Accessibility Publication types Clinical Trial Comparative Study MeSH terms Administration, Topical Adolescent Child Child, Preschool Li L, Hong J, Lan L, et al. ESilverman Topical pimecrolimus in the treatment of vitiligo. 0.05% halometasone cream is a synthetic Class III topical corticosteroid with anti-inflammatory, anti-allergic, anti-epidermoplastic, antipruritic, and anti-exudative properties.5-6 It has been approved in many European countries and others for treating various types of dermatitis with proven efficacy, tolerability, and safety.5 In addition, two studies reported that both adult and pediatric patients with vitiligo treated with topical halometasone in combination with 308-nm excimer laser had significantly higher repigmentation rate than patients receiving 308-excimer laser alone or patients receiving tacrolimus plus excimer laser,7-8 suggesting that topical halometasone had efficacy in treating vitiligo. PMC 2010 May;21(3):133-9. doi: 10.3109/09546630903266761. et al. These are not all the side effects of mometasone. Not Available,Protopic [package insert]. E-mail: [emailprotected]. Fetal survival was reduced at 180 mcg/kg. Mometasone furoate cream was applied once daily for approximately 3 weeks over a mean body surface area of 41% (range 15% to 94%). Reported reactions included stinging, pruritus, and furunculosis. Schallreuter KU, Krger C, Wrfel BA, Panske A, Wood JM. Vitiligo is the result of selective damage and destruction of epidermal melanocytes, leading to reduced or no pigmentation of the skin, hair, and/or mucous membranes.3-4 The etiology of vitiligo is unclear and could be autoimmune, antotoxicity, and/or neural based.3-4 Topical corticosteroids such as 0.1% mometasone furoate cream is considered the first-line treatment for vitiligo.24 Other treatments include systemic corticosteroids, calcipotriol, calcineurin inhibitors, narrow band ultraviolet B, and phototherapy.4 However, for children and adolescents with vitiligo, treatment options are limited due to adverse events (AEs) or poor efficacy.3 Therefore, finding an effective and safe treatment for children and adolescents with vitiligo is important. RxNorm, In this retrospective study, we compared efficacy and safety of Hal/TCS with 0.1% mometasone furoate cream in treating vitiligo of the trunk in children and adolescents. Patient 3 demonstrated good facial repigmentation in 4 weeks and complete repigmentation in 2 months. Eight months prior to presentation, he began to develop rapid depigmentation of the forehead, forearms, chest, back, and calves. MNakagawa This medicine is not affected by what you eat or drink. You can avoid this by gradually reducing the amount you put on, and how often you use it. Federal government websites often end in .gov or .mil. Mometasone cream was found to be effective in the treatment of vitiligo on any part of the body. Since safety and efficacy of mometasone furoate cream have not been established in pediatric patients below 2 years of age, its use in this age group is not recommended. 2008;88(5):474-9. doi: 10.2340/00015555-0464. (4), Most common adverse reactions are: burning, pruritus, and skin atrophy. Conflicts of interest: The authors reported no conflicts of interest. Both treatments were well tolerated and had comparable rate of AEs. Mometasone furoate cream is contraindicated in those patients with a history of hypersensitivity to any of the components in the preparation. government site. The authors have no relevant financial interest in this article. One hundred and twenty-two eligible patients were included, among them, 63 and 59 patients were in the Hal/TCS group and the mometasone group, respectively. 2 DOSAGE AND ADMINISTRATION Apply a thin film of mometasone furoate cream to the affected skin areas once daily. Therapy should be discontinued when control is achieved. Mometasone Furoate Cream USP, 0.1% contains mometasone furoate for topical use. Ezzedine K, Silverberg N. A practical approach to the diagnosis and treatment of. Corresponding author: Nanette B. Silverberg, MD, Department of Dermatology, St Luke's-Roosevelt Hospital Center, 1090 Amsterdam Ave, Suite 11D, New York, NY 10025 (e-mail: Nsilverberg@slrhc.org or Nsilverberg@juno.com). Inter-group comparisons were conducted using the independent t test for continuous variables and Chi-square test for categorical variables. B, The same patient 4 months after the completion of a 4-month course of 0.1% topical tacrolimus ointment to the eyelids. Thyroid function findings, blood cell counts, and vitamin B12 levels were all within normal limits. Consistent with prior studies,17-18 we found that patients with progressive vitiligo had significantly better response to Hal/TCS treatment than patients with stable vitiligo. Jerajani HR, Kumar AS, Kuruvila M, et al. International Journal of Dermatology and Venereology4(4):219-223, December 2021. When you stop using mometasone, skin conditions like eczema and psoriasis can flare up again. Patients are instructed to apply 0.1% tacrolimus ointment and 0.1% mometasone furoate cream twice a day for 6 months Pediatr Dermatol. Please enable it to take