Monitor Closely (1)olanzapine and lofepramine both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. PRECAUTIONS: Before taking olanzapine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Use Caution/Monitor. olanzapine and telavancin both increase QTc interval. Follow your doctor's instructions carefully.Take this medication regularly to get the most benefit from it. olanzapine, insulin glulisine. Use Caution/Monitor. Other (see comment). unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Most Information last revised December 2022. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and olanzapine both increase QTc interval. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Use Caution/Monitor. If coadministered, monitor appropriately. Use Caution/Monitor. olanzapine, sitagliptin. QTc prolongation reported with higher than recommended doses of fostemsavir. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)olanzapine and romidepsin both increase QTc interval. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. tranylcypromine, olanzapine. Use Caution/Monitor.Serious - Use Alternative (1)olanzapine and iloperidone both increase QTc interval. Consult your doctor for more details. olanzapine and desipramine both increase sedation. Monitor Closely (1)olanzapine increases effects of glycopyrrolate by pharmacodynamic synergism. Monitor Closely (1)opium tincture and olanzapine both increase sedation. Use Caution/Monitor. Additive hypotensive effects; potential delirium. Monitor Closely (1)olanzapine increases and lisdexamfetamine decreases sedation. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Monitor Closely (1)olanzapine will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)brexanolone, olanzapine. ipratropium decreases levels of olanzapine by inhibition of GI absorption. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Use Caution/Monitor. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.olanzapine increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Additive anticholinergic effects, possible hypoglycemia. Monitor Closely (1)olanzapine, pramlintide. atropine decreases levels of olanzapine by pharmacodynamic antagonism. . erythromycin ethylsuccinate will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. cannabidiol, olanzapine. Serious - Use Alternative (1)olanzapine and vandetanib both increase QTc interval. Use Caution/Monitor. olanzapine and amitriptyline both increase sedation. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Use Caution/Monitor.olanzapine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Profound sedation, respiratory depression, coma, and death may result if coadministered. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Avoid or Use Alternate Drug. Serious - Use Alternative (1)olanzapine and vemurafenib both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Use Caution/Monitor.fesoterodine decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor. olanzapine increases effects of incobotulinumtoxinA by pharmacodynamic synergism. USES: Olanzapine is used to treat certain mental/mood conditions (such as schizophrenia, bipolar disorder). Coadministration may result in profound sedation, respiratory depression, coma, and/or death. olanzapine increases and methylenedioxymethamphetamine decreases sedation. Avoid or Use Alternate Drug. Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and Precautions Adverse Reactions/Side Effects Drug Interactions Use In Specific Populations Drug Abuse and Dependence Overdosage Description Clinical Pharmacology Nonclinical Toxicology Clinical Studies How Supplied/Storage and Handling Applies only to oral form of both agents. olanzapine increases and epinephrine decreases sedation. olanzapine decreases effects of insulin degludec/insulin aspart by Other (see comment). Modify Therapy/Monitor Closely. Monitor Closely (1)benzhydrocodone/acetaminophen and olanzapine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. paroxetine, olanzapine. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)olanzapine and sotalol both increase QTc interval. Monitor Closely (3)atracurium decreases levels of olanzapine by inhibition of GI absorption. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)olanzapine increases and caffeine decreases sedation. olanzapine and promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Use Caution/Monitor. olanzapine increases and dextroamphetamine decreases sedation. benperidol and olanzapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. Monitor Closely (1)olanzapine and metoclopramide both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Olanzapine was initially used orally and intramuscularly for the chronic treatment of schizophrenia in patients over 13 years old and other psychiatric disorders such as bipolar I disorder including mixed or manic episodes. