Am J Med 87 (1989): 479, 12. Cohen JS "Peripheral neuropathy associated with fluoroquinolones." 1996-2021 MedicineNet, Inc. All rights reserved. Crystalluria and cylindruria have been reported with other quinolones. BMJ 323 (2001): 547. To use the sharing features on this page, please enable JavaScript. The following laboratory abnormalities appeared in 1.0% of patients receiving multiple doses of ofloxacin. Peripheral neuropathy may occur rapidly after initiating therapy and may potentially become permanent. Available for Android and iOS devices. Copyright: Merative US L.P. 1973, 2023. Although not all of these side effects may occur, if they do occur they may need medical attention. Many antibiotics, including ofloxacin, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium responsible for the development of inflammation of the colon (Clostridium difficile, pseudomembranous colitis). Angioedema, erythema multiforme, and toxic epidermal necrolysis have also been reported during postmarketing experience. Click here for an email preview. Tsuda S, Kato K, Karashima T, Inou YH, Sasai Y "Toxic pustuloderma induced by ofloxacin." In clinical trials using multiple-dose therapy, ophthalmologic abnormalities, including cataracts and multiple punctate lenticular opacities, have been noted in patients undergoing treatment with other quinolones. Br J Clin Pharmacol 30 (1990): 63-70, 14. What should I know about storage and disposal of this medication? Urology 37 (1991): 21-7, 8. Common symptoms for acute bronchitis include Ofloxacin has mild interactions with at least 94 different drugs. Some quinolones, including ofloxacin, may produce false-positive urine screening results for opiates using commercially available immunoassay kits. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin), cyclosporine (Neoral, Sandimmune), and theophylline (Theo-Dur). Seizures were more likely to occur in elderly patients and in patients with renal dysfunction. Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." In a couple of weeks, rock overlords Queens Of The Stone Age will return with their new album In Times New Roman; we've already posted the singles "Emotion Sickness" and "Carnavoyeur." Photo: Andreas Neumann. Symptoms and signs include cough, fever, shortness of breath, and chills. Acute bronchitis usually comes on quickly and gets better after several weeks. Complications of chronic bronchitis include COPD and emphysema. Clin Infect Dis 21 (1995): 1504-6, 19. Gonorrhea Treatment Recommendations Update. [Ref], Postmarketing reports: Anaphylactic reactions/shock, anaphylactoid reactions/shock, serum sickness[Ref], According to some authorities, anaphylactic reaction and anaphylactoid reaction were reported rarely and anaphylactic shock and anaphylactoid shock were reported very rarely. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean. Acute Bronchitis: How Long Do Symptoms Last? Additional adverse events, regardless of relationship to drug, reported from worldwide marketing experience with quinolones, including ofloxacin: Cardiovascular System: cerebral thrombosis, pulmonary edema, tachycardia, hypotension/shock, syncope, torsades de pointes. URL of this page: https://medlineplus.gov/druginfo/meds/a602029.html. Use. It is also important information to carry with you in case of emergencies. Chlamydia is the most common sexually transmitted disease in the U.S. Signs and symptoms of chlamydia, a bacterial infection, include vaginal discharge, abdominal pain, burning with urination, blood in the urine, and feelings of urinary urgency and frequency. Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue. Attacks of porphyria have been reported in patients with porphyria. "Vitamn C njdete v ovoc, ako s pomarane a jahody, a vitamn E v . There is a problem with Acute Bronchitis Treatment Treatment Medications and Home Remedies. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. What Are Side Effects Associated with Using Ofloxacin? What drugs interact with Floxin (ofloxacin)? Clin Infect Dis 29 (1999): 1598-9, 27. However, you should not flush this medication down the toilet. fatigue. Am J Obstet Gynecol 164 (1991): 1390-6, 11. Review/update the Quinolones form chelates with alkaline earth and transition metal cations. Causes of chronic bronchitis include Administration of quinolones with antacids containing calcium, magnesium, or aluminum, with sucralfate, with divalent or trivalent cations such as iron, or with multivitamins containing zinc or with Videx (didanosine) may substantially interfere with the absorption of quinolones resulting in systemic levels considerably lower than desired. Ofloxacin belongs to a class of drugs called quinolone antibiotics. Ofloxacin belongs to the class of drugs known as fluoroquinolone antibiotics. Stop using ofloxacin and call your doctor at once if you have symptoms such as: headache, hunger, irritability, numbness, tingling, burning pain, confusion, agitation, paranoia, problems with memory or concentration, thoughts of suicide, or sudden pain or movement problems in any of your joints. Blum A "Ofloxacin-induced acute severe hepatitis." Theophylline levels should be closely monitored and theophylline dosage adjustments made, if appropriate, when ofloxacin is co-administered. Antimicrob Agents Chemother 35 (1991): 1239-40, 16. Instead, the best way to dispose of your medication is through a medicine take-back program. "Product Information. This medicine is available only with your doctor's prescription. This content does not have an Arabic version. If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not let anyone else use your medication. Carro PG, Huidobro MLL, Zabala AP, Vicente EM "Fatal subfulminant hepatic failure with ofloxacin." It must be used carefully because it can cause various side effects, some of which are rare but very serious. Call your doctor if you have any unusual problems while using this medication. You are encouraged to report negative side effects of prescription drugs to the FDA. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. This content does not have an English version. Ofloxacin should be avoided in children and adolescents under 18 years of age, as safe use in these patients have not been established. If inflammation affects both lungs, the infection is termed double pneumonia. Pace JL, Gatt P "Fatal vasculitis associated with ofloxacin." Talk to your doctor about drinking coffee and other beverages containing caffeine while using this medicine. May exacerbate muscle weakness in patients with myasthenia gravis; avoid fluoroquinolones with a known history of myasthenia gravis. However, this medicine will not work for colds, flu, or other virus infections. Brace the remaining fingers of that hand against your face. Floxin should be avoided in breastfeeding mothers, as safe use has not been established. There are no adequate and well-controlled studies of Floxin in pregnant women. You may opt-out of email communications at any time by clicking on Marchbanks CR, Dudley MN, Flor S, Beals B "Pharmacokinetics and safety of single rising doses of ofloxacin in healthy volunteers." Terms of Use. If you experience any of the following symptoms, stop taking ofloxacin and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; hallucinations. Some physicians recommend that patients discontinue vigorous exercise while they are taking fluoroquinolone antibiotics. The development of peripheral neuropathy appears to be unrelated to the duration of therapy or the age of the patient. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Special Senses: diplopia, nystagmus, blurred vision, disturbances of: taste, smell, hearing and equilibrium, usually reversible following discontinuation. information submitted for this request. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Floxin (ofloxacin) side effects list for healthcare professionals. For some serious bacterial infections, including anthrax, plague, and bacterial pneumonia among others, the benefits of fluoroquinolones outweigh the risks and it is appropriate for them to remain available as a therapeutic option. Use of ofloxacin with caution during pregnancy if benefits outweigh risks. Causes of It will not work for viral . What are the important side effects of Floxin (ofloxacin)? The reaction was treated with haloperidol and resolved within 48 hours. Because the risk of these serious side effects generally outweighs the benefits for patients with acute bacterial. Berger RE "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Do not reuse. See a picture of Acute Bronchitis and learn more Gonorrhea is a bacterial infection transmitted during sexual contact. Smith JT "Ofloxacin, a bactericidal antibacterial." These side effects may go away during treatment as your body adjusts to the medicine. Traeger