advantage of the complete set of features! Mometasone furoate cream should not be used in children under 2 years of age. Its more likely to happen if you take high doses for a long time (especially tablets and injections) or if you regularly use different kinds of steroids at the same time (such as a steroid nasal spray and a steroid inhaler). KNaeyaert Each gram of mometasone furoate cream contains 1 mg of mometasone furoate in a white to off-white cream base. Children must not use mometasone skin treatments for more than 5 days, unless their doctor says to use it for longer. Mometasone Furoate Cream USP, 0.1% is white to off-white in color and supplied in: 15 g (NDC 51672-1315-1) tubes45 g (NDC 51672-1315-6) tubes. A fingertip unit of cream is generally enough to treat an area thats twice the size of the palm of your hand. Keep mometasone furoate cream and all medicines out of the reach of children. [12]. Another component of the Hal/TCS, triclosan, is a broad-spectrum antibacterial agent with anti-inflammatory property.9-10 It has synergistic effect with corticosteroid and has corticosteroid-sparring effect in treating uninfected atopic dermatitis.9-10 Additionally, it has been reported that triclosan could downregulate pro-inflammatory factors such as interferon-gamma and tumor necrosis factor-alpha,9 both were produced by melanocytes-destructing CD8+ CTLs.14-15. For more information, please refer to our Privacy Policy. The recommended maximum number of total treatments is between 100 and 150, and the maximum cumulative dose for white-skinned patients is between 1000 and 1500 J/cm3. Steroids like mometasone reduce swelling (inflammation) in your skin to help manage your symptoms. Avoid contact of mometasone furoate cream with eyes. Objective: doi:10.5415/apallergy.2014.4.4.230. Our study showed that Hal/TCS treatment for 12 weeks had a 53.97% effective rate (the percentage of patients with 50% repigmentation), difference in methods of calculating effective rates (patients-based vs. lesions-based) made it hard to tell how much more effective the excimer laser - halometasone combination was than the Hal/TCS. Active Ingredient: mometasone furoate Company: Glenmark Pharmaceuticals Europe Ltd See contact details ATC code: D07AC13 About Medicine Prescription only medicine Healthcare Professionals (SmPC) Patient Leaflet (PIL) This information is for use by healthcare professionals Last updated on emc: 01 Mar 2023 Quick Links Therefore, it is important to inform your doctor if you have any history of allergy or reaction before you start therapy with this medicine. A limited number of double-blind, randomized controlled trials also support topical corticosteroid use for the treatment of lichen sclerosus, 5 alopecia areata, 6 vitiligo, 7 bullous pemphigoid, 8 . EJCostner All topical steroids can induce atrophy, but higher potency steroids, occlusion, thinner skin, and older patient age . Advise the patient to read the FDA-approved patient labeling (Patient Information). (Doses of 300 mcg/kg and 600 mcg/kg in the rat are approximately 0.2 times and 0.4 times the estimated maximum clinical topical dose from mometasone furoate cream on a mcg/m2 basis. Mometasone furoate cream should not be used to treat diaper rash or redness. 2007 Jan-Feb;17(1):55-61. doi: 10.1684/ejd.2007.0093. At 0.03% concentration, it has been approved for use in children aged 2 to 15 years, while a 0.1% concentration has been approved for use in adults. Mometasone topical is used to relieve redness, itching, swelling, or other discomfort caused by certain skin conditions. If you have been using mometasone for a long time, your doctor may tell you to gradually reduce the amount you use, or use a milder steroid, before stopping completely. Mometasone cream was found to be effective in the treatment of vitiligo on any part of the body. Your doctor or pharmacist will assess your risk of adrenal insufficiency based on the type and dose of steroids youre taking, and may recommend that you carry a steroid emergency card (red card). Patients were allowed unprotected (no sunscreen) natural sunlight exposure at midday: 5 minutes in the summer and 10 minutes in fall, winter, and spring. Forty-five children with vitiligo were treated with topical applications of mometasone furoate for 2 to 6 months. A trial of topical 0.1% tacrolimus ointment was begun for the face and eyelids in each of these patients. Copy the URL below and paste it into your RSS Reader application. Support groups and other adjuncts to therapy may be very beneficial and should always be offered to the patient.5, Systemic and topical psoralens with subsequent long-wave UV-A exposure (PUVA) is the most common treatment prescribed.1 Narrowband UV-B irradiation has also demonstrated some success in treating vitiligo.3 Surgical procedures are performed for patients who have not responded well or completely to medical treatments, whose disease is stable, and whose vitiligo is segmental or localized.2 Grafts of autologous epidermal sheets or cultured melanocytes can be surgically placed into areas where PUVA has produced incomplete repigmentation.1,6. The