[Ref], Very common (10% or more): Musculoskeletal pain (up to 13.5%), Common (1% to 10%): Elevated creatine phosphokinase (CPK), myalgia, arthralgia, muscle disorders, cramps, Postmarketing reports: Muscle weakness, elevated CPK, rhabdomyolysis, muscle disorders (including myalgia, cramps)[Ref], Very common (10% or more): Anorexia (up to 12%), Common (1% to 10%): Anorexia and/or decreased appetite, hypertriglyceridemia, hyperamylasemia, abnormal enzyme levels, Uncommon (0.1% to 1%): Eating problems, disorders of thirst/fluid intake, Very rare (less than 0.01%): Lactic acidosis, Postmarketing reports: Hyperglycemia, redistribution/accumulation of body fat, hyperlactatemia, lactic acidosis, -Frequency not reported: Increased glucose levels[Ref], Lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) have been reported with the use of nucleoside analogs. Lamivudine and tenofovir are in a class of medications called nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs). Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. You may report side effects to FDA at 1-800-FDA-1088. Avoid eating or drinking anything that contains sorbitol (an artificial sweetener). It is also important information to carry with you in case of emergencies. It is very important that your doctor check your and your child's progress at regular visits, especially during the first few weeks that you take this medicine. Two rare but serious reactions to this medicine are lactic acidosis (too much acid in the blood) and liver toxicity. The presence of other medical problems may affect the use of this medicine. You may report them to the FDA. Side Effects Print Save Lamivudine Side Effects Medically reviewed by Drugs.com. Be sure your family knows which symptoms may be serious so that they can call your doctor if you are unable to seek treatment on your own. If you stop the medicine even briefly, the virus may become harder to treat. Pancreatitis (some cases fatal) has been reported in antiretroviral nucleoside-experienced pediatric patients using lamivudine alone or in combination with other antiretroviral agents. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. This treatment can slow the progression of the disease to a point at which you can live a long, healthy life. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. Keep the bottle tightly closed. Ask your doctor about your risk. For more information on how to take Symfi, see the FDA drug label. URL of this page: https://medlineplus.gov/druginfo/meds/a618028.html, pronounced as (e fa veer' ens)(la miv' ue deen)(te noe' fo veer). Increased serum amylase (greater than 175 units/L) has been reported in 9% of patients using efavirenz, lamivudine, and tenofovir DF. tell your doctor what herbal products you are taking, especially St. John's wort. This is not a complete list of side effects and others may occur. Store it at room temperature and away from excess heat and moisture (not in the bathroom). The UK is the first country to allow OTC access to Sanofi's tadalafil-based erectile dysfunction drug Cialis following a successful switch. Some birth control pills may not work as well while you are using this medicine. Martinez E, Mocroft A, GarciaViejo MA, PerezCuevas JB, Blanco JL, Mallolas J, Bianchi L, Conget I, Blanch J, Phillips A, Gatell "Risk of lipodystrophy in HIV-1-infected patients treated with protease inhibitors: a prospective cohort study." Do not use Symfi if the original seal over the container opening is broken or missing. May make these conditions worse. Unless your doctor tells you otherwise, continue your normal diet. You should not become pregnant while you are using this medicine and for 12 weeks after the last dose. You must use a barrier method of birth control along with any other method of birth control you have chosen during your treatment and for 12 weeks after your final dose. [Ref], Very common (10% or more): Elevated fasting cholesterol (19%), Uncommon (0.1% to 1%): Lipodystrophy, elevated fasting triglycerides, Frequency not reported: Higher 1,25 vitamin D levels, -Common (1% to 10%): Cholesterol abnormal, -Postmarketing reports: Hypercholesterolemia, hypertriglyceridemia, redistribution/accumulation of body fat, -Postmarketing reports: Hyperglycemia, lactic acidosis, redistribution/accumulation of body fat, -Postmarketing reports: Lactic acidosis, hypokalemia, hypophosphatemia, -Frequency not reported: Redistribution/accumulation of body fat (including central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement, "cushingoid appearance")[Ref]. Before taking this medicine You should not use this medicine if: Aids 14 (2000): 2895-902, 22. Safety and efficacy have not been established in children weighing less than 40 kg using Symfi and in children weighing less than 35 kg using Symfi Lo. Store this medicine in the original container at room temperature, away from moisture and heat. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. you should know that efavirenz, lamivudine, and tenofovir may make you dizzy, drowsy, unable to concentrate, have trouble falling asleep or staying asleep, have unusual dreams or have hallucinations (seeing things or hearing voices that do not exist). Copyright, 2023. Talk with your doctor before stopping. 4 CONTRAINDICATIONS SYMFI is contraindicated: 5 WARNINGS AND . Cerner Multum, Inc. "UK Summary of Product Characteristics." This medicine contains 400 milligrams (mg) efavirenz, 300 mg lamivudine, and 300 mg tenofovir disoproxil fumarate (equivalent to 245 mg tenofovir disoproxil). Lancet 357 (2001): 592-8, 21. denBrinker M, Wit FWNM, WertheimvanDillen PME, Jurriaans S, Weel J, vanLeeuwen R, Pakker NG, Reiss P, Danner SA, Weverling G "Hepatitis B and C virus co-infection and the risk for hepatotoxicity of highly active antiretroviral therapy in HIV-1 infection." For oral dosage form (Symfi Lo tablets): Adults and children weighing 35 kilograms (kg) or more1 tablet once a day at bedtime. These side effects may go away during treatment as your body adjusts to the medicine. Call your doctor right away if you or child have abdominal or stomach discomfort, cramping, nausea, vomiting, diarrhea, or a decreased appetite, muscle cramping or pain, unusual tiredness or weakness, trouble breathing, or yellow skin or eyes. Keep this medication in the container it came in, tightly closed, and out of reach of children. you should know that efavirenz, lamivudine, and tenofovir may cause changes in your thoughts, behavior, or mental health. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. Although not all of these side effects may occur, if they do occur they may need medical attention. Efavirenz, lamivudine, and tenofovir may cause other side effects. Am J Gastroenterol 96 (2001): 265, 23. All rights reserved. If appropriate, initiation of anti-hepatitis B therapy may be warranted.Important Differences Among Lamivudine-Containing ProductsEpivir tablets and oral solution (used to treat HIV-1 infection) contain a higher dose of the active ingredient (lamivudine) than Epivir-HBV tablets and oral solution (used to treat chronic hepatitis B virus infection). It will not keep you from spreading HIV to other people. Pancreatitis has been reported infrequently in adults, but has been more common in pediatric patients (up to 18% in 2 limited studies). Danner S, van Leeuwen R, Katlama C, Ingrand D, Weber J, Kitchen V "3TC in HIV positive, asymptomatic or mild ARC patients." Written by Cerner Multum. This medicine may increase the risk of kidney problems. Brand names: Symfi, Symfi Lo Descovy, Truvada, tenofovir, entecavir, emtricitabine, lamivudine, Vemlidy, Atripla, Viread, Baraclude. Tell your doctor about all your current medicines and any medicine you start or stop using. You may report side effects to the FDA at 1-800-FDA-1088. AIDS 12 (1998): 1735-44, 7. AHFS Patient Medication Information. "Evaluation of safety and efficacy of 3TC (lamivudine) in patients with asymptomatic or mildly symptomatic human immunodeficiency virus infection: a phase I/II study." In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Severe side effects may include depression, psychosis, or osteonecrosis. These side effects may be worse if you also drink alcohol, or take certain other medications such as antidepressants, medications for anxiety, medications for mental illness, medications for seizures, sedatives, sleeping pills, or tranquilizers. After 4 weeks of therapy, CNS symptoms of at least moderate severity were reported in 5% to 9% of patients using efavirenz-containing regimens. Take Symfi on an empty stomach and preferably at bedtime. Tell your doctor if you are taking any of these medications to be sure you do not receive the same medication twice. Pluda JM, Cooley TP, Montaner JS, Shay LE, Reinhalter NE, Warthan SN, Ruedy J, Hirst HM, Vicary CA, Quinn JB, et al. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Symfi; Symfi Lo; Descriptions. If the container has a small packet of drying agent(called a. Symfi contains three different medicines: efavirenz, lamivudine, and tenofovir disoproxil fumarate. This medicine can lower, but not fully prevent, the risk of spreading HIV to others. Available for Android and iOS devices. Efavirenz / lamivudine / tenofovir systemic 600 mg / 300 mg / 300 mg (L65). AIDS 13 (1999): 1659-67, 19. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient. What side effects can this medication cause? Order by 10pm (subject to change during promotions), available 7 days a week for 4.95. These side effects usually go away 2 to 4 weeks after starting treatment. If you notice any other effects, check with your healthcare professional. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Although efavirenz, lamivudine and tenofovir will not cure HIV, these medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Use an effective form of birth control to keep from getting pregnant. Duplication for commercial use must be authorized by ASHP. Efavirenz is associated with a low rate of serum enzyme elevations during therapy and is an uncommon, but well established cause of clinically apparent acute liver injury. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. You might also lose fat from the legs, arms, and face. Efavirenz, lamivudine, and tenofovir is a complete regimen and is not for use with other antiviral medications. Mylan Specialty (2018): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Call your doctor right away if you or your child notice a severe skin rash, blistering, peeling, or loosening of the skin, red skin lesions, sores or ulcers on the skin, or fever or chills while you or your child are using this medicine. Avoid driving or hazardous activity until you know how this medicine will affect you. Along with its needed effects, a medicine may cause some unwanted effects. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Weitzel T, Plettenberg A, Albrecht D, Lorenzen T, Stoehr A "Severe anaemia as a newly recognized side-effect caused by lamivudine." Medically reviewed by Drugs.com on Nov 23, 2022. Children weighing less than 40 kgUse is not indicated in these patients. What Is Symfi? Where can I find more information about Symfi? Do not miss a dose of Symfi, and do not change your dose or stop taking Symfi without first talking with your health care provider. It could harm the unborn baby or cause birth defects. What Is Symfi Lo? Using this medicine with any of the following medicines is not recommended. ALT increases greater than 3 x ULN have also been reported. Increased serum lipase (at least 2.5 times the upper limit of normal [2.5 x ULN]) and amylase (greater than 2 x ULN) have been reported in 10% and up to 4.2% of patients, respectively. Hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who discontinue lamivudine and are co-infected with HIV-1 and HBV. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Some symptoms may occur months to years after starting treatment. Version: 2.01. "Product Information. Do not change the dose or stop using this medicine without checking first with your doctor. Do not let anyone else take your medication. Not all possible interactions are listed here. These symptoms were severe in 2% of patients; therapy was discontinued in 2.1% of patients due to these side effects. you should know that efavirenz, lamivudine and tenofovir are also available individually with the brand names of Sustiva, Epivir, Epivir-HBV (used to treat hepatitis B), Vemlidy (used to treat hepatitis B), and Viread, as well as in combination with other medications with brand names of Atripla, Biktarvy, Combivir, Complera, Descovy, Epzicom, Genvoya, Odefsey, Stribild, Symfi, Triumeq, Trizivir, and Truvada. Take this medicine on an empty stomach at bedtime. Efavirenz is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Although not all of these side effects may occur, if they do occur they may need medical attention. Pharmacotherapy 26 (2006): 1111-33, 16. Your doctor may test you to see if you have HBV before you begin your treatment with efavirenz, lamivudine and tenofovir. 1 tablet orally once a dayUse: As a complete regimen for the treatment of HIV-1 infection, 1 tablet orally once a dayComments:-Symfi Lo(TM) is approved for patients weighing at least 35 kg.-Symfi(TM) is approved for patients weighing at least 40 kg.-Recommended for pediatric patients who can swallow a solid tabletUse: As a complete regimen for the treatment of HIV-1 infection. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Take efavirenz, lamivudine, and tenofovir at around the same time every day. Keep Symfi in the container that it came in and keep the container tightly closed. These are not all the possible side effects of Symfi Lo. Ask your doctor about this if you have any concerns. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). If your dose is different, do not change it unless your doctor tells you to do so. Symfi Lo is for use in adults and children who weigh at least 77 pounds (35 kilograms). This includes prescription and over-the-counter medicines, vitamins, and herbal products. This medicine contains 600 milligrams (mg) efavirenz, 300 mg lamivudine, and 300 mg tenofovir disoproxil fumarate (equivalent to 245 mg tenofovir disoproxil). At 1-800-FDA-1088 and face weighing less than 40 kgUse is not recommended UK Summary of Product Characteristics. needed,... To use a medicine, the risk of spreading HIV to other people for! Print Save lamivudine side effects Medically reviewed by Drugs.com and children who at. Your current medicines and any medicine you should know that efavirenz, lamivudine and. Your personal circumstances legs, arms, and out of reach of children 14! Until you know how this medicine approvals, alerts and updates may need medical attention container that came. 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