Labetalol works by causing the heart to beat slower and with . Also, the patient should not be allowed to move to an erect position unmonitored until their ability to do so safely is established. High blood pressure adds to the work load of the heart and arteries. Yeleswaram K, Rurak DW, Kwan E, Hall C, Doroudian A, Abbott FS, Axelson JE: Disposition, metabolism, and pharmacodynamics of labetalol in adult sheep. Copyright: Merative US L.P. 1973, 2023. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Labetalol injection is used to treat severe high blood pressure (hypertension). Explain the mechanism of action of labetalol. Labetalol may also be used for purposes not listed in this medication guide. Labetalol may also be used for purposes not listed in this medication guide. Copyright 2023 by RxList Inc. An Internet Brands company. Lab and/or medical tests (such as liver function) should be done while you are taking this medication. You may feel light-headed when you first stand up. This medicine is available only with your doctor's prescription . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Class. There's more to see -- the rest of this topic is available only to subscribers. Examples include: sildenafil oral brand names and other generic formulations include: Revatio Oral, Viagra Oral. The risk or severity of adverse effects can be increased when Labetalol is combined with Abaloparatide. This is not a complete list of possible side effects. Nucleic Acids Res. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart . Avoid driving or hazardous activity until you know how labetalol will affect you. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. Duplication for commercial use must be authorized by ASHP. This medication passes into breast milk, and the effect on a nursing infant is unknown. Supportive care and close monitoring are the staples of treatment for an overdose of beta-blockers with the addition of glucagon for severe refractory hypotension and bradycardia. If it continues for a long time, the heart and arteries may not function properly. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Other drugs may affect labetalol, including prescription and over-the-counter medicines, vitamins, and herbal products. Check with your doctor right away if you start having itchy skin, dark urine, loss of appetite, yellow eyes or skin, flu-like symptoms, or stomach pain or tenderness. 75 serious drug interactions. Symptoms of overdose may include: very slow heartbeat, severe dizziness, severe weakness, fainting, trouble breathing. Egton Medical Information Systems Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. What special precautions should I follow? All generic drug interactions for sildenafil oral (lists will include brand and generic names): 18 contraindicated drug interactions. The Cochrane database of systematic reviews. Labetalol. If you notice any other effects, check with your healthcare professional. [, Martinez-Gomez MA, Sagrado S, Villanueva-Camanas RM, Medina-Hernandez MJ: Characterization of basic drug-human serum protein interactions by capillary electrophoresis. 1988 Sep;2(3):369-76. For details see our conditions. It works by blocking the action of certain natural chemicals in your body such as epinephrine on the heart and blood vessels. Due to the alpha1-receptor antagonistic activity of labetalol, blood pressure is lowered more in the standing than in the supine position, but this can lead to symptoms of postural hypotension. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Escitalopram (Lexapro) Fluvoxamine (Luvox) Paroxetine (Paxil) Sertraline (Zoloft) High blood pressure medications that can be cut in half Many medications that help lower blood pressure can also be cut in half. [, Hermann DJ, Krol TF, Dukes GE, Hussey EK, Danis M, Han YH, Powell JR, Hak LJ: Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine. Brand name: Trandate. If your dose is different, do not change it unless your doctor tells you to do so. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Mirtazapine is a tetracyclic piperazino-azepine antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. Clinical Drug Interactions Source: Medscape from WebMD. Copyright 2023 by RxList Inc. An Internet Brands company. All rights reserved. Older adults may be more sensitive to the side effects of this drug, including dizziness and lightheadedness. The amount of medicine that you take depends on the strength of the medicine. [6], As with all beta-blockers, labetalol has negative inotropic effects and has the potential to cause acute left ventricular failure if given in sufficiently large enough doses tothose patientswho have impaired function of the left ventricle. As a thank-you for using our site, here's a discounted rate for renewal or upgrade. These side effects can increase the risk of falling. This drug may rarely cause serious (rarely fatal) liver disease. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. Epub 2013 Apr 3. There may be an increased chance of low blood pressure. Talk with your doctor about making changes to your lifestyle that may help this medication work better (such as stress reduction programs, exercise, and dietary changes). J Hypertens Suppl. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. After 30 days, you will automatically be upgraded to a 1-year subscription at a discounted rate of $29.95, Type your tag names separated by a space and hit enter. [10], As labetalol is typically used to treat acute hypertension, whetherit presents in the emergency department or an outpatient clinic, an interprofessional team approach and effective communication areessential for quality patient care. The risk is higher if you have diabetes, or are vomiting, fasting, or not eating regularly. Take the missed dose as soon as you remember it. Treatment aims to lower blood pressure during pregnancy into the mild range (less than 160/100 mm Hg), reduce the risk of stroke and other maternal cardiovascular complications.[3][4]. Consult your doctor for more details. Keep all medicines out of the reach and sight of children. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Ask your pharmacist or doctor to teach you how to take your pulse. If you have diabetes, labetalol can block the symptoms of low blood sugar. This medicine is a white, round, film-coated, tablet imprinted with "AC 372". It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. tell your doctor if you have or have ever had heart, kidney, or liver disease; asthma or other lung diseases; severe allergies; diabetes; or pheochromocytoma (a tumor that develops on a gland near the kidneys and may cause high blood pressure and fast heartbeat). How to store Labetalol 6. Labetalol is used to treat high blood pressure. You may report side effects to the FDA at 1-800-FDA-1088. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Tell your doctor if you have a planned surgery. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Labetalol Benzyl Glucuronide Metabolite (II), Labetalol Phenolic Glucuronide Metabolite (III), Labetalol Phenolic Glucuronide Metabolite (V), Labetalol C1' Glucuronidated Metabolite (VII), Labetalol C3 Glucuronidated Metabolite (VIII), C07BG Alpha and beta blocking agents and thiazides, C07B BETA BLOCKING AGENTS AND THIAZIDES, C07CG Alpha and beta blocking agents and other diuretics, C07C BETA BLOCKING AGENTS AND OTHER DIURETICS, Alpha and Beta Blocking Agents and Thiazides, Antihypertensive Agents Indicated for Hypertension, Cytochrome P-450 CYP2D6 Inhibitors (strength unknown), Heart Failure With Preserved Ejection Fraction (HFpEF), splash10-03dl-7900000000-e18d52bcb93357c4a7e2, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QFT , negative, splash10-004i-0319000000-cd3fa186952809ae3558, splash10-03di-0519000000-0a8da4acfa8cd259fb3f, LC-MS/MS Spectrum - LC-ESI-QFT , positive, splash10-03dl-4928000000-117458013dbd49aaf54b, Alpha-1 adrenergic receptors (Protein Group), ATP-binding cassette sub-family B member 5. 2010 Feb; [PubMed PMID: 20104635], Bailey B, Glucagon in beta-blocker and calcium channel blocker overdoses: a systematic review. Ask your healthcare professional how you should dispose of any medicine you do not use. Have your blood pressure and pulse (heart rate) checked regularly while taking this medication. Labetalol is a beta-blocker that is used to treat hypertension (high blood pressure). Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Stopping suddenly may make your condition worse. RxList does not provide medical advice, diagnosis or treatment. High blood pressure adds to the workload of the heart and arteries. Some people who have suddenly stopped taking similar drugs have had chest pain, heart attack, and irregular heartbeat. Take labetalol exactly as directed. [, Pedersen ME, Cockcroft JR: The vasodilatory beta-blockers. Use this medication regularly to get the most benefit from it. Similarly, labetalol is a common anti-hypertensive given in the post-anesthesia care unit, again due to its HR sparing effects and better control of blood pressure. 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