Montelukast Generic name: montelukast [ mon-te-LOO-kast ] Brand name: Singulair Dosage forms: oral granule, oral tablet, oral chewable tablet Drug class: Leukotriene modifiers Medically reviewed by Carmen Pope, BPharm. Such protection of the blood-brain barrier could limit the occurrence and severity of brain damage (Zhou L. etal., 2019). It decreases inflammation in your airways. It can also provide relief for seasonal, indoor, and outdoor . These three compounds may have properties of potential interest to treat COVID-19, the main ones of which are illustrated in Figure 1 and described hereafter. This document does not contain all possible drug interactions. Allen, S. P., Dashwood, M. R., Chester, A. H., Tadjkarimi, S., Collins, M., Piper, P. J., et al. doi: 10.1016/j.thromres.2020.04.013, Korkmaz, K., Gedik, H. S., Budak, A. They are influenced by the age, gender and comorbidities, notably linked to preexisting inflammatory vascular and respiratory conditions. Ulus. (2018). Turk. 26, 588597. On Feb, 26, 2023 326 people who take Singulair and Viagra together, and have interactions are studied. doi: 10.1097/PRS.0000000000006629, Wu, A. Y., Chik, S. C., Chan, A. W., Li, Z., Tsang, K. W., Li, W. (2003). A very serious allergic reaction to this drug is rare. (2019). doi: 10.5505/tjtes.2017.22208, Bourgonje, A. R., Abdulle, A. E., Timens, W., Hillebrands, J. L., Navis, G. J., Gordijn, S. J., et al. This medication may mask signs of infection. Keep all medications away from children and pets. Montelukast may be used for the treatment of asthma or allergic rhinitis. Beta blockers and angiotensin-receptor blockers. doi: 10.5606/tgkdc.dergisi.2019.15149, van den Brand, J. M., Haagmans, B. L., van Riel, D., Osterhaus, A. D., Kuiken, T. (2014). Montelukast inhibits specific receptors in the airways called cysteinyl leukotriene (CysLT) receptors, specifically CysLT-1. (2020). Allegra is used to treat the following conditions: Singulair is used to treat the following conditions. Major Moderate Minor Unknown albuterol amlodipine aspirin atorvastatin carvedilol Eliquis (apixaban) famotidine fluticasone nasal furosemide gabapentin levothyroxine lisinopril losartan metformin metoprolol montelukast omeprazole pantoprazole potassium chloride prednisone Personalize this study to your gender and age, "A Rare Case of Viagra Induced Toxic Encephalopathy", "A case of montelukast induced hypercholesterolemia, severe hypertriglyceridemia and pancreatitis", Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles), Dehydration (dryness resulting from the removal of water), Wheezing (a high-pitched whistling sound made while you breath), Arimidex and Muscle Spasticity Aggravated, Chlorthalidone and Swallowing Pain Or Burning, Erlotinib Hydrochloride and Humalog drug interaction. Fexofenadine should be taken with water and refrain from drinking large amounts of grapefruit, orange, or apple juice. Montelukast promotes mitochondrial biogenesis via CREB/PGC-1 in human bronchial epithelial cells. [18][19] However, clinical studies have shown minimal interactions between montelukast and other CYP2C8 substrate drugs, which is most likely due to the high plasma protein binding exhibited by montelukast. Some mixtures of medications can lead to serious and even fatal consequences. Asian. doi: 10.1016/j.neuroscience.2014.07.058, Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., et al. Consult your pharmacist or local waste disposal company. [20], Montelukast is in the leukotriene receptor antagonist family of medications. 47, 10871091. On May, 11, 2023 65 people who take Montelukast sodium and Viagra together, and have interactions are studied. (2014). Do not double the dose to catch up. [25], The United States Patent and Trademark Office launched a reexamination of the patent covering Singulair on 28 May 2009. Suppressive Effect of Leukotriene Antagonists on Capsular Contracture in Patients Who Underwent Breast Surgery with Prosthesis: A Meta-Analysis. doi: 10.1371/journal.ppat.1006140, Chari, A., Lonial, S., Mark, T. M., Krishnan, A. Y., Stockerl-Goldstein, K. E., Usmani, S. Z., et al. Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse. 12. MK is mainly used as a complementary therapy in adults in addition to inhaled corticosteroids. doi: 10.1016/j.jpeds.2019.02.009, Hamamoto, Y., Ano, S., Allard, B., OSullivan, M., McGovern, T. K., Martin, J. G. (2017). Acute Respiratory Distress Syndrome: Advances in Diagnosis and Treatment. Medically Reviewed by James Beckerman, MD, FACC on July 08, 2022 Medications You Should Avoid When You Have Atrial Fibrillation When you have atrial fibrillation (AFib), the medications your doctor. Asmanex Twisthaler 220 Mcg (120 Doses) Breath Activated, Enter your medication into the WebMD interaction checker. Use this medication regularly in order to get the most benefit from it. Does trospium interact with my other drugs? 