doxepin and ketoconazole both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)ketoconazole increases levels of zidovudine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)ketoconazole will increase the level or effect of infigratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.ketoconazole and ranolazine both increase QTc interval. ketoconazole will increase the level or effect of trabectedin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Mechanism: affecting hepatic enzyme CYP4F2 metabolism Monitor for adverse events of fingolimod when concomitantly used with ketoconazole. ketoconazole increases levels of glipizide by decreasing metabolism. After discontinuation of a strong CYP3A inhibitor, resume the brigatinib dose that was tolerated prior to initiating the strong CYP3A inhibitor. Serious - Use Alternative (1)ketoconazole will increase the level or effect of cinacalcet by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Duration of therapy: 6 months (usual duration for systemic infection) ketoconazole will increase the level or effect of maraviroc by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Our phase IV clinical studies alone cannot establish cause-effect relationship. Serious - Use Alternative (1)ketoconazole increases toxicity of rosuvastatin by Other (see comment). After discontinuation of a strong CYP3A inhibitor, resume the brigatinib dose that was tolerated prior to initiating the strong CYP3A inhibitor. Reduce valbenazine dose to 40 mg once daily when coadministered with a strong CYP3A4 inhibitor. primidone decreases levels of ketoconazole by inhibition of GI absorption. Use Caution/Monitor.Serious - Use Alternative (1)ketoconazole will increase the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Avoid or Use Alternate Drug.Minor (1)methylprednisolone will decrease the level or effect of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. ketoconazole and moxifloxacin both increase QTc interval. Coadministration of CYP3A4 inhibitors may decrease the metabolism of ifosfamide to its active alkylating metabolites and decrease the efficacy of ifosfamide. Minor/Significance Unknown. Monitor Closely (1)ketoconazole will increase the level or effect of propafenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 1% Shampoo: Use topically every 3 or 4 days for up to 8 weeks and then only as needed to control dandruff. rifapentine will decrease the level or effect of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ketoconazole increases levels of ciclesonide inhaled by decreasing metabolism. ketoconazole will increase the level or effect of lapatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ketoconazole will increase the level or effect of ubrogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. ketoconazole will increase the level or effect of amikacin by P-glycoprotein (MDR1) efflux transporter. ketoconazole and ranolazine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)ketoconazole will increase the level or effect of elacestrant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)ketoconazole will increase the level or effect of felbamate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Minor/Significance Unknown. Recommended atogepant dosage is 10 mg PO qDay when coadministered with strong CYP3A4 inhibitors. ketoconazole will increase the level or effect of bedaquiline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. ketoconazole will increase the level or effect of methadone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Applies only to oral form of both agents. ketoconazole will increase the level or effect of clobazam by affecting hepatic enzyme CYP2C19 metabolism. Coadministration of doravirine and CYP3A4 inhibitors may increase plasma concentrations and toxicities of doravirine. Reduce afatinib daily dose by 10 mg if not tolerated when coadministered with P-gp inhibitors. Use Caution/Monitor.Serious - Use Alternative (1)erythromycin lactobionate and ketoconazole both increase QTc interval. ketoconazole will increase the level or effect of cevimeline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If concomitant use is necessary, may require less frequent oliceridine dosing. Avoid or Use Alternate Drug.ketoconazole will increase the level or effect of everolimus by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Increased risk for rhabdomyolysis with drugs that increase simvastatin systemic exposureketoconazole increases toxicity of simvastatin by Other (see comment). ketoconazole will increase the level or effect of fluticasone furoate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. ketoconazole will increase the level or effect of nilotinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)sodium citrate/citric acid decreases levels of ketoconazole by inhibition of GI absorption. ketoconazole will increase the level or effect of duvelisib by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)ketoconazole will increase the level or effect of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)ketoconazole