Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). USES: Selegiline is an antidepressant (monoamine oxidase inhibitor) that treats depression by restoring the balance of certain natural substances (neurotransmitters) in the brain. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Use Caution/Monitor. Monitor Closely (1)almotriptan and selegiline both increase serotonin levels. selegiline increases toxicity of oxymorphone by unknown mechanism. Avoid or Use Alternate Drug. Contraindicated. Risk of acute hypertensive episode. Avoid or Use Alternate Drug. selegiline, pimozide. Monitor Closely (1)selegiline, iloperidone. Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. Avoid or Use Alternate Drug. Coadministration is contraindicated. Contraindicated (1)selegiline and tranylcypromine both increase serotonin levels. Contraindicated (1)selegiline increases toxicity of fentanyl by Other (see comment). Concurrent use or use within 14 days of selegiline treatment is contraindicated. Avoid concomitant use if possible. selegiline increases levels of ketamine by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Contraindicated. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Drug Interactions.) Contraindicated (1)selegiline and trimipramine both increase serotonin levels. Use Caution/Monitor. Hypoglycemic effects may be increased. Blood Pressure Elevation Related to Concomitant Medication. unspecified interaction mechanism. Risk of acute hypertensive episode. Avoid or Use Alternate Drug. selegiline increases effects of methylphenidate by pharmacodynamic synergism. Transdermal selegiline is contraindicated in patients taking selective serotonin reuptake inhibitors; dual serotonin and norepinephrine reuptake inhibitors; tricyclic antidepressants; bupropion. Coadministration is contraindicated. Selegiline hydrochloride capsules are contraindicated for use with meperidine (DEMEROL & other trade names). Avoid or Use Alternate Drug. MAOIs prevent this from happening, which makes more of these brain chemicals available to effect changes in both cells and circuits that have been impacted by depression.. MAOIs also affect other neurotransmitters in the brain and digestive system, causing . selegiline increases toxicity of methadone by unknown mechanism. Linezolid may increase serotonin as a result of MAO-A inhibition. . Hypoglycemic effects may be increased. Follow your doctor's instructions carefully. Serious - Use Alternative (1)granisetron, selegiline. Combination is contraindicated within 2 weeks of MAOI use. It is commonly referred to in the clinical and pharmacological literature as 1-deprenyl. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.Tell your doctor or pharmacist if you are using any of these medications before, during, or within 2 weeks after treatment with selegiline. . cannabidiol, selegiline. Use Caution/Monitor. Modify Therapy/Monitor Closely. Mechanism: unknown. This isn't an exhaustive list, but here are some common Paxlovid interactions to be aware of. selegiline increases effects of isoproterenol by pharmacodynamic synergism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Contraindicated. Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Question: Medications for Depressive Disorders: Contraindications for Selegiline (RM MH RN 10.0 Chp 22, Active Learning Template - Medication, RN QSEN - Safety) (Please fill every box, there are 9, thank you !) Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. CONTRAINDICATIONS: ELDEPRYL is contraindicated in patients with a known hypersensitivity to this drug. Mechanism: pharmacodynamic synergism. selegiline and nefazodone both increase serotonin levels. selegiline increases effects of insulin detemir by unknown mechanism. selegiline and morphine both increase serotonin levels. Increase dose of CYP2B6 substrate, as needed, when coadministered with cenobamate. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. selegiline, captopril. Use Caution/Monitor. Risk of acute hypertensive episode; separate by 14 days. commonly, these are generic drugs. unspecified interaction mechanism. unspecified interaction mechanism. Use caution when administering MAOIs and modafinil. selegiline and linezolid both increase serotonin levels. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). These medications can help prevent suicidal thoughts/attempts and provide other important benefits. unspecified interaction mechanism. WARNING: Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. selegiline increases toxicity of codeine by unknown mechanism. HOW TO USE: Read the Medication Guide provided by your pharmacist before you start using selegiline and each time you get a refill. This is not a complete list of side effects and others may occur. Effect of coadministration of a dual CYP3A4 and CYP2C19 inhibitor with fedratinib has not been studied. Selegiline hydrochloride capsules are contraindicated in patients with a known hypersensitivity to this drug. Opioids are not recommended for patients taking MAOIs or within 14 days of stopping MAOIs. The recipient will receive more details and instructions to access this offer. However, the chance exists that dangerous reactions, including sudden high blood pressure, may occur if doses higher than those used for Parkinson's disease are taken with certain . selegiline will increase the level or effect of solriamfetol by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. a heart rhythm medication, amiodarone. selegiline will increase the level or effect of fezolinetant by affecting hepatic enzyme CYP1A2 metabolism. Coadministration of ozanimod with MAO-B inhibitors may decrease exposure of the active metabolites of ozanimod, which may inhibit MAO. Monitor Closely (1)lumacaftor/ivacaftor, selegiline. selegiline and dihydroergotamine both increase serotonin levels. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Contraindicated. Risk of acute hypertensive episode. Managing the Psychological Symptoms of Patients With Parkinson's Disease? teriflunomide increases levels of selegiline by Other (see comment). Do not apply the patch to hairy/oily/red/cut/irritated/broken or scarred/calloused skin. . Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Lomitapide dose should not exceed 30 mg/day. Levodopa may enhance risk for acute hypertensive episode if coadministered with nonselective MAOIs. a thyroid medication, levothyroxine. DB06698. commonly, these are "preferred" (on formulary) brand drugs. Risk of acute hypertensive episode. Modify Therapy/Monitor Closely. Potential for increased CNS depression, drowsiness, dizziness or hypotension, so use with any MAOI should be cautious. In vitro studies suggest that lumacaftor may induce and ivacaftor may inhibit CYP2B6 substrates. Use Caution/Monitor. unspecified interaction mechanism. Antiparkinson Agents, MAO Type B Inhibitors. selegiline, trifluoperazine. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Risk of acute hypertensive episode. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Comment: Avoid fentanyl in patients who require concomitant administration MAOIs, or within 14 days of stopping an MAOI. Serious - Use Alternative (1)selegiline and lorcaserin both increase serotonin levels. Contraindicated. At least 14 days should elapse between discontinuation of rasagiline and initiation of another MAOI or discontinuation of another MAOI and initiation of rasagiline. Use Caution/Monitor. selegiline increases effects of insulin aspart by unknown mechanism. Contraindicated (2)selegiline increases effects of lisdexamfetamine by pharmacodynamic synergism. Contraindicated. Monitor Closely (1)cannabidiol, selegiline. selegiline increases toxicity of tapentadol by unknown mechanism. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Monitor Closely (1)sumatriptan and selegiline both increase serotonin levels. Contraindicated. affecting hepatic enzyme CYP2B6 metabolism. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). 18yrs: 5mg once daily (taken at same time each day). orthostatic hypotension, a form of . Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. selegiline increases effects of diethylpropion by pharmacodynamic synergism. Selegiline can improve your mood and feelings of well-being. Serious - Use Alternative (1)selegiline increases toxicity of difenoxin hcl by unknown mechanism. Avoid or Use Alternate Drug. Selegiline belongs to the class of medications called monoamine oxidase inhibitors (M.O.S..It is used to treat Parkinson's Disease. Drug information provided by: Merative, . Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Serum glucose should be monitored closely when MAOIs are added to any regimen containing antidiabetic medications. Serious - Use Alternative (1)selegiline increases toxicity of diphenoxylate hcl by unknown mechanism. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Contraindicated. Starting a new medication or changing the one you're currently on can bring up all sorts of questions and concerns. Comment: Oral contraceptives inhibit the N demethylatin of selegiline. Both methylene blue and selegiline may increase serotonin as a result of MAO-A inhibition. Prescriptions should be written for the smallest quantity consistent with good patient care, May potentiate dopaminergic side effects of levodopa and cause dyskinesia or exacerbate preexisting dyskinesia, which may, in turn, require a reduction of levodopa dose, In patients with bipolar disorder, treating a depressive episode may precipitate a mixed/manic episode; prior to initiating treatment, screen patients for any personal or family history of bipolar disorder, mania, or hypomania, Risk of melanoma development increased in Parkinson disease patients; monitor patients closely, Drug contains phenylalanine, a component of aspartame; each 1.25 mg tablet contains 1.25 mg phenylalanine; patients taking the 2.5 mg dose will receive 2.5 mg phenylalanine; before prescribing drug to a patient with PKU, consider combined daily amount of phenylalanine from all sources, including therapy, Concomitant use of dextromethorphan, may result in episodes of psychosis or bizarre behavior, Orthostatic hypotension may occur; incidence of orthostatic hypotension reported to be higher in geriatric patients 65 years, The available data on use in pregnant women are not sufficient to inform a drug-associated risk of adverse pregnancy-related outcomes; When treating a pregnant woman, the physician should carefully consider both the potential risks of taking an MAOI, particularly the risk of hypertensive crisis during pregnancy, along with the established benefits of treating depression with an antidepressant, There is no information regarding presence in human milk, or effects on milk production or breastfed infant; selegiline and metabolites were detected in rat milk at levels higher than those in maternal plasma; because of potential for serious adverse reactions in breastfed infants from therapy, including potential for hypertensive crisis, advise a woman that breastfeeding is not recommended during treatment and for 7 days after final dose. 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