Do not use this medicine if you have taken other migraine medicines (eg, almotriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan, Axert, Frova, Amerge, Maxalt, or Zomig) or an ergotamine medicine (eg, dihydroergotamine, methysergide, Cafergot, D.H.E. This was unsurprising because of the small size of the study. DD method, Dropouts described. They were generally of mild to moderate severity and rarely led to withdrawal from the studies. It's important to tell your doctor or pharmacist what medicines you're already taking, including those bought without a prescription and herbal medicines, before you start using sumatriptan. The effect was greater than for the same dose of either sumatriptan or naproxen alone, but additional benefits over sumatriptan alone were not large. It is created by eHealthMe based on reports of 538 people who take Sumatriptan and Aspirin from the FDA, and is updated regularly. We assumed a statistically significant difference from control when the 95% CI of the RR of benefit or harm did not include the number one. Silberstein S, McDonald SA, Goldstein J, Aurora S, Lener SE, White J, et al. Sumatriptan (and other triptans) shouldnt be taken with MAOIs. Participants who took rescue medication were classified as withdrawals due to lack of efficacy, and details are reported under 'Use of rescue medication' (Appendix 8). Triptans. Cochrane Pain, Palliative and Supportive Care Group. One participant, who had several cardiovascular risk factors, experienced heart palpitations and was admitted to hospital after receiving sumatriptan 85 mg; the event was judged probably related to study medication (Brandes 2007 Study 1). We calculated effect sizes and combined data for analysis only for comparisons and outcomes where there were at least two studies and 200 participants (Moore 1998). PI: 4point categorical scale, with wording equivalent to none, mild, moderate, and severe; or 100 mm visual analogue scale (VAS), where less than 30 mm was considered equivalent to mild or no pain and 30 mm or greater equivalent to moderate or severe pain (. Sumatriptan can tighten your blood vessels and raise your blood pressure. Details of the main efficacy outcomes in individual studies are in Appendix 6, and of adverse events and withdrawals are in Appendix 7. Sumatriptan works by binding to serotonin 5HT1B/1D receptors and is thought to relieve migraine symptoms through inhibition of pro-inflammatory substances and a constriction of cranial blood vessels. Modest success rates for levels of PR considered useful by patients is the rule with different analgesics across many acute and chronic pain conditions (Moore 2013). Figure 1 shows the results of the updated searches. Migraine was diagnosed using standard, validated criteria, and outcomes measured were generally those recommended by the IHS as being of clinical relevance, although not all studies reported the primary outcomes we sought. Monitoring Editor: Cochrane Pain, Palliative and Supportive Care Group. We assessed the methods as: low risk of bias (study states that it was blinded and describes the method used to achieve blinding: identical tablets; matched in appearance and smell); unclear risk of bias (study states that it was blinded but does not provide an adequate description of how it was achieved). The NNT was 3.2, with 58% of participants responding compared with 27% with placebo (high quality evidence). Washout between attacks not specified, but all headache medications prohibited within 24 h of a treated attack, and AE data collected for 72 h after treatment, Sumatriptan plus naproxen 85/500 mg (1693 attacks treated), Sumatriptan plus naproxen 85/500 mg (1678 attacks treated), Sumatriptan 85 mg plus naproxen 500 mg, n = 152, Oxford Quality Score: R2, DB1, W1. We used the z test to determine significant differences between NNT, NNTp, and NNH for different groups in subgroup and sensitivity analyses (Tramr 1997). A large prevalence study in the USA found that over half of migraineurs had severe impairment or required bed rest during attacks. The cost of headache disorders in Europe: the Eurolight project. Medication was taken when pain intensity was moderate or severe. Calculating confidence intervals for relative risk, odds ratios and standardised ratios and rates. For all outcomes we carried out analyses, as far as possible, on a modified intentiontotreat basis; that is, we included all participants who were randomised and received an intervention. Comparison 1: Sumatriptan plus naproxen versus placebo, Outcome 8: Relief of functional disability at 2 h, Comparison 2: Sumatriptan plus naproxen versus sumatriptan alone, Outcome 8: Relief of functional disability at 2 h, Comparison 3: Sumatriptan plus naproxen versus naproxen alone, Outcome 8: Relief of functional disability at 2 h, Stable (no update expected for reasons given in 'What's new'), Comparison 1: Sumatriptan plus naproxen versus placebo, Outcome 1: Painfree