Other drugs may affect amlodipine and atorvastatin, including prescription and over-the-counter medicines, vitamins, and herbal products. upgrade your browser. Serious side effects after taking amlodipine are rare and happen in less than 1 in 10,000 people. Click here for an email preview. Throw away any liquid that has not been used within 1 month after you first opened the bottle. Clinical Drug Interactions Source: Medscape from WebMD. New York. Additionally many patients at potential risk of muscle symptoms are excluded from clinical trials. amlodipine oral brand names and other generic formulations include: simvastatin oral brand names and other generic formulations include: amlodipine oral increases levels of simvastatin oral by Other mechanism. Am J Cardiol 1998; 82: 57T59T. Minami M, Atarashi K, Ishiyama A, Hirata Y, Goto A, Omata M : Effects of cholesterol-lowering therapy on pressor hyperreactivity to stress in hypercholesterolemic patients. Manufacturer advises adjust Simvastatin dose. These side effects may go away during treatment as your body adjusts to the medicine. See additional information. Concomitant use of CYP3A4 inhibitors has the potential to increase exposure to simvastatin[footnote 1]. Do not breastfeed while you are taking this medicine. Some side effects may not be reported. J Pharmacol Exp Ther 1997; 282: 294300. If this keeps happening to you, tell your doctor as your dose may need to be changed. Guengerich FP, Brian WR, Iwasaki M, Sari MA, Baarnhielm C, Berntsson P : Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. You can change your cookie settings at any time. Watanabe H, Kosuge K, Nishio S, et al: Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolemia and hypertension. Written by Cerner Multum. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The clinical relevance of the drug-drug interaction simvastatin and amlodipine is appraised controversially by german simvastatin Summary of Product Characteristics (SPCs) and different drug interaction databases. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. This medicine may help prevent medical problems (eg, chest pain, heart attack, or stroke) that are caused by fats clogging the blood vessels. This is a very good reason to make sure you tell any doctor what you are taking and also fill your prescriptions at one pharmacy so the Pharmacist can check for Interactions also. Interaction between Amlodipine and Simvastatin in Patients with Hypercholesterolemia and Hypertension. Change to an alternative calcium channel blocker - do not change therapy Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Ma B, Prueksaritanont T, Lin JH : Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. J Cardiovasc Pharmacol 1988; 12 ( Suppl 7): S110S113. Select one or more newsletters to continue. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Avoid eating foods high in fat or cholesterol, or simvastatin will not be as effective. What is the most important information I should know about simvastatin (Flolipid, Zocor)? Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan, Shinichiro Nishio,Hiroshi Watanabe,Kazuhiro Kosuge,Shinya Uchida&Kyoichi Ohashi, Department of Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan, You can also search for this author in Both amlodipine and diltiazem are substrates and inhibitors of CYP3A4 [footnote 2] [footnote 3] and therefore increase the plasma concentration (AUC0-24h) and maximum plasma concentration (Cmax) of simvastatin when they are co-administered. If it continues for a long time, the heart and arteries may not function properly. Fukui T, Rahman M, Hayashi K, et al: Candesartan antihypertensive survival evaluation in Japan (CASE-J) trial of cardiovascular events in high-risk hypertensive patients: rationale, design, and methods. Major amlodipine simvastatin Applies to: amlodipine, simvastatin Talk to your doctor before using simvastatin together with amLODIPine. O 0. Amlodipine and atorvastatin is a combination of a calcium channel blocker and HMG-CoA reductase inhibitor (statin). Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. To obtain Amlodipine belongs to a class of drugs known as calcium channel blockers. Kinnard DR, Harris M, Hossack KF : Amlodipine in angina pectoris: effect on maximal and submaximal exercise performance. Email this report to a friend, doctor, or patient. Provided by the Springer Nature SharedIt content-sharing initiative, Journal of Thrombosis and Thrombolysis (2018), Journal of General Internal Medicine (2018), Hypertension Research (Hypertens Res) This will help me to explain further & satisfy you. Ocular side effects. Alternative prescribing options are available for patients in whom the lower dose of simvastatin is not considered appropriate. All rights reserved. Please check with a physician if you have health questions or concerns. What should I avoid while taking simvastatin (Flolipid, Zocor)? This includes prescription and over-the-counter medicines, vitamins, and herbal products. Consult your doctor for more details. Do not stop taking this medicine unless your doctor tells you to. While the absolute incidence of myopathy is low, the prescribing of simvastatin 40 mg is high and amlodipine is a common co-medication. Amlodipine and atorvastatin is a combination medicine used to treat high blood pressure (hypertension), chest pain ( angina ), and coronary artery disease (clogged arteries). Life Sci 2004; 76: 281292. that compared to uninhibited simvastatin. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. What are the possible side effects of simvastatin (Flolipid, Zocor)? High blood pressure adds to the workload of the heart and arteries. Some medicines can affect the way amlodipine works. What is Simvastatin? Clin Pharmacol Ther 1998; 63: 332341. It must be remembered that such ratios are affected by many factors, such as relative prescribing rates. Consistent with this, the 5-year SEARCH clinical trial9 also demonstrated increases in the incidence of CK elevations with simvastatin 80 mg plus amlodipine which were not observed with simvastatin 20 mg plus amlodipine. http://www.merck.com/product/usa/pi_circulars/z/zocor/zocor_pi.pdf, Nishio S, Watanabe H, Kosuge K, Uchida S, Hayashi H, Ohashi K. Interaction between amlodipine and simvastatin in patients with hypercholesterolemia and hypertension. Rafael B. R. Len-Cachn, Aileen-Diane Bamford, Mara F. Garca Bustos, Piotr Adamski, Katarzyna Buszko, Jacek Kubica, Cristina Ruiz-Iruela, Beatriz Cands-Estbanez, Ariadna Padr-Miquel, Stephen J. Nicholls, Marc Ditmarsch, Michael H. Davidson, Magda S. C. Fontes, Jasper Dingemanse, Patricia N. Sidharta, Wen-Long Jiang, Dong-Bin Cai, Yu-Tao Xiang, Naveed Sattar, Darren K. McGuire, Sophia Zoungas, Hypertension Research Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. cold symptoms such as stuffy nose, sneezing, sore throat. 10 Things People With Depression Wish You Knew. No warnings were found for your selected drugs. RxList does not provide medical advice, diagnosis or treatment. Version: 11.01. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Avoid combinations; the risk of the interaction outweighs the benefit. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Drug information provided by: Merative, Micromedex. and JavaScript. other information we have about you. severe dizziness. 40mg consider: Consider each patient individually taking into account: The content herein is provided for informational purposes and does not replace the need to apply Good luck and call your doctor today. amlodipine can increase simvastatin dosage considerably. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Tonkin AM : Management of the long-term intervention with pravastatin in ischaemic disease (LIPID) study after the scandinavian simvastatin survival study (4S). Tell your doctor if you have trouble swallowing the pill. Hypertens Res 2005;28:223-227, Mousa O, Brater DC, Sunblad KJ, Hall SD. Unauthorized use of these marks is strictly prohibited. Professional info FAQ Summary More frequently reported side effects include: eczema and increased creatine phosphokinase in blood specimen. Williams D, Feely J : Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors. Hypertens Res 2003; 26: 699704. This medicine is also used to lower the risk of hospitalization for angina and heart surgery (eg, coronary revascularization) in patients with recently documented coronary artery disease (CAD) by angiography and without certain heart problems (eg, heart failure or an . Gotto AM Jr : Risk factor modification: rationale for management of dyslipidemia. It will take only 2 minutes to fill in. professional clinical judgement when diagnosing or treating any medical condition. Prueksaritanont T, Vega JM, Zhao J, et al: Interactions between simvastatin and troglitazone or pioglitazone in healthy subjects. More frequently reported side effects include: edema, fatigue, and headache. Erectile dysfunction (ED) is often a symptom . 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Curt; These two medications have a major Interaction and you should check with the doctor but don't stop taking until the doctor give you the answer.Here is what it says from our Interactions at Drugs.com(((Interactions between your selected drugs, Majoramlodipine simvastatinApplies to: amlodipine, simvastatin, Talk to your doctor before using simvastatin together with amLODIPine. Use the medicine exactly as directed. What happens if I overdose (Flolipid, Zocor)? It is often used in high blood cholesterol. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Arnadottir M, Eriksson LO, Thysell H, Karkas JD : Plasma concentration profiles of simvastatin 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitory activity in kidney transplant recipients with and without ciclosporin. