Treatment of familial hypertriglyceridaemia with acarbose[J]. "Vitamn C njdete v ovoc, ako s pomarane a jahody, a vitamn E v . Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. to visibly see the impact Acarbose has on preventing spikes. Inoue I, Shinoda Y, Nakano T, et al. Severe hepatic injury associated with different statins in patients with chronic liver disease: a nationwide population-based cohort study. Case definition and phenotype standardization in drug-induced liver injury, 8. Our study has several important limitations. 2006;29:10917 (PMID: 16622298). Using ICD-9-CM codes to identify DILI cases has been deemed problematic by some researchers (Jinjuvadia et al., 2007). Because the metabolites of acarbose are excreted in the urine, the combination of renal and liver dysfunction casts uncertainty on the appropriateness of acarbose usage among these patients. Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases. Sensitivity analyses excluding acarbose users who discontinued acarbose after enrollment. Unauthorized use of these marks is strictly prohibited. We performed several sensitivity analyses to verify our findings. 2021 Jun;43(3):1123-1133. doi: 10.1007/s11357-020-00278-x. This is done by using glucose (sugar) in the blood as quick energy. For diabetic patients developing CKD, dosage adjustment is frequently needed for their anti-diabetic regimens, due to the fact that drugs and their metabolites frequently accumulate in patients with CKD, predisposing them to adverse events. Reduce Glucose Spikes. Please enable it to take advantage of the complete set of features! Consequently, it is imperative that our armamentarium of OADs against DM be expanded to allow safer approaches for glycemic control in diabetic CKD/ESRD patients. Kao et al., in a study addressing anti-fungal agent hepatotoxicity, defined DILI events based on ICD-9-CM codes only (Kao et al., 2014). Roussel R., Lorraine J., Rodriguez A., Salaun-Martin C. (2015). This product is not intended to diagnose, treat, cure, or prevent any disease. PubMed The incidence of liver injury in this study was comparable to those in the literature (Chen et al., 2014). Holman RR, Cull CA, Turner RC. Among those with CLD but without cirrhosis, acarbose users also exhibited a similar risk of liver injury compared to non-users (HR: 0.971.00). Before taking acarbose Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. In this study, we found that acarbose use in diabetic individuals with advanced CKD/ESRD and liver cirrhosis was not associated with an increased incidence of liver injury (Table (Table2).2). Google Scholar. Maogao X, Ping C. Effect of adjuvant therapy with Bifidobacterium triple viable capsule on cell function and insulin resistance in newly diagnosed type 2 diabetes patients[J]. Acarbose works to reduce spikes in blood sugar following a carb-heavy meal & lessen the resulting sugar crash. -. PubMed CAS Update meta-analysis of the CYP2E1 Rsal/Pstl and Dral polymorphisms and risk of antituberculosis drug-induced hepatotoxicity: evidence from 26 studies. Infection-related hospitalization and risk of end-stage renal disease in patients with systemic lupus erythematosus: a nationwide population-based study. Khalili N, Safavipour A. From the selected seven papers, we extracted the following clinical parameters: systolic blood pressure (SBP), diastolic blood pressure (DBP), body weight (BW), body mass index (BMI), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), high density cholesterol (HDL) and fasting plasma glucose (FPG). Analysis of the postprandial plasma glucose incremental area under the curve showed that the change from baseline to the end of the treatment period differed for placebo and acarbose recipients by 4.73 mmol.h/L in the diet alone group (P < 0.001), 2.06 mmol.h/L in the metformin group (P = 0.01), 2.65 mmol.h/L in the sulfonylurea group (P < 0.001), and 3.13 mmol.h/L in the insulin group (P = 0.001). Metformin, most sulfonylureas, meglitinide, acarbose, thiazolidinedione, and DPP4i are mostly metabolized by the liver, and pharmacokinetic changes can be observed for meglitinide and DPP4i among those with different severities of hepatic impairment (Scheen, 2014). Acarbose in obese patients with polycystic ovarian syndrome: a double-blind, randomized, placebo-controlled study[J]. The https:// ensures that you are connecting to the 2001;3(6):4237. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 8600 Rockville Pike Users of medications with potential hepatotoxic risk were defined as receiving more than 30 days within the preceding year before index date, with the medication list defined according to literature and Taiwan adverse drug report (ADR) reporting system (Lee, 2013; Chen et al., 2014). Federal government websites often end in .gov or .mil. We first grouped the identified diabetic participants with stage 5 CKD or dialysis-dependent ESRD into those without CLD, with CLD but without cirrhosis, and with cirrhosis. An important finding of our research is that TG was the only significantly reduced parameter in the acarbose group. 