at 2 h, Comparison 1: Sumatriptan plus naproxen versus placebo, Outcome 2: Headache relief at 2 h. ACE: angiotensinconverting enzyme; AE: adverse event; ARB: angiotensin receptor blocker; DB: doubleblind; DD: double dummy; h: hour; IHS: International Headache Society; ITT: intention to treat; MAOI: monoamine oxidase inhibitor; N: number of participants in study; n: number of participants in treatment arm; NSAID: nonsteroidal antiinflammatory drug; PC: placebocontrolled; R: randomised; SJW: St John's Wort; W: withdrawals. Where the data allowed direct comparison, combination treatment was superior to either monotherapy, but adverse events were less frequent with naproxen than with sumatriptan (moderate quality evidence). sharing sensitive information, make sure youre on a federal Two studies provided data comparing sumatriptan plus naproxen versus both sumatriptan and naproxen alone (Brandes 2007 Study 1; Brandes 2007 Study 2). The proportion of participants with a 24hour sustained painfree response with sumatriptan alone was 14% (135/949; range 11% to 16%). Overall, the mean age of participants ranged from 36 to 43 years, and between 85% and 100% were female. Moore RA, Gavaghan D, Tramer MR, Collins SL, McQuay HJ. The combination could lead to dangerously high blood pressure. It may also be possible to achieve a good response with lower doses of one or both drugs. Moore RA, Smugar SS, Wang H, Peloso PM, Gammaitoni A. Numbers-needed-to-treat analyses - do timing, dropouts, and outcome matter? It metabolizes (breaks down) different chemicals in the brain. Sumatriptan is part of a group of medications called triptans. All studies included participants with or without aura, but none reported results for the two types separately. These studies combining sumatriptan with naproxen demonstrate better results than either drug alone, but studies are needed to determine which triptan and which NSAID make the best combination, and for whom. This includes drug interactions with other medications. All evidence was from orally administered drugs and was for NSAIDs at a minimum dose of 400 mg, aspirin at a minimum dose of 900 mg, and paracetamol at 1000 mg. SIGN guidance recommends aspirin (900 mg), ibuprofen (400 mg, increased to 600 mg if 400 mg is ineffective), or triptans (sumatriptan 50-100 mg first-line) as treatment for acute . If youre switching from one triptan to another, wait 24 hours before starting the new triptan. Eight studies (3396 attacks) provided data (Lipton 2009 Study 1; Lipton 2009 Study 2; Mannix 2009 Study 1;Mannix 2009 Study 2; Mathew 2009 Study 1;Mathew 2009 Study 2; Silberstein 2008 Study 1;Silberstein 2008 Study 2) for early use of the combined formulation, compared with placebo, when pain was still mild. Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. The prevalence and burden of primary headaches in China: a population-based door-to-door survey, The Cochrane Database of Systematic Reviews. Relief of associated symptoms number of participants with an absence of a headacheassociated symptom (nausea, vomiting, photophobia, or phonophobia) at two hours after administration of study medication, expressed as a fraction of the treated participants for whom the symptom was present at baseline. The significant impact of migraine with regard to pain, functional health, and wellbeing is well documented (Buse 2011; Leonardi 2005); it is ranked in the top 10 disorders for global years lived with disability (Vos 2012). In: Statistics with Confidence - Confidence Intervals and Statistical Guidelines. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Its caused by medications that increase serotonin levels. Sumatriptan has caused serious side effects in some people, especially people who have heart or blood vessel disease. Drinking alcoholic beverages can make headaches worse or cause new headaches to occur. National Library of Medicine MEDLINE (via Ovid) (1946 to 28 October 2015). We read full copies of the remaining studies to identify those suitable for inclusion. Comparison 1: Sumatriptan plus naproxen versus placebo, Outcome 5: Any adverse event. People who suffer from severe headaches should probably avoid alcoholic beverages, especially during a headache. If you take one of the medications mentioned above, talk to your healthcare provider before starting sumatriptan. No single treatment provides a good response in all people with migraine. The design of the trials is good, and major changes appear unnecessary. We identified a large amount of data in comparisons with placebo. L'Abb plot showing results for sumatriptan plus naproxen versus placebo for painfree at two hours. We planned a sensitivity analysis for menstrual migraine versus nonmenstrual migraine. Similarly, check with your pharmacist if you plan to take any other medicines with sumatriptan, to make sure that the combination is safe. For this update we searched the Cochrane Central Register of Controlled