Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.Minor (1)ofloxacin, glimepiride. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. clozapine and ofloxacin both increase QTc interval. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration; separate by 4-8 hours. Minor/Significance Unknown. Minor/Significance Unknown. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated. Manage and view all your plans together even plans in different states. selinexor, ofloxacin. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Mechanism: Displacement of GABA from receptors in brain. Monitor Closely (1)eliglustat and ofloxacin both increase QTc interval. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsade de Pointes. Mechanism: Displacement of GABA from receptors in brain. lofepramine and ofloxacin both increase QTc interval. Monitor Closely (1)ofloxacin increases effects of nateglinide by pharmacodynamic synergism. unspecified interaction mechanism. Administer oral quinolone antibiotics at least 1 hr before or 4 hr after lanthanum. ofloxacin increases effects of nateglinide by pharmacodynamic synergism. Monitor Closely (1)solifenacin and ofloxacin both increase QTc interval. Minor/Significance Unknown. The above information is provided for general Do not reuse.Use this medication regularly in order to get the most benefit from it. Use Caution/Monitor. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Use Caution/Monitor. Avoid or Use Alternate Drug. Contraindicated. Comment: Risk of CNS stimulation/seizure. Use Caution/Monitor. Other (see comment). escitalopram increases toxicity of ofloxacin by QTc interval. ofloxacin and panobinostat both increase QTc interval. quinidine will increase the level or effect of ofloxacin by basic (cationic) drug competition for renal tubular clearance. Monitor Closely (1)triclabendazole and ofloxacin both increase QTc interval. Mechanism: Displacement of GABA from receptors in brain. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval. Minor/Significance Unknown. Avoid or Use Alternate Drug. Minor/Significance Unknown. asenapine and ofloxacin both increase QTc interval. Either increases toxicity of the other by pharmacodynamic synergism. Other (see comment). Monitor Closely (1)ezogabine, ofloxacin. sodium bicarbonate decreases levels of ofloxacin by inhibition of GI absorption. Potential dysglycemia. Use Caution/Monitor. Interaction applies only to oral quinolones. ofloxacin and lenvatinib both increase QTc interval. ofloxacin, tolfenamic acid. Either increases effects of the other by QTc interval. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. Serious - Use Alternative (1)ofloxacin and sotalol both increase QTc interval. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. USES: Ofloxacin is used to treat outer ear infections (swimmer's ear or ear canal infections) and middle ear infections. Potential dysglycemia. Minor/Significance Unknown. Minor/Significance Unknown. Mechanism: Displacement of GABA from receptors in brain. Minor/Significance Unknown. ceritinib and ofloxacin both increase QTc interval. Use Caution/Monitor. formoterol and ofloxacin both increase QTc interval. ofloxacin and pitolisant both increase QTc interval. Monitor Closely (1)gilteritinib and ofloxacin both increase QTc interval. Minor (1)methyclothiazide will increase the level or effect of ofloxacin by basic (cationic) drug competition for renal tubular clearance. Use Caution/Monitor. Monitor Closely (1)erythromycin ethylsuccinate and ofloxacin both increase QTc interval. Use Caution/Monitor. Minor/Significance Unknown. Avoid taking selinexor with other medications that may cause dizziness or confusion. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Applies only to oral form of both agents. Applies only to oral form of both agents. Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended. ofloxacin, tolmetin. Potential dysglycemia. Studies indicate that less than 5% of an administered dose is recovered in the urine as the Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Potential dysglycemia. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently. Comment: Risk of CNS stimulation/seizure. Monitor Closely (1)lofepramine and ofloxacin both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Contraindicated. Monitor Closely (1)trifluoperazine and ofloxacin both increase QTc interval. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Comment: Risk of CNS stimulation/seizure. Serious - Use Alternative (1)vemurafenib and ofloxacin both increase QTc interval. Minor/Significance Unknown. Comment: Risk of CNS stimulation/seizure. metformin will increase the level or effect of ofloxacin by basic (cationic) drug competition for renal tubular clearance. Applies only to oral form of both agents. Individual plans may vary Use Caution/Monitor. Monitor Closely (1)ofloxacin increases effects of insulin aspart by pharmacodynamic synergism. Applies only to oral form of both agents. Applies only to oral forms of hormone. See how Associated Conditions Comment: Risk of CNS stimulation/seizure. Minor/Significance Unknown. Minor/Significance Unknown. To treat bacterial corneal ulcer, the dose is 1 to 2 drops into the affected eye (s) every 30 minutes on days 1 and 2, then 1 to 2 drops . Use Caution/Monitor. Avoid or Use Alternate Drug. Applies only to oral form of both agents. ferric citrate will decrease the level or effect of ofloxacin by drug binding in GI tract. Applies only to oral form of both agents. Monitor Closely (1)magnesium oxide decreases levels of ofloxacin by inhibition of GI absorption. Serious - Use Alternative (1)ibutilide and ofloxacin both increase QTc interval. Monitor Closely (1)formoterol and ofloxacin both increase QTc interval. Serious - Use Alternative (1)rose hips decreases levels of ofloxacin by inhibition of GI absorption. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently. Most Panobinostat is known to significantly prolong QT interval. Avoid or Use Alternate Drug. saquinavir increases levels of ofloxacin by QTc interval. indapamide and ofloxacin both increase QTc interval. Minor/Significance Unknown. Contraindicated. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Potential dysglycemia. ofloxacin, rosiglitazone. Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Coadministration of quinolone antibiotics and corticosteroids may increase risk of tendon rupture. Comment: Risk of CNS stimulation/seizure. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. QTc interval. Use Caution/Monitor. Minor (1)ofloxacin increases levels of oxazepam by decreasing metabolism. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Other (see comment). quercetin decreases effects of ofloxacin by pharmacodynamic antagonism. buprenorphine and ofloxacin both increase QTc interval. Monitor Closely (1)trimagnesium citrate anhydrous decreases levels of ofloxacin by inhibition of GI absorption. Comment: Risk of CNS stimulation/seizure. Use Caution/Monitor. Monitor Closely (1)ofloxacin increases effects of glyburide by pharmacodynamic synergism. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin. Potential dysglycemia. Monitor Closely (1)ofloxacin decreases effects of fosphenytoin by unknown mechanism. Minor/Significance Unknown. Each drug may increase the photosensitizing effect of the other. Modify Therapy/Monitor Closely. sodium citrate/citric acid decreases levels of ofloxacin by inhibition of GI absorption. Do not use it later for another infection unless your doctor tells you to.It is important to keep the infected ear(s) clean and dry. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. Increased phototoxicity. Minor/Significance Unknown. US residents can call their local poison control center at 1-800-222-1222. Comment: Risk of CNS stimulation/seizure. Monitor Closely (1)ofloxacin and fostemsavir both increase QTc interval. chloroquine increases toxicity of ofloxacin by QTc interval. Use Caution/Monitor. quinidine and ofloxacin both increase QTc interval. Minor/Significance Unknown. azithromycin and ofloxacin both increase QTc interval. Mechanism: Displacement of GABA from receptors in brain. ofloxacin, mefenamic acid. Monitor Closely (1)ofloxacin will decrease the level or effect of estropipate by altering intestinal flora. ofloxacin increases effects of insulin glargine by pharmacodynamic synergism. sucralfate decreases levels of ofloxacin by inhibition of GI absorption. Minor (1)ofloxacin increases levels of estazolam by decreasing metabolism. Use Caution/Monitor. ofloxacin and fostemsavir both increase QTc interval. Mechanism: pharmacodynamic synergism. Monitor Closely (1)ofloxacin increases effects of tolazamide by pharmacodynamic synergism. Monitor Closely (1)trimipramine and ofloxacin both increase QTc interval. Minor/Significance Unknown.ofloxacin, metformin. Use Caution/Monitor. ofloxacin decreases effects of ethotoin by unknown mechanism. Other (see comment). Minor (1)ofloxacin increases levels of loprazolam by decreasing metabolism. alfuzosin and ofloxacin both increase QTc interval. vorinostat and ofloxacin both increase QTc interval. Applies only to oral form of both agents. Monitor Closely (1)dronedarone and ofloxacin both increase QTc interval. Coadministration of quinolone antibiotics and corticosteroids may increase risk of tendon rupture. Modify Therapy/Monitor Closely. Mechanism: Displacement of GABA from receptors in brain. Low risk of contraceptive failure. Avoid or Use Alternate Drug. Minor (1)ofloxacin increases levels of lormetazepam by decreasing metabolism. Use Caution/Monitor. Escherichia coli. trimipramine and ofloxacin both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Properly discard this product when it is expired or no longer needed. Other (see comment). Comment: Risk of CNS stimulation/seizure. Modify Therapy/Monitor Closely. Minor (1)ofloxacin, ketorolac. Use Caution/Monitor. Avoid or Use Alternate Drug. commonly, these are generic drugs. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Then 1 to 2 drops, 4 times daily on days 3 through 7. Use Caution/Monitor. ezogabine, ofloxacin. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Monitor Closely (1)crizotinib and ofloxacin both increase QTc interval. Modify Therapy/Monitor Closely. Monitor Closely (1)corticotropin and ofloxacin both increase Other (see comment). Modify Therapy/Monitor Closely. Studies indicate that less than 5% of an administered dose is recovered in the urine as the desmethyl or N-oxide metabolites. Use Caution/Monitor. Monitor Closely (1)ofloxacin increases effects of insulin glulisine by pharmacodynamic synergism. lefamulin and ofloxacin both increase QTc interval. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.Minor (1)ofloxacin, insulin regular human. QTc interval. Use Caution/Monitor. ofloxacin increases effects of warfarin by unspecified interaction mechanism. Minor/Significance Unknown. Minor/Significance Unknown. ofloxacin, oxaprozin. aminolevulinic acid oral, ofloxacin. Minor/Significance Unknown. Minor/Significance Unknown. Be sure to read these instructions before using the eardrops . Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Monitor Closely (1)iloperidone and ofloxacin both increase QTc interval. ofloxacin will decrease the level or effect of biotin by altering intestinal flora. Avoid or Use Alternate Drug. Minor (1)ofloxacin, aceclofenac. Applies only to oral forms of hormone. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Comment: Risk of CNS stimulation/seizure. atomoxetine and ofloxacin both increase QTc interval. Monitor Closely (1)aripiprazole and ofloxacin both increase QTc interval. Monitor Closely (1)clarithromycin and ofloxacin both increase QTc interval. If you have any questions, check with your doctor or health care professional. Coadministration of quinolone antibiotics and corticosteroids may increase risk of tendon rupture. Use Caution/Monitor. buprenorphine subdermal implant and ofloxacin both increase QTc interval. Monitor Closely (1)ofloxacin and voriconazole both increase QTc interval. Monitor Closely (1)lithium and ofloxacin both increase QTc interval. Potential dysglycemia. Use Caution/Monitor. Comment: Risk of CNS stimulation/seizure. levoketoconazole and ofloxacin both increase QTc interval. Use Caution/Monitor. Minor/Significance Unknown. Comment: Risk of CNS stimulation/seizure. Modify Therapy/Monitor Closely. ofloxacin will increase the level or effect of quinine by basic (cationic) drug competition for renal tubular clearance. Monitor Closely (1)ofloxacin increases effects of insulin glargine by pharmacodynamic synergism. Potential dysglycemia. Other (see comment). Use Caution/Monitor. Minor (1)ofloxacin, sulindac. Coadministration of quinolone antibiotics and corticosteroids may increase risk of tendon rupture. Comment: Risk of CNS stimulation/seizure. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsade de Pointes. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval. Coadministration of quinolone antibiotics and corticosteroids may increase risk of tendon rupture. Monitor Closely (1)ofloxacin decreases effects of phenytoin by unknown mechanism. Use Caution/Monitor. This indicates a small degree of biliary excretion of ofloxacin. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Use Caution/Monitor. Comment: Amifampridine can cause seizures. Separate by 2 hours. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)degarelix and ofloxacin both increase QTc interval. Avoid or Use Alternate Drug. Minor (1)ofloxacin, diflunisal. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Minor (1)ofloxacin will decrease the level or effect of balsalazide by altering intestinal flora. Aerobic and facultative gram-negative microorganisms. Other (see comment). Applies only to oral form of both agents. Avoid or Use Alternate Drug. Use Caution/Monitor. Modify Therapy/Monitor Closely. 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