Use Caution/Monitor. Use Caution/Monitor. Coadministration may increase risk for adverse effects of CYP3A4 substrates. Monitor Closely (1)nevirapine will decrease the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)ozanimod increases toxicity of modafinil by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Monitor INR more frequently if coadministered with inhibitors of these isoenzymes and adjust warfarin dose if needed. Depending on how well your body tolerates the drug, your doctor may increase your daily dose at least every 3 . Use Caution/Monitor. Potential for additive CNS stimulation. modafinil will decrease the level or effect of leniolisib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Use Caution/Monitor. The recipient will receive more details and instructions to access this offer. Use Caution/Monitor. Contraindicated (1)phenelzine increases effects of modafinil by pharmacodynamic synergism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Caution if coadministered with drugs with narrow therapeutics indexes. modafinil will increase the level or effect of cimetidine by affecting hepatic enzyme CYP2C19 metabolism. Effect of interaction is not clear, use caution. Minor/Significance Unknown. epinephrine racemic and modafinil both decrease sedation. Use Caution/Monitor. cinnarizine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Monitor Closely (2)saquinavir will increase the level or effect of modafinil by pharmacodynamic synergism. Minor/Significance Unknown. Clopidogrel efficacy may be reduced by drugs that inhibit CYP2C19. Use Caution/Monitor. Use Caution/Monitor. dopexamine and modafinil both decrease sedation. Monitor Closely (1)primidone will decrease the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. HOW TO USE: Read the Medication Guide provided by your pharmacist before you start using modafinil and each time you get a refill. Effect of interaction is not clear, use caution. Monitor CYP3A substrates if coadministered. Concomitant therapy may reduce therapeutic effectiveness. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Use Caution/Monitor. Minor/Significance Unknown. Effect of interaction is not clear, use caution. modafinil will decrease the level or effect of omaveloxolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Option #3 - Sulbutiamine. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Effect of interaction is not clear, use caution. Use Caution/Monitor. Monitor Closely (1)prochlorperazine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)triclofos increases and modafinil decreases sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. papaveretum increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)itraconazole will increase the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)dexmedetomidine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Monitor Closely (1)perphenazine increases and modafinil decreases sedation. Fexinidazole inhibits CYP3A4. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)sofosbuvir/velpatasvir increases levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. modafinil will increase the level or effect of ambrisentan by affecting hepatic enzyme CYP2C19 metabolism. Monitor Closely (1)modafinil will increase the level or effect of flibanserin by affecting hepatic enzyme CYP2C19 metabolism. Monitor Closely (1)ethanol increases and modafinil decreases sedation. modafinil and diethylpropion both decrease sedation. View the formulary and any restrictions for each plan. To view formulary information first create a list of plans. Minor/Significance Unknown. NOTES: Do not share this medication with others. Use Caution/Monitor. Monitor Closely (1)melatonin increases and modafinil decreases sedation. Monitor Closely (1)modafinil will increase the level or effect of belzutifan by affecting hepatic enzyme CYP2C19 metabolism. modafinil will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. Effect of interaction is not clear, use caution. triprolidine increases and modafinil decreases sedation. Minor (1)modafinil will increase the level or effect of lansoprazole by affecting hepatic enzyme CYP2C19 metabolism. Other (see comment). Minor/Significance Unknown. Use Caution/Monitor. Effect of interaction is not clear, use caution. Sharing it is against the law.Lab and/or medical tests (such as blood pressure, heart rate) may be done while you are taking this medication. Avoid or Use Alternate Drug. Oral dosage Adults, including Geriatric Adults The recommended dose is 200 mg PO once daily as a single dose in the morning. Or, if your doctor directs you to, the total daily dose of modafinil may be divided into a morning dose and a noon dose.For obstructive sleep apnea, take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. dexchlorpheniramine increases and modafinil decreases sedation. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. Drug information provided by: Merative, Micromedex US Brand Name. information submitted for this request. Modafinil is a medication that promotes wakefulness. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Use Caution/Monitor. Uses Warnings Before taking Side effects Dosage Interactions FAQ What is modafinil? Monitor Closely (1)selegiline increases effects of modafinil by pharmacodynamic synergism. This effect was not observed with istradefylline 20 mg/day. Monitor Closely (1)triprolidine increases and modafinil decreases sedation. If unavoidable, reduce CYP3A substrate dose according to product labeling. Use Caution/Monitor. serdexmethylphenidate/dexmethylphenidate and modafinil both decrease sedation. alprazolam increases and modafinil decreases sedation. Medically reviewed by Drugs.com. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Monitor Closely (1)tazemetostat will decrease the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. iloperidone increases and modafinil decreases sedation. Use Caution/Monitor. rifampin will decrease the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. saquinavir will increase the level or effect of modafinil by pharmacodynamic synergism. Consider reducing the cannabidiol dose when coadministered with a strong CYP2C19 inhibitor. For these uses, take the drug either in the morning . Use Caution/Monitor. For oral dosage form (tablets): For narcolepsy or obstructive sleep apnea/hypopnea syndrome: Adults and teenagers 17 years of age and older200 milligrams (mg) once a day, in the morning. haloperidol increases and modafinil decreases sedation. Either decreases effects of the other by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)efavirenz will decrease the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. modafinil will decrease the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Ask your doctor for advice about good sleep habits. If you are a Mayo Clinic patient, this could Use Caution/Monitor. pimozide increases and modafinil decreases sedation. Use Caution/Monitor. Monitor Closely (1)quetiapine increases and modafinil decreases sedation. The chief metabolite (40 - 50% of the dose), modafinil acid, has no pharmacological activity. caffeine and modafinil both decrease sedation. Consult your doctor before breast-feeding. Use caution when administering MAOIs and modafinil. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)promethazine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. nevirapine will decrease the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. This website also contains material copyrighted by 3rd parties. Start abrocitinib 50 mg qDay when coadministered with CYP2C19 inhibitors. Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Monitor Closely (2)modafinil will decrease the level or effect of clozapine by affecting hepatic enzyme CYP1A2 metabolism. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)ivosidenib will decrease the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Published: February 22, 2012. Minor/Significance Unknown. Avoid or Use Alternate Drug. Monitor Closely (1)fluphenazine increases and modafinil decreases sedation. Use Caution/Monitor. modafinil will decrease the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. cyclophosphamide will increase the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Portions of this document last updated: May 01, 2023. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. This drug can be taken with or without food. Effect of interaction is not clear, use caution. As to max dosage no one really knows. Potential for additive CNS stimulation. Effect of interaction is not clear, use caution. Monitor Closely (1)modafinil will increase the level or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Adderall, methylphenidate, Ritalin, Concerta, modafinil, dextroamphetamine, armodafinil, Provigil, Nuvigil, Sunosi. ozanimod increases toxicity of modafinil by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Coadministration of flibanserin with strong CYP2C19 inhibitors may increase flibanserin exposure and increase the risk of hypotension, syncope, and CNS depression. Modafinil vs Adderall: What's the difference? Use Caution/Monitor. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. loxapine increases and modafinil decreases sedation. You may report side effects to Health Canada at 1-866-234-2345. Use Caution/Monitor. Use caution when administering MAOIs and modafinil. cyproheptadine increases and modafinil decreases sedation. Cost, availability, and insurance. oxycodone increases and modafinil decreases sedation. anastrozole will increase the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor for hypertension with concomitant use. Minor/Significance Unknown. Risk of acute hypertensive episode. Effect of interaction is not clear, use caution. perphenazine increases and modafinil decreases sedation. Monitor Closely (1)motherwort increases and modafinil decreases sedation. Dosage Adults, including Geriatric Adults the recommended dose is 200 mg PO once daily as a dose! 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