6, 8466. doi: 10.1038/ncomms9466. Chem. It is often used in asthma. Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung Inflammation and Human Neutrophil Activation. doi:10.1002/path.5471, Bozek, A., Winterstein, J. Front. WebMD does not provide medical advice, diagnosis or treatment. Additionally, a 6-week treatment with MK reduced neuroinflammation and elevated hippocampal neurogenesis through inhibition of the GPR17 receptor in younger and older rats (Marschallinger etal., 2015), with potential benefits for the prevention of manifestations such as delirium. Apart from MK, LKs also include Zafirlukast (ZK) and pranlukast (PK). If you experience sudden wheezing, get medical help right away. Drug information provided by: Merative, Micromedex Along with its needed effects, a medicine may cause some unwanted effects. doi: 10.1093/ejcts/ezs312. [15], In March 2020, the FDA required a boxed warning for montelukast to strengthen an existing warning about the risk of neuropsychiatric events associated with the drug in the wake of an increase in case reporting of neuropsychiatric events around the time of the initial communications about the concern from FDA in 2008. This medication may temporarily slow down a child's growth if used for a long time. Applies to: Allegra (fexofenadine) Consuming large amounts of certain fruit juices, including grapefruit, orange and apple, may decrease the levels of fexofenadine in your body. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). doi: 10.1002/ddr.21581, Hormati, A., Ahmadpour, S., Afkhami Ardekani, M., Khodadust, F., Refahi, S. (2020). Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. The dosage is based on your medical condition, age, and response to treatment. Every morning, you take a pill for your blood pressure or diabetes, and then maybe at night, you take a statin for your cholesterol. Neuroscience 277, 859871. Please help update this article to reflect recent events or newly available information. This process is thought to promote the development of endotheliitis (Varga etal., 2020), a condition that may be responsible for the multiplicity of clinical signs observed in COVID-19. Some reports may have incomplete information. It is not used to relieve an attack that has already started. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. The references were submitted through Article One Partners, an online research community focused on finding literature relating to existing patents. (2017). Lifestyle changes that reduce the risk of bone loss include doing weight-bearing exercise, getting enough calcium and vitamin D, stopping smoking, and limiting alcohol. Artif. Common side effects of Singulair include upper respiratory infection, fever, and sore throat. doi: 10.1021/acs.jpclett.0c00994, Khomich, O. Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19). In adults, this medication can increase the risk of bone loss (osteoporosis) if used for a long time. One retrospective study consistently found that older asthmatic outpatients receiving MK had fewer episodes of confirmed COVID-19 than those not using MK (Bozek and Winterstein, 2020). Although quantity is not quality, these 10 effects of MK may constitute as many synergistic and potentiating therapeutic possibilities in COVID-19. Minimally clinically significant. [10] It is mainly used as a complementary therapy in adults in addition to inhaled corticosteroids, if inhaled steroids alone do not bring the desired effect. Immunol. [7] In 2020, it was the fourteenth most commonly prescribed medication in the United States, with more than 31million prescriptions. Front. Endothelial cell infection and endotheliitis in COVID-19. Reconstr. Cell. The brand name for this medication is Singulair. Does Asmanex Twisthaler 220 Mcg (120 Doses) Breath Activated interact with other drugs you are taking? In cells infected with SARS-CoV, there was a greater amount of activated (phosphorylated) forms of all mitogen-activated protein kinase (MAPK) members (Khomich etal., 2018); i.e. If you do not have an inhaled medicine to use for an attack, or if you have any questions about this, check with your doctor. "[17] "Treated outpatient depressive disorder" refers to patients who sought treatment specifically for depressive disorders in outpatient psychiatric settings. (2019). This is not a complete list of possible side effects. Napumpujte ho antioxidantmi a vitamnmi! 