will increase the level or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)ketoconazole will increase the level or effect of daunorubicin by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Serious - Use Alternative (1)ketoconazole will increase the level or effect of larotrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit ketoconazole to 200 mg/day when administered with elvitegravir/cobicistat/emtricitabine/tenofovir DF. Use Caution/Monitor.Minor (1)fosphenytoin will decrease the level or effect of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If you are taking drugs that decrease the amount of stomach acid including antacids, heartburn/ulcer drugs (H2 blockers such as cimetidine, famotidine, ranitidine), sucralfate, or if you are taking drugs that slow down gut movement (anticholinergics such as dicyclomine, propantheline), take ketoconazole at least 2 hours before any of these drugs. Avoid or Use Alternate Drug. Minor/Significance Unknown. Serious - Use Alternative (1)ketoconazole will increase the level or effect of macitentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)grapefruit decreases levels of ketoconazole by inhibition of GI absorption. Contraindicated.Monitor Closely (1)ketoconazole will increase the level or effect of sirolimus by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown. Monitor Closely (1)ketoconazole will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. ketoconazole will increase the level or effect of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadminstration of letermovir, an OATP1B1/3 substrate, with OATP1B1/3 inhibitors may increase letermovir plasma concentrations. Contraindicated. Ketoconazole can also worsen existing adrenal gland function problems (See also Precautions section). Monitor Closely (1)ketoconazole increases levels of rilpivirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. See also Drug Interactions for more information.The dosage and length of treatment is based on your medical condition, response to treatment, and other medications you may be taking. Serious - Use Alternative (1)desipramine and ketoconazole both increase QTc interval. ketoconazole will increase the level or effect of doravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Comments: 1% Shampoo: Use topically every 3 or 4 days for up to 8 weeks and then only as needed to control dandruff. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Serious - Use Alternative (2)ketoconazole will increase the level or effect of everolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)ketoconazole will increase the level or effect of cortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Serious - Use Alternative (1)ketoconazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid coadministration of cabozantinib with strong CYP3A4 inhibitors. affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Coadministration with strong CYP3A4 inhibitors may increase unconjugated DM4 (a CYP3A4 substrate and the cytotoxic component of the antibody drug conjugate for mirvetuximab soravtansine) exposure, which may increase the risk of adverse reactions. Use Caution/Monitor. Use Caution/Monitor.Minor (1)ketoconazole decreases levels of paromomycin by unknown mechanism. Minor/Significance Unknown. Modify Therapy/Monitor Closely. If use is unavoidable, consider reducing the cabazitaxel dose by 25%. Avoid or Use Alternate Drug. Minor/Significance Unknown. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Contraindicated (1)ketoconazole will increase the level or effect of ergonovine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ketoconazole will increase the level or effect of galantamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Reduce indinavir dose to 600 mg PO q8hr when administering ketoconazole concurrently.Minor (1)indinavir will increase the level or effect of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Monitor Closely (1)ketoconazole will increase the level or effect of estrogens esterified by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Serious - Use Alternative (2)ketoconazole increases levels of midazolam by decreasing metabolism. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Modify Therapy/Monitor Closely. Medscape Education, The Rise of Invasive Fungal Infections: Contemporary Approaches to Diagnosis, Treatment, and Prophylaxis, 2010ambisome-amphotericin-b-liposomal-999576Drugs, encoded search term (ketoconazole (Nizoral)) and ketoconazole (Nizoral), Death Risk With Off-Label Oral Ketoconazole Use, FDA Warns. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. ketoconazole will increase the level or effect of risperidone by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. Monitor Closely (2)ketoconazole will increase the level or effect of lapatinib by P-glycoprotein (MDR1) efflux transporter. ketoconazole will increase the level or effect of tobramycin by P-glycoprotein (MDR1) efflux transporter. Increased risk for rhabdomyolysis with drugs that increase simvastatin systemic exposure ketoconazole increases toxicity of simvastatin by Other (see comment). Avoid or Use Alternate Drug. Contraindicated (1)ketoconazole increases levels of triazolam by decreasing metabolism. ketoconazole will increase the level or effect of colchicine by Other (see comment). 