Available at: 18. WebTenofovir alafenamide (TAF, Vemlidy) is a prodrug of tenofovir, which is indicated for the treatment of chronic hepatitis B (HBV) in adults with compensated liver disease. Talk to your doctor about the risks of taking tenofovir. One hundred and forty-six patients with TAF-to-TDF switch (Switch group) were compared with 146 patients matched for sex, age, and third antiretroviral agent class who continued unchanged TAF-containing regimen (Control group). For booster agents, cobicistat was used more frequently in Control than Switch group, whereas ritonavir use was similar between the groups. 14. Author to whom correspondence should be addressed. Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus. Lengauer, H.; Makuc, D.; terk, D.; Perdih, F.; Pichler, A.; Trdan Luin, T.; Plavec, J.; asar, Z. Co-crystals, salts or mixtures of both? Hanttu et al. Vemlidy is indicated for the treatment of CHB in ; Lang, J.-P. Counterintuitive solid-state syntheses of indium-thiolate-phen cations as efficient and selective fluorescent biosensors for HIV-1ds-DNA and Sudan Ebolavirus RNA sequences. During the study period, lipid lowering medication was started for 11 patients in Switch group and for 17 patients in Control group (P = 0.191). ; Hitchcock, M.J.M. [. This is a retrospective study evaluating the effects of switching from TAF to TDF on plasma lipid concentrations, cardiovascular risk score, body weight, and other laboratory parameters. For correlation analyses Pearson's r and Spearman's were conducted, as appropriate. ; Sibeko, S.; Mlisana, K.P. : Honoraria, lecture fees, and conference support from Gilead, Merck and GSK/ViiV. The decrease in LDL-C from BL to FU-2 in Switch group did not reach statistical significance (P = 0.079). It was developed by Gilead Sciences based on the protide technology of Chris McGuigan for use in the treatment of HIV/AIDS and chronic hepatitis B, and is applied in the form of tenofovir alafenamide fumarate (TAF). Get new journal Tables of Contents sent right to your email inbox, http://creativecommons.org/licenses/by/4.0, https://www.eacsociety.org/guidelines/eacs-guidelines/, https://tools.acc.org/ldl/ascvd_risk_estimator/index.html#!/calulate/estimator/, QAD_2022_04_25_KAUPPINEN_AIDS-D-22-00002_SDC1.docx; [Word] (16 KB), QAD_2022_04_25_KAUPPINEN_AIDS-D-22-00002_SDC2.docx; [Word] (17 KB), QAD_2022_04_25_KAUPPINEN_AIDS-D-22-00002_SDC3.docx; [Word] (13 KB), QAD_2022_04_25_KAUPPINEN_AIDS-D-22-00002_SDC4.docx; [Word] (16 KB), Switching from tenofovir alafenamide to tenofovir disoproxil fumarate improves lipid profile and protects from weight gain, Articles in PubMed by Kai Juhani Kauppinen, Articles in Google Scholar by Kai Juhani Kauppinen, Other articles in this journal by Kai Juhani Kauppinen, High efficacy of switching to bictegravir/emtricitabine/tenofovir alafenamide in people with suppressed HIV and preexisting M184V/I, Relationship between weight gain and insulin resistance in people living with HIV switching to integrase strand transfer inhibitors-based regimens, Switch back from TAF to TDF or rather switch forward from metabolic toxicities of drugs to metabolic health of people living with HIV, No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART, Trends in diabetes incidence and associated risk factors among people with HIV in the current treatment era, Privacy Policy (Updated December 15, 2022). However, you should not flush this medication down the toilet. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. This difference, albeit statistically nonsignificant, was probably driven by the 5-year age difference between the groups. The groups were matched for sex, age (10 years), ethnicity, and third ART class. Gotham, D.; Hill, A.; Pozniak, A.L. Drug information Pronounce: Tenofovir Alafenamide Other Names Vemlidy, TAF, tenofovir alafenamide fumarate Drug Class Antiviral (Hepatitis B Virus Nucleoside Tenofovir disoproxil fumarate (tenofovir DF) can cause serious, life-threatening side effects. Rezaei, T.; Khalili, S.; Baradaran, B.; Mosafer, J.; Rezaei, S.; Mokhtarzadeh, A.; de la Guardia, M. Recent advances on HIV DNA vaccines development: Stepwise improvements to clinical trials. ; Amini, M.M. Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). Consequently, a switch from TDF to TAF seems to increase body weight [1215]. Zhao, H.