If you accidentally ingest itraconazole prescribed to your pet, call your physician or the national Poison Control Center hotline at 800-222-1222. An asymptomatic carrier state in one of the cats is always possible. Independence America Holdings Corp. All Rights Reserved, Itraconazole, known as by the names Sporanox,Intrafungol, Onmel, is an antifungal drug used in dogs and cats to inhibits the growth of. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Cats.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com. .medication-table .table-row .item-title{ margin: 0 auto; font-size: 14px; ITRAFUNGOL has not been shown to be safe in pregnant cats and should only be used in pregnant or lactating cats when the benefits outweigh the potential risks. Copyright 2023 Animalytix LLC. The most common side effects are loss of appetite and liver toxicity, both of which are quite rare. Itraconazole is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian. Most pets do not see any side effects while taking this medication: Rarely, inflammation of the skin, skin ulcers, and swelling of the legs can occur in dogs. Veterinarians can legally prescribe medications for off-label use under certain circumstances. The syringe allows for the most accurate dosing in cats. ITRAFUNGOL is metabolized by the liver (mainly CYP3A) and can cause elevated liver enzymes (see Animal Safety). The dose is 5 mg/kg once daily on alternate weeks. The FDA-approved brands are highly bioavailable in cats but because the drug has a long half-life, it may not reach appropriate concentrations for up to one week. (A Step By Step Guide). Although GI and liver effects can occur, they appear to be very dose-dependent in cats. Already have a myVCA account? Compounded itraconazole should not be used to treat cats with ringworm as it has been found to be less effective than the FDA-approved brands. TULISSIN (tulathromycin injection) for Swine, TULISSIN (tulathromycin injection) for Bovine, Tenotryl (enrofloxacin) injectable solution for Swine, Tenotryl (enrofloxacin) injectable solution for Cattle, TIA 12.5% (tiamulin hydrogen fumarate) Liquid Concentrate, Copyright 1999, 2023 Virbac Corporation, All rights reserved, Approximately 1.3 million cats are treated annually, While any cat can be affected, young, weak or immunosuppressed animals are more susceptible, Cats can be exposed to infective spores via contact with carrier cats, contaminated blankets, bedding, toys, brushes and fleas, Hair loss (alopecia) appearing in single or multiple circular or irregular patches, Lesions occurring primarily on the head, ears, tail and front paws, About 50% of humans exposed to infected cats acquire an infection, even if the cats are not showing signs of infection, Spores in the environment can remain infectious for up to 18 months, Clinical improvement was seen within 7 days of starting treatment, Clinical cure occured well in advance of mycological cure, 90% had at least 1 negative fungal culture by the end of the study, 98% had complete resolution of all clinical lesions, compared to 15% of untreated cats by the end of the study, Time to mycological cure was significantly shorter (P = 0.0003) for cats in the treated group versus control, Daily ITRAFUNGOL dose is 5 mg/kg (0.5 mL/kg) on alternating weeks for three treatment cycles, Itraconazole accumulates in hair and skin, giving residual antifungal activity between doses and after the last dose, Residual concentrations in hair and skin remain above therapeutic levels during non-treatment weeks, FDA-approved drugs have data demonstrating that the drugs are safe, effective and properly manufactured so they have the intendedquality and effect, The labeling for ITRAFUNGOL is written specifically for cats and includes all necessary information, including associated risks, so you canuse the drug safely and effectively in cats. It is common to check liver values while using itraconazole, especially if any signs of a digestive upset have occurred. In case of pain or irritation, seek medical advice. In cats, gastrointestinal effects such as lack of appetite, vomiting, and weight loss, as well as liver toxicity can occur. Four weeks after Itrafungol (Itraconazole) Oral Solution for Cats 10 mg/ml, 52 ml. In case of accidental contact with eyes, rinse thoroughly with water. Itraconazole may cause vomiting, diarrhea, weight loss, depression, and decreased appetite in dogs and cats. Itraconazole (Sporanox, Itrafungol) is a triazole antifungal that is extremely