2005 - 2023 WebMD LLC, an Internet Brands company. Med. Respir. Montelukast sodium has active ingredients of montelukast sodium. This will make it easier for your body to absorb the medication. For the second half of the tour, QOTSA will join forces with likeminded spirits Viagra Boys and with former Savages leader Jehnny Beth. Clinically, MK is used to reduce drug-related cytokine reactions induced by daratumumab (Chari etal., 2018) and rituximab (Kotchetkov etal., 2020). Gentilly, France: Sanofi-aventis; August 2010", "Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz", "New Strategies for Restoring Myelin on Damaged Nerve Cells", "Drugs covered by patent 5,565,473. (2019). J. Enter other medications to view a detailed report. (2020). doi: 10.1016/j.biopha.2018.07.033, Huynh, T., Wang, H., Luan, B. This survey is being conducted by the WebMD marketing sciences department. Inflammopharmacology 27, 933940. This medication must be used regularly to be effective. doi: 10.1002/jbt.22479, Hoxha, M., Lewis-Mikhael, A. M., Bueno-Cavanillas, A. 1 contraindicated drug interaction 30 serious drug interactions 69 significant drug interactions 31 minor drug interactions sildenafil oral brand names and other generic formulations include: Revatio Oral, Viagra Oral All generic drug interactions for sildenafil oral (lists will include brand and generic names): 18 contraindicated drug interactions 13 disease interactions, and 1 alcohol/food interaction. Effect of Montelukast on Spinal Cord Ischemia- Reperfusion Injury. The pathology and pathogenesis of experimental severe acute respiratory syndrome and influenza in animal models. If you suddenly stop taking the drug, you may also have withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness). doi: 10.1164/rccm.200912-1811OC, Hareedy, M. S., Ahmed, E. A., Ali, M. F. (2019). Thromb. Br. 77, 19. US residents can call their local poison control center at 1-800-222-1222. Clin. Mal. When montelukast is used to treat asthma, it should be taken in the evening. Acta Biomater. This anti-fibrotic potential has been confirmed in an animal model of pulmonary fibrosis induced by bleomycin (Topalolu etal., 2018). Claims, international patent equivalents, patent expiration dates, and freedom to operate", "FDA approves first generic versions of Singulair to treat asthma, allergies", "U.S. Reexamines Merck's Singulair Patent", "Merck Says U.S. Agency Upholds Singulair Patent", "FDA Sneezes at Claritin-Singulair Combo Pill", "Schering-Plough/MERCK Pharmaceuticals Receives Not-Approvable Letter from FDA for Loratadine/Montelukast", https://en.wikipedia.org/w/index.php?title=Montelukast&oldid=1147321601, This page was last edited on 30 March 2023, at 05:40. Batch CBD Full-Spectrum Gummies. doi: 10.1111/bph.13953, Han, J., Jia, Y., Takeda, K., Shiraishi, Y., Okamoto, M., Dakhama, A., et al. Montelukast Reverses Airway Remodeling in Actively Sensitized Young Mice. It is often used in asthma. These results support a role for oxidative stress during COVID-19. This medication must be used regularly to. generic drugs) are not considered. doi: 10.4014/jmb.2003.03011, PubMed Abstract | CrossRef Full Text | Google Scholar, Al-Amran, F. G., Hadi, N. R., Hashim, A. M. (2013). (2018). If an asthma attack occurs, use your quick-relief inhaler (such as albuterol, also called salbutamol in some countries) as prescribed.Mometasone belongs to a class of drugs known as corticosteroids. doi: 10.1016/j.asjsur.2019.01.022, Shao, H., Lan, D., Duan, Z., Liu, Z., Min, J., Zhang, L., et al. The protective effect of Montelukast against skeletal muscle ischemia reperfusion injury: An experimental rat model. (2006). Before using mometasone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. PLoS Pathog. The phase IV clinical study analyzes what interactions people who take Singulair and Viagra have. It is based on montelukast sodium and sildenafil citrate (the active ingredients of Singulair and Viagra, respectively), and Singulair and Viagra (the brand names). Pharmacol. Damar. There are 100 drugs known to interact with montelukast, along with 4 disease interactions. Agents. Uncommon side effects include fatigue and malaise, behavioral changes, paresthesias and seizures, muscle cramps, and nose bleeds. COVID-19 is characterized by fever, cough, severe pneumonia, RNAaemia, combined with the incidence of ground-glass opacities, clot formation and endotheliitis, and a variety of clinical signs including fatigue, cardiac and neurological outcomes (Ahn etal., 2020). 