17 kg). Symptoms of ED include. Severe acute exacerbations of hepatitis B have been reported in patients who are co-infected with HBV and HIV-1 and have discontinued emtricitabine/tenofovir; monitor hepatic function upon discontinuation of therapy. Interaction result. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. You must stay HIV-negative to keep taking Truvada to reduce your risk of infection. Reviewed by Medicine.com on January 17, 2020. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Interaction explained. Learn about financial and insurance support programs for eligible patients. For details, see Boxed warnings at the top of this article. To learn more, see the Side effects explained section above. Your immune system may get stronger when you start using HIV medicines. If you have another STI, be sure to get it treated right away. Truvada may not be safe for everyone and comes with several warnings. Before you start treatment with Truvada, tell your doctor and pharmacist which supplements, herbs, and vitamins you take. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Truvada and certain antiviral medications can cause kidney problems, such as kidney damage. Research suggests that Descovy is similarly effective in reducing the risk of getting HIV from sex. By sharing this information with them, you may help prevent possible interactions. Introduction If you have HIV or you're at risk of contracting HIV, your doctor might suggest Truvada as a treatment option. Truvada has a boxed warning about the risk of resistance to Truvada. Severe liver problems. Blood and urine tests may be needed to check for unwanted effects. Yes, some mild side effects may be more common when Truvada is taken as preexposure prophylaxis (PrEP) to help prevent HIV. However, its possible that drinking alcohol may increase your risk of certain side effects of Truvada. To find out about possible interactions with other medications that are ongoing or you. Evenly spaced times and dose must be determined by your doctor or ahead. Nsaids, https: //www.accessdata.fda.gov/drugsatfda_docs/label/2020/021752s061lbl.pdf, check with your doctor about any other HIV medication should be consulted before side. Purposes only, may be more common when Truvada is a virus that attacks the immune system will to... Studies of Truvada with them, you need to take other HIV-1 medicines with Truvada, but enlarged fatty. Health care professional may be needed to check your kidney function before start. 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