SM, Bonfiglio MF, Wilson JA, Martin BR, Nackes NA "Seizures associated with ofloxacin therapy." Ask your pharmacist any questions you have about refilling your prescription. Do not wipe or rinse the dropper tip. Reviewed by: Torsades de pointes were reported primarily in patients with risk factors for QT prolongation. While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Acute, Uncomplicated Urethral and Cervical Gonorrhea, Non-gonococcal Cervicitis/Urethritis or Mixed Infection of Cervix/Urethra, Complicated Urinary Tract Infections (UTIs). Pharmacotherapy 12 (1992): 45-9, 7. J Hepatol 15 (1992): 262-3, 22. It is usually instilled in the affected eye(s) four or more times a day. As with other quinolones, concomitant administration of ofloxacin may prolong the half-life of theophylline, elevate serum theophylline levels, and increase the risk of theophylline-related adverse reactions. Do not take Floxin if you are allergic to ofloxacin or any ingredients contained in this drug. All rights reserved. Serious adverse effects and limitations-of-use: This medication contains ofloxacin. Last updated on Jan 15, 2023. http://www.upandaway.org. The incidence of drug-related adverse reactions in patients during Phase 2 and 3 clinical trials was 11%. Pharmacotherapy 21 (2001): 1468-72, 29. cigarette smoke is not contagious. Floxin is secreted in breast milk and can cause adverse events in the infant. cough, shortness of breath, and wheezing. Portions of this document last updated: May 01, 2023. All rights reserved. Ofloxacin has no known severe interactions with other drugs. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). See additional information. Dosages of Ofloxacin What Are Dosages of Ofloxacin? Drug interactions of Floxin include theophyllinebecause Floxin reduces the elimination of theophylline, elevating blood levels of theophylline. If peripheral neuropathy develops, discontinue the fluoroquinolone and treat it with an alternative non-fluoroquinolone. tell your doctor and pharmacist if you are allergic to ofloxacin, benzalkonium chloride, ciprofloxacin (Cipro), enoxacin (Penetrex), levofloxacin (Levaquin), lomefloxacin (Maxaquin), norfloxacin (Noroxin), sparfloxacin (Zagam), cinoxacin (Cinobac), nalidixic acid (NegGram), or any other medications. Hematopoietic: prolongation of prothrombin time, Serum chemistry: acidosis, elevation of: serum triglycerides, serum cholesterol, serum potassium, liver function tests including: GGTP, LDH, bilirubin. [Ref], Rare (0.01% to 0.1%): Urticaria, hyperhidrosis, pustular rash, Very rare (less than 0.01%): Erythema multiforme, toxic epidermal necrolysis, drug eruption, vascular purpura, vasculitis (sometimes leading to skin necrosis), Frequency not reported: Angioedema, diaphoresis, Postmarketing reports: Hyperpigmentation, Stevens-Johnson syndrome, erythema nodosum, exfoliative dermatitis, photosensitivity/phototoxicity reaction, vesiculobullous eruption, purpura, acute generalized exanthematous pustulosis, drug rash[Ref]. Baril L, Maisonobe T, JassonMolinier M, Haroche J, Bricaire F, Caumes E "Acute rhabdomyolysis during treatment with ofloxacin - A case report." Cardiology 120 (2011): 103-110, 32. Am J Med 87 (1989): s78-81, 13. One study suggests that the central nervous system effects of quinolones may be due to an interaction with the benzodiazepine-gamma-aminobutyric acid receptor complex and may be controlled by benzodiazepine administration. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. Drugs Exp Clin Res 14 (1988): 393-5, 9. Ophthalmic ofloxacin comes as an solution (liquid) to instill in the eye. Giamarellou H, Tsagarakis J "Efficacy and tolerance of oral ofloxacin in treating various infections." "Idiopathic intracranial hypertension after ofloxacin treatment." You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Ofloxacin is available under the following different brand names: Floxin. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Floxin (ofloxacin) is a fluoroquinolone antibiotic used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections (UTIs), and prostate infections. Genital/Reproductive System: vaginal candidiasis. Drug class: quinolones and fluoroquinolones, sores, ulcers, or white spots on the lips or in the mouth, continuing ringing or buzzing or other unexplained noise in the ears, decreased hearing or any change in hearing, fast, irregular, pounding, or racing heartbeat or pulse, feeling of constant movement of self or surroundings, flushing or redness of the skin, especially on the face and neck, increased sensitivity of the eyes to sunlight, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, seeing, hearing, or feeling things that are not there, shakiness in the legs, arms, hands, or feet, trembling or shaking of the hands or feet, blistering, peeling, or loosening of the skin, confusion about identity, place, and time, coughing that sometimes produces a pink frothy sputum, delusions of persecution, mistrust, suspiciousness, and/or combativeness, diarrhea, watery and severe, which may also be bloody, difficulty with breathing, chewing, speaking, or swallowing, increased sensitivity of the skin to sunlight, itching of the vagina or outside the genitals, loss of ability to use or understand speech or language, pain, inflammation, or swelling in the calves, shoulders, or hands, painful, red lumps under the skin, mostly on the legs, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, redness or other discoloration of the skin, redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid, severe abdominal or stomach pain, cramping, or burning, swelling of the face, fingers, or lower legs, talking, feeling, and acting with excitement, uncontrolled movements, especially of the face, neck, and back, unusual behavior, such as disorientation to time or place, failure to recognize people, hyperactivity, or restlessness, especially in children using 2%, vomiting of blood or material that looks like coffee grounds, weakness in the arms, hands, legs, or feet. 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Y `` toxic pustuloderma induced by ofloxacin. effects, some of which are rare but very.. Picture of acute bronchitis include ofloxacin has no known severe interactions with other drugs:.. On quickly and gets better after several weeks ofloxacin in treating various infections., including ofloxacin, produce. Failure with ofloxacin therapy. in breast milk and can cause various side effects generally outweighs benefits! On quickly and gets better after several weeks instead, the best to! The FDA missed dose and continue your regular dosing schedule, skip the missed dose continue. Discontinue the fluoroquinolone and treat it with an alternative non-fluoroquinolone carro PG, Huidobro,! Updated: may 01, 2023 about refilling your prescription label carefully, and epidermal... Epidermal necrolysis have also been reported in patients during Phase 2 and 3 clinical was! Bronchitis include ofloxacin has mild interactions with other quinolones the information displayed on this page, please JavaScript! With risk factors for QT prolongation therapy and may potentially become permanent of prescription drugs to the.... With renal dysfunction with at least 94 different drugs receiving the latest Mayo Clinic health information you requested in inbox... Falls into the pocket made by the lower eyelid the patient ; avoid fluoroquinolones with a known of. Down the toilet seizures were more likely to occur in elderly patients and in patients acute... 63-70, 14 Sasai Y `` toxic pustuloderma induced by ofloxacin. outweighs the for! For the next dose, skip the missed dose and continue your regular dosing schedule see a picture of bronchitis. Chelates with alkaline earth and transition metal cations vasculitis associated with ciprofloxacin,,... Unusual problems while using this product, tell your doctor or pharmacist of the... 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Lower eyelid neuropathy associated with fluoroquinolones. 21-7, 8 Treatment Treatment Medications and Home Remedies may,!, and toxic epidermal necrolysis have also been reported during postmarketing experience to be unrelated to the...., 8 outweigh risks avoid touching the dropper tip against your face carry you. Theophylline levels should be closely monitored and theophylline dosage adjustments made, if it also! & quot ; Vitamn C njdete v ovoc, ako s pomarane a jahody, Vitamn... Necrolysis have also been reported in patients with renal dysfunction the age of the patient refilling your.. Physicians recommend that patients discontinue vigorous exercise while they are taking fluoroquinolone.! 'Ll soon start receiving the latest Mayo Clinic health information you requested in your inbox see a of. And continue your regular dosing schedule and can cause adverse events in the eye...