-Q. Do not let anyone else take your medication. Mallon PW, Brunet L, Hsu RK, Fusco JS, Mounzer KC, Prajapati G, et al. It estimates 10-year risk for ASCVD, defined as coronary death or nonfatal myocardial infarction, or fatal or nonfatal stroke based on age, sex, race, TC, high-density lipoprotein cholesterol (HDL-C), systolic blood pressure, blood pressure lowering medication use, diabetes status, and smoking. Data are given as mean (standard deviation). Pues viagra para ti", espet Gustavo al funcionario policial que le llam hace unas semanas por telfono, habindose acreditado el agente previamente. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. It serves as the key component of Genvoya, Human immunodeficiency virus infection (HIV), also known as acquired immune deficiency syndrome (AIDS), is an infectious disease that involves the production of new DNA genome from RNA genome via the viruss own reverse transcriptase enzyme [, In current medical practice, inhibiting the retroviral process is a major approach to suppressing the replication of viruses to minimize liver damage when modulating immune system dysfunction in HIV [. TDF as part of preexposure prophylaxis (PrEP) slightly decreased body weight [9], whereas TAF has been associated with body weight increase [10,11]. Correspondence to Kai Juhani Kauppinen, Haartmaninkatu 4, PO Box 372, 00029 Helsinki University Hospital, Helsinki, Finland. Ask your health care provider if there are interactions between tenofovir alafenamide and the other medicines you take. International Journal of Molecular Sciences. The decrease in TC and HDL-C from BL to FU-2 remained statistically significant in Switch group. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. This work was supported by the Finnish Subsidy for Health Science Research and Finnish Society for Study of Infectious Diseases. Contact your health care provider right away if you have any of the following symptoms that could be Ruderman SA, Crane HM, Nance RM, Whitney BM, Harding BN, Mayer KH, et al. Nevertheless, no significant correlations were observed between baseline age and the within group changes in primary variables, which was the main focus of our study. The recommended uses may not always be consistent with FDA-approved uses of tenofovir alafenamide. Candidates for inclusion in a universal antiretroviral regimen: Tenofovir alafenamide. All lipid values, including LDL cholesterol, were measured directly using enzymatic methods from Abbot Laboratories (Lake Bluff, Illinois, USA). Before taking tenofovir alafenamide, tell your health care provider: Ask your health care provider about possible side effects from tenofovir alafenamide. [40][41][42] The FDA approved the TAF-based treatment regimen for treatment of HIV-1 in November 2015. The percentage change in weight did not correlate with percentage change in LDL cholesterol or other lipid parameters. However, spot urine sample proteinuria increased slightly in Switch group, indicating the importance to monitor kidney function even among these patients. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Yuan, F.-L.; Yuan, Y.-Q. Conceptualization, G.T. The median (IQR) time between the baseline measurement and TAF-to-TDF switch was 4.6 weeks (1.615.9). Since the co-crystal and salt are distinctive classes of pharmaceutical solids and have significant regulatory implications, our work here exhibits a definitive advantage in clarifying the real identity of the drug when other spectroscopic tools fail. In order to be human-readable, please install an RSS reader. bictegravir sodium), 200 mg of emtricitabine (FTC), and 25 mg of tenofovir alafenamide (TAF) (equivalent to 28 mg of tenofovir alafenamide fumarate). If you become pregnant while taking tenofovir, call your doctor. Npoje s vysokm obsahom antioxidantov, ako s vitamny C a Liaw, Y.F. Your doctor may test you to see if you have HBV before you begin your treatment with tenofovir. 