Either increases levels of the other by Other (see comment). It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb. metformin, insulin inhaled. Minor/Significance Unknown. Minor (1)agrimony increases effects of metformin by pharmacodynamic synergism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)omacetaxine decreases effects of metformin by pharmacodynamic antagonism. Either increases toxicity of the other by pharmacodynamic synergism. Patient should be closely observed for loss of blood glucose control; when drugs are withdrawn from a patient receiving metformin, patient should be observed closely for hypoglycemia. Minor (1)prednisolone decreases effects of metformin by pharmacodynamic antagonism. Monitor Closely (1)metformin, insulin lispro. Diminished symptoms of hypoglycemia. indinavir decreases effects of metformin by Other (see comment). This includes prescription and over-the-counter medicines, vitamins, and herbal products. Minor/Significance Unknown. It may take several years of metformin therapy to develop vitamin B12 deficiency. Use Caution/Monitor. Otherwise, call a poison control center right away. Use Caution/Monitor. pegvisomant increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown. amoxapine increases effects of metformin by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Brand names: Fortamet, Glucophage, Glucophage XR, Glumetza. Minor/Significance Unknown. Increased risk of lactic acidosis. Use Caution/Monitor. Minor/Significance Unknown. Minor (1)amoxapine increases effects of metformin by pharmacodynamic synergism. fleroxacin increases effects of metformin by pharmacodynamic synergism. Use Caution/Monitor. cimetidine will increase the level or effect of metformin by basic (cationic) drug competition for renal tubular clearance. Theoretical interaction. metformin will increase the level or effect of triamterene by basic (cationic) drug competition for renal tubular clearance. (See also Side Effects section.) Patient should be closely observed for loss of blood glucose control; when drugs are withdrawn from a patient receiving metformin, patient should be observed closely for hypoglycemia. cyclopenthiazide decreases effects of metformin by pharmacodynamic antagonism. Minor/Significance Unknown. methyltestosterone increases effects of metformin by pharmacodynamic synergism. Minor (1)bendroflumethiazide decreases effects of metformin by pharmacodynamic antagonism. clomipramine increases effects of metformin by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Last updated on Apr 5, 2023. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. If it is near the time of the next dose, skip the missed dose. Use Caution/Monitor. Monitor for signs of onset of lactic acidosis such as respiratory distress, somnolence, and non-specific abdominal distress or worsening renal function; concomitant metformin use in patients with renal insufficiency or hepatic impairment not recommended. Minor/Significance Unknown. Patient should be closely observed for loss of blood glucose control; when drugs are withdrawn from a patient receiving metformin, patient should be observed closely for hypoglycemia. Avoid or Use Alternate Drug. Monitor Closely (1)norgestimate decreases effects of metformin by pharmacodynamic antagonism. Thiazide dosage >50 mg/day may increase blood glucose. Use Caution/Monitor. Use Caution/Monitor. Most Minor/Significance Unknown. metformin will increase the level or effect of procainamide by basic (cationic) drug competition for renal tubular clearance. Other (see comment). Use Caution/Monitor. Use Caution/Monitor. dienogest/estradiol valerate decreases effects of metformin by pharmacodynamic antagonism. Monitor Closely (1)nicardipine decreases effects of metformin by pharmacodynamic antagonism. Share cases and questions with Physicians on Medscape consult. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. chlorothiazide decreases effects of metformin by pharmacodynamic antagonism. Minor (1)horse chestnut seed increases effects of metformin by pharmacodynamic synergism. May require a dose reduction. Use Caution/Monitor. You should not breastfeed while using this medicine. Minor/Significance Unknown. However, be sure to take the dosage your doctor prescribes for you. Metformin is only part of a complete treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Thiazide dosage >50 mg/day may increase blood glucose. Corticosteroids may diminish hypoglycemic effect of antidiabetic agents. Administration of intravascular iodinated contrast agents in metformin-treated patients has led to rare cases of acute decrease in renal function and the occurrence of lactic acidosis. Minor/Significance Unknown. But metformin toxicity or overdosage that causes lactic acidosis has been associated with hypoglycemia. Concurrent use may increase risk of hypoglycemia; monitor glucose levels. trazodone increases effects of metformin by pharmacodynamic synergism. Monitor Closely (1)metformin, insulin detemir. Monitor Closely (1)metformin increases levels of erdafitinib by decreasing renal clearance. The American College of Radiology Guidelines (2018) recommend temporarily stopping metformin in patients with eGFR is <30 mL/min/1.73 m2 or who are undergoing arterial catheter studies that might result in emboli to the renal arteries. Do not take two doses at one time. Minor (2)hydrochlorothiazide will increase the level or effect of metformin by basic (cationic) drug competition for renal tubular clearance. Patient should be closely observed for loss of blood glucose control; when drugs are withdrawn from a patient receiving metformin, patient should be observed closely for hypoglycemia. sertraline increases effects of metformin by pharmacodynamic synergism. Consider alternatives that are not OCT2 substrates or consider reducing the dose of OCT2 substrates based on tolerability. The mild side effects of Actos that are less common** can include: muscle pain. nifedipine decreases effects of metformin by pharmacodynamic antagonism. Revatio: This drug is used to treat PAH. Increases risk for hypoglycemia and lactic acidosis. dabrafenib decreases effects of metformin by pharmacodynamic antagonism. Monitor Closely (1)saquinavir decreases effects of metformin by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Coadministration with OCT2 and MATE1 substrates may increase their plasma concentrations. ciprofloxacin increases effects of metformin by pharmacodynamic synergism. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. (Theoretical interaction). ethinylestradiol decreases effects of metformin by pharmacodynamic antagonism. ofloxacin increases effects of metformin by pharmacodynamic synergism. Continue to withhold metformin for 48 hr subsequent to the procedure and reinstituted only after renal function has been reevaluated and found to be normal. diatrizoate increases toxicity of metformin by unspecified interaction mechanism. Growth hormone products may decrease insulin sensitivity, particularly at higher doses. nortriptyline increases effects of metformin by pharmacodynamic synergism. Experts believe the cause may be increased glucose consumption due to anaerobic metabolism, coupled with decreased oral intake of food and carbohydrates, decreased liver glucose production, and decreased glucose absorption. Minor/Significance Unknown. Other (see comment). Increases risk for hypoglycemia and lactic acidosis. Use Caution/Monitor. Metformin is an FDA-approved antidiabetic agent that manages high blood sugar levels in type 2 diabetes patients. Minor (1)metformin decreases levels of folic acid by unspecified interaction mechanism. hydroxyprogesterone caproate (DSC) decreases effects of metformin by pharmacodynamic antagonism. cephalexin increases toxicity of metformin by decreasing renal clearance. Monitor Closely (1)risperidone, metformin. levothyroxine decreases effects of metformin by pharmacodynamic antagonism. Use Caution/Monitor. horse chestnut seed increases effects of metformin by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Thiazide dosage >50 mg/day may increase blood glucose. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. Ask your doctor about your risk. fluoxetine increases effects of metformin by pharmacodynamic synergism. Consult your pharmacist or local waste disposal company. Monitor Closely (1)dolutegravir will increase the level or effect of metformin by decreasing renal clearance. . Minor (1)pegvisomant increases effects of metformin by pharmacodynamic synergism. particularly in patients who may have other risk factors for metformin toxicity. Monitor Closely (1)cinnamon increases effects of metformin by pharmacodynamic synergism. The following information describes commonly recommended dosages for ED. Use Caution/Monitor. Interaction especially seen in the treatment of hypokalemia. Use Caution/Monitor. Minor/Significance Unknown. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Monitor Closely (1)histrelin decreases effects of metformin by pharmacodynamic antagonism. Minor (1)metformin will increase the level or effect of quinine by basic (cationic) drug competition for renal tubular clearance. Patient should be closely observed for loss of blood glucose control; when drugs are withdrawn from a patient receiving metformin, patient should be observed closely for hypoglycemia. The American College of Radiology Guidelines (2018) recommend temporarily stopping metformin in patients with eGFR is <30 mL/min/1.73 m2 or who are undergoing arterial catheter studies that might result in emboli to the renal arteries. Use Caution/Monitor. Use Caution/Monitor. octreotide decreases effects of metformin by pharmacodynamic antagonism. Interaction especially seen in the treatment of hypokalemia. Use Caution/Monitor. Monitor Closely (1)diatrizoate increases toxicity of metformin by unspecified interaction mechanism. Monitor Closely (1)glycopyrrolate increases toxicity of metformin by unspecified interaction mechanism. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. potassium chloride increases effects of metformin by pharmacodynamic synergism. nelfinavir decreases effects of metformin by Other (see comment). Use Caution/Monitor. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Quinolone antibiotic administration may result in hyper- or hypoglycemia. The American College of Radiology Guidelines (2018) recommend temporarily stopping metformin in patients with eGFR is <30 mL/min/1.73 m2 or who are undergoing arterial catheter studies that might result in emboli to the renal arteries. Monitor Closely (1)norelgestromin decreases effects of metformin by pharmacodynamic antagonism. Use Caution/Monitor. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)cephalexin increases toxicity of metformin by decreasing renal clearance. Minor/Significance Unknown. Monitor Closely (1)exenatide injectable solution, metformin. Patient should be closely observed for loss of blood glucose control; when drugs are withdrawn from a patient receiving metformin, patient should be observed closely for hypoglycemia. Use Caution/Monitor. perphenazine decreases effects of metformin by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Either increases levels of the other by Other (see comment). Monitor Closely (1)sulfamethoxypyridazine increases effects of metformin by unspecified interaction mechanism. Increases risk for hypoglycemia and lactic acidosis. enalapril increases toxicity of metformin by unspecified interaction mechanism. Use Caution/Monitor. Minor (1)imipramine increases effects of metformin by pharmacodynamic synergism. . Use Caution/Monitor. Get emergency medical help if you have even mild symptoms such as: feeling dizzy, light-headed, tired, or very weak; Common metformin side effects may include: This is not a complete list of side effects and others may occur. Monitor Closely (1)progesterone intravaginal gel decreases effects of metformin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Use Caution/Monitor. . Minor/Significance Unknown. Metformin Information. Acute renal failure or lactic acidosis may result. progesterone, natural decreases effects of metformin by pharmacodynamic antagonism. Other (see comment). Use Caution/Monitor. Metformin pregnancy and breastfeeding warnings. Minor/Significance Unknown. Follow your doctor's instructions about using metformin if you are pregnant or you become pregnant. 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