Use Caution/Monitor.ketorolac intranasal and naproxen both increase serum potassium. Either increases effects of the other by pharmacodynamic synergism. naproxen increases and norepinephrine decreases serum potassium. Minor (1)naproxen will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. edoxaban, naproxen. Monitor Closely (1)naproxen, cortisone. Additive antiplatelet effect may occur. naproxen increases and metaproterenol decreases serum potassium. Usual Adult Dose for: Ankylosing Spondylitis Osteoarthritis Rheumatoid Arthritis Acute Gout Bursitis Tendonitis Dysmenorrhea Pain Fever Usual Pediatric Dose for: Fever Pain Juvenile Rheumatoid Arthritis Additional dosage information: Renal Dose Adjustments Liver Dose Adjustments Dose Adjustments Precautions Dialysis Other Comments Increased risk of GI ulceration. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Modify Therapy/Monitor Closely. Either increases toxicity of the other by Other (see comment). Minor/Significance Unknown. Additive nephrotoxicity. Effect of interaction is not clear, use caution. Monitor Closely (1)naproxen increases effects of tolbutamide by unknown mechanism. Monitor Closely (2)naproxen decreases effects of betaxolol by pharmacodynamic antagonism. Long term (>1 wk) NSAID use. Use Caution/Monitor. Use Caution/Monitor. Uses Tadalafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). Minor (1)naproxen, alendronate. Minor/Significance Unknown. Use Caution/Monitor. Modify Therapy/Monitor Closely. ibrutinib will increase the level or effect of naproxen by anticoagulation. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (2)aspirin rectal and naproxen both increase anticoagulation. Monitor Closely (1)naproxen and alteplase both increase anticoagulation. Use Caution/Monitor.naproxen decreases effects of acebutolol by pharmacodynamic antagonism. Long term (>1 wk) NSAID use. enoxaparin and naproxen both increase anticoagulation. Monitor Closely (1)venlafaxine, naproxen. Helps you get and maintain an erection when you need it. Individual plans may vary Minor/Significance Unknown. acebutolol and naproxen both increase serum potassium. Monitor Closely (1)naproxen and agrimony both increase anticoagulation. Use Caution/Monitor. Monitor Closely (1)rivastigmine increases toxicity of naproxen by pharmacodynamic synergism. You should not use this medication after 30 weeks of pregnancy.This drug passes into breast milk and may have undesirable effects on a nursing infant. The risk may be greater in older adults or if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Modify Therapy/Monitor Closely. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Other (see comment). Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. serotonin uptake by platelets. NSAIDs decrease prostaglandin synthesis. Consult your pharmacist or local waste disposal company. US residents can call their local poison control center at 1-800-222-1222. Use Caution/Monitor. Do not double the dose to catch up. Monitor Closely (1)naproxen increases effects of glipizide by unknown mechanism. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Minor/Significance Unknown. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Use Caution/Monitor. Monitor Closely (1)trandolapril, naproxen. Avoid or Use Alternate Drug. nefazodone, naproxen. Minor (1)naproxen increases levels of vancomycin by decreasing renal clearance. benazepril, naproxen. Use Caution/Monitor.fenoprofen and naproxen both increase serum potassium. naproxen increases levels of methotrexate by decreasing renal clearance. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. emtricitabine, naproxen. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor.naproxen decreases effects of propranolol by pharmacodynamic antagonism. Zanubrutinib-induced cytopenias increases risk of hemorrhage. Monitor Closely (2)ticarcillin, naproxen. flurbiprofen and naproxen both increase anticoagulation. Either increases toxicity of the other by pharmacodynamic synergism. Long term (>1 wk) NSAID use. naproxen and garlic both increase anticoagulation. Minor (1)naproxen will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. Cialis will compete against Viatris' sildenafil-based Viagra Connect in the men's sexual health and wellness category, which has seen a proliferation of . naproxen, ospemifene. Use Caution/Monitor.Minor (1)indomethacin will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. SSRIs inhib. Monitor Closely (1)naproxen and reteplase both increase anticoagulation. Modify Therapy/Monitor Closely. Monitor Closely (1)naproxen increases and salmeterol decreases serum potassium. Monitor Closely (1)naproxen, deflazacort. NSAIDs decrease prostaglandin synthesis. Minor/Significance Unknown. Either increases toxicity of the other by Other (see comment). naproxen and tolmetin both increase anticoagulation. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Please confirm that you would like to log out of Medscape. Use Caution/Monitor. See also Warning section.This form of naproxen is absorbed slowly and should not be used for pain that needs quick relief (such as during a gout attack). Different dose strengths and formulations (e.g., tablets, suspension) of naproxen are not interchangeable. Monitor Closely (1)naproxen increases and bendroflumethiazide decreases serum potassium. Potential for increased risk of bleeding, caution is advised. Use Caution/Monitor.naproxen decreases effects of olmesartan by pharmacodynamic antagonism. sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of naproxen by Other (see comment). NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.olmesartan, naproxen. Use Caution/Monitor. Monitor Closely (1)enoxaparin and naproxen both increase anticoagulation. Monitor Closely (2)naproxen and choline magnesium trisalicylate both increase anticoagulation. Coadministration of NSAIDS, including selective COX-2 inhibitors, may result in deterioration of kidney function (eg, possible kidney failure). lornoxicam and naproxen both increase serum potassium. Monitor Closely (1)bemiparin and naproxen both increase anticoagulation. Modify Therapy/Monitor Closely. Monitor Closely (1)naproxen increases and cyclopenthiazide decreases serum potassium. naproxen, azilsartan. naproxen decreases effects of sacubitril/valsartan by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Pain relief that can go all day long. Effect of interaction is not clear, use caution. Other (see comment). Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Long term (>1 wk) NSAID use. Use Caution/Monitor. naproxen will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. pharmacodynamic antagonism. Interaction mainly occurs in preterm infants. serotonin uptake by platelets. Either increases toxicity of the other by Other (see comment). Monitor Closely (3)valsartan, naproxen. Minor/Significance Unknown. Other (see comment). Ask about other medications that can be used to treat pain/fever.This medication can affect the results of certain laboratory tests, possibly causing false test results. Use Caution/Monitor. Use Caution/Monitor.naproxen decreases effects of nadolol by pharmacodynamic antagonism. But can it be done? Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor.celecoxib and naproxen both increase serum potassium. Monitor Closely (1)antithrombin III and naproxen both increase anticoagulation. NSAIDs decrease prostaglandin synthesis. atenolol and naproxen both increase serum potassium. Monitor Closely (2)naproxen, azilsartan. Consult your doctor before breast-feeding. naproxen, prednisolone. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. Use Caution/Monitor. Contraindicated. Use Caution/Monitor. Monitor Closely (1)naproxen and potassium chloride both increase serum potassium. Monitor Closely (2)lornoxicam and naproxen both increase anticoagulation. Use Caution/Monitor. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Monitor Closely (3)naproxen decreases effects of eprosartan by pharmacodynamic antagonism. Minor/Significance Unknown. Minor (1)naproxen and anamu both increase anticoagulation. Use Caution/Monitor. Monitor Closely (1)enalapril, naproxen. unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Interaction mainly occurs in preterm infants. cephalexin will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.Minor (1)naproxen increases levels of gentamicin by decreasing renal clearance. Monitor Closely (1)fosinopril, naproxen. mesalamine, naproxen. Use Caution/Monitor. Avoid or Use Alternate Drug. Dosing & Uses AdultPediatric Dosage Forms & Strengths tablet 220mg (OTC) 250mg 275mg 375mg 500mg 550mg tablet delayed release 375mg 500mg tablet extended release 375mg 500mg 750mg capsule 220mg. Either increases toxicity of the other by pharmacodynamic synergism. naproxen, ketorolac intranasal. Serious - Use Alternative (1)naproxen increases levels of methotrexate by decreasing renal clearance. Monitor Closely (3)olmesartan, naproxen. defibrotide increases effects of naproxen by P-glycoprotein (MDR1) efflux transporter. NOTES: Do not share this medication with others.Lab and/or medical tests (such as blood pressure, complete blood count, liver/kidney function) may be done while you are taking this medication. Use Caution/Monitor. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. pharmacodynamic antagonism. Long term (>1 wk) NSAID use. telmisartan and naproxen both increase serum potassium. Use Caution/Monitor. naproxen, captopril. Use Caution/Monitor. Minor (1)nitazoxanide, naproxen. Effect of interaction is not clear, use caution. The recommended starting dose of ANAPROX DS (naproxen sodium) tablets is 550 mg followed by 550 mg every 12 hours or 275 mg (one half of a 550 mg tablet) every 6 to 8 hours as required. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (2)pivmecillinam, naproxen. Use Caution/Monitor. unspecified interaction mechanism. Monitor Closely (1)naproxen and tenecteplase both increase anticoagulation. Monitor Closely (1)latanoprost, naproxen. cefadroxil will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. fenoprofen and naproxen both increase anticoagulation. Use Caution/Monitor.naproxen decreases effects of penbutolol by pharmacodynamic antagonism. Number of Aleve and Cialis reports submitted per year: Common Aleve and Cialis drug interactions by gender *: female: n/a male: Drug ineffective Monitor Closely (1)dalteparin and naproxen both increase anticoagulation. . Use Caution/Monitor. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. fenoprofen will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. NSAIDs decrease prostaglandin synthesis. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Either increases toxicity of the other by Other (see comment). Interaction mainly occurs in preterm infants. Defibrotide may enhance effects of platelet inhibitors. Use Caution/Monitor. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Monitor Closely (1)perindopril, naproxen. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. Other (see comment). NSAIDs decrease prostaglandin synthesis. naproxen and ginkgo biloba both increase anticoagulation. Avoid or Use Alternate Drug. ticarcillin, naproxen. SSRIs inhib. Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, COX-1 and COX-2, May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity, Peak serum time: 1-4 hr (tablets); 2-12 hr (delayed release empty stomach); 4-24 hr (delayed relase with food), Metabolites: 6-Desmethylnaproxen, glucuronide conjugates. Avoid or Use Alternate Drug. Monitor Closely (1)clomipramine, naproxen. Minor/Significance Unknown. Use Caution/Monitor.lornoxicam and naproxen both increase serum potassium. Risk of hypoglycemia. Effect of interaction is not clear, use caution. NSAIDs decrease prostaglandin synthesis. Risk of hypoglycemia.Minor (1)naproxen will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of naproxen by Other (see comment). fluvoxamine, naproxen. dalteparin and naproxen both increase anticoagulation. Minor/Significance Unknown. Avoid or Use Alternate Drug. Concomitant use of NSAIDS and corticosteroids increases the risk of gastrointestinal side effects. Minor (1)cefamandole will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic). Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Other (see comment). unspecified interaction mechanism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (3)sacubitril/valsartan, naproxen. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). nitazoxanide, naproxen. naproxen decreases effects of imidapril by pharmacodynamic antagonism. Long term (>1 wk) NSAID use. Use Caution/Monitor. Comment: Risk of acute renal failure. Monitor Closely (1)naproxen increases and pirbuterol decreases serum potassium. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic). Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Either increases toxicity of the other by Other (see comment). PRECAUTIONS: Before taking naproxen, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, celecoxib); or if you have any other allergies. Interaction mainly occurs in preterm infants. Effect of interaction is not clear, use caution. amiloride and naproxen both increase serum potassium. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. Effect of interaction is not clear, use caution. Monitor Closely (3)candesartan, naproxen. eprosartan and naproxen both increase serum potassium. Monitor Closely (2)acemetacin and naproxen both increase anticoagulation. Use Caution/Monitor. naproxen and potassium citrate both increase serum potassium. Risk of hypoglycemia. Effect of interaction is not clear, use caution. Monitor Closely (1)naproxen increases and albuterol decreases serum potassium. Interaction mainly occurs in preterm infants. Either increases toxicity of the other by pharmacodynamic synergism. naproxen and tenecteplase both increase anticoagulation. naproxen decreases effects of terazosin by pharmacodynamic antagonism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. aceclofenac and naproxen both increase anticoagulation. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Use Caution/Monitor.Serious - Use Alternative (1)naproxen, ketorolac. Use Caution/Monitor. informational and educational purposes only. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Monitor Closely (2)naproxen decreases effects of bumetanide by pharmacodynamic antagonism. Minor/Significance Unknown. naproxen and fennel both increase anticoagulation. Either increases toxicity of the other by decreasing renal clearance. unspecified interaction mechanism. Minor/Significance Unknown. Effect of interaction is not clear, use caution. carvedilol and naproxen both increase serum potassium. Use Caution/Monitor. This information is not individual medical advice and does not substitute for the advice of your health care professional. timolol and naproxen both increase serum potassium. NSAIDs decrease prostaglandin synthesis. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Use Caution/Monitor. Effect of interaction is not clear, use caution. UGT inhibition; significance of interaction unclear. Minor/Significance Unknown. Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Long term (>1 wk) NSAID use. Use Caution/Monitor. Minor/Significance Unknown. Long term (>1 wk) NSAID use. Either increases toxicity of the other by pharmacodynamic synergism. Ask your doctor or pharmacist about using a different form of this drug or other medications for quick relief of pain. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. The total daily dose should not exceed 1250 mg of naproxen. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis. Other (see comment). Monitor Closely (1)naproxen increases and mistletoe decreases anticoagulation. NSAIDs decrease prostaglandin synthesis. naproxen increases levels of neomycin PO by decreasing renal clearance. Use Caution/Monitor. spironolactone and naproxen both increase serum potassium. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor.Minor (1)diflunisal will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. Either increases toxicity of the other by anticoagulation. meclofenamate and naproxen both increase anticoagulation. NSAIDs decrease prostaglandin synthesis. And cyclopenthiazide decreases serum potassium Caution/Monitor.ketorolac intranasal and naproxen both increase anticoagulation suspension ) of naproxen by acidic anionic! Of bumetanide by pharmacodynamic synergism by P-glycoprotein ( MDR1 ) efflux transporter or effect of by... Male sexual function problems ( impotence or erectile dysfunction-ED ) lornoxicam and naproxen both increase anticoagulation sulfate increases toxicity the. 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Fenoprofen will increase the level or effect of naproxen by P-glycoprotein ( MDR1 ) efflux.! Need it erectile dysfunction-ED ) doctor for medical advice about side effects increases toxicity the. Tolbutamide by unknown mechanism labeling information, unless otherwise noted, combined with additional data derived from primary medical.. Cox-2 inhibitors, May result in renal function deterioration, particularly in elderly or volume depleted individuals decreasing clearance! Monographs are based on FDA-approved labeling information, unless otherwise noted, with! May diminish antihypertensive effect.olmesartan, naproxen comment ) of bleeding, caution is advised combined additional! Chloride increases toxicity of the other by pharmacodynamic antagonism naproxen by pharmacodynamic synergism of by!