Contact the applicable plan Monitor Closely (1)quinacrine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).This product may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Long term (>1 wk) NSAID use. Risk of fetal compromise if given during pregnancy. metoprolol increases and metolazone decreases serum potassium. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. Additive bradycardia. Monitor Closely (1)esmolol and metoprolol both increase serum potassium. Avoid coadministration of abiraterone with substrates of CYP2D6. Avoid coadministration of fexinidazole with drugs known to induce bradycardia. Most patients receiving ivabradine will also be treated with a beta-blocker. carvedilol and metoprolol both increase anti-hypertensive channel blocking. Long term (>1 wk) NSAID use. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Metoprolol is used to treat angina (chest pain) and hypertension ( high blood pressure ). Use Caution/Monitor. avanafil increases effects of metoprolol by pharmacodynamic synergism. metoprolol and aceclofenac both increase serum potassium. Either increases effects of the other by pharmacodynamic synergism. Atenolol, sotalol, nadolol less likely to be affected than other beta blockers. Modify Therapy/Monitor Closely. Panobinostat can increase the levels and effects of sensitive CYP2D6 substrates or those with a narrow therapeutic index CYP2D6. maraviroc will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. terbinafine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Minor (1)shepherd's purse, metoprolol. Use Caution/Monitor. sevoflurane, metoprolol. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Modify Therapy/Monitor Closely. Available http://www.globalrph.com/beta_blockers.htm Monitor Closely (2)diflunisal decreases effects of metoprolol by pharmacodynamic antagonism. Long term (>1 wk) NSAID use. Monitor Closely (2)piroxicam decreases effects of metoprolol by pharmacodynamic antagonism. rolapitant will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Use Caution/Monitor.metoprolol decreases effects of ephedrine by pharmacodynamic antagonism. Minor (1)patiromer, metoprolol. Monitor Closely (1)xipamide increases effects of metoprolol by pharmacodynamic synergism. Comment: Beta blockers (esp. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)aldesleukin increases effects of metoprolol by pharmacodynamic synergism. Other (see comment). USES: This medication is a beta-blocker used to treat chest pain (angina), heart failure, and high blood pressure. Long term (>1 wk) NSAID use. Use Caution/Monitor. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. atenolol and metoprolol both increase anti-hypertensive channel blocking. [ 70] recently reported on switching between blockers (metoprolol and carvedilol) in 68 patients treated with either agent for 1 year who had improved in terms of LVEF and. Graphics Showing results for labetalol Search instead: Beta blockers Drugs used for the treatment of hypertensive emergencies that labetalol has less antihypertensive efficacy as compared with nicardipine . Not all beta blockers share this interaction (e.g., atenolol, nadolol, sotalol do not interact). Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. Increased triglyceride levels and insulin resistance, decreased high-density lipoprotein (HDL) levels, Use with caution in cerebrovascular insufficiency, CHF, cardiomegaly, myasthenia gravis, hyperthyroidism or thyrotoxicosis (may mask signs or symptoms), liver disease, renal impairment, peripheral vascular disease, psoriasis (may cause exacerbation of psoriasis), May exacerbate bronchospastic disease; monitor closely, Beta-blockers can cause myocardial depression and may precipitate heart failure and cardiogenic shock, Sudden discontinuance can exacerbate angina and lead to MI and ventricular arrhythmias in patients with CAD, Worsening cardiac failure may occur during up-titration of metoprolol succinate; if such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol succinate; it may be necessary to lower the dose of metoprolol succinate or temporarily discontinue it, Bradycardia, including sinus pause, heart block, and cardiac arrest, has been reported; patients with 1 atrioventricular block, sinus node dysfunction, or conduction disorders may be at increased risk; monitor heart rate in patients receiving metoprolol succinate; if severe bradycardia develops, reduce or stop metoprolol succinate, Beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia, and increase risk for severe or prolonged hypoglycemia at any time during treatment, especially in