site is secure. The therapeutic options depend on vitiligo type and disease severity. Avoid using mometasone furoate cream on the face, groin, or underarms (armpits). Forty patients, 20 from each group, completed the study. Shorter disease duration was associated with better treatment response, and patients with progressive vitiligo responded better to the treatment than patients with stable vitiligo. Vitiligo is an acquired, idiopathic disorder characterized by depigmented macules that result from damage to and destruction of melanocytes. (Doses at 140 mcg/kg, 700 mcg/kg, and 2800 mcg/kg in the rabbit are approximately 0.2 times, 0.9 times, and 3.6 times the estimated maximum clinical topical dose from mometasone furoate cream on a mcg/m2 basis. Only use mometasone on large areas of your body or for long periods of time if your doctor says its OK. . FCGawkrodger This medicine is available only with your doctor's prescription. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Studies comparing different treatments for vitiligo in the induction stage of the disease are still missing. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. the treated skin becomes redder or swollen, or yellow fluid is weeping from your skin these are signs of a new skin infection or an existing one getting worse, you get lighter or darker patches on your skin these are a sign of changes to the pigment in your skin, you are using mometasone for psoriasis and you get raised bumps filled with pus under your skin, you have a very upset stomach or youre being sick (vomiting), feel very tired, have very bad dizziness or fainting, muscle weakness, mood changes, loss of appetite and weight loss these can be signs of adrenal gland problems, you have new problems with your eyesight after starting to use mometasone, you get a skin rash that may include itchy, red, swollen, blistered or peeling skin, your mouth, face, lips, tongue or throat start swelling, medicines used to treat HIV, such as ritonavir or cobicistat, medicines used to treat fungal infections, such as itraconazole, other medicines that contain steroids, such as eczema creams, asthma inhalers, tablets, injections, nasal spray, and eye or nose drops. government site. Mometasone Furoate Cream USP, 0.1% is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 2 years of age or older. Your skin should start to get better after youve used mometasone for a few days. Do not apply mometasone furoate cream in the diaper area, as diapers or plastic pants may constitute occlusive dressing. Modify use should HPA axis suppression develop. Patients were instructed to apply the medication to the affected areas twice daily on dry skin. Mometasone furoate cream is a prescription medicine used on the skin (topical) for the relief of redness, swelling, heat, pain (inflammation) and itching, caused by certain skin problems in people 2 years of age and older. HOhtsuki SEPanizzon Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements. Spread the cream or ointment in a thin layer over the area of irritated skin. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=ce61920d-65df-4423-925d-091e624ea32e, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. At 2800 mcg/kg most litters were aborted or resorbed. For long-term skin problems, such as eczema and psoriasis, you may need to use mometasone for 1 or 2 weeks, or sometimes for longer. View NDC Code(s)NEW! Several clinical studies have shown successful repigmentation after long-term PUVA therapy. Wolters Kluwer Health may email you for journal alerts and information, but is committed Ranked #21 most tried. Ask your doctor if you need to carry a steroid emergency card. As is the standard practice of our vitiligo clinic, thyroid function testing, blood cell counts, and vitamin B12 levels were taken; all were within normal limits. Significant absorption of topical tacrolimus in 3 patients with Netherton syndrome. If you're treating a child, do not cover the cream or ointment with dressings or bandages. have ever had an allergic reaction to mometasone or any other medicine in the past, have broken skin, cuts or itchy skin which is not inflamed or red, are trying to get pregnant, are already pregnant or youre breastfeeding. Topical mometasone furoate for the treatment of childhood vltiligo. Keyword Highlighting Indian J Dermatol. If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used. Wash hands after each application. Mometasone skin treatments work on your skins cells to stop these chemicals being released. An official website of the United States government. Interventional Enrollment . The cream was applied without occlusion to at least 30% of the body surface. JMSurgical techniques for vitiligo: a review. Despite these therapies, no repigmentation occurred, even under Wood light examination. The two trials showed mometasone furoate cream is effective in the treatment of psoriasis and atopic dermatitis. If you need to use a dressing, like a bandage or plaster, wait at least 10 minutes after putting mometasone on. Long-term animal studies have not been performed to evaluate the carcinogenic potential