10479810, 19 November 2019. Tenofovir DF and tenofovir AF may cause other side effects. Sax, P.E. Data on body weight are shown in Table 4. Where can I find more information about tenofovir alafenamide? What special dietary instructions should I follow? Statistical analyses were carried out using SPSS version 27 (SPSS, Inc., Chicago, Illinois, USA). Editors select a small number of articles recently published in the journal that they believe will be particularly Lesbats, P.; Engelman, A.N. The median (IQR) risk score decreased from 6.3% (2.411.5) at baseline to 6.0% (3.211.4) at FU-2, P = 0.012, in Switch group and increased from 8.4% (3.014.8) to 9.1% (4.6 15.6), P = 0.162, respectively in Control group. In addition, we did not have data on adherence which would have been interesting for the increasing number of tablets in some cases after the switch. tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. In Switch group at FU-1, total cholesterol (TC) and LDL-C decreased 12.1% and 12.4% (P < 0.001 in both), respectively. Abdool Karim, Q.; Abdool Karim, S.S.; Frohlich, J.A. ; Kharsany, A.B.M. ; methodology, J.-W.W. and L.L. dietary measures or lipid lowering medication) a similar cardiovascular risk reduction is observed [20]. However, in both groups, there was a statistically significant increase in LDL-C between FU-1 and FU-2 timepoints, the reason of which remains unclear. The specific reasons for the TAF-to-TDF switches were not systemically registered, but it was mainly due to economic reasons after the availability of generic TDF preparations in Finland. Daily oral emtricitabine (FTC, F)/tenofovir disoproxil fumarate (TDF) combination is approved for HIV pre-exposure prophylaxis (PPrEP) in men and women. Tenofovir alafenamide fumarate (TAF) is a newer, more potent prodrug of tenofovir (TFV), and in combination with FTC, has recently been approved for prevention of HIV through rectal transmission. Research grant from Gilead and Merck. Tenofovir alafenamide fumarate (TAF), a new prodrug of tenofovir and a potential successor of tenofovir disoproxil fumarate (TDF), has been approved in the United States and Europe for treating adolescents and adults with chronic hepatitis B infection. 25. Glidden DV, Mulligan K, McMahan V, Anderson PL, Guanira J, Chariyalertsak S, et al. ; Panicker, C.Y. If control participants had more lipid measurements, FU-2 value refers to the last lipid measurements whilst remaining on the TAF-containing regimen. Do not mix tenofovir DF oral powder with liquid. The authors declare no conflict of interest. ; Wohl, D.; Yin, M.T. In the current real-world setting study, we have investigated the effect of switching from TAF to TDF on blood lipids, cardiovascular risk score, and body weight, by comparing participants who switched TAF to TDF with no other changes in the regimen to those who remained on unchanged TAF-containing regimen. Last Reviewed: September 24, 2020 Treatment with HIV medicines is called antiretroviral therapy (ART). Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.. FU-2 weights were measured a median of 105 (79131) weeks after the BL in Switch group and 100 (85108) weeks in Control group. In this uncontrolled study, the decrease observed in total cholesterol was similar to that reported in our study, albeit the observation period was shorter than ours. He armed himself with a balaclava, latex gloves, condoms and Viagra pills and posed as a cab driver in a Mercedes to roam the streets of Brighton, East Sussex. Provided in collaboration with NIHs Office of AIDS Research. Mahapatra, S.; Thakur, T.S. Tenofovir alafenamide (TAF) is a prodrug of tenofovir as a potent nucleotide reverse transcriptase inhibitor. The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Keep a supply of tenofovir DF and tenofovir AF on hand. What magnitude of clinical significance may the observed effect on plasma lipids have? This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Take the missed dose as soon as you remember it. Combinations of the nucleo(t)side reverse transcriptase inhibitors (NRTIs) emtricitabine (FTC) and either tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide (TAF) are two oral regimens with demonstrated efficacy as HIV pre-exposure prophylaxis (PrEP). In case of overdose, call the poison control helpline at 1-800-222-1222. Tenofovir DF oral powder must be added to 2 to 4 ounces of soft food such as applesauce, baby food, or yogurt. Baseline characteristics are shown in Table 1. tell your doctor if you have or ever had HIV. ; Chao, M.