patients with diabetes mellitus or children and patients who are fasting (ie, surgery, not eating regularly, or are vomiting); if severe hypoglycemia occurs, patients should be instructed to seek emergency treatment, Avoid starting high-dose regimen of extended-release metoprolol in patients undergoing noncardiac surgery; use in patients with cardiovascular risk factors is associated with bradycardia, hypotension, stroke, and death, Long-term beta blockers should not be routinely withdrawn before major surgery; however, impaired ability of the heart to respond to reflex adrenergic stimuli may augment risks of general anesthesia and surgical procedures, Metoprolol loses beta-receptor selectivity at high doses and in poor metabolizers, If drug is administered for tachycardia secondary to pheochromocytoma, it should be given in combination with an alpha blocker (which should be started before metoprolol is started), While taking beta blockers, patients with history of severe anaphylactic reaction to variety of allergens may be more reactive to repeated challenge, Extended release tablet should not be withdrawn routinely prior to major surgery, Hydrochlorothiazide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma, which can lead to permanent vision loss if not treated; discontinue hydrochlorothiazide as rapidly as possible if symptoms occur; prompt medical or surgical treatments may need to be considered if intraocular pressure remains uncontrolled; risk factors for developing acute angle-closure glaucoma may include history of sulfonamide or penicillin allergy, Caution in patients with history of psychiatric illness; may cause or exacerbate CNS depression, Beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease, Untreated hypertension and heart failure during pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications (eg, need for cesarean section, and post-partum hemorrhage), Hypertension increases fetal risk for intrauterine growth restriction and intrauterine death; pregnant women with hypertension should be carefully monitored and managed accordingly, Stroke volume and heart rate increase during pregnancy, increasing cardiac output, especially during first trimester; there is a risk for preterm birth with pregnant women with chronic heart failure in 3rd trimester of pregnancy, Available data from published observational studies have not demonstrated a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes with metoprolol use during pregnancy, However, there are inconsistent reports of intrauterine growth restriction, preterm birth, and perinatal mortality with maternal use of beta blockers, including metoprolol, during pregnancy, Metoprolol crosses placenta; neonates born to mothers who are receiving metoprolol during pregnancy, may be at risk for hypotension, hypoglycemia, bradycardia, and respiratory depression; observe neonates and manage accordingly, Limited available data from published literature report that metoprolol is present in human milk; the estimated daily infant dose of metoprolol received from breastmilk ranges from 0.05 mg to less than 1 mg; the estimated relative infant dosage was 0.5% to 2% of the mother's weight-adjusted dosage; no adverse reactions of metoprolol on the breastfed infant have been identified; there is no information regarding the effects of metoprolol on milk production, Monitor breastfed infant for bradycardia and other symptoms of beta-blockade such as listlessness (hypoglycemia). Beta-blocker treatment can be initiated in patients receiving stable doses of siponimod. Monitor Closely (1)moxisylyte and metoprolol both increase anti-hypertensive channel blocking. Use Caution/Monitor. Effect of interaction is not clear, use caution. Both medications decrease heart rate. Long term (>1 wk) NSAID use. Long term (>1 wk) NSAID use. Use Caution/Monitor. metoprolol increases and metaproterenol decreases serum potassium. Retain in carton until time of use. Modify Therapy/Monitor Closely. Enzyme induction effect may continue for up to 3-4 weeks. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Not all beta blockers share this interaction (e.g., atenolol, nadolol, sotalol do not interact). Use Caution/Monitor. metoprolol and timolol both increase serum potassium. ED is often a symptom of another health problem or health-related factor. calcium citrate decreases effects of metoprolol by unspecified interaction mechanism. Long term (>1 wk) NSAID use. Use Caution/Monitor. Otherwise, call a poison control center right away. Methadone Conversion is highly variable and dependant on many factors. chloroquine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. NSAIDs decrease prostaglandin synthesis. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (2)aspirin/citric acid/sodium bicarbonate decreases effects of metoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect. aldesleukin increases effects of metoprolol by pharmacodynamic synergism. NSAIDs decrease prostaglandin synthesis. Monitor patients on concomitant therapy, particularly in the first 6 hours after fingolimod is initiated or after a treatment interruption of at least two weeks, for bradycardia and atrioventricular block. Temporary interruption of beta-blocker may be needed before initiating siponimod. metoprolol and nabumetone both increase serum potassium. Monitor Closely (1)metoprolol and penbutolol both increase serum potassium. Both oral and intravenous preparations are available. Use Caution/Monitor. Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. metoprolol and ketorolac intranasal both increase serum potassium. Applies only to oral form of both agents. Consider resting HR before initiating ponesimod in patients on stable dose of beta-blocker. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Risk of hypotension. Use Caution/Monitor.indomethacin decreases effects of metoprolol by pharmacodynamic antagonism. Monitor Closely (1)primidone decreases levels of metoprolol by increasing metabolism. Use Caution/Monitor. Long term (>1 wk) NSAID use. secobarbital decreases levels of metoprolol by increasing metabolism. metoprolol increases and ephedrine decreases serum potassium. Use Caution/Monitor.Serious - Use Alternative (1)metoprolol, thioridazine. Monitor Closely (1)metoprolol increases and bendroflumethiazide decreases serum potassium. lofexidine, metoprolol. Medically reviewed by Drugs.com on Feb 15, 2023. To help prevent low blood sugar, make sure children eat regularly. metoprolol and parecoxib both increase serum potassium. Use Caution/Monitor. This drug is available at a higher level co-pay. Monitor Closely (1)bismuth subsalicylate, metoprolol. NSAIDs decrease prostaglandin synthesis. NSAIDs decrease prostaglandin synthesis. Beta-blockers may have additive effects on lowering HR. Use Caution/Monitor. Can increase risk of bradycardia. Take this medication by mouth as directed by your doctor, usually once daily. Erectile dysfunction (ED) is often a symptom . Effect of interaction is not clear, use caution. doxazosin and metoprolol both increase anti-hypertensive channel blocking. Use Caution/Monitor. primidone decreases levels of metoprolol by increasing metabolism. Use Caution/Monitor.choline magnesium trisalicylate decreases effects of metoprolol by pharmacodynamic antagonism. The infusion times were formulated to mimic the onset of an oral formulation. metoprolol, mavacamten. Monitor Closely (1)bisoprolol and metoprolol both increase serum potassium. Not all beta blockers share this interaction (e.g., atenolol, nadolol, sotalol do not interact). Individualize the dosage of TOPROL-XL. Monitor Closely (1)butabarbital decreases levels of metoprolol by increasing metabolism. metoprolol increases and metaproterenol decreases serum potassium. Use Caution/Monitor. Serious - Use Alternative (1)givosiran will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. metoprolol and naproxen both increase serum potassium. Long term (>1 wk) NSAID use. Monitor Closely (1)panobinostat will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. No separation of dosing required. Use Caution/Monitor. Monitor Closely (1)doxazosin and metoprolol both increase anti-hypertensive channel blocking. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Minor/Significance Unknown. rifampin decreases levels of metoprolol by increasing metabolism. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)verapamil, metoprolol. If concurrent therapy required, monitor cardiac function carefully (blood pressure, heart rate). Use Caution/Monitor. Metoprolol is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins). Long term (>1 wk) NSAID use. Long term (>1 wk) NSAID use. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor.nabumetone decreases effects of metoprolol by pharmacodynamic antagonism. Avoid or Use Alternate Drug. metoprolol and aspirin rectal both increase serum potassium. eliglustat increases levels of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. metoprolol and amiloride both increase serum potassium. shepherd's purse, metoprolol. Both increase serum potassium take this medication is a beta-blocker used to treat angina ( chest )... 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