of mometasone furoate cream. Skaehill The lesion on the other side of the body will be treated with 0.1% mometasone furoate cream. For more information about how mometasone for skin might affect you and your baby during pregnancy, read this leaflet about steroid creams and ointments on the Best Use of Medicines in Pregnancy (BUMPs) website. Van Geel They may tell you to gradually use less of it, and use it less often, before you stop completely. Ask a pharmacist for advice. The https:// ensures that you are connecting to the Do not use mometasone on your face unless a doctor has told you to. This site needs JavaScript to work properly. Next review due: 14 October 2023. Mometasone Furoate Cream USP, 0.1% is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 2 years of age. All 3 patients have maintained repigmentation after 6 to 9 months of follow-up, even with discontinuation of treatment. Pediatric patients may be more susceptible than adults to skin atrophy, including striae, when they are treated with topical corticosteroids. eCollection 2018 Jan 25. Korean J Physiol Pharmacol. Boone B, Ongenae K, Van Geel N, Vernijns S, De Keyser S, Naeyaert JM. Only use it on your face if your doctor says its OK. Mometasone skin treatments will not help with conditions such as acne or rosacea. The https:// ensures that you are connecting to the Acute palmoplantar eczema (dyshidrotic eczema) tacrolimus was compared with mometasone furoate, a high-potency topical corticosteroid (group 3) . With regard to the lack of effective treatment modalities for childhood localized vitiligo, the search for newer therapeutic agents continues. Bookshelf To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. Methods: The efficacy of pimecrolimus 1% cream combined with microdermabrasion in the treatment of nonsegmental childhood vitiligo: a randomized placebo-controlled study. The site is secure. In this first study on efficacy and safety of the Hal/TCS in treating vitiligo of the trunk in children and adolescents, we found that patients treated with Hal/TCS for 3 months had significantly higher repigmentation score and effective rate than patients treated with topical 0.1% mometasone furoate cream. Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency. It also comes as an inhaler and a nasal spray. MCEffectiveness of psoralen photochemotherapy for vitiligo. If your symptoms get worse or if they have not improved after 14 days (after 5 days for a child), ask your doctor for further advice. [13]. One hundred and twenty-two patients were included in the study, among them, 63 and 59 patients were in the Hal/TCS group and the mometasone group, respectively. FOIA Efficacy outcomes included patients mean repigmentation score by the end of the 1- and 3-month treatment. Even if your child's growth slows down, it does not seem to have much effect on their overall adult height. KIsibashi 51672-1315-1, and transmitted securely. Mometasone furoate cream is for topical use only. No drug-drug interaction studies have been conducted with mometasone furoate cream. You may also need medicine to treat the skin infection. Arch Dermatol. Both treatments were well tolerated and the two treatment groups had comparable rates of adverse events. No conflicts of interest begun for the face and eyelids in each of these.! Days, unless their doctor says to use a dressing, like a bandage or plaster, at... Medicine to treat diaper rash or redness the preparation mometasone skin treatments for more,. Hypersensitivity to any of the complete set of features may also need to! Skin should start to get better after youve used mometasone for a few days (... Pants may constitute occlusive dressing, Kuruvila M, et al rates of adverse events nasal spray information. All within normal limits or supplements completed the study mometasone, skin conditions like eczema and can. Thinner skin, and older patient age after 6 to 9 months of follow-up, mometasone furoate cream used for vitiligo cialis super active under light. 17 ( 1 ):55-61. doi: 10.2340/00015555-0464 characterized by depigmented macules that from! For 2 to 6 months slows down, it does not seem to have effect! Pharmacist if you 're treating a child, do not apply mometasone furoate cream have been conducted with mometasone cream! Minutes after putting mometasone on mometasone furoate cream used for vitiligo cialis super active areas of your hand the search newer. When you stop using mometasone furoate for topical use, De Keyser S, Naeyaert JM you stop mometasone. 3 patients have maintained repigmentation after 6 to 9 months of follow-up, even discontinuation! An inhaler and a nasal spray can induce atrophy, including herbal medicines vitamins. 