beneficial for animal dermatophytosis. Not for use in humans. Itraconazole works as an antifungal medication by stopping the fungi from creating an enzyme needed to produce their cell membrane. Itraconazole concentrations in cats hair vary; an increase occurs during treatment to a median value of 3.0 g/g (mean 5.2g/g) at the end of the third dosing week and concentrations drop slowly to 1.5g/g (mean 1.9 g/g) at 14 days after final dosing. Photo: Andreas Neumann. If side effects are seen, it may be possible to discontinue the drug temporarily and restart it at a lower dose or frequency. Keep this and all medications out of reach of children. Improvement was seen in inoculation site erythema and skin thickening by Day 7 and in crusts and scales by Day 14. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. Never give your pet two doses at once or give extra doses. Fungal infections in the cat are relatively common. It has been noted that the FDA-approved human brand Sporanox is better given without food, meaning this solution form is best given directly by mouth at least one hour before or after a meal, for best absorption. Signs of decreased appetite, jaundice, vomiting or diarrhea should be reported to your veterinarian. Capsules of itraconazole should be stored at controlled room temperatures between 5977 F and liquid Itrafungol should be stored at 6877 F. Brief exposure to temperatures between 5986 F are acceptable. The most effective dosage form for cats is one of the FDA-approved liquid solutions. Your veterinarian will monitor your pet to be sure that the medication is working. The typical dose is 100 to 400 mg daily based upon the type and severity of the fungal infection. It is used predominantly to treat cats with ringworm fungal infections that have multiple lesions or a carrier state. Each mL of ITRAFUNGOL Oral Solution contains 10 mg itraconazole (Ph. In a margin of safety study, ITRAFUNGOL (itraconazole oral solution) was administered orally to 9-10 week old healthy kittens once daily at 0X (saline control), 1X (5 mg/kg), 3X (15 mg/kg), and 5X (25 mg/kg) the therapeutic dose for 17 alternating weeks (9 total weeks of dosing) followed by an 8 week recovery period. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. Available Dosages: } Log in 24/7 to access your pets health care information. 1. background: #fcb040; line-height: 50px; By This is because inquisitive cats often pick the fungus up when checking out dark moist locations where it tends to exist naturally. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. Fungal and algal skin disease. This includes aspergillosis, cryptococcosis, coccidioidomycosis, sporotrichosis, blastomycosis, and histoplasmosis. Itraconazole is used in both dogs and cats to treat infections caused by fungi. Liver enzyme concentrations should be monitored. Our database mirrors the FDA's central repository of drug labels and package inserts under the Structured Product Labeling standard. margin: 0!important; This effect is irreversible and causes structural degeneration. The veterinary product Itrafungol is an oral solution of itraconazole that is labeled for use in cats. One cat in group 4 (5X; Cat #26302) lost 22% of its body weight and had a number of episodes of vomiting, salivation, and anorexia during the treatment period. In case of accidental ingestion, rinse mouth with water and seek medical advice. Cats are essentially treated on weeks one, three, and five, and left untreated on weeks two and four. 2023 This website is owned and operated by Cliverse Media DAO LTD. Safety has been evaluated in cats as young as 9 to 10 weeks old. Select one or more newsletters to continue. Do not invert the bottle (Figure 2). 4th edition: 2012;588-602. Do not administer to cats with hypersensitivity to itraconazole or one of the other ingredients. Mild gingival bleeding and perioral irritation (patchy alopecia and erythema) was noted in cats in the 3X and 5X groups. VetLabel.com provides the full animal health subset of the FDA's repository. After both a 3X and 5X overdose for 6 weeks, reversible changes in serum biochemical parameters occurred (increased ALT, ALP, AST and bilirubin) indicating liver involvement. Other infrequent adverse reactions included less than 3 cases each of somnolence, depression, and increased salivation. Excursions permitted between 59-86F (15-30C). See the Terms of Use for further details. Smoothie. Safety has been evaluated in cats as young as 9 to 10 weeks old. Follow the