-Y. FU-1 value refers to the next consecutive lipid measurement at least 2 months after BL. Do not use tenofovir alafenamide if the original seal over the container opening is broken or missing. Napumpujte ho antioxidantmi a vitamnmi! These data indicate that the baseline age difference does not explain the results. Ask your pharmacist for a list of the ingredients. In the Control group, the last body weight on TAF was first recorded as FU-2 value. Uses Before taking Warnings Side effects Overdose Dosage FAQ Warning To use the sharing features on this page, please enable JavaScript. Your health care provider will tell you what to do if you have side effects. ; Lang, J.P. Metalorganic frameworks via emissive metal-carboxylate zwitterion intermediates. This medicine is available only with your doctor's prescription. Isolation of first row transition metal-carboxylate zwitterions. You should not breastfeed if you are infected with HIV or if you are taking tenofovir. In Switch group, there was no statistically significant weight change during the study period. ; Zhang, W.-H.; Young, D.J. MDPI and/or ; Kernan, M.R. Please enable scripts and reload this page. : Honoraria, lecture fees, and conference support from Gilead, Merck and GSK/ViiV. 6. Atherosclerotic Cardiovascular Disease (ASCVD) Risk Estimator by American College of Cardiology and American Heart Association. In Switch group vs. Control group, 18% vs. 21% of patients used a statin, 1% vs. 1% ezetimibe and 1% vs. 0% fibrate medication. The percentage change (median (IQR)) in TC was 12.1% (20.90), in LDL-C 12.4% (21.75.1), in HDL-C 8.2% (18.24.2), and in TG 11.1% (32.511.4). ; Favvas, E.P. Switch group switched from TAF to TDF. modify the keyword list to augment your search. Last updated on Jun 11, 2022. In Switch group, baseline value (BL) refers to the last lipid measurement while receiving TAF. Instead, the best way to dispose of your medication is through a medicine take-back program. Duplication for commercial use must be authorized by ASHP. ; Bai, H.-Z. most exciting work published in the various research areas of the journal. The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV include recommendations on the use of tenofovir alafenamide as part of an antiretroviral therapy (ART) regimen to treat both HIV and HBV infection in people with HIV/HBV coinfection. In order to focus on lipid changes directly caused by TAF-to-TDF switch, no other changes in ART were allowed during the follow-up and we excluded participants who changed their lipid lowering medication from the lipid analyses. You may be trying to access this site from a secured browser on the server. The manufacturer submitted a price of $19.55 per 25 mg tablet, which, at the recommended dose of 25 mg daily, costs $19.55 per patient per day. 5. [, Hahn, J.; Park, Y.K. Uses for Tenofovir Alafenamide In recent years, concerns have been raised about increasing obesity rates among PHIV. Language links are at the top of the page across from the title. Disclaimer/Publishers Note: The statements, opinions and data contained in all publications are solely 2020, 21, 9213. On the other hand, the weight gain in Control group was of similar magnitude than that observed in PHIV taking ART in general [21], or in general population [22]. However, it remains unclear whether the efficacy of TAF in decreasing the hepatitis B surface antigen (HBsAg) level, and In conclusion, TAF-to-TDF switch led to decreases in plasma lipid concentrations and was associated with stable body weight, whereas continuous use of TAF increased body weight. Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV, tenofovir disoproxil fumarate/tenofovir alafenamide. This product is available in the following dosage forms: Tablet Before Using The strength of this study is the fact that all PHIV at our clinic switching from TAF to TDF and meeting the inclusion criteria were included and matched with control participants continuing TAF-based regimen. Hill A, Hughes SL, Gotham D, Pozniak AL. If you experience any of the following symptoms after you stop taking tenofovir, call your doctor immediately: extreme tiredness, weakness, nausea, vomiting, loss of appetite, yellowing of the skin or eyes, dark-colored urine, light-colored bowel movements, and muscle or joint pain. Womens health is once again the center of a political ping-pong match with evidence-based science on one side and anti-choice advocates on the other. Tenofovir alafenamide (TAF) was approved in 2015 for use both in HIV and HBV infection. Clinical indications include treatment and prevention of HIV infection, usually in combination with other reverse transcriptase, protease or integrase inhibitors. Tenofovir is also approved for use in chronic hepatitis B as a single agent. Dependent samples t-test and Wilcoxon signed rank test, both with Bonferroni correction, were used as post hoc -analyses for repeated measures ANOVA and Friedman test respectively. ; Gi, K. New Tenofovir Alafenamide Succinate Salt with Endothermic Peak Measured by Differential Scanning Calorimetry, Useful in Pharmaceutical Composition. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient. Despite the reported association of excessive weight gain with the initiation of TAF and INSTIs [10,11], there are no previous data on the effect of switching away from these agents on body weight. The first look at the 'middle aged Love Island' set has been released, which has already been nicknamed the 'Viagra House' by locals after single parents searched for love This research was funded by the National Natural Science Foundation of China, grant number 51873185. Pues viagra para ti", espet Gustavo al funcionario policial que le llam hace unas semanas por telfono, habindose acreditado el agente previamente. Body weight increased from 83.4 kg at baseline to 84.9 kg at FU-2 (P = 0.025) in Control group but remained stable in Switch group (83.183.7 kg, P = 0.978). The ethics committee evaluation is not required for this type of retrospective study. A zwitterionic 1D/2D polymer co-crystal and its polymorphic sub-components: A highly selective sensing platform for HIV ds-DNA sequences. WebBetween Jan 17, 2017, and May 14, 2018, we screened 1453 individuals, of whom 1053 were enrolled: 351 participants were randomly assigned to the tenofovir alafenamide, Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. your express consent. Descriptive statistics are presented as means with standard deviations (SD), medians with interquartile ranges (IQR), or frequencies with percentages, as appropriate. At BL, the participants had received TAF medication for a median (IQR) of 76 (50103) weeks vs. 33 (2351) weeks in Switch vs. Control group, respectively. WinGX suite for smallmolecule single-crystal crystallography. Vigan, M.; Loglio, A.; Grossi, G.; Lampertico, P. Tenofovir alafenamide (TAF) treatment of HBV, what are the unanswered questions? 1 and Table 4, Supplemental Digital Content, https://links.lww.com/QAD/C503. WebVEMLIDY (tenofovir alafenamide) tablets, for oral useInitial U.S. Approval: 2015 WARNING: LACTIC ACIDOSIS/SEVERE HEPATOMEGALY WITH STEATOSIS and POST TREATMENT This switch caused a statistically significant decrease in plasma lipids, which was reflected in decreased ASCVD score, and was associated with less weight gain compared to Control group that remained on an unchanged TAF containing regimen. Zinc and cadmium complexes of pyridinemethanol carboxylates: Metal carboxylate zwitterions and metalorganic frameworks. Take tenofovir exactly as directed. WebAdditional information about drug interactions is available in the Adult and Adolescent Antiretroviral Guidelines and the HIV Drug Interaction Checker. The laboratory samples were collected after an overnight fast.Data are given as mean (standard deviation) if not stated otherwise. difficulty falling asleep or staying asleep. 12. 1996-2023 MDPI (Basel, Switzerland) unless otherwise stated. How should tenofovir alafenamide be stored? In Control group no statistically significant changes were seen. Saumoy M, Sanchez-Quesada JL, Ordonez-Llanos J, Podzamczer D. Data is temporarily unavailable. To learn more about OIs, read the HIVinfo What is an Opportunistic Infection? 23: 9213. Ask your pharmacist any questions you have about refilling your prescription. ; Liu, Q.; Zhang, W.-H.; Young, D.J. Small but statistically significant increases were notified in spot urine sample protein (U-Prot), plasma alanine aminotransferase (P-ALT), and plasma alkaline phosphatase (P-ALP) values in Switch group. 21. This is the most serious Esta actitud por Search for Similar Articles Squillace N, Ricci E, Menzaghi B, De Socio GV, Passerini S, Martinelli C, et al. Below, check out the tour dates, The groups were comparable for HIV transmission mode, time since diagnosis of HIV, and duration of ART. No changes in ART were allowed during the study period. https://doi.org/10.3390/ijms21239213, Wang J-W, Liu L, Yu K-X, Bai H-Z, Zhou J, Zhang W-H, Hu X, Tang G. On the Single-Crystal Structure of Tenofovir Alafenamide Mono-Fumarate: A Metastable Phase Featuring a Mixture of Co-Crystal and Salt. De Clercq, E. Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. articles published under an open access Creative Common CC BY license, any part of the article may be reused without Tenofovir alafenamide fumarate is a lipophilic prodrug of tenofovir which is preferentially metabolized in lymphatic tissue resulting in high concentrations of tenofovir Armaghan, M.; Lu, W.Y.J. In addition, FU-1 value was collected at a temporal midpoint between BL and FU-2. Silverman MG, Ference BA, Im K, Wiviott SD, Giugliano RP, Grundy SM, et al. Tenofovir DF is also used to treat chronic (long term) HBV in adults and children 2 years of age and older weighing 22 pounds (10 kilograms) or more. However, virologic response, a surrogate marker for adherence, remained excellent in Switch group. If you are receiving kidney dialysis treatment. People on ART take a combination of HIV medicines (called an HIV treatment regimen) every day. ; Wiebe, N.; Smith, N.; Keiser, P.; Naicker, S.; Tonelli, M. Systematic review and meta-analysis: Renal safety of tenofovir disoproxil fumarate in HIV-infected patients. Tenofovir disoproxil fumarate (TDF) has widely been used for treatment of human immunodeficiency virus (HIV) infection for almost two decades, and it remains among the preferred agents in treatment guidelines, together with a newer tenofovir prodrug, tenofovir alafenamide (TAF) [1,2]. Your doctor may test you for HIV before you begin your treatment. Department of Chemistry, Zhejiang University, Hangzhou 310028, China, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. This may cause you to develop symptoms of those infections. Switch group switched from TAF to TDF. In our study, we observed a stable body weight over 2 years among those who switched TAF to TDF, whereas continuing unchanged TAF-containing regimen led to approximately 1.5 kg weight gain during the same period. Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal.Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, Multiple requests from the same IP address are counted as one view. Be careful not to miss doses or run out of tenofovir. HIV related characteristics are shown in Table 2. ; writingreview and editing, G.T., X.H., W.-H.Z. The control participants were required to have at least two lipid measurements while taking TAF. The ASCVD score was numerically higher in Control than Switch group at baseline. Tenofovir alafenamide is an antiviral prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronichepatitis B virus infection (HBV) in adults and children 12 years of age and older who meet certain requirements, as determined by a health care provider. Shown in Table 2. ; writingreview and editing, G.T., X.H., W.-H.Z TAF seems to increase body on... And treatment of Human Immunodeficiency Virus opening is broken or missing ; writingreview and,..., Y.K provider: ask your health care provider if there are interactions between alafenamide! Guidelines for the treatment of Opportunistic Infections in Adults and Adolescents with HIV, tenofovir disoproxil fumarate/tenofovir.! Baby food, or are breastfeeding ( IQR ) time between the groups were matched for,! Pearson 's r and Spearman 's were conducted, as appropriate are breastfeeding doctor about the risks of tenofovir!, cobicistat was used more frequently in Control group, the last lipid measurements, FU-2 value = )! Temporarily unavailable HIV before you begin your treatment correlation analyses Pearson 's r and Spearman 's were conducted, appropriate... Lang, J.P. Metalorganic frameworks via emissive metal-carboxylate zwitterion intermediates co-crystal and its polymorphic:... Brunet L, Hsu RK, Fusco JS, Mounzer KC, G! Antioxidantov, ako s vitamny C a Liaw, Y.F, Brunet L, Hsu,. Statistical analyses were carried out using SPSS version 27 ( SPSS, Inc. Disclaimer, U.S. Department of and! Be authorized by ASHP carried out using SPSS version 27 ( SPSS, Inc., Chicago Illinois... Juhani Kauppinen, Haartmaninkatu 4, PO Box 372, 00029 Helsinki University Hospital, Helsinki,.. The results PO Box 372, 00029 Helsinki University Hospital, Helsinki, Finland potent reverse! 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