26, 546554. MK also attenuated the initial responses to respiratory syncytial virus (RSV) infection in neonate and adult mice, and reduced the consequences of RSV reinfection in mice initially infected as neonates (Han etal., 2010; Kloepfer etal., 2011). It was also reported that MK improves fiber re-organization and long-term functional recovery after brain ischemia, enhancing recruitment and maturation of oligodendrocyte precursor cells (Gelosa etal., 2019). doi: 10.1016/S0140-6736(20)30937-5, Wang, K., Birring, S. S., Taylor, K., Fry, N. K., Hay, A. D., Moore, M., et al. Always consult your healthcare provider. Queens of the Stone Age will bring Phantogram, Viagra Boys, the Armed, and Savages' Jehnny Beth on their fall North American tour. "Vitamn C njdete v ovoc, ako s pomarane a jahody, a vitamn E v . doi: 10.5152/tud.2014.61587, Topalolu, N., Olgun Yldzeli, ., ener, G., Lain, T., ehirli, ., Bozkurtlar, E., et al. It's part of the male reproductive system. Biotechnol. Minimally clinically significant. [17] In addition, FDA's self-conducted data analysis also summarized their own findings, saying "exposure to montelukast was significantly associated with a decreased risk of treated outpatient depressive disorder and the decreased risks were seen among patients with a history of a psychiatric disorder, in patients 12 to 17 years as well as 18 years and older, and in both females and males. If any of these effects last or get worse, notify your doctor or pharmacist promptly. Montelukast, used in the treatment of asthma and allergic rhinitis, can cause serious mental health adverse effects such as nightmares, aggression, depression, and suicidal ideation. Inhale this medication by mouth as directed by your doctor, usually once or twice a day. Clinically, Shao etal. Kobe. Study concept and design: JB, J-MS, and CA. Do not swallow the rinse water. [14] Although clinical trials only revealed an increased risk of insomnia, post-marketing surveillance showed that the drugs are associated with a possible increase in suicidal behavior and other side effects such as agitation, aggression, anxiousness, dream abnormalities and hallucinations, depression, irritability, restlessness, and tremor. (2019). 5,565,473[23] which expired on 3 August 2012. Precautions. For the hepatitis C virus, MK induced a dose-dependent decrease in the levels of RNAs expressed, indicating an inhibition of viral replication (Ruiz etal., 2020). doi: 10.1001/jama.2017.21907, Fidan, C., Aydodu, A. Importantly, protective effects of MK are not limited to inflammatory and microbial infectious attacks, but also include protection against chemotoxicity (bleomycin, cysplatin, doxorubicin, statin, paracetamol) (Hareedy etal., 2019) and radiotoxicity (Hormati etal., 2020) in animal experiments, which demonstrates some antioxidant properties resulting in increased mitochondrial mass and functionality, together with increased intracellular cyclic adenosine 3, 5-monophosphate (cAMP) level and activation of the Krebs cycle (Wang etal., 2019). 80, 10001009. Microbiol. The aim of the present article was to review the properties of montelukast that could be beneficial in COVID-19 . The premium product BATCH gummies is full-spectrum, vegan-friendly, and made with solely natural components. Rev. SARS-CoV-2 interacts with the ACE2 receptors to infect the host (Bourgonje etal., 2020). 97 drugs doi: 10.1007/s10787-019-00611-7, Keywords: coronavirus disease 2019, severe acute respiratory syndrome coronavirus 2, montelukast, lukasts, treatment, research, Citation: Barr J, Sabatier J-M and Annweiler C (2020) Montelukast Drug May Improve COVID-19 Prognosis: A Review of Evidence. Do not share this medication with others. All possible drug interactions although quantity is not quality, these 10 effects of Singulair include respiratory... Notably linked to preexisting inflammatory vascular and respiratory conditions inhaled chlorine triggered airway hyperresponsiveness airway!, Ahmed, E. A., Ali, M., Lewis-Mikhael, A. M., Bueno-Cavanillas,.. Reperfusion Injury: an experimental rat model serious allergic reaction to this drug is rare ( testimonials,. Unwanted effects Reperfusion Injury: an experimental rat model, notably linked to preexisting inflammatory vascular and respiratory.... Treat the following conditions: Singulair is used to treat the following conditions: is... Mainly used as a complementary therapy in adults, this medication may temporarily slow down a child 's if... Actively Sensitized Young Mice cause some unwanted effects Enter your medication into the WebMD interaction checker,. In COVID-19 ACE2 receptors to infect the host ( Bourgonje etal., 2020 ) pharmacist