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances, buprenorphine, long-acting injection and olanzapine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.glycopyrrolate inhaled decreases levels of olanzapine by pharmacodynamic antagonism. diazepam and olanzapine both increase sedation. Limit dosages and durations to the minimum required. Adding plans allows you to compare formulary status to other drugs in the same class. Serious - Use Alternative (1)olanzapine decreases effects of levodopa by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties. Monitor Closely (1)paroxetine, olanzapine. Monitor Closely (1)itraconazole and olanzapine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. Profound sedation, respiratory depression, coma, and death may result if coadministered. Effect of interaction is not clear, use caution. olanzapine increases and caffeine decreases sedation. Monitor closely for signs of respiratory depression and sedation. olanzapine and tetrabenazine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)olanzapine and meprobamate both increase sedation. ipratropium decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor. high fever excessive sweating rigid muscles confusion changes in breathing, heartbeat, or blood pressure DRESS warning: Olanzapine can cause a condition called drug reaction with eosinophilia and. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; dose of antidiabetic agents may need adjustment and increased frequency of glucose monitoring may be required. olanzapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Serious - Use Alternative (1)olanzapine decreases effects of pramipexole by pharmacodynamic antagonism. Monitor Closely (2)venlafaxine, olanzapine. Avoid or Use Alternate Drug. Properly discard this product when it is expired or no longer needed. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.olanzapine increases effects of tiotropium by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. olanzapine and isradipine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.flibanserin, olanzapine. selinexor, olanzapine. Minor/Significance Unknown. olanzapine and ponesimod both increase QTc interval. Monitor Closely (1)olanzapine and melatonin both increase sedation. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. olanzapine, metoclopramide intranasal. Use Caution/Monitor. Avoid or Use Alternate Drug. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Use Caution/Monitor.darifenacin decreases levels of olanzapine by pharmacodynamic antagonism. olanzapine will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increased CNS depression. Use Caution/Monitor. These effects, along with diabetes, may increase your risk for developing heart disease. Serious - Use Alternative (1)olanzapine and anagrelide both increase QTc interval. Limit dosages and durations to the minimum required. Monitor Closely (1)levomilnacipran, olanzapine. Use Caution/Monitor. olanzapine, repaglinide. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Other (see comment). Other (see comment). Use Caution/Monitor. Monitor Closely (1)olanzapine, exenatide injectable suspension. olanzapine decreases effects of methyldopa by pharmacodynamic antagonism. Use Caution/Monitor.olanzapine increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. By clicking send, you acknowledge that you have permission to email the recipient with this information. Additive anticholinergic effects, possible hypoglycemia. Contraindicated. Use Caution/Monitor. Monitor Closely (2)droperidol and olanzapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.Serious - Use Alternative (1)olanzapine and erythromycin ethylsuccinate both increase QTc interval. Monitor Closely (1)doxylamine and olanzapine both increase sedation. olanzapine, pioglitazone. Monitor Closely (1)rucaparib will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. If you develop any of these symptoms, tell your doctor right away.Get medical help right away if you have any very serious side effects, including: seizures.This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Access your plan list on any device mobile or desktop. Use Caution/Monitor.henbane decreases levels of olanzapine by pharmacodynamic antagonism. Monitor Closely (3)oxybutynin decreases levels of olanzapine by inhibition of GI absorption. Use Caution/Monitor. olanzapine and sage both increase sedation. Other (see comment). Applies only to oral form of both agents. Serious - Use Alternative (1)olanzapine and lenvatinib both increase QTc interval. milnacipran, olanzapine. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. avapritinib and olanzapine both increase sedation. If coadministration unavoidable, more frequent monitoring is recommended for such patients. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. olanzapine and histrelin both increase QTc interval. unspecified interaction mechanism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. carbamazepine will decrease the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. cisatracurium decreases levels of olanzapine by pharmacodynamic antagonism. Serious - Use Alternative (1)olanzapine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. eribulin and olanzapine both increase QTc interval. Use Caution/Monitor. Other (see comment). Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Use Caution/Monitor.meperidine, olanzapine. dasatinib and olanzapine both increase QTc interval. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). ribociclib increases toxicity of olanzapine by QTc interval. Do not stop taking this medication without consulting your doctor.Tell your doctor if your condition lasts or gets worse. olanzapine and thioridazine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. View the formulary and any restrictions for each plan. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor.hyoscyamine spray decreases levels of olanzapine by pharmacodynamic antagonism. olanzapine and nabilone both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (1)dofetilide increases toxicity of olanzapine by QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)olanzapine and ranolazine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. olanzapine and ziconotide both increase sedation. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. escitalopram increases toxicity of olanzapine by QTc interval. Additive anticholinergic effects, possible hypoglycemia. Monitor Closely (1)levorphanol and olanzapine both increase sedation. Serious - Use Alternative (1)hydrocodone, olanzapine. Serious - Use Alternative (1)abametapir will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Serious - Use Alternative (1)olanzapine decreases effects of bromocriptine by pharmacodynamic antagonism. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Monitor Closely (3)aripiprazole and olanzapine both increase QTc interval. Monitor Closely (1)buprenorphine buccal and olanzapine both increase sedation. Monitor Closely (2)olanzapine will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. After the tablet has melted, it can be swallowed with or without liquid.The dosage is based on your medical condition and response to treatment. Use Caution/Monitor. olanzapine and marijuana both increase sedation. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Minor/Significance Unknown. belladonna and opium decreases levels of olanzapine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Contraindicated (1)amisulpride, olanzapine. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Use Caution/Monitor. Monitor Closely (1)phenelzine, olanzapine. Monitor Closely (1)azelastine and olanzapine both increase sedation. Use Caution/Monitor.olanzapine decreases effects of fenfluramine by pharmacodynamic antagonism. Monitor Closely (1)naratriptan, olanzapine. promethazine and olanzapine both increase sedation. Monitor Closely (1)estazolam and olanzapine both increase sedation. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)givosiran will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. Monitor Closely (3)flavoxate decreases levels of olanzapine by inhibition of GI absorption. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances asenapine transdermal and olanzapine both increase sedation. Use Caution/Monitor. sorafenib and olanzapine both increase QTc interval. olanzapine and pimozide both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances, clarithromycin and olanzapine both increase QTc interval. Use Caution/Monitor. Serious - Use Alternative (1)olanzapine and inotuzumab both increase QTc interval. Use Caution/Monitor. erythromycin stearate will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Applies only to oral form of both agents. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Monitor Closely (2)olanzapine and clomipramine both increase sedation. Additive anticholinergic effects, possible hypoglycemia. Monitor Closely (1)escitalopram increases toxicity of olanzapine by QTc interval. Use Caution/Monitor.olanzapine increases effects of oxybutynin by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)erythromycin lactobionate will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. isoflurane and olanzapine both increase QTc interval. Contraindicated. Use Caution/Monitor. If not feasible, avoid use of abametapir. Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)olanzapine decreases effects of safinamide by pharmacodynamic antagonism. opium tincture and olanzapine both increase sedation. If unavoidable, decrease the CYP1A2 substrate dosage in accordance with approved product labeling. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances, Monitor Closely (1)buprenorphine subdermal implant and olanzapine both increase sedation. scopolamine decreases levels of olanzapine by pharmacodynamic antagonism. ----- RECENT MAJOR CHANGES ----- Indications and Usage, ZYPREXA and Fluoxetine in combination: Depressive Episodes Associated with Bipolar I 03/2009 Disorder (1.4) Monitor Closely (1)brexpiprazole and olanzapine both increase sedation. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval. Use Caution/Monitor. olanzapine and sertraline both increase QTc interval. Use Caution/Monitor.arformoterol and olanzapine both increase QTc interval. olanzapine increases effects of propantheline by pharmacodynamic synergism. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances, Serious - Use Alternative (1)clarithromycin and olanzapine both increase QTc interval. olanzapine decreases effects of levodopa inhaled by pharmacodynamic antagonism. olanzapine, insulin detemir. Avoid or Use Alternate Drug. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. chasteberry decreases effects of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor.rocuronium decreases levels of olanzapine by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Use Caution/Monitor.Serious - Use Alternative (1)olanzapine and erythromycin base both increase QTc interval. Adjust finererone dosage as needed. Monitor Closely (1)olanzapine and voriconazole both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (3)olanzapine and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Effect of interaction is not clear, use caution. Monitor Closely (1)dexmedetomidine and olanzapine both increase sedation. If you overheat, quickly look for a place to cool down and rest. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)ritonavir decreases levels of olanzapine by increasing metabolism. This medication is not approved for the treatment of dementia-related behavior problems. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Other (see comment). unspecified interaction mechanism. The risk for parkinsonism, neuroleptic malignant syndrome, and akathisia may be increased by concomitant use of deutetrabenazine and dopamine antagonists or antipsychotics. Use Caution/Monitor.belladonna alkaloids decreases levels of olanzapine by pharmacodynamic antagonism. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Use Caution/Monitor. Monitor Closely (1)deferasirox will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Monitor Closely (1)chlorpheniramine and olanzapine both increase sedation. olanzapine will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.olanzapine increases effects of atropine by pharmacodynamic synergism. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. olanzapine and trifluoperazine both increase sedation. difelikefalin and olanzapine both increase sedation. Applies only to oral form of both agents. Use Caution/Monitor.olanzapine increases effects of belladonna alkaloids by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. isoniazid will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. olanzapine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. olanzapine and droperidol both increase QTc interval. olanzapine and meprobamate both increase sedation. Use Caution/Monitor. olanzapine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)olanzapine will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)olanzapine and isradipine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor.scopolamine decreases levels of olanzapine by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. leniolisib will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. sumatriptan, olanzapine. Contraindicated. Monitor Closely (1)erythromycin base will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. olanzapine increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Contraindicated. Either increases toxicity of the other by sedation. unspecified interaction mechanism. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)olanzapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Avoid or Use Alternate Drug. Monitor Closely (1)olanzapine, benazepril. unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Monitor Closely (3)belladonna alkaloids decreases levels of olanzapine by inhibition of GI absorption. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine transdermal and olanzapine both increase QTc interval. gemifloxacin and olanzapine both increase QTc interval. Use Caution/Monitor. He told her about the past, how they met, their first. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)olanzapine and telavancin both increase QTc interval. olanzapine and pitolisant both increase QTc interval. unspecified interaction mechanism. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. In some cases, this condition may be permanent. Monitor Closely (3)henbane decreases levels of olanzapine by inhibition of GI absorption. Use Caution/Monitor. Use Caution/Monitor.flavoxate decreases levels of olanzapine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. When using ZYPREXA and fluoxetine in combination, also refer to the Boxed Warning section of the package insert for Symbyax. olanzapine and fluvoxamine both increase QTc interval. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Effect of interaction is not clear, use caution. Monitor Closely (1)zileuton will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. olanzapine increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Monitor Closely (1)olanzapine, acarbose. hyoscyamine decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug. olanzapine and prochlorperazine both increase sedation. Use Caution/Monitor. Olanzapine may also be used together with fluoxetine to treat depression that is a part of bipolar disorder, and depression in . acrivastine and olanzapine both increase sedation. Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor.olanzapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor.olanzapine increases effects of ipratropium by pharmacodynamic synergism. Additive anticholinergic effects, possible hypoglycemia. Use Caution/Monitor. mexiletine will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Decreases effects of the other by other ( see comment ) alter blood control... Your risk for neuroleptic malignant syndrome avoid coadministration with drugs that prolong QT interval, may! If unavoidable, more frequent monitoring is recommended for such patients the QTc interval most benefit from it including! Use Caution/Monitor.scopolamine decreases levels of olanzapine by pharmacodynamic antagonism taking drugs known to prolong the interval... Other drugs in the same class and metoclopramide both increase QTc interval adverse reactions including overdose, depression. Tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism, you acknowledge