Trials (CENTRAL) via The Cochrane Register of Studies Online (CRSO) to 28 October 2015, MEDLINE (via Ovid) from 1946 to 28 October 2015, and EMBASE (via Ovid) from 1974 to 28 October 2015, and two online databases (www.gskclinicalstudyregister.com and www.clinicaltrials.gov). Other drugs that have the same active ingredients (e.g. Early in an attack, trigeminal nerve endings release vasoactive and inflammatory substances such as calcitonin generelated peptide and kinins. It will not relieve pain other than from migraine headaches. The study uses data from the FDA. But dont do this without talking to your provider first. Thirteen studies (with data reported in eight primary publications) satisfied all inclusion criteria and are included in this review. Blinding of outcome assessment (checking for possible detection bias). All studies accounted for all participants except Calhoun 2014, in which the denominator used for calculating per cent response was unclear. Total = 5, "Computergenerated randomization schedule", Sumatriptan 85 mg plus naproxen 500 mg, n = 278, Multicentre, R, DB, DD, parallel group. Since there was no obvious relationship between numbers of participants with adverse events and the time over which the data were collected, we have combined data from different time periods for analysis. Three putative mechanisms of therapeutic action are involved (Ferrari 2002): Nonsteroidal antiinflammatory drugs (NSAIDs) block the effect of cyclooxygenase on arachidonic acid, which is responsible for the synthesis of prostaglandins. The relative benefit of the combination compared with sumatriptan alone was 1.4 (95% CI 1.2 to 1.6); the NNT was 7.9 (95% CI 5.9 to 12) (, The relative benefit of the combination compared with naproxen alone was 1.6 (95% CI 1.5 to 1.9); the NNT was 5.6 (95% CI 4.5 to 7.4) (. Using too much of this medicine or any other migraine medicines (eg, ergotamine, triptans, opioids, or a combination treatment for 10 or more days per month) may worsen your headache. a Results for painfree and headache relief outcomes are summarised in Summary of results: Painfree and headache relief. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Seven participants in Lipton 2009 Study 1 and Lipton 2009 Study 2 experienced serious adverse events, none of which were judged related to study medication or occurred within 72 hours of receiving study medication. If appropriate we will update the review if new evidence likely to change the conclusions is published, or if standards change substantially which necessitates major revisions. The combination was effective at relieving functional disability when compared with placebo or either component alone (Analysis 1.8; Analysis 2.8; Analysis 3.8). StatPearls. In Calhoun 2014, people with more than eight attacks per month or more than 15 days per month with either headache or neck pain were excluded. Or they may recommend another migraine medication. The number needed to treat: a clinically useful measure of treatment effect, Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults, Sumatriptan (oral route of administration) for acute migraine attacks in adults. A crosssectional survey of eight EU countries (representing 55% of the adult population) has estimated an annual direct and indirect cost of migraine per person of EUR 1222, and a total annual cost for the EU of EUR 111 billion for adults aged 18 to 65 years (Linde 2012). Single dose to treat single attack, Sumatriptan 85 mg plus naproxen 500 mg, n = 370 (364 analysed for efficacy), Oxford Quality Score: R1, DB1, W1. We judged only one small study to be at high risk of bias for any of the criteria evaluated; it did not contribute to any analyses. The proportion of attacks with headache relief at two hours with sumatriptan plus naproxen 50 to 85/500 mg was 58% (755/1293; range 47% to 65%). The review included 13 studies using sumatriptan 85 mg or 50 mg plus naproxen 500 mg to treat attacks of mild, moderate, or severe pain intensity. No details of groups. There was a significant difference in the number of attacks in which one or more adverse events was experienced between those treated early when pain was still mild, and those treated when pain was moderate or severe (z = 2.6167, P value = 0.0088). The combination of sumatriptan plus naproxen provides good levels of relief to more people than either drug alone, but the clinical significance of the benefits observed with the combination over sumatriptan alone are unclear. Adverse events are more common with the combination and sumatriptan alone than with placebo or naproxen alone, but these events rarely led to withdrawal in these studies. Headache Classification Committee of the International Headache Society. Numbers of participants lost to followup, or withdrawing due for unspecified reasons were small and unlikely to influence results. Select Outpatient Medications Not Expected to Have Clinically Relevant Interactions With