Otic RouteFollowing otic administration of a 0.3% solution to adults with perforated tympanic membranes, the maximum serum concentration detected was 10 ng/ml. Consider taking steps to minimize the risk of QT/QTc interval prolongation and TdP, such as avoidance, electrolyte monitoring and repletion, and ECG monitoring, especially in patients with additional risk factors for TdP. Concomitant use may cause an increased blood glucose-lowering effect with risk of hypoglycemia. Ethinyl Estradiol; Norethindrone Acetate: (Moderate) It would be prudent to recommend alternative or additional contraception when oral contraceptives (OCs) are used in conjunction with antibiotics. Siponimod: (Major) Concomitant use of siponimod and ofloxacin increases the risk of QT/QTc prolongation and torsade de pointes (TdP). Levonorgestrel; Ethinyl Estradiol; Ferrous Bisglycinate: (Moderate) It would be prudent to recommend alternative or additional contraception when oral contraceptives (OCs) are used in conjunction with antibiotics. Once in the systemic circulation, ofloxacin is widely distributed throughout the body, with highest concentrations appearing in the lungs, gallbladder, prostate, bile, tonsils, liver, muscle, and genitourinary tissue. Ofloxacin absorption may be reduced as quinolone antibiotics can chelate with divalent or trivalent cations. Discontinue the quinolone if a hypoglycemic reaction occurs and initiate appropriate therapy immediately. Aluminum Hydroxide; Magnesium Hydroxide; Simethicone: (Moderate) Administer magnesium hydroxide at least 2 hours before or 2 hours after ofloxacin. The degree of QT prolongation associated with sertraline is not clinically significant when administered within the recommended dosage range; QT prolongation has been described at 2 times the maximum recommended dose. Tell your doctor if you are pregnant or plan to become pregnant. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Sertraline: (Moderate) Concomitant use of ofloxacin and sertraline may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Consider taking steps to minimize the risk for QT/QTc interval prolongation and TdP, such as electrolyte monitoring and repletion and ECG monitoring, if concomitant use is necessary. Clarithromycin: (Major) Concomitant use of ofloxacin and clarithromycin increases the risk of QT/QTc prolongation and torsade de pointes (TdP). Gilteritinib: (Moderate) Concomitant use of ofloxacin and gilteritinib may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Ofloxacin absorption may be reduced as quinolone antibiotics can chelate with divalent or trivalent cations. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Because of this risk for serious and potentially permanent side effects, quinolones should only be used for the treatment of uncomplicated urinary tract infection or acute bacterial exacerbation of chronic bronchitis in cases where alternative treatment options cannot be used. Quinolones have been associated with a risk of QT prolongation and TdP. Examples of compounds that may interfere with quinolone bioavailability include antacids and multivitamins that contain calcium. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. Concomitant use may cause an increased blood glucose-lowering effect with risk of hypoglycemia. Fluoroquinolones have the potential to cause QT prolongation and possibly torsade de pointes (TdP) by blocking human cardiac potassium (K+) channel currents. visual impairment / Early / 1.0-3.0hepatic necrosis / Delayed / 0-1.0hepatic failure / Delayed / 0-1.0renal failure (unspecified) / Delayed / 0-1.0interstitial nephritis / Delayed / 0-1.0seizures / Delayed / 0-1.0cardiac arrest / Early / 0-1.0torsade de pointes / Rapid / 0-1.0respiratory arrest / Rapid / 0-1.0tendon rupture / Delayed / 0-1.0angioedema / Rapid / 0-1.0anaphylactoid reactions / Rapid / 0-1.0erythema multiforme / Delayed / 0-1.0laryngeal edema / Rapid / 0-1.0bronchospasm / Rapid / 0-1.0toxic epidermal necrolysis / Delayed / 0-1.0exfoliative dermatitis / Delayed / 0-1.0vasculitis / Delayed / 0-1.0anaphylactic shock / Rapid / 0-1.0erythema nodosum / Delayed / 0-1.0Stevens-Johnson syndrome / Delayed / 0-1.0serum sickness / Delayed / 0-1.0pancytopenia / Delayed / 0-1.0agranulocytosis / Delayed / 0-1.0aplastic anemia / Delayed / 0-1.0thrombotic thrombocytopenic purpura (TTP) / Delayed / 0-1.0hemolytic anemia / Delayed / 0-1.0hearing loss / Delayed / 0-1.0rhabdomyolysis / Delayed / 0-1.0hyposthenuria / Delayed / 1.0C. Risk factors: Using ofloxacin (Ocuflox) for too long. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. Lefamulin: (Major) Concomitant use of ofloxacin and lefamulin increases the risk of QT/QTc prolongation and torsade de pointes (TdP). Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent. Tell your doctor if you are breast-feeding. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct. Certain antibiotics (i.e., tetracyclines and quinolones) may chelate with the magnesium in sodium picosulfate; magnesium oxide; anhydrous citric acid solution. Olanzapine; Samidorphan: (Moderate) Concomitant use of ofloxacin and olanzapine may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Ocuflox may contain a preservative that can discolor soft contact lenses. 400 mg PO every 12 hours for 5 to 7 days. Monotherapy is recommended for stable patients with naturally occurring plague, although dual therapy can be considered for patients with large buboes. Ketoconazole: (Contraindicated) Avoid concomitant use of ketoconazole and ofloxacin due to an increased risk for torsade de pointes (TdP) and QT/QTc prolongation. Consider taking steps to minimize the risk of QT/QTc interval prolongation and TdP, such as avoidance, electrolyte monitoring and repletion, and ECG monitoring, especially in patients with additional risk factors for TdP. Avoid concomitant use if possible, especially in patients with additional risk factors for TdP. The highest concentrations averaging 2.41 mg/L occurred 2 hours after the dose. Triclabendazole: (Moderate) Concomitant use of triclabendazole and ofloxacin may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Discontinue the quinolone if a hypoglycemic reaction occurs and initiate appropriate therapy immediately. Mifepristone: (Major) Concomitant use of ofloxacin and mifepristone increases the risk of QT/QTc prolongation and torsade de pointes (TdP). However, the Ofloxacin 0.3% eye drops are a good substitute for eardrops. Some quinolones, including ofloxacin, have been associated with QT prolongation and infrequent cases of arrhythmia. Aluminum Hydroxide; Magnesium Hydroxide: (Moderate) Administer magnesium hydroxide at least 2 hours before or 2 hours after ofloxacin. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. NSAIDs in combination with very high doses of quinolones have been shown to provoke convulsions in preclinical studies and postmarketing. Concomitant use may cause an increased blood glucose-lowering effect with risk of hypoglycemia. Sorafenib: (Major) Concomitant use of sorafenib and ofloxacin increases the risk of QT/QTc prolongation and torsade de pointes (TdP). These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. Hypoglycemia, sometimes resulting in coma, can occur. Ofloxacin absorption may be reduced as quinolone antibiotics can chelate with divalent or trivalent cations. The medications of this class act by preventing the growth of bacteria. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. The solution should be warmed by holding the bottle in the hand for 12 minutes to avoid dizziness which may result from instillation of a cold solution.The patient should lie with the affected ear upward during installation of the drops. Consider taking steps to minimize the risk of QT/QTc interval prolongation and TdP, such as avoidance, electrolyte monitoring and repletion, and ECG monitoring, especially in patients with additional risk factors for TdP. Ofloxacin 0.3%; oph. Consider taking steps to minimize the risk for QT/QTc interval prolongation and TdP, such as electrolyte monitoring and repletion and ECG monitoring, if concomitant use is necessary. Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent. Buprenorphine: (Major) Concomitant use of ofloxacin and buprenorphine increases the risk of QT/QTc prolongation and torsade de pointes (TdP). Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries (e.g., patches, rings) are not available. Silent mutations and genetic polymorphisms in potassium channels may further increase the risk of QT prolongation in patients taking fluoroquinolones. Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries (e.g., patches, rings) are not available. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Following oral administration, the absolute bioavailability of ofloxacin is roughly 98%. Pyridoxine, Vitamin B6: (Moderate) Administer oral products that contain calcium at least 2 hours before or 2 hours after ofloxacin. Ofloxacin exhibits concentration-dependent pharmacodynamics where the ratio of area under the concentration curve of free drug to minimal inhibitory concentration (free AUC:MIC) appears to best correlate with antibacterial activity. . Before using ofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolones (such as ciprofloxacin, levofloxacin); or if you have any other allergies. Magnesium: (Moderate) Administer oral products that contain magnesium at least 2 hours before or 2 hours after ofloxacin. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. The degree of QT prolongation associated with fostemsavir is not clinically significant when administered within the recommended dosage range; QT prolongation has been described at 4 times the recommended daily dose. Avoid concomitant use if possible, especially in patients with additional risk factors for TdP. A history of hypersensitivity . Consider taking steps to minimize the risk for QT/QTc interval prolongation and TdP, such as electrolyte monitoring and repletion and ECG monitoring, if concomitant use is necessary. Patients with renal impairment or renal failure, especially those with a creatinine clearance of 50 mL/minute or less, should have their systemic ofloxacin dosage adjusted. It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in enterohepatic circulation via changes in GI flora. Drospirenone; Estradiol: (Moderate) It would be prudent to recommend alternative or additional contraception when oral contraceptives (OCs) are used in conjunction with antibiotics. Nabumetone: (Moderate) Use quinolones and nonsteroidal anti-inflammatory drugs (NSAIDs) concomitantly with caution due to potential increased risk of CNS stimulation and convulsive seizures. Hypoglycemia, sometimes resulting in coma, can occur. For ophthalmic and otic dosages, see indications. Ofloxacin present in these eye drops act by preventing an enzyme necessary for the bacterial DNA to reproduce, thus impeding the bacterial cell division. Drug Info: Basics, Side Effects, Dosage & More. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain aluminum hydroxide. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Concomitant use may cause an increased blood glucose-lowering effect with risk of hypoglycemia. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives. Ocuflox is thought to exert bactericidal effect by inhibiting DNA gyrase, an essential enzyme that is a critical catalyst in the duplication . The FDA-approved dosage is 400 mg PO every 12 hours for 10 to 14 days. The delayed-release didanosine capsules do not contain a buffering agent and would not be expected to interact with ofloxacin. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. Perphenazine; Amitriptyline: (Minor) QT/QTc prolongation can occur with concomitant use of ofloxacin and perphenazine although the risk of developing torsade de pointes (TdP) is low. Avoid concomitant use if possible, especially in patients with additional risk factors for TdP. Whenever clinical judgment dictates, examine patients receiving ophthalmic ofloxacin with the aid of magnification, such as slitlamp biomicroscopy, and where appropriate, fluorescein staining. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. NSAIDs in combination with very high doses of quinolones have been shown to provoke convulsions in preclinical studies and postmarketing. This medication acts on the enzymes, DNA gyrase and topoisomerase IV, which prevent human excessive super coiling of DNA during replication or transcription. Consider taking steps to minimize the risk for QT/QTc interval prolongation and TdP, such as electrolyte monitoring and repletion and ECG monitoring, if concomitant use is necessary. Consider taking steps to minimize the risk of QT/QTc interval prolongation and TdP, such as avoidance, electrolyte monitoring and repletion, and ECG monitoring, especially in patients with additional risk factors for TdP. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. Consider taking steps to minimize the risk for QT/QTc interval prolongation and TdP, such as electrolyte monitoring and repletion and ECG monitoring, if concomitant use is necessary. Avoid concomitant use if possible, especially in patients with additional risk factors for TdP. This medication belongs to a class of drugs called quinolone antibiotics.This medication treats only bacterial ear infections. Ocuflox may cause blurred vision and may impair your thinking or reactions. US: This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus. Following oral administration, the ofloxacin 0.3 % solution to adults with perforated tympanic membranes, the absolute of... 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