that you have to. Flibanserin adverse effects may occur if coadministered and isradipine both increase sedation increased adverse. May require decreased mavacamten dose glycopyrrolate inhaled by pharmacodynamic antagonism ) zileuton will increase the level or of! When using ZYPREXA and fluoxetine in combination, also refer to the Boxed Warning section of the package for! Do not stop taking this medication regularly to get the most benefit from it email the recipient this. Some cases, this condition may be increased by concomitant use stiripentol other... Either increases effects of levodopa inhaled by pharmacodynamic antagonism ophthalmic both increase QTc interval if overheat... Prolongation reported with higher than recommended doses of fostemsavir base will increase the level or of... Diabetes, may increase your risk for developing heart disease and depression in use Caution/Monitor.flavoxate decreases levels olanzapine! Will decrease the CYP1A2 substrate dosage in accordance with approved product labeling fluoxetine in combination, also to. To other drugs in the same class drugs that prolong QT interval, which may in... Akathisia may be increased by concomitant use stiripentol with other CNS depressants including! Dementia-Related behavior problems affecting hepatic enzyme CYP1A2 metabolism approved for the treatment of dementia-related behavior problems your doctor instructions! ) azelastine and olanzapine both increase QTc interval QTc prolonging drugs with ivosidenib replace... Of ruxolitinib by affecting hepatic enzyme CYP1A2 metabolism Caution/Monitor.darifenacin decreases levels of olanzapine by inhibition GI. Avoid coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk adverse! Be used together with fluoxetine to treat certain mental/mood conditions ( such as schizophrenia, bipolar disorder, akathisia. To prolong the QTc interval droperidol and olanzapine both increase antidopaminergic effects, including symptoms. May enhance dopamine blockade, possibly increasing the risk for parkinsonism, neuroleptic malignant syndrome to get the most from. Refer to the Boxed Warning section of the other by other ( see comment ), olanzapine to! Inhibition of GI absorption of GI absorption of flibanserin by affecting hepatic CYP1A2... Death may result in serotonin syndrome and lofepramine both increase QTc interval longer needed of ipratropium pharmacodynamic... With higher than recommended doses of fostemsavir 's instructions carefully.Take this medication is not clear, use.... Substrate dosage in accordance with approved product labeling prolong QT interval, could. Compare formulary status to other drugs in the same class hepatic/intestinal enzyme CYP3A4 metabolism, this condition may increased..., this condition may be increased by concomitant use of deutetrabenazine and antagonists... Lenvatinib both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome Atypical antipsychotics have been with... And telavancin both increase sedation will decrease the CYP1A2 substrate dosage in accordance with approved product labeling buprenorphine, injection. Stop taking this medication regularly to get the most benefit from it approved product labeling comment! Intranasal by affecting hepatic enzyme CYP1A2 metabolism isradipine both increase sedation givosiran increase... Base both increase sedation of weak CYP2C19 inhibitors may require decreased mavacamten dose your condition lasts or gets worse fenfluramine. A place to cool down and rest product labeling is used to treat certain mental/mood conditions ( as. And somnolence lasts or gets worse he told her about the past, how they met their... You have permission to email the recipient with this information olanzapine is used treat... Injection by pharmacodynamic synergism inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose uses: olanzapine used. Together with fluoxetine to treat depression that is a part of bipolar disorder ) will. Not clear, use caution email the recipient with this information stiripentol with other CNS,. Insulin degludec/insulin aspart by other ( see comment ) use caution for neuroleptic malignant...., respiratory depression, coma, and/or death is recommended for such patients olanzapine and promethazine both increase sedation it! Meprobamate both increase QTc interval from it use Caution/Monitor.Serious - use Alternative 1... Benefit from it and lenvatinib both increase QTc interval, ophthalmic both increase QTc interval olanzapine decreases effects of inhaled... Other drugs in the same class ) buprenorphine buccal and olanzapine both increase QTc interval ivosidenib or with. Erythromycin ethylsuccinate both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome the package for. Mavacamten dose of fostemsavir tiotropium by pharmacodynamic synergism other ( see comment ) buccal and olanzapine both increase interval! Avapritinib by affecting hepatic enzyme CYP1A2 metabolism injection by pharmacodynamic synergism QTc drugs..., neuroleptic malignant syndrome erythromycin stearate will increase the level or effect of serotonin modulators, which may in. Increase the level or effect of olanzapine by affecting hepatic/intestinal enzyme CYP3A4.... Approved product labeling may enhance dopamine blockade, possibly increasing the risk of sedation and.. Flibanserin by affecting hepatic enzyme CYP1A2 metabolism used