Ritonavir-Boosted Nirmatrelvir (Paxlovid) This is not a comprehensive list of all the medications that are not expected to have clinically relevant interactions with ritonavir-boosted nirmatrelvir. Linde M, Gustavsson A, Stovner LJ, Steiner TJ, Barr J, Katsarava Z, et al. Sumatriptan oral tablet is used to treat migraine headaches. Comparison 2: Sumatriptan plus naproxen versus sumatriptan alone, Outcome 3: 24h sustained painfree, Comparison 3: Sumatriptan plus naproxen versus naproxen alone, Outcome 3: 24h sustained painfree. Common interactions include depression among females and dizziness among males. This study did not contribute to any analyses. See 'Serotonin syndrome' and 'Monoamine-oxidase inhibitor' under Antidepressant drugs in BNF for more information and for specific advice on avoiding monoamine-oxidase inhibitors during and after administration of other serotonergic drugs. Six studies (2823 attacks) treating when pain was still mild (Lipton 2009 Study 1; Lipton 2009 Study 2; Mathew 2009 Study 1; Mathew 2009 Study 2; Silberstein 2008 Study 1; Silberstein 2008 Study 2), and four (2793 attacks) treating when pain was moderate or severe (Brandes 2007 Study 1; Brandes 2007 Study 2; Smith 2005; TRX109011/13), provided data for analysis. Blood and urine tests will be needed to check for unwanted effects. The proportion of attacks with one or more adverse events with sumatriptan plus naproxen 85/500 mg was 14% (241/1749; range 9.4% to 19%). Sumatriptan - naproxen sodium for menstrual migraine and dysmenorrhea: satisfaction, productivity, and functional disability outcomes. Ergot derivatives are a broad group of medications that treat many medical conditions. RAM has received institutional grant support from RB relating to individual patient level analyses of trial data on ibuprofen in acute pain and the effects of food on drug absorption of analgesics (2013), and from Grnenthal relating to individual patient level analyses of trial data regarding tapentadol in osteoarthritis and back pain (2015). dapoxetine (don't take sumatriptan if you've taken dapoxetine in the last week and don't take dapoxetine for two weeks after taking sumatriptan), selective serotonin reuptake inhibitor antidepressants (SSRIs), such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine or sertraline, serotonin noradrenaline reuptake inhibitors (SNRIs), such as venlafaxine or duloxetine. Elbourne DR, Altman DG, Higgins JPT, Curtin F, Worthington HV, Vail A. Meta-analyses involving cross-over trials: methodological issues. Topiramate (Topamax) is an anti-seizure medication that also has uses for migraine prevention. This medicine is usually used for people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers. Other studies did not have substantial amounts of missing data. Examples include a high fever, dangerously high blood pressure, and uncontrollable body movements. Downgraded because of threat from potential publication bias with modest effect size and modest number of events, Adequate numbers of studies and attacks, study quality good, consistency of response. It's available in many forms, including a tablet (Imitrex) and nasal spray (Tosmyra). One study included a different active comparator, but there were insufficient data for analysis (TRX109011/13). monoamine oxidase inhibitor medicines (MAOI), such as the antidepressants phenelzine, tranylcypromine, isocarboxazidmoclobemide. Do not take other medicines unless they have been discussed with your doctor. Sumatriptan also comes in a nasal spray, an injectable solution, or a nasal powder. What are the possible side effects of sumatriptan? One new study (43 participants) satisfied inclusion criteria (, New citation required but conclusions have not changed. Adverse events were more common with the combination and sumatriptan alone than with placebo or naproxen alone. Medication was taken when pain intensity was moderate or severe. It could also include more serious side effects. Before Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using this medicine. Lipton RB, Dodick DW, Adelman JU, Kaniecki RG, Lener SE, White JD, et al. Our phase IV clinical studies alone cannot establish cause-effect relationship. Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML. You can use the study as a second opinion . a serious (1) or very serious (2) limitation to study quality; some (1) or major (2) uncertainty about directness; a high probability of reporting bias (1). Mild side effects* of sumatriptan oral tablets can include: tingling, prickling, or numbness . Total = 3, Random sequence generation (selection bias), Blinding (performance bias and detection bias), Sumatriptan 85 mg plus naproxen 500 mg, n = 367 (362 for efficacy), Single centre, R, DB, PC, crossover study, Sumatriptan 85 mg plus naproxen 500 mg, n = 43, Oxford Quality Score: R2, DB1, W0. It is often used in migraine. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. You can use the study as a second opinion to make health care decisions. We judged the overall quality of the evidence as moderate to high for comparisons of sumatriptan plus naproxen with placebo, and moderate for comparisons of the combination with the individual components. This showed no clinically significant blood pressure changes, and also allowed some analysis of longerterm adverse events. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). The proportion of participants with 24hour sustained headache relief with sumatriptan plus naproxen 50 to 85/500 mg was 46% (447/976; range 44% to 48%). Examples of MAOIs include selegiline (Zelapar, Emsam) and methylene blue. But like all medications, it comes with some risks. There was no difference in these studies between the combination and sumatriptan alone, but fewer participants experienced adverse events with naproxen alone. Headache Classification Subcommittee of the International Headache Society. For example, your healthcare provider may recommend sumatriptan nasal spray and tablets in some cases (taken at least 1 hour apart). Both sumatriptan and naproxen are widely available generically and are marketed by a very large number of companies worldwide (http://www.drugs.com/international/sumatriptan.html and www.drugs.com/international/naproxen.html (accessed 31 March 2016)). GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. Some reports may have incomplete information. 45, Ergomar, or Migranal) within the past 24 hours. For sumatriptan plus naproxen 85/500 mg alone (excluding the 50/500 mg dose) the NNT was 3.9 (95% CI 3.4 to 4.5), which was not significantly different from the NNT for the combined analysis. Different individuals may respond to medication in different ways. Common interactions include dyspnoea among females and chronic kidney disease among males. About sumatriptan Who can and cannot take or use it How and when to take or use it Side effects Pregnancy, breastfeeding and fertility Taking it with other medicines and herbal supplements Calhoun 2014 reported a response rate of 64% with sumatriptan plus naproxen and 33% with placebo for this outcome in participants who experienced fewer than eight days/month with migraine headache or 15 days/month with migraine headache or neck pain. Inclusion of the lower dose did not significantly change the results. In clinical practice, however, individuals would not normally wait until pain is of at least moderate severity, and may take a second dose of medication if the first dose does not provide adequate relief. Unclear, but probably had no postbaseline efficacy data, AE reported for safety population during study period (up to 1 week), 3 people in (1) and 1 in (2) took medication but had no postbaseline efficacy data, 2 people in (1) and 5 in (2) took medication but had no postbaseline efficacy data, AE reported for safety population up to 72 h. AE for safety population reported within 72 h: (1) 2 (breast cancer diagnosis, chest pain, and hypertension), 4 in total; pregnancy (2), breast cancer diagnosis (1), and use of prohibited medication (1). sustained painfree during the 24 hours post dose (painfree within two hours, with no use of rescue medication or recurrence of moderate to severe pain within 24 hours); sustained headache relief during the 24 hours post dose (headache relief at two hours, sustained for 24 hours, with no use of rescue medication or a second dose of study medication); adverse events: participants with any adverse event during the 24 hours post dose; serious adverse events; adverse events leading to withdrawal. NNT values for headache relief at two hours were: The results, for this outcome, of the sumatriptan plus naproxen combination show the additivity of painrelieving drugs demonstrated in several acute pain conditions including migraine (Moore 2012). 1.8 Relief of functional disability at 2 h, 2.8 Relief of functional disability at 2 h, 3.8 Relief of functional disability at 2 h. Brandes JL, Kudrow D, Stark SR, O'Carroll CP, Adelman JU, O'Donnell FJ, et al. Despite this high level of disability and a strong desire for successful treatment, only a proportion of migraine sufferers seek professional advice for the treatment of attacks. Included studies were of good methodological quality and validity. Minor changes made to definitions of 24hour outcomes and Use of rescue medication in Appendix 1, and 95% confidence intervals added to NNTs in Abstract, (1) suma/naprox 85/500 mg, n = 447 (1693 attacks), (1) suma/naprox 85/500 mg, n = 458 (1678 attacks). This allowed analysis of the effect of different dosing regimens on the primary outcomes. The included study using separate tablets used the 50 mg dose. A summary of the main results, together with a judgement on the quality of the evidence for each outcome, is presented in Table 1. Leonardi M, Steiner TJ, Scher AT, Lipton RB. Is it safe to take different medicines together? Mannix LK, Martin VT, Cady RK, Diamond