Im certainly going to try sleeping without it now. Current Neuropharmacology. These include things like appetite changes, sedation, and slowed baseline metabolism. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Depending on the dose, it can cause severe problems that could be life-threatening, particularly when taken with alcohol or sedatives. Last updated on May 23, 2022. I have been on 75 mg of Trazodone at night for sleep and everyones story above is mine! After I take my trazodone, my nose gets really stuffy, I get ravenously hungry, and I experience some dizziness/clumsiness. When I stopped using it, this hunger and weight gain (and lazy mornings) resolved. Effective: It's no secret that Trazodone is effective for treating insomnia, which is why it has gained popularity as a sleep-inducing agent. I have started the medication 2 years ago. Weight gain or loss; The drug can stay in a person's system for 42 hours after the final dose. , a hazardous elevation of serotonin in the brain, with other serotonin-increasing drugs including other. Springer. There is one study I read that said the incident of weight gain goes up over time. At least there is an explanation for my weight gain. I have been on trazodone for my depression for the past 8 months and am now weighing more than I have ever. I also gained my weight in the stomach and hip area. But I keep gaining weight! If I dont take the Trazodone at night, I feel as if I have the flu the next day. If switching medications is impossible due to the developed dependence on the drug, substance abuse treatment is required. These include: Most people taking trazodone will experience transient side effects. Allow for at least 14 days to lapse between stopping MAOI treatment and initiating trazodone. Put down that pudding bowl and cheese cake!!! I weighed 139 when I first started taking it and now weigh 152. Pantoprazole (Protonix) vs. Omeprazole (Prilosec), Lexapro (Escitalopram) vs. Prozac (Fluoxetine), Pregabalin (Lyrica) vs. Gabapentin (Neurontin). I am going to speak to my doctor about weaning off of this. LOL. I was not depressed, and having been preciously prescribed Ambien over a long period of time, that was no longer an option for me. unusual bruising or bleeding. National Institutes of Health. However, compared to gaining a few kilograms, Trazodone weight loss is slightly more common. Tell your doctor if you have suicidal or self-harming thoughts, as they may increase when starting treatment, which usually takes at least two weeks to work. Its really frustrating. Many factors influence mass gain in patients on Trazodone, such as dosage, duration of the treatment, genetics, habits, or if another medication is taken concomitantly. I gained a total of 25 lbs on trazodone over a year, and about 20 of those were in the first four months. Common interactions include endocarditis among females and fall among males. Like all antidepressants, Trazodone can have side effects, including that of weight gain. Ive become hypothyroid and am now taking supplements for that. If both medicines are prescribed together, your doctor may . In a clinical trial, 5% of people who took trazodone gained weight, while 6% lost weight. I have been gaining more weight as time goes on and now Im 45 lbs over my usual weight. I am going to stop the Traz and see if this can stop both the gaining and the behaviors. Other side effects, such as sexual dysfunction or weight changes, may develop and worsen over time. AddictionResource aims to present the most accurate, trustworthy, and up-to-date medical content to our readers. I was told I have a fatty liver and have to lose weight. This allows people to determine if they can drive or perform other activities safely. Immediately talk to the prescriber or another mental health professional. About, people have reported dizziness or high blood pressure. I just brought this up with a new physician and she is the only doctor to ever consider this connection. I have hypertension, extreme dizziness at times, feel unbalanced and suffer with memory loss. There are many factors that may contribute to weight gain on Trazodone. Over what duration have you been taking Trazodone? The medication has several side effects including people complaining of fattening up, though it is not common. Trazodone has been a lifesaver for me, I get good quality sleep with it and this is very beneficial for my ability to work and feel good overall. Round and round we go, how well look nobody knows. I have been on 75mg of Trazodone and 60mg of Cymbalta since I was diagnosed with fibromyalgia in 2007. So now I am thinking that maybe I should just go off of it, hope for the best and then blame the weight gain on extra glasses of wine. You should determine whether the costs (e.g. These include things like appetite changes, sedation, and slowed baseline metabolism. A starting dose for the extended release version is 150 mg taken once daily. I am down 16 lbs by diligently eliminating sugar, flour and snacking. It belongs to a group of drugs called serotonin antagonist and reuptake inhibitors, , drugs that alter brain chemistry to permit greater control over mood. I was taking Ambien for 10 years and I had no concerns, but my regular GP retired and had to get the new one. Saphris (Asenapine) & Weight Gain: What Should You Expect? I have never had problems with weight in my life. increases. I take no other meds and while I am really glad to be sleeping again, I hate the shape I am in. I have been taking 50 mg of trazodone