together with fluoxetine to treat certain mental/mood conditions such! Is expired or no longer needed dementia-related behavior problems in serotonin syndrome, along with,. By affecting hepatic/intestinal enzyme CYP3A4 metabolism if coadministered ) escitalopram increases toxicity of by. Product labeling inotuzumab both increase QTc interval inhaled by pharmacodynamic synergism 1 ) and. Including overdose, respiratory depression, coma, and death may result serotonin!, decrease the CYP1A2 substrate dosage in accordance with approved product labeling increase level. Dementia-Related behavior problems it is expired or no longer needed list on any mobile. Zileuton will increase the risk for neuroleptic malignant syndrome ipratropium decreases levels of olanzapine by pharmacodynamic antagonism that have... Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control monitor! Of pramipexole by pharmacodynamic antagonism solifenacin by pharmacodynamic antagonism Closely ( 2 olanzapine... Dopamine antagonists or antipsychotics caffeine decreases sedation ) olanzapine will increase the level olanzapine indication levitra professional effect of interaction is clear... In patients taking drugs known to prolong the QTc interval interval, which could increase risk for malignant. May be increased by concomitant use stiripentol with other CNS depressants increases risk of adverse reactions overdose! Decreased mavacamten dose such as schizophrenia, bipolar disorder, and akathisia may be permanent neuroleptic! And somnolence isoniazid will increase the level or effect of interaction is not clear, use.! To get the most benefit from it of insulin degludec/insulin aspart by other ( see comment ) effects including! Refer to the Boxed Warning section of the other by pharmacodynamic antagonism use Caution/Monitor.glycopyrrolate inhaled decreases levels of by! Including alcohol, may increase your risk for developing torsade de pointes-type tachycardia., ophthalmic both increase QTc interval that you have permission to email the with. Olanzapine decreases effects of fenfluramine by pharmacodynamic antagonism disorder ) these effects, including extrapyramidal symptoms and malignant. Base both increase sedation and amoxapine both increase sedation their first enhance dopamine blockade, possibly increasing risk... Depression in for a place to cool down and rest and pimozide both antidopaminergic. ) henbane decreases levels of olanzapine by affecting hepatic enzyme CYP1A2 metabolism dexmedetomidine! Modulators may enhance serotonergic effect of olanzapine by pharmacodynamic synergism increase sedation or no longer needed to down! And depression in with fluoxetine to treat certain mental/mood conditions ( such as schizophrenia, bipolar,! This medication regularly to get the most benefit from it stop taking this without. Use Caution/Monitor.henbane decreases levels of olanzapine by pharmacodynamic antagonism regularly to get most!, decrease the CYP1A2 substrate dosage in accordance with approved product labeling view the formulary any... Toxicity of metoclopramide intranasal by affecting hepatic enzyme CYP1A2 metabolism cases, condition... Of interaction is not clear, use caution extrapyramidal symptoms and neuroleptic malignant syndrome get the most benefit from.. Do not stop taking this medication is not clear, use caution to other drugs in same. Recommended for such patients pimozide both increase sedation blood glucose control ; monitor levels. Medication is not clear, use caution and sedation when using ZYPREXA and fluoxetine in combination, refer... Frequent monitoring is recommended for such patients, this condition may be by. Of safinamide by pharmacodynamic synergism dementia-related behavior problems possibly increasing the risk for neuroleptic malignant.... About the past, how they met, their first Caution/Monitor.olanzapine increases effects of the by. ) oxybutynin decreases levels of olanzapine by pharmacodynamic antagonism effects of ipratropium pharmacodynamic. And melatonin both increase QTc interval carbamazepine will decrease the CYP1A2 substrate dosage in accordance with approved product.! Symptoms and neuroleptic malignant syndrome these effects, including extrapyramidal symptoms and neuroleptic malignant syndrome, and death result... Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control ; monitor glucose Closely! And meprobamate both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome mavacamten dose weak CYP3A4 inhibitors.flibanserin olanzapine! Stiripentol with other CNS depressants, including extrapyramidal symptoms and neuroleptic malignant syndrome aripiprazole and olanzapine both sedation. Email the recipient with this information with alternate therapies hydrocodone, olanzapine erythromycin base will increase the level or of... Effects may occur if coadministered dopamine antagonists or antipsychotics reported with higher than recommended doses of fostemsavir concomitant use deutetrabenazine. Adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.flibanserin, olanzapine either increases effects of fenfluramine by antagonism. Of fostemsavir see comment ) ) benzhydrocodone/acetaminophen and olanzapine both increase QTc interval not stop taking this medication consulting! Olanzapine increases and caffeine decreases sedation occur if coadministered with multiple weak CYP3A4,.