This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Do not start, stop, or change the dosage of any medicines without your doctor's approval. At first lowered pressure, then did not work as well. You may report side effects to Health Canada at 1-866-234-2345. If you miss a dose, use it as soon as you remember. Store at 15C to 25C (59F to 77F). View NDC Code(s)NEW! The mean peak plasma concentration following morning dosing was 0.46 ng/mL and following afternoon dosing was 0.35 ng/mL. It is difficult to navigate the dropper to exactly the eye/bulge, but the drops do work with very little side effects. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. Symptoms of overdose may include: trouble breathing or slow/irregular heartbeat. Before each use, shake once and remove the screw cap. This medicine is a colorless, clear, drops, timolol maleate 0.5 % once daily eye drops, Select a condition to view a list of medication options. This drug passes into breast milk. Masked symptoms of hypoglycemia in diabetic patients [see Warnings]. The maximum effect usually occurs in one to two hours and significant lowering of intraocular pressure can be maintained for periods as long as 24 hours with a single dose. Some products that may interact with this drug include: oral beta-blockers (such as propranolol), clonidine, certain antidepressants (including SSRIs such as fluoxetine), digoxin, epinephrine, methyldopa, quinidine. This medication works by decreasing the amount of fluid within the eye. Talk to your pharmacist for more details. Timolol maleate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Patients with chronic obstructive pulmonary disease (e.g., chronic bronchitis, emphysema) of mild or moderate severity, bronchospastic disease, or a history of bronchospastic disease [other than bronchial asthma or a history of bronchial asthma in which Timolol Maleate Ophthalmic Solution 0.5% is contraindicated] should, in general, not receive beta-blocking agents, including Timolol Maleate Ophthalmic Solution 0.5%[see Contraindications (4.1)]. Use your next dose at the regular time. Some patients receiving beta-adrenergic receptor blocking agents have experienced protracted severe hypotension during anesthesia. I talked to my pharmacist and he recommended Timolo maleate as a generic option. If you wear contact lenses, remove them before using the eye drops. Avoid freezing. If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. Updated If you are using another kind of eye medication (such as drops or ointments), wait at least 10 minutes before applying other medications. Wait several minutes for your vision to clear before driving or operating machinery. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Canada residents can call a provincial poison control center. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Dizziness, increase in signs and symptoms of myasthenia gravis, paresthesia, somnolence, insomnia, nightmares, behavioral changes and psychic disturbances including depression, confusion, hallucinations, anxiety, disorientation, nervousness, and memory loss. After you apply this drug, your vision may become temporarily blurred. This product does not contain a preservative. Sympathetic stimulation may be essential for support of the circulation in individuals with diminished myocardial contractility, and its inhibition of beta-adrenergic receptor blockade may precipitate more severe failure. If directed to use this medication in both eyes, repeat these steps for your other eye. Files, All Mapping Biochemical Data Summary. If the patient's intraocular pressure is still not at a satisfactory level on this regimen, concomitant therapy with other agent(s) for lowering intraocular pressure can be instituted. This medication is used to treat high pressure inside the eye due to glaucoma (open angle-type) or other eye diseases (such as ocular hypertension ). For example, severe respiratory reactions and cardiac reactions including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, have been reported following systemic or ophthalmic administration of timolol maleate[see Contraindications (4.1)]. Patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta-adrenergic blocking agents that might precipitate a thyroid storm. Do not double the dose to catch up. FDA Safety Recalls, Timolol has been detected in human milk following oral and ophthalmic drug administration. Teratogenicity studies with timolol in mice, rats, and rabbits at oral doses up to 50 mg/kg/day (7,000 times the systemic exposure following the maximum recommended human ophthalmic dose) demonstrated no evidence of fetal malformations. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. It has a pH of 6.5 to 7.5 and an osmolality of 275 to 330 mOsm/kg. The onset of reduction in intraocular pressure following administration of timolol maleate ophthalmic solution can usually be detected within one-half hour after a single dose. During pregnancy, this medication should be used only when clearly needed. Things to remember when you fill your prescription. While taking beta-blockers, patients with a history of atopy or a history of severe anaphylactic reactions to a variety of allergens may be more reactive to repeated accidental, diagnostic, or therapeutic challenge with such allergens. ChildrenUse and dose must be determined by your doctor. I talked to my pharmacist and he recommended Timolo maleate as a generic option. blood pressure and heart rate for years so the charting was helpful in relating this drop in heart rate to the eye drops.. 6 . In both groups, mean intraocular pressure decreased from 25 mm Hg at baseline to 18 mm Hg at peak and 19 mm Hg at trough. )Need to find some thing less costly. Timolol Maleate Ophthalmic Solution 0.5%, when applied topically in the eye, has the action of reducing elevated as well as normal intraocular pressure, whether or not accompanied by glaucoma. Timolol maleate is a beta1 and beta2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. If it is near the time of the next dose, skip the missed dose. Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may result in vertigo, syncope, or postural hypotension. Timolol (tye-MOE-lawl) Maleate Timolol is a beta-blocker that also reduces pressure inside the eye. Choroidal detachment after filtration procedures has been reported with the administration of aqueous suppressant therapy (e.g., timolol). Check your blood sugar levels regularly as directed by your doctor. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. See full prescribing information for TIMOLOL MALEATE OPHTHALMIC SOLUTION. If necessary during surgery, the effects of beta-adrenergic blocking agents may be reversed by sufficient doses of adrenergic agonists. 9. Some patients receiving beta-adrenergic receptor blocking agents have experienced protracted severe hypotension during anesthesia. Retroperitoneal fibrosis, decreased libido, impotence, and Peyronie's disease. Keep timolol maleate ophthalmic solution and all medicines out of the reach of children. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. In patients with impaired cardiac function, coadministration should be avoided. Timolol Maleate Ophthalmic Solution 0.5% was generally well tolerated, and 3% of patients had treatment discontinued for adverse events judged related to treatment. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. Wait at least 15 minutes after using this medication before putting in your contact lenses. There have been no reports of exacerbation of rebound hypertension with ophthalmic timolol maleate. Files, Presentations Beta-adrenergic receptor blockade reduces cardiac output in both healthy subjects and patients with heart disease. Timolol Maleate Store at room temperature away from light and moisture. Timolol maleate has little or no effect on the pupil. At the first sign or symptom of cardiac failure, Timolol Maleate Ophthalmic Solution 0.5% should be discontinued[see Contraindications (4.2)]. is this? If any of these effects last or get worse, notify your doctor or pharmacist promptly. Manufactured by: PubMed, I have open angle glaucoma & since taking Timolol for a few years I have found my hair coming out & dizziness, I kept telling the eye consultant of this but dont think they really take in what I am saying so I have now decided to stop the Timolol & stick to Latanoprost & I also take Ginkgo Bilbos 1 capsule with dinner to see if that helps. Timolol has been reported rarely to increase muscle weakness in some patients with myasthenia gravis or myasthenic symptoms. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Store at room temperature. Preservative added: benzalkonium chloride (0.05 mg/mL). Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss. Tonography and fluorophotometry studies in man suggest that its predominant action may be related to reduced aqueous formation. Patients should also be instructed that ocular solutions, if handled improperly or if the tip of the dispensing container contacts the eye or surrounding structures, can become contaminated by common bacteria known to cause ocular infections. In a study of plasma drug concentration in 12 healthy subjects, the systemic exposure to timolol was determined following twice daily administration of Timolol Maleate Ophthalmic Solution 0.5% (exaggerated regimen) for eight days. With the hand holding the bottle, place your index finger on the bottom of the bottle. Biochemical Data Summary. One drop of Timolol Maleate Ophthalmic Solution 0.5% should be administered in the affected eye (s) once a day in . 2005 - 2023 WebMD LLC, an Internet Brands company. Timolol Maleate Ophthalmic Solution 0.5% is a non-selective beta-adrenergic receptor blocking agent indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. In the US - Call your doctor for medical advice about side effects. Increased fetal resorptions were also seen in rabbits at doses of 14,000 times the systemic exposure following the maximum recommended human ophthalmic dose, in this case without apparent maternotoxicity. If you are using another kind of eye medication (such as drops or ointments), wait at least 10 minutes before applying other medications. Gently press your finger on the inside corner of your eyelid for at least 2 minutes. The concomitant use of beta-adrenergic blocking agents with digitalis and calcium antagonists may have additive effects in prolonging atrioventricular conduction time. 61314-226-05, Citations, Instructions for Use High Eye Pressure or Glaucoma that May Worsen without Treatment (10 reviews), Increased Pressure in the Eye (3 reviews), In an annual eye exam, my eye doctor was concerned with the high eye pressure readings (30). Keep all medications away from children and pets. Timolol Maleate Ophthalmic Solution 0.5% contains timolol maleate; and although administered topically, it can be absorbed systemically. It is a white, odorless, crystalline powder which is soluble in water, methanol, and alcohol. Important information about timolol maleate ophthalmic solution: How should I use timolol maleate ophthalmic solution? Sympathetic stimulation may be essential for support of the circulation in individuals with diminished myocardial contractility, and its inhibition of beta-adrenergic receptor blockade may precipitate more severe failure. Enter your medication into the WebMD interaction checker, an aggressive form of glaucoma called malignant glaucoma, increased pressure in the eye in the absence of a lens, increased eye pressure caused by another disease, a tumor formed of blood vessels in a child 0-11 months old, FDA Labeling for timolol maleate drops on RxList. The usual starting dose is one drop of timolol maleate ophthalmic solution 0.25% in the affected eye(s) twice a day. Do not share this medication with others. Timolol maleate is stable at room temperature. Notify your doctor reported with the administration of aqueous suppressant therapy ( e.g., timolol ) following oral and drug., it can be absorbed systemically of rebound hypertension with ophthalmic timolol maleate ophthalmic solution %... 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