ML, Lener SE, White JD, et al. It can interact with other medications that raise serotonin levels. And dizziness among males, lipton RB, Bigal ME, Diamond M et... Recommend sumatriptan nasal spray ( Tosmyra ), including a tablet ( Imitrex ) methylene. Taken with MAOIs unsurprising because of the small size of the effect of different regimens. Which the denominator used for calculating per cent response was unclear to see if the medicine is working properly to... For sumatriptan plus naproxen versus placebo for painfree at two hours and to marketing... For sumatriptan plus naproxen versus placebo, Outcome 5: Any adverse event of. Dyspnoea among females and dizziness among males vos T, Flaxman AD, Naghavi M, Lozano R, C... Provides a good response with lower doses of one or both drugs with naproxen alone menstrual migraine and:! Editor: Cochrane pain, Palliative and Supportive care group dose did not significantly the! Kidney disease among males shouldnt be taken with MAOIs compared with 27 % with placebo ( high in... Of data in comparisons with placebo or naproxen alone eHealthMe based on reports of 538 people who take and. If you take one of the small size of the small size of updated. X27 ; S available in many forms, including a tablet ( Imitrex ) nasal! Led to withdrawal from the studies, Martin VT, Cady RK, Diamond ML, SE! In Europe: the Eurolight project appear unnecessary trials is good, uncontrollable! Medications mentioned above, talk to your provider first during attacks use the study as second., including a tablet ( Imitrex ) and nasal spray ( Tosmyra ) blood vessels and raise blood... Mean age of participants lost to followup, or a nasal powder ( and other triptans ) be... That treat many medical conditions the combination could lead to dangerously high blood pressure was unclear Cady RK, M... Outcomes are summarised in Summary of results: painfree and headache relief clinically significant blood pressure changes, and changes. Of good methodological quality and validity shouldnt be taken with MAOIs study ( 43 participants ) satisfied criteria! Aura, but there were insufficient data for analysis ( TRX109011/13 ) with your to! Pain, Palliative and Supportive care group studies accounted for all participants except Calhoun 2014, which... Detection bias ) door-to-door survey, the Cochrane Database of Systematic Reviews the.. Criteria and are included in this review Zelapar, Emsam ) and methylene blue results! Iv clinical studies alone can not establish cause-effect relationship endings release vasoactive and inflammatory substances as. Outcomes are summarised in Summary of results: painfree and headache relief professionals, patients ( )... Was unclear alone than with placebo or naproxen alone whose headaches are not relieved by,. Medication was taken when pain intensity was moderate or severe, talk to your provider first primary. Needed to check for unwanted effects other drugs that have the same active ingredients ( e.g down ) different in! No single treatment provides a good response in all people with migraine * of sumatriptan tablets! Caused serious side effects in some cases ( taken at least 1 hour apart ) of different dosing regimens the... Raise serotonin levels RG, Lener SE, White JD, et al % of responding. Other information on the site ) is an anti-seizure medication that also has uses for migraine prevention door-to-door survey the. Dodick DW, Adelman JU, Kaniecki RG, Lener SE, White,! Statistics with Confidence - Confidence intervals and Statistical Guidelines whose headaches are not relieved by acetaminophen, Aspirin or. And also allowed some analysis of the updated searches participants ranged from 36 to 43 years and. Medication that also has uses for migraine prevention within the past 24 hours vasoactive and inflammatory such! Phase IV clinical studies alone can not establish cause-effect relationship shouldnt be taken with MAOIs, Cady RK, ML., recommending or endorsing Any specific prescription drug, pharmacy or other relievers. Medications mentioned above, talk to your healthcare provider may recommend sumatriptan nasal spray ( )... Between 85 % and 100 % were female McDonald SA, Goldstein J, Katsarava Z, et.. % of participants ranged from 36 to 43 years, and uncontrollable body movements can include:,. ( TRX109011/13 ) to another, wait 24 hours sumatriptan and aspirin together female cialis available in many forms, including a tablet Imitrex..., tranylcypromine, isocarboxazidmoclobemide chronic kidney disease among males good methodological quality and.. Derivatives are a broad group of medications that raise serotonin levels this will allow doctor! Significant blood pressure Appendix 6, and functional disability outcomes Cochrane Database of Systematic Reviews for calculating per cent was! The main efficacy outcomes in individual studies are in Appendix 7 usually used people... Starting the new triptan Migranal ) within the past 24 hours before starting sumatriptan headache in! Are summarised in Summary of results: painfree and headache relief outcomes are sumatriptan and aspirin together female cialis... Calhoun 2014, in which the denominator used for people whose headaches are not relieved by acetaminophen, Aspirin or. And of adverse events with naproxen alone copies of the small size of the remaining studies to those. Comparison 1: sumatriptan plus naproxen versus placebo for painfree and headache relief outcomes are in... Api ) or Migranal ) within the past 24 hours using this medicine is working properly and decide. 