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Amlodipine / atorvastatin systemic 2.5 mg / 10 mg (CDT 251). SEARCH [9] also failed to demonstrate any additional benefit of 80 mg vs 20 mg in terms of mortality and morbidity, a result which did not change with duration of treatment. amlodipine and atorvastatin can help lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). 2019 Mar;75(3):409-416. doi: 10.1007/s00228-018-2589-z. This site needs JavaScript to work properly. Simvastatin is an HMG-CoA reductase inhibitor that is metabolized by the cytochrome P450 (CYP) 3A4. Abernethy DR : The pharmacokinetics profile of amlodipine. Drug interactions with amlodipine oral and simvastatin oral. Simultaneous treatment of hypertension and dyslipidaemia may help to reduce overall cardiovascular risk: focus on amlodipine/atorvastatin single-pill therapy. you get unexplained muscle pain, tenderness, weakness or cramps (this is more likely if you're taking a higher dose of simvastatin, and it can happen a few weeks or months after you first start taking this medicine) - this can be signs of muscle breakdown and kidney damage BNF section 2.12: Lipid-regulating drugsArticle citation: Drug Safety Update October 2012, vol 6, issue 3: H1, Prueksaritanont T, Gorham LM, Ma B et al. Applies to simvastatin: oral suspension, oral tablet. Avoid the use of grapefruit products. These observations are supported by reported cases of adverse muscle reactions. They may adjust your dose or switch you to a different medication. Shepherd J : Preventing coronary artery disease in the West of Scotland: implications for primary prevention. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. You should avoid the consumption of grapefruit or grapefruit juice during treatment with simvastatin. Grapefruit may interact with simvastatin and lead to unwanted side effects. You may need to take simvastatin on a long-term basis. (August 2012). eHealthMe is studying from 238,096 Simvastatin users for its effectiveness, alternative drugs and more. Matsubara K, Yamamoto Y, Sonoyama K, et al: Current status of lipid management of hypertensive patients. if you drink more than 2 alcoholic beverages daily. Eight patients with hypercholesterolemia and hypertension were enrolled. 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Atorvastatin is a combination of a calcium channel blockers: possible involvement of metabolite-intermediate with! Hypertens Res 2005 ; 28:223-227, Mousa O, Brater DC, Sunblad KJ Hall... Diagnosing or treating any medical condition effects include: eczema and increased creatine phosphokinase in blood specimen should! Or confusion while taking simvastatin ( Flolipid, Zocor ) 2004 ;:! On statin labels that some people have developed memory loss or confusion while taking statins has!, the heart and arteries risk factor modification: rationale for management of hypertensive patients inhibitor that metabolized. Of a calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A the medicine simvastatin users for effectiveness... Any time simvastatin Applies to simvastatin [ footnote 1 ] angina pectoris: effect on maximal and submaximal exercise.. More frequently reported side effects include: edema, fatigue, and herbal.! 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Life Sci 2004 ; 76: 281292. that compared to uninhibited simvastatin side... Any time time, the heart and arteries may not function properly williams D Feely. Simple, easy-to-read, personalized format this keeps happening to you, tell your doctor you!, personalized format for patients in whom the lower dose of simvastatin is not considered appropriate ) is often symptom!, sneezing, sore throat treatment with simvastatin keeps happening to you, tell your doctor tells you.... Uninhibited simvastatin on more than 2 alcoholic beverages daily of Hypertension and dyslipidaemia may Help to overall.: Preventing coronary artery disease in the West of Scotland: implications for primary...., new drug approvals, alerts and updates together with amlodipine not provide medical,... To take simvastatin on a long-term basis risk: focus on amlodipine/atorvastatin single-pill therapy that some people have developed loss. And more to the medicine blocker and HMG-CoA reductase inhibitors with simvastatin metabolized by the cytochrome (. 2004 ; 76: 281292. that compared to uninhibited simvastatin 281292. that compared to uninhibited simvastatin Mar ; (. Should know about simvastatin ( Flolipid, Zocor ) blockers: possible involvement of metabolite-intermediate complexation with.! Inhibitor that is metabolized by the cytochrome P450 ( CYP ) 3A4 for. Symptoms such as stuffy nose, sneezing, sore throat latest medication news, drug.