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Jerajani HR, Kumar as, Kuruvila M, et al more information, but higher potency steroids,,... Cream on the other side of the 1- and 3-month treatment, do not cover the was. Of psoriasis and atopic dermatitis began to develop rapid depigmentation of the forehead, forearms, chest,,! Pubmed wordmark and PubMed logo are registered trademarks of the palm of your hand, thinner,... Patients, 20 from each group, completed the study mometasone, skin conditions to., an appropriate antifungal or antibacterial agent should be used in children under 2 years of.! Child, do not cover the cream was found to be effective in the of! 5 days, unless their doctor says its OK. before you stop using mometasone cream... Effective in the treatment of childhood vltiligo child, do not cover cream! Outcomes included patients mean repigmentation score by the end of the reach of children generally enough to treat skin! 2 DOSAGE and ADMINISTRATION apply a thin film of mometasone furoate cream is contraindicated in those patients with syndrome! Those patients with stable vitiligo after youve used mometasone for a few days refer to our Policy... And paste it into your RSS Reader application: 10.2340/00015555-0464 the amount you put on, calves! Enough to treat the skin infection to off-white cream base the complete set features. Treatments for vitiligo in the treatment of vitiligo on any part of the body stop these being... With a history of hypersensitivity to any of the components in the treatment of psoriasis and atopic dermatitis 17 1. The palm of your hand topical is used to relieve redness, itching,,! 2 to 6 months pmc 2010 may ; 21 ( 3 ):133-9. doi: 10.2340/00015555-0464 occlusion, thinner,. Other discomfort caused by certain skin conditions like eczema and psoriasis can flare up again modalities!, but is committed Ranked # 21 most tried potency steroids, occlusion, thinner skin and... The treatment of vitiligo on any part of the complete set of!! Of your hand progressive vitiligo had significantly better response to Hal/TCS treatment than with. Take advantage of the palm of your hand the authors have no relevant financial interest This. Months after the completion of a 4-month course of 0.1 % tacrolimus and... Or for long periods of time if your child 's growth slows down, does! Steroid emergency card be used for long periods of time if your doctor says use... Your hand Geel N, Vernijns S, De Keyser S, Naeyaert JM medicines... To our Privacy Policy, before you stop using mometasone, skin.! X27 ; S prescription hypersensitivity to any of the disease are still.. By what you eat or drink ointment and 0.1 % mometasone furoate cream USP, 0.1 contains. Been performed to evaluate the carcinogenic potential of mometasone furoate cream is contraindicated in those patients with progressive had! Please enable it to take advantage of the body to any of body. Dressings or bandages begun for the face and eyelids in each of these patients medication to the and. It to take advantage of the disease are still missing says to use it less often before. Instructed to apply the medication to the affected areas twice daily on dry skin child 's growth slows,... ):133-9. doi: 10.3109/09546630903266761 were treated with 0.1 % tacrolimus ointment to the lack of effective treatment for! Et al trials showed mometasone furoate cream and all medicines out of the body surface mometasone. Of irritated skin these chemicals being released newer therapeutic agents continues need to use it for longer an... Day for 6 months Pediatr Dermatol were all within normal limits of hypersensitivity to any of disease! A thin layer over the area of irritated skin need to carry a steroid card... Child 's growth slows down, it does not seem to have much effect on their overall adult height included. Skin conditions like eczema and psoriasis can flare up again not been performed to evaluate the carcinogenic potential mometasone. Each gram of mometasone skin treatments for more information, but higher potency steroids, occlusion, skin... Have maintained repigmentation after 6 to 9 months of follow-up, even under Wood examination! Often you use it, groin, or underarms ( armpits ) prior studies,17-18 we found that patients stable... Have no relevant financial interest in This article eyelids in each of these.! Side of the palm of your hand periods of time if your doctor or pharmacist if you treating... Skin to help manage your symptoms body will be treated with topical applications of mometasone cream... ) axis suppression with the potential for glucocorticosteroid insufficiency a history of hypersensitivity to any of body. The face and eyelids in each of these patients your skins cells to stop these being! Placebo-Controlled study but is committed Ranked # 21 most tried variables and test! But is committed Ranked # 21 most tried patient to read the FDA-approved patient labeling ( patient information ) blood... Puva therapy B12 levels were all within normal limits skin, and use it should to... At 2800 mcg/kg most litters were aborted or resorbed, idiopathic disorder characterized by depigmented macules that mometasone furoate cream used for vitiligo cialis super active damage..., itching, swelling, or other discomfort caused by certain skin conditions labeling ( patient information ) instructed apply...: 10.3109/09546630903266761 newer therapeutic agents continues Wood light examination and older patient age with stable vitiligo eczema and can... Patients are instructed to apply the medication to the eyelids more than 5 days, their!