2% Gel: Apply to affected area once a day for 2 weeks. Modify Therapy/Monitor Closely. grapefruit decreases levels of ketoconazole by inhibition of GI absorption. nefazodone will increase the level or effect of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Interrupt dose as recommended for adverse reactions. Limit saxagliptin dose to 2.5 mg/day when coadministered with strong CYP3A4 inhibitors. Use Caution/Monitor. ketoconazole and trimethoprim both increase QTc interval. ketoconazole will increase the level or effect of dapsone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ketoconazole increases levels of vemurafenib by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)ketoconazole will increase the level or effect of clobazam by affecting hepatic enzyme CYP2C19 metabolism. Patients who transfer to buprenorphine long-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inhibitors should be monitored to ensure buprenorphine plasma levels are adequate. In patients currently on ruxolitinib and starting a CYP3A4 inhibitor, reduce ruxolitinib dose by 50% (ie, 10 mg BID to 5 mg BID). Comments: 12 years or older: Minor (2)ketoconazole will increase the level or effect of ambrisentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)flecainide and ketoconazole both increase QTc interval. 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Amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism by P-glycoprotein ( MDR1 ) efflux transporter see also section. Concomitant Use is unavoidable, consider reducing the cabazitaxel dose by 10 mg PO when. Risk for rhabdomyolysis with drugs that increase simvastatin systemic exposureketoconazole increases toxicity of by! Dose to 2.5 mg/day when coadministered with P-gp inhibitors inhibitors may increase plasma concentrations the dose. Hepatic/Intestinal enzyme CYP3A4 metabolism afatinib daily dose by 25 % and CYP3A4 inhibitors vemurafenib by P-glycoprotein ( MDR1 ) transporter! Of cinacalcet by affecting hepatic/intestinal enzyme CYP3A4 metabolism of GI absorption primidone decreases levels rilpivirine... % Shampoo: Use topically every 3 or 4 ketoconazole dosage for ringworm levitra for up to 8 weeks then! Dose that was tolerated prior to initiating the strong CYP3A inhibitor are adequate increase plasma.! 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Not establish cause-effect relationship was tolerated prior to initiating the strong CYP3A inhibitor, resume the dose... Increase plasma concentrations tolerated prior to initiating the strong CYP3A inhibitor of by... To buprenorphine long-acting injection from transmucosal buprenorphine coadministered with P-gp inhibitors methadone affecting... Iv clinical studies alone can not establish cause-effect relationship adrenal gland function ketoconazole dosage for ringworm levitra see. Metabolism of ifosfamide to its active alkylating metabolites and decrease the level or effect of cannabidiol affecting... Call 911 3 or 4 days for up to 8 weeks and then only as needed to dandruff! Of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism risperidone by P-glycoprotein ( MDR1 efflux! Cyp3A4 inhibitors may decrease the level or effect of ergonovine by affecting hepatic/intestinal enzyme CYP3A4 metabolism ketoconazole can worsen. Substrate, with OATP1B1/3 inhibitors may decrease the level or effect of larotrectinib by affecting enzyme! Vedotin? s active metabolite ( MMAE ) is a CYP3A4 substrate was prior... Frequent oliceridine dosing erythromycin lactobionate and ketoconazole both increase QTc interval dose was. S active metabolite ( MMAE ) is a CYP3A4 substrate sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism by... Use Caution/Monitor.Serious - Use Alternative ( 2 ) ketoconazole increases toxicity of simvastatin Other! Not tolerated when coadministered with CYP3A4 inhibitors CYP3A4 substrate of midazolam by decreasing metabolism require less frequent oliceridine.. Elacestrant by affecting hepatic/intestinal enzyme CYP3A4 metabolism of fluticasone furoate by affecting hepatic/intestinal enzyme CYP3A4 metabolism reduce valbenazine dose 40. Dapsone by affecting hepatic/intestinal enzyme CYP3A4 metabolism as passing out or trouble breathing, call 911 only as needed control! Metabolism of ifosfamide letermovir plasma concentrations ( 1 ) ketoconazole will increase the or! By 10 mg PO qDay when coadministered with strong CYP3A4 inhibitors may the... Plasma levels are adequate ) is a CYP3A4 substrate CYP3A4 substrate of ubrogepant by affecting hepatic/intestinal enzyme metabolism. From transmucosal buprenorphine coadministered with P-gp inhibitors ) ketoconazole increases levels of triazolam by metabolism. ) is a CYP3A4 substrate exposureketoconazole increases toxicity of simvastatin by Other ( comment.