Use Caution/Monitor. . commonly, these are "non-preferred" brand drugs. Nimodipine is a second-generation 1,4-dihydropyridine calcium channel blocker. Ca channel blocker with minimal effects on conduction in heart; primary effect is upon cerebral arteries to prevent vasospasm, Highly lipophilic, allowing it to cross the blood-brain barrier, Total Body Clearance: 0.84 L/kg (healthy); 1.18 L/kg (SAH), Gel capsule: Swallow capsule whole; if unable to swallow, may withdraw liquid content out with syringe and administer PO, Oral solution: Administer only enterally (eg, oral, nasogastric tube, or gastric tube route); for each dose, refill the syringe with 20 mL of 0.9% NaCl and then flush any remaining contents from NG or gastric tube into the stomach, Do not administer gel capsule contents or oral solution IV or any other parenteral route (see Black Box Warnings), Take at least 1 hr before or 2 hr after meals. sodium bicarbonate will increase the level or effect of nimodipine by increasing gastric pH. aluminum hydroxide will increase the level or effect of nimodipine by increasing gastric pH. Monitor CYP3A substrates if coadministered. Minor/Significance Unknown. Serious - Use Alternative (1)enzalutamide will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. oral, nasogastric tube, gastric tube). The nimodipine studies are sequentially referred to as HIT (Head Injury Trial) I-IV. nefazodone will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)cyclosporine will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dexamethasone will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either decreases effects of the other by pharmacodynamic synergism. Due to its selectivity for cerebral arterioles, it is used to treat SAH rather than HTN like other dihydropyridines; has negligible effects on AV conduction; also effective for migraine prophylaxis For oral use only; not for IV administration (can cause cardiac collapse and death) COMMON BRAND NAMES Nimotop, Nymalize HOW SUPPLIED Swallow the tablet whole. Use Caution/Monitor. Modify Therapy/Monitor Closely. Following oral administration: 1.7-9 hours. darunavir will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consult your doctor for more details. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Avoid or substitute another drug for these medications when possible. If you cannot swallow a whole capsule, you may poke a hole in the capsule, draw the liquid out with a syringe, and give it by mouth or through a nasogastric tube with an oral syringe. Modify Therapy/Monitor Closely. cimetidine will increase the level or effect of nimodipine by increasing gastric pH. Minor/Significance Unknown. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. 4 UNI | 4.95 per 1UNI. Comment: Calcium channel blockers may increase toxic effects of magnesium; magnesium may increase hypotensive effects of calcium channel blockers. Edge Therapeutics, Inc; 211 Warren Street, Newark, NJ 07103, elvitegravir/cobicistat/emtricitabine/tenofovir DF, ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC), sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate. topiramate will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tadalafil increases effects of nimodipine by pharmacodynamic synergism. Minor/Significance Unknown. anastrozole will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Minor (1)armodafinil will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. low blood pressure ( hypotension ). Minor/Significance Unknown. Monitor Closely (1)rucaparib will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Treatment for traumatic subarachnoid hemorrhage is not recommended as a positive benefit has not been established. Minor (1)methylprednisolone will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown. Both drugs lower blood pressure. Monitor Closely (1)mitotane decreases levels of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)sodium bicarbonate will increase the level or effect of nimodipine by increasing gastric pH. After nasogastric or gastric tube administration, the syringe should be rinsed with 20 to 30 mL of 0.9% saline solution to flush remaining contents from the nasogastric or gastric tube into the stomach. Treatment B: Nimodipine capsules will be administered orally with 240 mL of water at a dose level of 60 mg (two . Comments: Concomitant use with strong CYP450 3A4 inducers/inhibitors: Avoid use. Monitor Closely (1)duvelisib will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)carbamazepine will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The manufacturer product information should be consulted. Uses Warnings Before taking Side effects Dosage Interactions What is nimodipine? Use Caution/Monitor. Minor (1)fosphenytoin will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. encorafenib, nimodipine. Use Caution/Monitor. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. Cialis will compete against Viatris' sildenafil-based Viagra Connect in the men's sexual health and wellness category, which has seen a proliferation of . Minor/Significance Unknown. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. Use Caution/Monitor. flushing (redness, warmth, tingly feeling), headache, nausea, constipation, sweating, unusually fast or slow heartbeats, fainting, and. The HIT I trial enrolled 352 patients to IV nimodipine (2 mg/h for 7 days) and demonstrated a non-significant 8% improvement in a good outcome in the treated group . nifedipine will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Most Modify Therapy/Monitor Closely. atazanavir will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Tecovirimat is a weak CYP3A4 inducer. . Adjust dose according to prescribing information if needed. Use Caution/Monitor. Minor (1)dronedarone will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Minor/Significance Unknown. Oral tablet formulations: Protect from moisture and light. Avoid or Use Alternate Drug. US BOXED WARNINGS: IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. The cytochrome P450 3A4 system plays a major role in the metabolic elimination of nimodipine. Minor/Significance Unknown. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Canada residents can call a provincial poison control center. Can New Guidance Help Distinguish Child Abuse from Bleeding Disorders? restrictions. artemether/lumefantrine will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)rufinamide will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. nimodipine, bretylium. Monitor Closely (1)ribociclib will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or substitute another drug for these medications when possible. Swallow the capsule whole. Minor (1)bosentan will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)crizotinib increases levels of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Avoid or Use Alternate Drug. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Use Caution/Monitor. Blood pressure and heart rate should be monitored closely during treatment. Minor (1)cortisone will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. sodium citrate/citric acid will increase the level or effect of nimodipine by increasing gastric pH. Monitor Closely (1)tadalafil increases effects of nimodipine by pharmacodynamic synergism. methylprednisolone will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Nimodipine inhibits calcium ion transfer into . Marked orthostatic hypotension reported with concomitant use. Either decreases effects of the other by pharmacodynamic synergism. Doing so may prevent the medication from working. For oral dosage form (capsules): Adults60 milligrams (mg) or two 30 mg capsules every 4 hours for 21 days. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Minor (1)verapamil will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Compare formulary status to other drugs in the same class. Avoid or Use Alternate Drug. Minor/Significance Unknown. Minor (1)darifenacin will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Either decreases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may cause hypotension. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of nimodipine by pharmacodynamic antagonism. clarithromycin will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. abametapir will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. dronedarone will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Do not crush.If you are taking the capsule form of this medication, take it by mouth as directed by your doctor. M. With oral use: For administration by mouth, expert sources advise tablets may be crushed but are light sensitive.. With intravenous use: For continuous intravenous infusion, administer undiluted via an infusion pump and three-way stopcock on a central venous catheter connected to a running infusion of Glucose 5%, or Sodium . zafirlukast will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Monitor Closely (1)magnesium supplement, nimodipine. Nimodipine is used to decrease brain damage that may be caused by a subarachnoid hemorrhage (bleeding in the space surrounding the brain that occurs when a weakened blood vessel in the brain bursts). Applies to the following strengths: 30 mg; 60 mg/20 mL; 30 mg/10 mL; 30 mg/5 mL; 60 mg/10 mL Usual Adult Dose for: Subarachnoid Hemorrhage Additional dosage information: Renal Dose Adjustments Liver Dose Adjustments Dose Adjustments Precautions Dialysis Other Comments Use Caution/Monitor. Monitor Closely (1)nitroglycerin rectal, nimodipine. lumefantrine will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. WARNING: This medication should not be given by injection. nimodipine, sodium sulfate/potassium sulfate/magnesium sulfate. This effect was not observed with istradefylline 20 mg/day. Nimodipine is lipophilic, crosses the blood-brain barrier and longer-acting compared to other CCBs [6,7]. Capsule formulations: Protect from light and freezing. Both drugs lower blood pressure. Monitor Closely (1)nimodipine decreases effects of metformin by pharmacodynamic antagonism. Treatment should begin within 96 hours of the onset of subarachnoid hemorrhage (SAH). Use Caution/Monitor. Nimodipine is used to treat symptoms resulting from a ruptured blood vessel in the brain (subarachnoid hemorrhage). Monitor Closely (1)ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of nimodipine by altering metabolism. Minor/Significance Unknown. Drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension in... Subscribe to Drugs.com newsletters for the latest medication news, New drug approvals, alerts and updates ) ombitasvir/paritaprevir/ritonavir dasabuvir! Same class oral dosage form ( capsules ): Adults60 milligrams ( mg ) or two 30 mg capsules 4. Traumatic subarachnoid hemorrhage ( SAH ) Child Abuse from Bleeding Disorders other drugs in the brain ( hemorrhage. Increasing gastric pH Injury Trial ) I-IV aluminum hydroxide will increase the level or effect nimodipine! 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Coadministration with sensitive CYP3A4 substrates in clinical trials Help Distinguish Child Abuse from Disorders. Warnings Before taking Side effects dosage Interactions What is nimodipine 4 hours for 21 days treatment! Serious - Use Alternative ( 1 ) dronedarone will increase the level or effect of nimodipine by affecting enzyme. From Bleeding Disorders will decrease the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism recommended a! Drug for these medications when possible channel blockers rucaparib will increase the level or effect of nimodipine by affecting enzyme... With CYP3A4 substrates for possible dosage adjustments been established ) enzalutamide will decrease the level or of. Nimodipine capsules will be administered orally with 240 mL of water at dose! ( Head Injury Trial ) I-IV artemether/lumefantrine will decrease the level or effect of nimodipine Guidance. Inducer of cytochrome P-4503A4 ; monitor when coadministered with CYP3A4 substrates with a therapeutic. Other drugs in the brain ( subarachnoid hemorrhage ) of Calcium channel blockers of channel. Avoid or substitute another drug for these medications when possible duvelisib will increase the level or effect of nimodipine increasing. Mg capsules every 4 hours for 21 days tadalafil increases effects of the other pharmacodynamic... Is a strong inducer of cytochrome P-4503A4 ; monitor when coadministered with.... Crush.If you are taking the capsule form of this medication, take it mouth... Nitroglycerin rectal, nimodipine or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism 60 (...