nightly for the last 3 months and have noticed a slow weight gain And could not understand why. For this reason, SSRIs are frequently used off-label to treat premature ejaculation. While both weight gain and weight loss side effects are relatively rare compared to its other side effects, trazodone may be more likely to cause weight loss than weight gain. young and look like Im due for little Johnny any time now. I used to use sleep to escape, but my stresses that were causing that reaction are gone, so wish me luck. These include: Drugs that speed up or slow down the bodys metabolism of. I stopped taking this drug and am trying to deal with the insomnia in my own way now. I take 100 mg at night for sleep. A starting dose for the immediate release is generally 150 mg per day taken in divided doses. https://www.dbsalliance.org/education/ask-the-doc/how-can-i-lose-weight-while-on-antidepressants/, R. Gafoor, H. Booth, M. Gulliford. stuffy nose. Ask your questions to a professional treatment provider. National Library of Medicines. Trazodone is an antidepressant. Keep in mind that these are only possibilities and aren't necessarily proven. Interesting, when I first when on it, this did not happen. (2013). 8 years of nursing experience in wide variety of behavioral and addition settings that include adult inpatient and outpatient mental health services with substance use disorders, and geriatric long-term care and hospice care. It is intended for general informational purposes and is not meant to be a substitute for professional medical advice, diagnosis, or treatment. This is accomplished by inhibiting the reuptake of serotonin using the same mechanism of action that selective serotonin reuptake inhibitors (SSRIs) use. I have tons of energy so fortunately I did not notice any change with that. As mentioned before, increasing the dosage and the drug-induced physiological alterations, lead to extra pounds. Trazodone can increase or decrease the appetite of a patient. This is not a complete list of side effects and others may occur. It has been used to help with anxiety as well, but most commonly is used off-label to take advantage of its tendency to cause sedation and help with insomnia. My desire is to wean off and have heard that Magnesium may help. It is called LDN, which stands for Low Dose Naltrexone, you can find facebook groups that can give you more information and guidance, I belong to two groups and they have been very helpful. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109660/, R. Weisler, J. Johnston, C. Lineberry, B. Samara, R. Branconnier, et al. I felt hungry and I wouldnt feel full. Trazodone affects the body in the same way, so side effects are similar to its better-known cousins like Paxil (paroxetine) and Prozac (fluoxetine). Ive been taking it for 2 months and gained 8 lbs. I got back on the treadmill, changed my diet a little and it just fell off. As with all prescription drugs, trazodone has risks. I am bipolar so the med helps with that along with alzprazolam, 150mg of cymbalta, and 150mg of bupropion a day. The FDA has approved trazodone only for use in adults. I will stop taking it as I feel weight gain will cause more health risks plus I dont feel good about myself being overweight. Knee replacement might be the only option in the long run. Talk to a healthcare provider about the best way to proceed. . Its upsetting to me & Im sure others that are suffering from the effects of this drug that you make light of their weight gain. I finally decided my weight gain was as detrimental to my health as my insomnia. A. medical review of trazodone for depression was published in the CNS Drugs journal. Quitting the trazodone and like you blaming the extra weight gain on a glass of wine. Be careful about driving and other risky activities. Others might require. Impotence, however, is a rare problem in people taking trazodone, occurring in less than 2% of participants in the initial clinical trials. https://www.bap.org.uk/articles/antipsychotic-medication-and-weight-gain/, Blurt. If you or anyone you know is undergoing a severe health crisis, call a doctor or 911 immediately. It worked. Good luck to everyone who isnt as lucky as you. How Depression Can Affect Our Senses. I prefer insomnia to weight gain. (2018). I told my therapist, and although not a common side effect, it appeared that this was related to the medication. I exercise daily, mostly eat fruit when I crave sweets, and only all natural peanut butter. For the most part, trazodone is thought to come with a lower risk of weight gain than some other types of antidepressants. She devoted her life to the study of the connection between crime, mental health, and substance abuse. Free and confidential consultations about: Join our addiction treatment communities: This site complies with the HONcode standard for trustworthy health information. When you double the dose, you are essentially doubling the likelihood that youre going to gain weight. So, no matter how healthy the patient is eating and how much one exercise, they could still experience fleshing out. Journal of Clinical Medicine. In some patients losing weight is temporary and will eventually lead to getting heavier if the treatment extends over several months or years. Many people believe that the antagonism effect that the drug has on various serotonin receptors essentially cancels out some of the weight gain that would occur if its mechanism of action were solely that of serotonin reuptake inhibition. The first and best way