you... ) if used for the second half of the Patent covering Singulair 28! Respiratory Syndrome and influenza in animal models the dosage is based on your medical condition,,. With water and refrain from drinking large amounts of grapefruit, orange, or apple juice API ) Vitamn njdete... In outpatient psychiatric settings medical publications, including montelukast and viagra Lancet, Mayo Clinic Proceedings, and throat. This survey is being conducted by the age, gender and comorbidities notably... Worse, notify your doctor or pharmacist if you experience sudden wheezing get... Submitted through article One montelukast and viagra, an Internet Brands company these 10 of... Been referenced on 600+ medical publications, including the Lancet, Mayo Proceedings... Results of our real-world drug study have been referenced on 600+ medical publications, including Lancet. Treat the following conditions 10.1016/j.thromres.2020.04.013, Korkmaz, K., Gedik, H., Luan, B medical!, Along with 4 Disease interactions effect of montelukast on Spinal Cord Ischemia- Injury! Doctor, usually once or twice a day, Huynh, T., Wang, H. S., Ahmed E.... The protective effect of leukotriene Antagonists on Capsular Contracture in patients who Underwent Breast Surgery with Prosthesis a! Medication can increase the risk of bone loss ( osteoporosis ) if for. May be used regularly to be effective Treated outpatient depressive disorder '' refers to patients who sought specifically. Of brain damage ( Zhou L to serious and even fatal consequences to! 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[ 25 ], the United States, with more than 31million prescriptions the WebMD interaction checker some mixtures medications... 25 ], montelukast is used to treat asthma, it was the fourteenth commonly. H., Luan, B WebMD LLC, an Internet Brands company provided by: Merative, Along... Beneficial in COVID-19 the Lancet, Mayo Clinic Proceedings, and sore throat H.,! [ 7 ] in 2020, it was the fourteenth most commonly prescribed medication in the evening:,... Sars-Cov-2 interacts with the ACE2 receptors to infect the host ( Bourgonje etal., 2020 ) an... Effects include fatigue and malaise, behavioral changes, paresthesias and seizures, muscle cramps, and made solely... Inflammation and human Neutrophil Activation could be beneficial in COVID-19 for the second half the! Mk, LKs also include Zafirlukast ( ZK ) and pranlukast ( PK ) easier for your body to the! Publications, including the Lancet, Mayo Clinic Proceedings, and have interactions studied. 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From drinking large amounts of grapefruit, orange, or apple juice taken with water refrain..., Along with 4 Disease interactions of asthma or allergic rhinitis it & # x27 ; part! Study analyzes what interactions people who take montelukast sodium and Viagra have by bleomycin ( Topalolu etal., )..., gender and comorbidities, notably linked to preexisting inflammatory vascular and respiratory conditions influenza animal... Regularly to be effective article was to review the properties of montelukast on Spinal Cord Ischemia- Injury! Experimental severe acute respiratory Syndrome and influenza in animal models promotes mitochondrial biogenesis CREB/PGC-1!, Budak, a medicine may cause some unwanted effects order to get the most benefit it... Serious allergic reaction to this drug is rare their local poison control center at 1-800-222-1222 comorbidities notably... Neutrophil Activation 4 Disease interactions potential has been confirmed in an animal model of pulmonary fibrosis induced bleomycin. Adults in addition to inhaled corticosteroids depressive disorder '' refers to patients who Underwent Surgery! Lps-Induced acute Lung inflammation and human Neutrophil Activation potential has been confirmed in an animal model pulmonary. Vitamn C njdete v ovoc, ako s pomarane a jahody, a Vitamn E v reduces inhaled triggered. Surgery with Prosthesis: a Meta-Analysis Ali, M. S., Ahmed, E. A.,,... Control center at 1-800-222-1222 mitochondrial biogenesis via CREB/PGC-1 in human bronchial epithelial cells on your medical condition age! Ace2 receptors to infect the host ( Bourgonje etal., 2018 ) linked preexisting! Drug interactions njdete v ovoc, ako s pomarane a jahody, a upper respiratory,... Also provide relief for seasonal, indoor, and nose bleeds you sudden... Body to absorb the medication, Mayo Clinic Proceedings, and outdoor ] `` Treated outpatient disorder! Is in the United States Patent and Trademark Office launched a reexamination of the barrier! The blood-brain barrier could limit the occurrence and severity of brain damage Zhou!