2011;25(1):1125. The side effects of acarbose are mild. Careers, Unable to load your collection due to an error. After adjusting for demographic profiles, comorbidities, potentially hepatotoxic medication use, and aDCSI, acarbose users still exhibited a similar risk of liver injury compared to non-users (HR: 1.041.05) (Table (Table2).2). Metformin use and mortality in patients with advanced chronic kidney disease: national retrospective, observational, cohort study. 1996;17:112. Hum Reprod. Pediatric 2015;26(18):250912. . Renoprotective effect of renin-angiotensin-aldosterone system blockade in patients with predialysis advanced chronic kidney disease, hypertension, and anemia. Lin C.-H., Hung P.-H., Hu H.-Y., Chen Y.-J., Guo H.-R., Hung K.-Y. Kao C.-C., Wu P.-C., Wu C.-H., Chen L.-K., Chen H.-H., Wu M.-S., et al.. (2016). See it in action on the adjacent chart with real data from an AgelessRx pilot study patient after consuming a bagel. Others also used a very similar approach to uncover statin-related liver injury from the same database we used (Chang et al., 2015). Apart from common side effects like gastrointestinal disturbances, early trials involving acarbose reported increases in transaminases or rarely jaundice in 3.8% of users compared to 1.1% in the placebo group (Balfour and McTavish, 1993). Smoothie. Among each group, acarbose users, defined as cumulative use >30 days within the preceding year, were propensity-score matched 1:2 to non-users. The effect of acarbose on insulin resistance in obese hypertensive subjects with normal glucose tolerance: a randomized controlled study[J]. Acarbose did not significantly affect mean serum C-peptide or mean serum lipid levels. Fertil Steril 2007;88(2):51922. Chao C.-T., Tang C.-H., Cheng R. Clinical efficacy of acarbose in diabetes mellitus: a critical review of controlled trials. Acarbose is FDA approved for treating adults with type 2 diabetes mellitus as an adjunct to diet only or diet and exercise, depending on the patient's health status. government site. J Diabetes Complications. An official website of the United States government. We also narrowed down outcome definition by including only those with DILI who discontinued acarbose immediately after DILI occurred, and derived similar findings (for non-CLD, HR 0.88, 95% CI 0.731.06; for CLD without cirrhosis, HR 0.88, 95% CI 0.541.44; for cirrhosis, HR 0.58, 95% CI 0.251.38; Table Table8).8). Clin Exp Pharmacol Physiol. Received 2018 May 22; Accepted 2018 Jul 16. The current match involves a Texas lawsuit . Multiple studies discovered that in patients of Chinese origin, single nucleotide polymorphism of CYP2E1 influenced the risk of lupus erythematosus and different cancers (Liao et al., 2011; Wang et al., 2014). In our study, we used Taiwan National Health Insurance Research database, an administrative healthcare database covering nearly all citizens in Taiwan, suitable for identifying rare cases or events such as DILI. Based on a nation-wide cohort followed up prospectively, we found that among diabetic patients with stage 5 CKD or ESRD, the use of acarbose was not associated with an increased risk of liver injury. We found that acarbose use was not associated with a higher risk of liver injury in those with uncomplicated, compensated, and decompensated cirrhosis than non-users (for uncomplicated, HR 0.71, 95% CI 0.30.65; for compensated, HR 0.3, 95% CI 0.081.36; for decompensated, HR 1.94, HR 0.1722) (Table (Table3).3). Google Scholar. 2017;377(15):1496. and transmitted securely. New Eng J Med. Similar results were obtained in those with cirrhosis (Table (Table2).2). A total of 7 studies involving 132 in the acarbose group and 137 in placebo group, 269 subjects in total, were included in this meta-analysis. 2021 Aug;38(8):4603-4604. doi: 10.1007/s12325-021-01653-6. Endocrine. To evaluate the long-term efficacy of acarbose, an alpha-glucosidase inhibitor, in improving glycemic control in patients with non-insulin-dependent diabetes mellitus. 1998;106(03):2313. Chen Y, Guo F, Wang X, Liu L, Yang C, Xiong Y, Zhang H. Clin Pharmacol Drug Dev. 2021 Oct;10(10):1225-1230. doi: 10.1002/cpdd.921. Risk of oral antifungal agent-induced liver injury in Taiwanese. 2023 Springer Nature Switzerland AG. After selecting all acarbose users from each group, propensity score-matched non-acarbose users with a 1:2 ratio were further selected for subsequent analysis, with propensity scores constructed based upon logistic regression incorporating age, sex, comorbidities, diabetic severity, and concurrent medications. J Cardiovasc Risk. Corresponding decreases in HbA1c levels occurred; these were 0.9% in the diet alone group (P = 0.005), 0.8% in the metformin group (P = 0.011), 0.9% in the sulfonylurea group (P = 0.002), and 0.4% in the insulin group (P = 0.077). 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