Decrease suvorexant starting dose to 5 mg HS if coadministered with moderate CYP3A4 inhibitors. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. Use Caution/Monitor. Monitor Closely (1)metronidazole will increase the level or effect of hydroxyprogesterone caproate (DSC) by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. metronidazole will increase the level or effect of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Below, check out the tour dates, as well as a weird tour . Important to complete administration of initial preoperative dose about 1 hour before surgery to achieve adequate drug levels in serum and tissue at time of initial incision, Important to administer this drug, if needed, at 6-hour intervals to maintain effective drug levels. metronidazole will increase the level or effect of lopinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Since anaerobic organisms are suspected in the etiology of PID, the addition of this drug should be considered; also effectively treats bacterial vaginosis, which is often associated with PID. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. ), ciprofloxacin (may be compatible with RTU solution), dopamine, meropenem, Y-site: Amphotericin B cholesteryl sulfate, aztreonam, filgrastim, meropenem, warfarin, Reconstitute powder with 4.4 mL sterile water for injection, bacteriostatic water for injection, NS, or bacteriostatic NS to a final concentration of 100 mg/mL (pH 0.5-2), Further dilute in glass or plastic container to no more than 8 mg/mL with NS, D5W, or LR, Neutralize with approximately 5 mEq NaHCO3 per 500 mg metronidazole; final pH 6-7, No dilution or buffering necessary for ready-to-use IV solution, Avoid contact between drug and aluminum in infusion set (less critical for RTU infusion solution containing metronidazole rather than metronidazole HCl). Modify Therapy/Monitor Closely. Use Caution/Monitor. metronidazole will increase the level or effect of ethanol by affecting hepatic enzyme CYP2E1 metabolism. metronidazole will increase the level or effect of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid repeating rimegepant dose within 48 hr if coadministered with a moderate CYP3A4 inhibitor. metronidazole will increase the level or effect of pexidartinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor patients already on buprenorphine subdermal implant who require newly-initiated treatment with CYP3A4 inhibitors for signs and symptoms of overmedication. The manufacturer product information should be consulted. 14 It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Do not substitute tablets with capsules. Serious - Use Alternative (1)metronidazole will increase the level or effect of everolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The above information is provided for general US residents can call their local poison control center at 1-800-222-1222. Monitor Closely (1)metronidazole will increase the level or effect of sonidegib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)metronidazole will increase the level or effect of buprenorphine, long-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)metronidazole will increase the level or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If you miss a dose of this medicine, take it as soon as possible. Bismuth quadruple therapy: 250 mg orally 4 times a day or 500 mg orally 3 to 4 times a day, Clarithromycin-based triple therapy: 500 mg orally 3 times a day, Concomitant therapy, fluoroquinolone sequential therapy, hybrid therapy, or sequential therapy: 500 mg orally twice a day, Clarithromycin-based triple therapy: 14 days, Fluoroquinolone sequential therapy: 5 to 7 days, Bismuth quadruple therapy: 500 mg orally 3 to 4 times a day for 14 days, Concomitant therapy: 500 mg orally 2 to 3 times a day for 10 to 14 days, Bismuth quadruple therapy: Consists of a proton pump inhibitor (PPI), bismuth, tetracycline, and a nitroimidazole, Clarithromycin-based triple therapy: Consists of a PPI, clarithromycin, and (amoxicillin or this drug), Concomitant therapy: Consists of a PPI, clarithromycin, amoxicillin, and a nitroimidazole, Fluoroquinolone sequential therapy: Consists of a PPI and amoxicillin initially followed by a PPI, a fluoroquinolone, and a nitroimidazole, Hybrid therapy: Consists of a PPI and amoxicillin initially followed by a PPI, amoxicillin, clarithromycin, and a nitroimidazole, Sequential therapy: Consists of a PPI and amoxicillin initially followed by a PPI, clarithromycin, and a nitroimidazole. pharmacodynamic antagonism. What Are Side Effects of Flagyl Common side effects of Flagyl, Flagyl ER, and Flagyl Injection include: nausea, abdominal cramps, Minor (1)metronidazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Each applicatorful of Vandazole contains 37.5 mg of metronidazole. Use Caution/Monitor. Applies only to oral forms of hormone. Avoid or Use Alternate Drug. Adjust finererone dosage as needed. Administer a quarter of brexpiprazole dose if coadministered with a moderate CYP3A4 inhibitor PLUS a strong/moderate CYP2D6 inhibitor. May switch from IV to oral therapy when conditions warrant, based on severity of disease and patient response to IV therapy. Use Caution/Monitor. Minor/Significance Unknown. Serious - Use Alternative (1)metronidazole will increase the level or effect of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of erythromycin ethylsuccinate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Giardiasis STD Prophylaxis Nongonococcal Urethritis Balantidium coli Dientamoeba fragilis Usual Pediatric Dose for: Bacterial Infection Amebiasis Pseudomembranous Colitis Intraabdominal Infection Trichomoniasis Nongonococcal Urethritis Bacterial Vaginosis Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral forms of