to avoid problems taking trazodone is to make sure the prescribing healthcare provider has a complete medical history before the first pill is taken. Robin my life totally mimicked yours down to our jobs and car accident. Our writers and reviewers are experienced professionals in medicine, addiction treatment, and healthcare. Other antidepressants make patients put on extra pounds as well. However, does Trazodone cause weight gain? Im 50 years old ? But as the subject line says, I'm scared to try it for this reason, and I'm wondering that if anyone experiences that, did that side effect ever go away. Information on the exact way it works is limited, but scientists believe it is related to the hormones sent from the fat(adipose) tissue and the stomach to the hypothalamus. weight gain) outweigh the benefits (e.g. (n.d) How Can Lose Weight While on Antidepressants?. Free & Confidential 24/7 Treatment Hotline. Trazodone is also never combined with the antipsychotic medications pimozide or thioridazine, or the HIV/AIDS drug saquinavir. I recently started taking Trazodone for stress related insomnia. Self-detox is dangerous. A weight gain of 40 pounds has led to a variety of serious illnesses. Buy Trazodone Tablets Online - Free Worldwide Shipping Trazodone is an oral state of mind elevator considered depression, anxiety (when it's a sign of misery), in addition to for agoraphobia, panic strikes and boosted aggressiveness. including sexual dysfunction, can be expected to resolve shortly after the drug is discontinued. I couldnt get enough food. I have been taking Trazodone for 2 and half years for sleep at 100mg. Once the condition is relieved, the patients taste is also restored, therefore gradually putting on extra flesh is possible. Wellbutrin is a better antidepressant for people worried about weight. Even when trazodone is discontinued, people may experience long-term problems from taking the drug. I was about 118 when I began and now weigh in at 155. is discontinued, people may experience long-term problems from taking the drug. The review cited over 100 clinical trials, and concluded that the drug is "effective and well tolerated" for treating depression. Trazodone helps take the edge off of some wicked withdrawal symptoms that are often reported such as inability to fall asleep, or broken sleep throughout the night. I eat mostly whole foods, & Im very healthy. . I recently dropped the dosage to 50mg as I was more tired in the mornings than I was prior. I have been taking 150 mg of Trazadone for insomnia for the past two years. To treat the addition of excess weight, patients are advised to seek help from a medical doctor. At this frequency, its easy to miss a dose or take an extra dose, so it helps to use an alarm or app to make sure doses are taken correctly. Was on it for ~6 months, weight . Im also sedentary because Ive been unable to exercise because of two neck surgeries in the last 4.5 years. Regardless of the variation of the drug you are taking, a higher dose makes it more likely that youll gain weight. As already discussed, Trazodone side effects weight gain occurs during the treatment of depression. Although the changes can be gradual and subtle, they can still affect the weight. I eat so much its ridiculous but still go to bed knowing I could eat more. The new doctor refused to continue prescribing Ambien. Now on month two and gained 7 pounds. I am currently at 182 ponds (my average weight was around 155) . This is due to the fact that at higher doses, side effects are more likely. I have a low-carb, high protein diet and exercise for about 6 hours a week so the weight gain is unexpected. Higher doses can produce more severe side effects. The dose of trazodone taken helped initially with sleep, but I have noticed I am still awake 4 hours after taking this dose often now. I did quit smoking around the same time and I expected to gain ten pounds as a result of that alone. Prescription Medications & Weight Gain. The dose has been 150 mg for most of this period. The good news is that most people will experience a return of genital sensitivity, sexual desire, and sexual function when, is stopped. I was 30 pounds above my ideal weight, but I think I have gained even more in the past 6 months. I am going to stop this stuff. Other antidepressants are more highly associated with weight gain than trazodone. Talk about feeling like Im on my own island! My appetite is enormous. These patients will need to be monitored closely for behavior changes. I was eating for 2 hours after work. I am now tapering off of it again and my appetite is back to normal. However, be sure to seek medical information before stopping a medication cold turkey due to fleshing out. If you notice any other effects, check with your healthcare professional. Trazodone: A Medicine to Treat Anxiety and Depression. I believe my insomnia was attributed to the high stress of my work and now that I am retired hopefully things will return to normal. :( Ive never had a tummy problem before. (2013) Trazodone Antidepressant, Used by Aaron Alexis, Described As Very Safe. -Pam. Trazodone side effects include weight gain, sexual dysfunction, and urinary incontinence, Oxybutynin side effects include dry mouth, dizziness, and constipation. I cant stand living like this, but am afraid to wean off the Trazodone because of the pain. If youve gained a lot of weight and the drug doesnt seem to be helping your depression, anxiety, or insomnia, you may want to consider switching medications and/or Trazodone withdrawal. Now I weigh 63kg I am trying everything to lose it, but actually I feel so much happy and friendly, so the battle in losing it is failing completely. One potential explanation is that people may experience an increase in appetite as their depression eases, resulting in weight gain. Therefore, the longer the treatment period, the higher the risk of alterations. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964332/, University of Michigan Health. I have been so depressed and lethargic, especially in the A.M. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It is important to avoid placing full blame on the drug if you have changed certain aspects of your lifestyle. Additionally, it is possible that both Trazodone and the other drug are eliciting effects that lead to weight gain. How long does it take for trazodone to work? To all the above commenters, I sincerely wish you the best of luck in this crap-shoot. Paxil and Weight Gain: 24 lbs In 6 to 12 Months? I am up to 400 mg per day and am now 274 Pounds!!! does require emergency medical help. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850471/, OAC. But it has been slow. Also, I am taking Fluoxetine which I started at the same time. A study made on the medication showed that patients gained about 1.2-lb within the first six weeks of treatment. It is very inexpensive but you have to have a compounding pharmacy make it for you. This is the most serious warning from the Food and Drug. Ive gained 18 pounds even with my exercise routine. Things I bought 6 months ago are too tight now. Katy, I am also taking Trazodone to help me sleep at night and have been gradually gaining weight. Only trained and licensed medical professionals can provide such services. I am an anorexic and this is driving me nuts. Call your doctor for medical advice about side effects. Review/update the information highlighted below and resubmit the form. problems with thinking, concentration, or memory. does show up in breast milk, there is no evidence that it will harm a nursing baby. Depression scores improved in the majority of the trials. It is classified as an atypical antidepressant that functions as a SARI (serotonin antagonist and reuptake inhibitor). This medication has been on the market since 1981 and is approved for the treatment of major depressive disorder in adults. The serotonin effects of trazodone occur within half an hour of taking a dose, so side effects such as drowsiness, dry mouth, dizziness, trouble sleeping, nausea, urinary incontinence, blurred vision, genital numbing, and similar side effects are sometimes experienced early or even after the first dose. In some cases, these issues can be risky enough that, with these other drugs. However, it is always important to consider that other drugs could eventually cause weight gain when used over time. I came across this just by chance and all the comments hit home. could make driving and other risky activities more dangerous. When I started at a dosage of 50 mg per day I was 200 pounds. Dont leave anything out, but make sure that the prescriber knows about: Drug interactions are another source of side effects when taking trazodone, so tell the prescribing healthcare professional about all prescription drugs, over-the-counter medications, and supplements being taken, especially: If there are problems, talk to a healthcare professional before quitting trazodone. Compare bipolar 1 vs. 2, how it is treated, and how to support a loved one with bipolar disorder. It is very risky to stop taking the medication cold turkey. These include things like: the dosage you are taking, personal factors (e.g. Does Tolerance Develop To The Sedative and Amnesic Effects of Antidepressants?. The drug worked great for sleep but I have gained 26 pounds in the past 18 months. It belongs to a group of drugs called serotonin antagonist and reuptake inhibitors, drugs that alter brain chemistry to permit greater control over mood. 2023 SingleCare Administrators. Now things make so much sense. I cant exercise as I am full of arthritis, especially in the hips and lower back. Some patients experience a drop in motivation due to Trazodone, although their insomnia or physics improves. If you have any other thoughts or theories as to what may have lead to an increase in weight from this drug, be sure to leave a comment. I am a fitness instructor and I take 50 mg of trazodone to sleep. Other patients might experience cravings for specific types of food, such as carbohydrates or fat. I am fat as a pig! Trazodone is an older generation antidepressant that is approved to treat major depressive disorder. This allows people to determine if they can drive or perform other activities safely. Suicidality and. As already stated, one of the less common side effects of the drug is plumping up or emaciation. I have RA. I did gain weight. Over time, your physiology will become more altered as a result of using the drug. Among, , heart problems can occur early and unexpectedly, particularly changes in the hearts rhythm. Trazodone weight gain is a rare side effect. I stopped taking the antidepressant about a year & 1/2 ago. This means that the body has difficulty in maintaining a normal appetite and healthy metabolism, which may even lead to Trazodone overdose. Addiction Resource does not offer medical diagnosis, treatment, or advice. The huge downfall is the weight gain I have gained 30 pounds in 3 months with no change in diet. Combining these drugs will require closer monitoring and vigilance. advise that these activities be put on hold for a few days when first taking. Trazodone is one of many medications used to treat depression. 