directions on the drug label or as provided by your veterinarian. } Itraconazole is classified as a fungistatic triazole compound. Easy to administer: Oral solution features a cherry-caramel liquid formulation2. You should wash your hands and any exposed skin after administering the oral solution or handling your pet during treatment. width: 115px; display: block; Contraindications Do not administer to cats with hypersensitivity to itraconazole or one of the other ingredients. Product Insert, KETOCHLOR Shampoo (chlorhexidine gluconate, ketoconazole), ALLERMYL (Piroctone Olamine) Medicated Shampoo, KERATOLUX (Piroctone Olamine) Medicated Shampoo. Moriello, K., Coyner, K. et. In general, if ringworm is found on one cat in a household of multiple cats, all cats should receive administration of itraconazole treatment together at the same time. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Set up your myVCA account today. The hydroxy-itraconazole remains near or below the quantification limit in feline plasma after a single dose of itraconazole oral solution at 5 mg/kg. It should be used with extreme caution in pets with liver disease or with low stomach acid production and used carefully in pets with heart disease. Avoid contamination of the solution. 5. It is common for fungal infections to require several weeks of treatment. The FDA-approved, labeled dosage for itraconazole (Itrafungol) for cats to treat Microsporum canis is 5 milligrams/kilogram by mouth given once daily for seven days on alternating weeks, This lasts for three treatment cycles. plus the active control once daily for ve weeks. Affiliate of Mars Inc. 2023 | Copyright VCA Animal Hospitals all rights reserved. Many drugs are commonly prescribed for off label . The human capsules are not absorbed as well in cats and their dosage size will far exceed the needed dose for most cats, making liquid forms more practical and effective. In most cats, ALT values peaked just above the upper limit of the reference range and were continuing to trend upward or were elevated yet stable at the end of the study. Continuing treatment at least one month beyond a negative ringworm culture or PCR is the general standard. These effects are usually mild and transient. This brand includes a dosing syringe for accurate dosing. Two days later it was allot bigger, hair falling out, it looked to me like ringworm. Keep this and all medications out of reach of children. } flex-wrap: wrap; The current match involves a Texas lawsuit . Use with caution in cats with renal dysfunction. Overdoses can also cause liver irritation. @media screen and (max-width:1024px) { .medication-table h2{ Queens of the Stone Age will bring Phantogram, Viagra Boys, the Armed, and Savages' Jehnny Beth on their fall North American tour. Itraconazole may cause vomiting, diarrhea, weight loss, depression, and decreased appetite in dogs and cats. Itraconazole should be used with caution in pets that are pregnant, breeding, or nursing, as its safety has not been established in these cases. (A Step By Step Guide), Gastroenteritis In Cats: Causes, Symptoms, & Treatment, How To Give Your Cat A Pill (With 7 Proven Tips! All rights reserved. FDA recommends that veterinarians prescribe FDA-approved Itrafungol for cats10. If clinical signs suggestive of liver dysfunction develop, treatment should be discontinued. The solution should be administered orally using the enclosed graduated dosing syringe. Use with caution in cats with impaired liver function. It is very important to always continue treatment as directed. Treatment of ringworm in cats is typically successful. Veterinary information provided here is not intended as a substitute for direct consultation with a qualified veterinary professional. Please click here for full prescribing information. Dr. Vanderhoof is also a copywriter specializing in the animal health field and founder of Paramount Animal Health Writing Solutions, which can be found at www.animalhealthco Maayan is a senior content editor on the Cats.com team. Of the 266 cats that received at least one dose of itraconazole oral solution, adverse reactions included 35 cases (13%) of one or more elevated hepatic enzymes and 8 cases (3%) of gastrointestinal upset, including decreased appetite, vomiting and/or diarrhea. Diagnosis and Treatment of Dermatophytosis in Dogs and Cats: Clinical Consensus Guidelines of the World Association for Veterinary Dermatology.Vet Dermatol. 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