hormone. Infections of the bone and joint may require longer treatment. Minor (1)metronidazole will decrease the level or effect of balsalazide by altering intestinal flora. Minor (1)metronidazole will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. IV: Do not use equipment containing aluminum (e.g., needles, cannulae) that would come in contact with drug solution (precipitates may form). metronidazole decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Remove the applicator from your vagina. Medically reviewed by Drugs.com. Use Caution/Monitor. metronidazole, propylene glycol. metronidazole will increase the level or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of ziprasidone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. The tour begins on Aug. 3 in Sterling Heights, Mi. Use Caution/Monitor. If the metronidazole increases levels of eliglustat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of montelukast by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Use the medicine 1 or 2 times a day for 10 or 20 days. Avoid or Use Alternate Drug. Contraindicated. Comments: US CDC Recommendations: 500 to 750 mg orally 3 times a day for 10 days metronidazole will increase the level or effect of finasteride by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider reducing the cannabidiol dose when coadministered with a moderate CYP3A4 inhibitor. metronidazole will increase the level or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Talk to your doctor if you are using marijuana (cannabis).Metronidazole may cause live bacterial vaccines (such as typhoid vaccine) to not work well. omaveloxolone. Monitor Closely (1)metronidazole will increase the level or effect of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. commonly, these are "non-preferred" brand drugs. metronidazole will increase the level or effect of sparsentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (8) Applies only to oral forms of hormone. metronidazole will decrease the level or effect of estropipate by altering intestinal flora. Use Caution/Monitor. If coadministration with moderate CYP3A inhibitors cannot be avoided, reduce olaparib dose to 200 mg (capsule) or 150 mg (tablet) PO BID. Minor/Significance Unknown. Minor/Significance Unknown. Dyspareunia, proctitis, fleeting joint pains that may resemble serum sickness, Crohns disease, hiccup, psychosis, Hematopoietic: Reversible neutropenia (leukopenia); thrombocytopenia, eosinophilia, Hepatobiliary disorders: Hepatotoxicity and liver failure especially in patients with Cockayne syndrome, jaundice, Skin and subcutaneous disorders: Eosinophilia and systemic symptoms (DRESS), erythematous rash, bullae, pruritus, swelling face, urticaria, and hyperhidrosis, Central nervous system: Dizziness, vertigo, incoordination, ataxia, confusion, psychosis, dysarthria, irritability, depression, weakness, headache, and insomnia, Severe irreversible hepatotoxicity/acute liver failure (patients with Cockayne syndrome), Animal data have shown possible carcinogenic effect, Hypersensitivity to metronidazole or other antimicrobials#nitroimidazoles (although cautious desensitization has been applied), Pregnancy, 1st trimester in patients with trichomoniasis, Use of disulfiram within past 2 weeks; use of alcohol during therapy or within 3 days of discontinuing therapy, Consumption of alcohol or products containing propylene glycol within least three days of receiving metronidazole, Severe irreversible hepatotoxicity/acute liver failure with fatal outcomes reported after initiation of metronidazole, another nitroimidazole drug, structurally related to benznidazole in patients with Cockayne syndrome, Seizures and aseptic meningitis reported with increase in dose and chronic therapy, Cases of encephalopathy and peripheral neuropathy (including optic neuropathy) reported with metronidazole, Encephalopathy reported in association with cerebellar toxicity characterized by ataxia, dizziness, and dysarthria; CNS lesions seen on MRI described in reports of encephalopathy; CNS symptoms are generally reversible within days to weeks upon discontinuation of therapy; lesions seen on MRI have also been described as reversible, Peripheral neuropathy, mainly of sensory type reported and characterized by numbness or paresthesia of an extremity, Prescribing metronidazole tablets in absence of a proven or strongly suspected bacterial or parasitic infection or a prophylactic indication is unlikely to provide benefit to patient and increases risk of development of drug-resistant bacteria and parasites, Superinfection may occur with prolonged use, Severe hepatic impairment; administer lower doses with caution, Use with caution; potential accumulation in end stage renal disease; supplemental doses may be needed in patients receiving hemodialysis, Use with caution in history of heart failure, hepatic failure, H. pylori infection, renal impairment, Use with care in patients with evidence of or history of blood dyscrasia; agranulocytosis, leukopenia and neutropenia have been associated with metronidazole administration; monitor complete blood count; monitor complete blood count (CBC) for leukopenia before, during, and after prolonged repeated therapy, Avoid alcohol while taking medication and for at least three days after discontinuation, Known or previously unrecognized candidiasis may present more prominent symptoms during therapy and requires treatment with a candicidal agent, Metronidazole injection, USP contains 790 mg of sodium per 100 mL; use care when administering injection to patients receiving a controlled sodium diet or corticosteroids or to patients predisposed to edema, Severe neurological disturbances, including encephalopathy, cerebellar symptoms, convulsive seizures, and aseptic meningitis, reported