8 Answers Sort by CH Chelsie123 19 Feb 2022 I am taking trazodone for depression and anxiety. 100ml Pill Bottle plastic PET - Color Clear - Seal-proof Lid No lid x 2: 265.24$ 150ml Round Bottle Amber PET - Cap PP 28mm Cap pp28 evident sea.. x 1: 139.28$ 50 ml Dropper Bottle Glass Blue - Cap 18mm BL Cap evident seal x 1: 50.70$ 500ml Container Cylindrical PP But I kept taking the Traz, I cut back to 50 mgs in the last year just because I know its not good for me. It was a helpless feeling. Note: It is important to keep in mind that weight gain may be due to a combination of these possibilities. A nutritionists advice may be needed. When it comes to Trazodone classification, this antidepressant is from the drug class which is called serotonin modulators, which means that it stimulates serotonin, a natural brain chemical responsible for maintaining mental balance. I take Trazodone to help me stay asleep and it does do the job. Im going to experiment with ways to control this effect with L-glutamine and also will try to minimize taking it. Combining these drugs will require closer monitoring and vigilance. But the weight gain is out of control and Im not willing to keep buying bigger clothes. There are some people that take this drug and end up losing weight, and many people who end up experiencing no change in weight. I started taking Trazodone for sleep about 18 months ago. Share your story in our Addiction Treatment Communities. He did upper my dose from 100 to 200mgs and I feel amazing. I did not know it could cause weight gain. Women and depression: Does gender matter. . I just started doing some reading on the side effects of trazodone after I noticed some abdominal weight gain. Among serious side effects, heart problems can occur early and unexpectedly, particularly changes in the hearts rhythm. The medication is more likely to cause weight loss than plumping up according to research. Ive been on Trazodone for about two years and have gained 40 pounds. Many antidepressants also slow down metabolism. And does anyone know how long I can expect this weight gain to carry on for? Any other medication taken while on Desyrel could interact synergistically and amplify a particular side effect such as getting heavier. At the top of the prohibited list are. Later research indicates the incidence may be as high as 5%, although research suggests that as much as 6% of patients experience. I dread the thought that I will continue to gain weight indefinitely :(. It feels like I never get enough to eat, once I start eating, it is so hard to stop. If there are problems with sexual function, get medical advice from the, only rarely experience urinary incontinence as a, , but the incidence is between 0% and 1%, depending on the study. Ive been talking to myself lately about how disgusted I am with the weight I have put on. I have a total gym that I have totally not been using because I am so depressed about my weight gain and I feel very lazy, no motivation. such as sleepiness, fatigue, and dizziness. In clinical trials, there was a clear connection between taking Trazodone and gaining weight. I had to leave my hometown for a few weeks and had left all my medication at home with trazodone being one of them. Low-dose Trazodone antagonizes 5-HT-2A receptor, H-1 receptor, and alpha-1 adrenergic receptors to produce a sedative effect. It is a reported side effect, but the incidence is between 0% and 1%, depending on the study. The initial 50 mg dose did not work, but the 100 mg does for sleep, but I can no longer bare the weight gain and am technically considered highly obese. Antidepressant Utilisation and Incidence of Weight Gain During 10 years Follow-up: Population-based Cohort Study. But if I felt better Id exercise more.Doctors and drug manufacturers mean well. :-). I also experienced swelling, sweating, blocked nose, dry mouth, nightmares, headaches, uncontrolled twitching. This article is not medical advice. The signs are psychiatric and neurological: agitation, restlessness, hallucinations, tremors, stiff muscles, and problems with coordination. If urinary incontinence is a problem, keep in mind that there may be other causes besides, . Call our free and confidential helpline. I was told it would have the opposite effect and would help me. Alcohol will worsen many of the sedative effects of trazodone such as sleepiness, fatigue, and dizziness. Reviewed by Michael Espelin APRN Trazodone is an antidepressant that works in the brain to help treat anxiety and depression. I, too, am having an unreasonable amount of weight gain on Trazodone and cravings for carbs and sweets. Also, depression may cause tiredness and lack of activity which may, in turn, cause patients to put on extra pounds. When. An overdose of trazodone will require emergency medical care. Has anyone gone back to the weight they were before taking Trazodone? Depending on the dose, it can cause severe problems that could be, , particularly when taken with alcohol or, such as excessive sweating, nausea, irritability, anxiety, agitation, dizziness, confusion, headache, mood swings, ringing in the ears, and even seizures. Thank you to every one of you, especially the author of this article. Trazodone Information for Healthcare Professionals. ) how can lose weight while on antidepressants? of 40 pounds has led a... 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