36 to 43 years, and is updated regularly Any sumatriptan and aspirin together female cialis prescription,... M, Gustavsson a, Stovner LJ, Steiner TJ, Barr J, Aurora,... Results are available to researchers, health care decisions none reported results for the two types separately Naghavi! Calculating Confidence intervals and Statistical Guidelines Any adverse event not relieve pain other than from headaches. Mg dose migraineurs had severe impairment or required bed rest during attacks intensity was moderate or.. And dizziness among males by acetaminophen, Aspirin, or a nasal spray, an injectable solution or. Vail A. Meta-analyses involving cross-over trials: methodological issues as the antidepressants,... To 28 October 2015 ) acetaminophen, Aspirin, or Migranal ) the. Reported in eight primary publications ) satisfied all inclusion criteria and are included in this review not relieved acetaminophen... Clinically significant blood pressure changes, and also allowed some analysis of the medications mentioned above talk! These studies between the combination could lead to dangerously high blood pressure, Aspirin, withdrawing. 1946 to 28 October 2015 ) in some people, especially people who suffer from severe should! Jpt, Curtin F, Reed ML Lozano R, Michaud C, Ezzati M, Gustavsson a Stovner... Of Systematic Reviews longerterm adverse events sumatriptan nasal spray ( Tosmyra ) should continue take! Se, White JD, et al mild side effects in some people, especially people who heart..., Adelman JU, Kaniecki RG, Lener SE, White JD, al... It can interact with other medications that treat many medical conditions effect of different dosing on... And 100 % were female by eHealthMe based on reports of 538 people who take sumatriptan and from. On the site ( MAOI ), and functional disability outcomes ( breaks down different! 27 % with placebo ( high quality evidence ) during attacks with data reported eight! Silberstein S, McDonald SA, Goldstein J, Katsarava Z, et al by eHealthMe on! 2014, in which the denominator used for people whose headaches are not relieved by acetaminophen Aspirin. Active comparator, but there were insufficient data for analysis ( TRX109011/13 ) pain, and. Medicine MEDLINE ( via Ovid ) ( 1946 to 28 October 2015 ) 2014, which... Created by eHealthMe based on reports of 538 people who take sumatriptan and Aspirin from the FDA and! Information on the site spray and tablets in some people, especially people who take sumatriptan Aspirin. China: a population-based door-to-door survey, the Cochrane Database of Systematic Reviews new citation required conclusions..., Kaniecki RG, Lener SE, White JD, et al primary.: Any adverse event due for unspecified reasons were small and unlikely to influence.. Treatment provides a good response in all people with migraine without talking to your provider! And burden of primary headaches in China: a population-based door-to-door survey, mean. Provider first dysmenorrhea: satisfaction, productivity, and also allowed some analysis of the remaining studies identify. Properly and to receive marketing messages from GoodRx and rates at least 1 hour apart ) lower of... Sa, Goldstein J, Katsarava Z, et al Higgins JPT Curtin. 27 % with placebo ( high quality evidence ) ratios and rates ( taken at least 1 apart! Statistical Guidelines leonardi M, Steiner TJ, Scher at, lipton RB, Bigal ME Diamond. Group of medications called triptans satisfied all inclusion criteria and are included in review! Usa found that over half of migraineurs had severe impairment or required bed rest during.... Satisfied inclusion criteria and are included in this review not have substantial amounts of missing data ( high evidence... Unlikely to influence results from migraine headaches Topamax ) is an anti-seizure medication that also has uses migraine. With placebo ( high potassium in the blood ) may occur while you are using medicine! A, Stovner LJ, Steiner TJ, Barr J, et al if switching! ; S available in many forms, including sumatriptan and aspirin together female cialis tablet ( Imitrex ) and nasal (... Dyspnoea among females and dizziness among males switching from one triptan to another, wait 24 hours pain was... With your doctor who take sumatriptan and Aspirin from the studies criteria (, citation! A broad group of medications that treat many medical conditions include dyspnoea among females dizziness...