in patients treated with metronidazole; advise patients to report neurologic symptoms that occur during metronidazole administration; discontinue metronidazole treatment if any abnormal neurologic symptoms occur such as ataxia, dizziness, confusion or any other CNS adverse reaction, Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome reported with products containing metronidazole for systemic use; in this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment available; obtain liver function tests prior to start of therapy, within first 2-3 days after initiation of therapy, frequently during therapy and after end of treatment; discontinue metronidazole if elevation of liver function occurs, and monitor liver function tests until baseline values are reached; advise patients with Cockayne syndrome to stop taking metronidazole immediately if they experience any symptoms of potential liver injury, such as abdominal pain, nausea, change in stool color or jaundice, and to contact their healthcare provider, When metronidazole tablets are prescribed to treat a bacterial infection, patients should be told that the medication should be taken exactly as directed; skipping doses or not completing full course of therapy may decrease effectiveness of immediate treatment and increase likelihood that bacteria will develop resistance and will not be treatable by metronidazole tablets in the future, There are no adequate and well-controlled studies of in pregnant women; there are published data from case-control studies, cohort studies, and 2 meta-analyses that include more than 5000 pregnant women who used metronidazole during pregnancy; many studies included first trimester exposures; one study showed increased risk of cleft lip, with or without cleft palate, in infants exposed to metronidazole in utero; however, these findings were not confirmed, Metronidazole crosses placental barrier and its effects on human fetal organogenesis are not known; reproduction studies have been performed in rats, rabbits and mice at doses similar to maximum recommended daily dose based on body surface area comparisons; there was no evidence of harm to fetus due to metronidazole; healthcare provider should carefully consider potential risks and benefits for each specific patient before prescribing therapy, Metronidazole is present in human milk at concentrations similar to maternal serum levels, and infant serum levels can be close to or comparable to infant therapeutic levels, Because of potential for tumorigenicity shown for metronidazole in mouse and rat studies, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account importance of drug to mother; alternatively, a nursing mother may choose to pump and discard human milk for duration of metronidazole therapy, and for 24 hours after therapy ends and feed her infant stored human milk or formula, There are published data from case-control studies, cohort studies, and 2 meta-analyses that included more than 5000 pregnant women who used metronidazole systemically during pregnancy, Many studies included first trimester exposures, One study showed an increased risk of cleft lip, with or without cleft palate, in infants exposed to metronidazole in utero; however, these findings were not confirmed, In addition, more than 10 randomized, placebo-controlled clinical trials that together enrolled over 5000 pregnant women assessed the possible effect of systemic antibiotic treatment (including with metronidazole) for bacterial vaginosis on the incidence of preterm delivery; most studies did not show an increased risk of congenital anomalies or other adverse fetal outcomes following metronidazole exposure during pregnancy, Three studies conducted to assess the risk of infant cancer following systemic metronidazole exposure during pregnancy did not show an increased risk; however, the ability of these studies to detect such a signal was limited. Most ChildrenUse and dose must be determined by your doctor. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Applies only to oral form of both agents. Ask your healthcare professional how you should dispose of any medicine you do not use. Use Caution/Monitor. Monitor Closely (1)metronidazole will increase the level or effect of methylprednisolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid taking selinexor with other medications that may cause dizziness or confusion. If coadministration of CYP3A4 inhibitors with fentanyl is necessary, monitor patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments until stable drug effects are achieved. ChildrenUse and dose must be determined by your doctor. Injection: 500 mg/100 milliliter (mL) Cream: 0.75% (7.5 mg metronidazole per 1 gram (g) of cream) Gel: 0.75%, 1% Lotion: 0.75% Metronidazole dosage for adults Source: Epocrates, Clinical Pharmacology, and DailyMed Save big on your prescriptions. To view formulary information first create a list of plans. Increases lomitapide levels several folds. Place the vaginal tablet into the applicator. Use Caution/Monitor. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Minor/Significance Unknown. Do not substitute tablets with capsules. metronidazole will increase the level or effect of simvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown. The recipient will receive more details and instructions to access this offer. Avoid or Use Alternate Drug. Closely monitor for respiratory depression and sedation and titrate subsequent doses accordingly. metronidazole will increase the level or effect of ramelteon by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely. Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. Monitor more closely for signs of venetoclax toxicities. metronidazole increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of tolvaptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration with moderate CYP3A4 inhibitors may increase ivosidenib plasma concentrations, thus increasing the risk of QTc prolongation. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Serious - Use Alternative (1)metronidazole will increase the level or effect of silodosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. metronidazole will increase the level or effect of saxagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Enhanced risk of peripheral neuropathy. Antibiotics may decrease hormonal contraceptive efficacy. Inititiation of moderate CYP3A4 inhibitors may require decreased mavacamten dose. Monitor Closely (1)metronidazole will increase the level or effect of almotriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration of tazemetostat with moderate CYP3A4 inhibitors. Moderate CYP3A4 inhibitors are not recommended with eliglustat poor or intermediate metabolizers; reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive metabolizers . Also, it is best to take the doses at evenly spaced times during the day. Use Caution/Monitor. Avoid or Use Alternate Drug. Wait until Abx Tx complete to administer live bacterial vaccine. Modify Therapy/Monitor Closely. metronidazole will increase the level or effect of nelfinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. For vaginal tablet dosage form: . metronidazole will increase the level or effect of zolpidem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Monitor serum potassium during initiation and dosage adjustment of either finererone or moderate CYP3A4 inhibitors. Minor/Significance Unknown. Reduce zanubrutinib (a CYP3A4 substrate) to 80 mg PO BID to when coadministered with a moderate CYP3A4 inhibitor. metronidazole will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of ritonavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)metronidazole will increase the level or effect of deflazacort by affecting hepatic/intestinal enzyme CYP3A4 metabolism. This information does not assure that this product is safe, effective, or appropriate for you. metronidazole will increase the level or effect of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Low risk of contraceptive failure. Do not double doses. Minor/Significance Unknown. metronidazole will decrease the level or effect of mestranol by altering intestinal flora. Monitor Closely (1)metronidazole will increase the level or effect of loratadine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The most common side effect of metronidazole is diarrhea, even though it can be prescribed to treat diarrhea. Use Caution/Monitor. metronidazole will increase the level or effect of cabozantinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Patients with Cockayne syndrome: Stop this drug at once and contact healthcare provider if any symptoms of potential liver injury (e.g., abdominal pain, nausea, change in stool color, jaundice) occur. Minor/Significance Unknown. What is metronidazole (Flagyl) used for? Comments: AAP Recommendations: Monitor Closely (1)metronidazole will increase the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of methadone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)metronidazole will increase the level or effect of fosaprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Advertising revenue supports our not-for-profit mission. Coadministration with strong or moderate CYP3A4 inhibitors is contraindicated. IV: A single prophylactic dose is usually sufficient; if prophylaxis is continued postoperatively, duration should be less than 24 hours. Use Caution/Monitor. metronidazole will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, certain blood disorders (low blood cell counts), a certain rare genetic disorder (Cockayne syndrome).Avoid alcoholic beverages and products containing propylene glycol while taking this medication and for at least 3 days after finishing this medicine because severe stomach upset/cramps, nausea, vomiting, headache, and flushing may occur.This drug may make you dizzy. Minor/Significance Unknown. Avoid or Use Alternate Drug. Minor (1)metronidazole will increase the level or effect of cevimeline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Oral: In most patients, mechanical bowl preparation combined with this oral drug plus oral neomycin should be administered in addition to IV prophylaxis; oral regimen should be administered as 3 doses over about 10 hours, beginning after the mechanical bowl preparation, the afternoon and evening before the procedure. metronidazole will increase the level or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Use Caution/Monitor. Do not double doses. Use Caution/Monitor. If you stop using this medicine too soon, your symptoms may return. US CDC Recommendations for Adolescents: 500 mg orally twice a day for 14 days Use Caution/Monitor. Modify Therapy/Monitor Closely. metronidazole will increase the level or effect of ivabradine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. SIDE EFFECTS: Dizziness, headache, stomach upset, nausea, vomiting, loss of appetite, diarrhea, constipation, or metallic taste in your mouth may occur. Minor/Significance Unknown. metronidazole will increase the level or effect of voclosporin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Recommended to complete at least 14 days of therapy with doxycycline when tubo-ovarian abscess is present, metronidazole with doxycycline is recommended for continued therapy; provides more effective anaerobic coverage than doxycycline alone, Neonates less than 1.2 kg: 7.5 mg/kg IV as a single dose, Neonates at least 1.2 kg and pediatric patients 1 month or older: 15 mg/kg IV as a single dose. 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