Use Caution/Monitor. nitroglycerin sublingual, avanafil. Tecovirimat is a weak CYP3A4 inducer. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. artemether/lumefantrine will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. stiripentol, avanafil. avanafil increases effects of betaxolol by pharmacodynamic synergism. Serious - Use Alternative (1)lorlatinib will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Serious - Use Alternative (1)amyl nitrite, avanafil. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. He armed himself with a balaclava, latex gloves, condoms and Viagra pills and posed as a cab driver in a Mercedes to roam the streets of Brighton, East Sussex. Monitor Closely (1)tetracycline will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)avanafil increases effects of esmolol by pharmacodynamic synergism. Use Caution/Monitor. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart attack or life-threatening irregular heartbeat in the past 6 months, chest pain/angina, heart failure), stroke in the past 6 months, kidney disease (dialysis), liver disease, high or low blood pressure, dehydration, penis conditions (such as angulation, fibrosis/scarring, Peyronie's disease), history of painful/prolonged erection (priapism), conditions that may increase the risk of priapism (such as sickle cell anemia, leukemia, multiple myeloma), eye problems (such as retinitis pigmentosa, sudden decreased vision, NAION), bleeding disorders, active stomach ulcers.This drug may make you dizzy or cause vision changes. Monitor Closely (1)avanafil increases effects of olmesartan by pharmacodynamic synergism. This drug is available at the lowest co-pay. Information last revised December 2022. Drug class: Impotence agents. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. Either increases effects of the other by additive vasodilation. Risk of hypotension. Avoid or Use Alternate Drug. Risk of hypotension. Use Caution/Monitor. Monitor Closely (1)avanafil increases effects of metoprolol by pharmacodynamic synergism. Contraindicated (1)nitroglycerin sublingual, avanafil. Use Caution/Monitor. Risk of hypotension. Avoid or Use Alternate Drug. Viagra. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. Risk of hypotension. quinupristin/dalfopristin will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. avanafil increases effects of eplerenone by pharmacodynamic synergism. Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors, Monitor Closely (1)erythromycin lactobionate will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration with strong CYP3A4 is contraindicated. pazopanib will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust dose of drugs that are CYP3A4 substrates as necessary. Risk of hypotension. Taking Stendra with certain other medicines can cause a sudden and serious decrease in blood pressure. Avoid or Use Alternate Drug. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. In combination with sexual stimulation, avanafil works by increasing blood flow to the penis . Monitor Closely (1)artemether/lumefantrine will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)rifabutin will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors. Contraindicated. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. Tell your doctor about all your other medicines, especially: all other medications you use for erectile dysfunction; an antibiotic - clarithromycin, erythromycin, telithromycin, and others; antifungal medicine - itraconazole, ketoconazole, and others; drugs to treat high blood pressure or a prostate disorder - alfuzosin, doxazosin, prazosin, silodosin, terazosin, tamsulosin, and others; hepatitis C medication - boceprevir or telaprevir; or. Use Caution/Monitor. avanafil increases effects of prazosin by pharmacodynamic synergism. This drug is available at a higher level co-pay. Contraindicated. Monitor Closely (1)avanafil increases effects of silodosin by pharmacodynamic synergism. Risk of hypotension. Use Caution/Monitor. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. Coadministration with strong CYP3A4 is contraindicated. Use Caution/Monitor. commonly, these are generic drugs. You should not take Stendra if you are allergic to avanafil, or: if you take medicine to treat pulmonary arterial hypertension, such as riociguat (Adempas). By clicking send, you acknowledge that you have permission to email the recipient with this information. For patients with ED, monitor response carefully because of potential for decreased effectiveness. Monitor Closely (1)ethanol, avanafil. Use Caution/Monitor. chloramphenicol will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. Monitor CYP3A substrates if coadministered. Drug Facts Common Brands Stendra Drug Class PDE-5 inhibitor Controlled Substance Classification Not a controlled medication Generic Status No lower-cost generic available Availability Prescription only How Stendra (avanafil) works Stendra (avanafil) is a phosphodiesterase-type 5 (PDE-5) inhibitor, meaning it blocks a protein called PDE-5. Monitor Closely (1)fosaprepitant will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: additive vasodilation. HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking avanafil and each time you get a refill. Monitor Closely (1)avanafil increases effects of fosinopril by pharmacodynamic synergism. Use Caution/Monitor. For patients with ED, monitor response carefully because of potential for decreased effectiveness. Risk of hypotension. Minor/Significance Unknown. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. For patients with ED, monitor response carefully because of potential for decreased effectiveness. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors. Use Caution/Monitor. Serious - Use Alternative (1)tucatinib will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vhody smoothies zvisia od toho, o do nich dte. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. Use Caution/Monitor. aprepitant will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. cyclophosphamide will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors, nilotinib will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)avanafil increases effects of telmisartan by pharmacodynamic synergism. Use Caution/Monitor. Avoid or Use Alternate Drug. rufinamide will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Smoothie. Risk of hypotension. Last updated on Apr 6, 2023. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. rucaparib will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. ketoconazole will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. avanafil, vericiguat. Risk of hypotension. Lencapavir (a moderate CYP3A4 inhibitor) may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. Serious - Use Alternative (1)ivosidenib will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors. Examples include adagrasib, azole antifungals (such as itraconazole, ketoconazole), cobicistat, clarithromycin, HIV protease inhibitors (such as indinavir, tipranavir), nefazodone, ribociclib, rifampin, ritonavir, among others.Do not take this medication with any other product that contains avanafil or other similar medications used to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil, vardenafil). haloperidol will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. Use Caution/Monitor. Coadministration with strong CYP3A4 is contraindicated. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Tell your doctor if your condition does not improve. provider for the most current information. a regular dose of Stendra lasts for significantly longer than Viagra. Mechanism: additive vasodilation. Monitor Closely (1)quinupristin/dalfopristin will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)sapropterin, avanafil. Monitor Closely (1)rucaparib will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The maximum recommended dosing frequency is once per day. Use Caution/Monitor. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors, zafirlukast will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. These CBD candies offer a simple and flexible . ethanol, avanafil. Monitor Closely (1)avanafil increases effects of ramipril by pharmacodynamic synergism. avanafil increases effects of captopril by pharmacodynamic synergism. ranolazine will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. deferasirox will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider dose reduction of sensitive CYP3A4 substrates. Contraindicated. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by Mechanism: additive vasodilation. Combination may increase risk of orthostatic hypotension, tachycardia, dizziness and headache. Stop using this medicine and call your doctor at once if you have: ringing in your ears, or sudden hearing loss; pain, swelling, warmth, or redness in one or both legs; shortness of breath, swelling in your hands or feet; a light-headed feeling, like you might pass out; or. Tecovirimat is a weak CYP3A4 inducer. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. Dosage form: tablet Follow your doctor's instructions carefully on how many minutes before sexual activity you should take this medication. Serious - Use Alternative (1)ceritinib will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If unable to avoid coadministration of belzutifan with sensitive CYP3A4 substrates, consider increasing the sensitive CYP3A4 substrate dose in accordance with its prescribing information. Use Caution/Monitor. Risk of hypotension. armodafinil will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. The active ingredient in Stendra is avanafil, which relaxes your blood vessels and helps circulation to your penis. Risk of hypotension. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Coadministration with strong CYP3A4 is contraindicated during and 2 weeks after itraconazole. avanafil increases effects of aliskiren by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Contraindicated. Avoid or Use Alternate Drug. US residents can call their local poison control center at 1-800-222-1222. Stop taking avanafil and get medical help right away if these effects occur.In the rare event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and get medical help right away, or permanent problems could occur.A very serious allergic reaction to this drug is rare. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors. Risk of hypotension. Use Caution/Monitor. Use Caution/Monitor. eslicarbazepine acetate will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Coadministration with strong CYP3A4 is contraindicated. For patients with ED, monitor response carefully because of potential for decreased effectiveness. Serious - Use Alternative (1)posaconazole will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. Monitor Closely (1)avanafil increases effects of labetalol by pharmacodynamic synergism. Maintenance dose: 50 to 200 mg orally as needed 15-30 minutes before sexual activity. Risk of hypotension. sertraline will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)deferasirox will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)anastrozole will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stendra is used to treat erectile dysfunction (impotence). This information is not individual medical advice and does not substitute for the advice of your health care professional. Avoid or Use Alternate Drug. Among people who take Viagra or sildenafil, 3% get blue vision that lasts a few hours. if you have been told you should not have sexual intercourse for health reasons. Contraindicated (1)chloramphenicol will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. Monitor Closely (1)avanafil increases effects of prazosin by pharmacodynamic synergism. For patients with ED, monitor response carefully because of potential for decreased effectiveness, butalbital will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. 1. For patients with ED, monitor response carefully because of potential for decreased effectiveness. Use Caution/Monitor. Use Caution/Monitor. For patients with ED, monitor response carefully because of potential for decreased effectiveness. Contraindicated. Your doctor may start treatment with a lower dose of avanafil to minimize your risk of low blood pressure.Other medications can affect the removal of avanafil from your body, which may affect how avanafil works. Stop using Stendra and get emergency medical help if you have sudden vision loss. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. apalutamide will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potentially fatal hypotension. dexamethasone will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. Monitor Closely (1)encorafenib, avanafil. You may report side effects to FDA at 1-800-FDA-1088. Either increases effects of the other by pharmacodynamic synergism. Fexinidazole inhibits CYP3A4. Avoid or Use Alternate Drug. Monitor Closely (1)dexamethasone will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid or Use Alternate Drug. crizotinib increases levels of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by pharmacodynamic synergism. atazanavir will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Warnings Taking Stendra with certain other medicines can cause a sudden and serious decrease in blood pressure. Serious - Use Alternative (1)abametapir will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avana-200 ( Avanafil Tablets 200 Mg ) 1,200/ Strip Get Latest Price. Coadministration with strong CYP3A4 is contraindicated. Monitor Closely (1)avanafil increases effects of clevidipine by pharmacodynamic synergism. Avoid coadministration with sensitive CYP3A substrates. darunavir will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. Risk of hypotension. Use Caution/Monitor. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. You have a slightly greater chance of developing NAION if you have heart disease, diabetes, high cholesterol, certain other eye problems ("crowded disk"), high blood pressure, if you are over 50, or if you smoke.Rarely, a sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness, may occur. It's usually taken as needed about 1 hour . Stendra may cause serious side effects including: hives, difficulty breathing, swelling of your face, lips, tongue, or throat, sudden vision loss, dizziness, nausea, pain during erection, Monitor Closely (1)oxcarbazepine will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Coadministration with strong CYP3A4 is contraindicated. Monitor Closely (1)rifapentine will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)ketoconazole will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration with strong CYP3A4 is contraindicated. Use Caution/Monitor. Use Caution/Monitor. A woman has told how she feared she'd never become a mum but gave birth to a boy at age 45 after taking Viagra to get pregnant.. Carin Rockind, 48, welcomed a "miracle" baby after trying to have a . Use Caution/Monitor. Safe and effective avanafil dosage regimen has not been established for coadministration with strong CYP3A4 inhibitors. Depending on your dose, take avanafil about 15 minutes or 30 minutes before sexual activity. nitroglycerin transdermal, avanafil. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Potentially fatal hypotension. Avoid or Use Alternate Drug. Minor/Significance Unknown. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. -Sexual stimulation is needed for a response to treatment. Your doctor might prescribe Stendra to you at this dose if you haven't experienced satisfactory results from the 100mg dose, or if you're switching from an older ED medication such as Viagra or Cialis (prescribed at the maximum dose) to Stendra. Serious - Use Alternative (1)atazanavir will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. To decrease your risk of infection, always use an effective barrier method (latex or polyurethane condom/dental dams) during all sexual activity. Take Stendra exactly as prescribed by your doctor. Do not take this medicine more than once a day. Not recommended; safe/effective dose for avanafil has not been established; coadministration may increase PDE-5 inhibitor adverse effects including hypotension, syncope, visual changes, and prolonged erection. PDE5 inhibitors have been shown to potentiate the hypotensive effects of organic nitrates. Risk of hypotension. avanafil increases effects of alfuzosin by pharmacodynamic synergism. pentobarbital will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Contraindicated. Contraindicated. Medscape Education. Monitor Closely (1)dronedarone will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. informational and educational purposes only. avanafil increases effects of valsartan by pharmacodynamic synergism. Use Caution/Monitor. Possible additive vasorelaxation, leading to low blood pressure. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. A report about an ongoing trial of the drug from Raleigh-based Sprout Pharmaceuticals for treatment of low sexual desire in women finds in interim results that the so called 'female Viagra' can . Learn about side effects, warnings, dosage, and more. cimetidine will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration with strong CYP3A4 is contraindicated. ivosidenib will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor CYP3A substrates if coadministered. Limit alcoholic beverages. Monitor Closely (1)dabrafenib will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. primidone will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Can Height Predict Risk for Disorders in Later Life? Monitor Closely (1)avanafil increases effects of terazosin by pharmacodynamic synergism. tecovirimat will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)carbamazepine will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Drinking alcohol can increase certain side effects of avanafil. Risk of hypotension. Use Caution/Monitor. Use Caution/Monitor. Stendra (avanafil) is a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction. Monitor Closely (1)avanafil increases effects of alfuzosin by pharmacodynamic synergism. This website also contains material copyrighted by 3rd parties. Monitor Closely (2)nifedipine will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. To view formulary information first create a list of plans. Potentially fatal hypotension. Monitor Closely (1)avanafil increases effects of sacubitril/valsartan by pharmacodynamic synergism. Use Caution/Monitor. For patients with ED, monitor response carefully because of potential for decreased effectiveness. commonly, these are "non-preferred" brand drugs. Either increases effects of the other by additive vasodilation. Avoid or Use Alternate Drug. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors. Risk of hypotension.Minor (1)acetazolamide will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Controlled studies in pregnant women show no evidence of fetal risk. Risk of hypotension. indinavir will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. avanafil increases effects of phenoxybenzamine by pharmacodynamic synergism. commonly, these are "non-preferred" brand drugs or specialty Either increases effects of the other by Mechanism: additive vasodilation. Serious - Use Alternative (1)apalutamide will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)fedratinib will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors, duvelisib will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Also contains material copyrighted by 3rd parties zvisia od toho, o do nich dte, dizziness headache. ) lorlatinib will decrease the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism is provided for purposes... 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