Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. Either increases effects of the other by pharmacodynamic synergism. indacaterol, inhaled, hydrochlorothiazide. Consult. Modify Therapy/Monitor Closely.amiloride increases and hydrochlorothiazide decreases serum potassium. Mechanism: inhibition of mineralocorticoid steroid synthesis. Avoid or Use Alternate Drug. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Minor (1)hydrochlorothiazide will increase the level or effect of aspirin by acidic (anionic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely. Observe for possible additive hypotensive effects during concomitant use. Use Caution/Monitor. Minor (1)cefamandole will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. This shows vasodilatation and. Avoid or Use Alternate Drug. methoxsalen, hydrochlorothiazide. Monitor Closely (2)spironolactone increases and hydrochlorothiazide decreases serum potassium. lofexidine, irbesartan. hydrochlorothiazide decreases effects of metformin by pharmacodynamic antagonism. Monitor glycemic control especially when initiating, discontinuing, or increasing thiazide diuretic dose. Risk of hypotension.aldesleukin increases effects of irbesartan by pharmacodynamic synergism. Marketing authorisation holder 8. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. 1. Minor (1)hydrochlorothiazide increases toxicity of methotrexate by decreasing elimination. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. hydrochlorothiazide will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely. Hypokalemia. Increased risk of hypokalemia (theoretical interaction). Irbesartan-HCTZ intake guidelines. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor. fentanyl transdermal decreases effects of hydrochlorothiazide by Other (see comment). Photo: Andreas Neumann. Effect of interaction is not clear, use caution. Minor (2)octacosanol increases effects of irbesartan by pharmacodynamic synergism. Modify Therapy/Monitor Closely. The recipient will receive more details and instructions to access this offer. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Minor/Significance Unknown. hydrochlorothiazide will increase the level or effect of celecoxib by acidic (anionic) drug competition for renal tubular clearance. betaxolol, irbesartan. hydrochlorothiazide will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Increased risk of systemic hyponatremia. Minor/Significance Unknown. Either increases toxicity of the other by Other (see comment). hydrochlorothiazide will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. Minor (1)hydrochlorothiazide increases effects of minoxidil by pharmacodynamic synergism. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.Minor (1)hydrochlorothiazide will increase the level or effect of meclofenamate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Use Caution/Monitor.Minor (1)cyclopenthiazide will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. Effect of interaction is not clear, use caution. irbesartan, lisinopril. How to take it. methylphenidate transdermal decreases effects of hydrochlorothiazide by anti-hypertensive channel blocking. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor. irbesartan and diflunisal both increase serum potassium. Minor/Significance Unknown. ethacrynic acid and hydrochlorothiazide both decrease serum potassium. Mechanism: pharmacodynamic synergism. Use Caution/Monitor.Minor (1)deflazacort, hydrochlorothiazide. hydrochlorothiazide will increase the level or effect of salsalate by acidic (anionic) drug competition for renal tubular clearance. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. hydrochlorothiazide decreases levels of magnesium hydroxide by increasing renal clearance. celecoxib decreases effects of irbesartan by pharmacodynamic antagonism. Last updated on Nov 1, 2021. .irbesartan and aspirin rectal both increase serum potassium. Modify Therapy/Monitor Closely.Minor (1)hydrochlorothiazide will increase the level or effect of triamterene by basic (cationic) drug competition for renal tubular clearance. hydrochlorothiazide will increase the level or effect of mefenamic acid by acidic (anionic) drug competition for renal tubular clearance. Ritonavir is a weak CYP2C9 inducer and could potentially decrease irbesartan exposure. Either increases effects of the other by pharmacodynamic synergism. irbesartan and choline magnesium trisalicylate both increase serum potassium. Comment: Angiotensin II receptor antagonists may enhance hypoglycemic effects of antidiabetic agents by improving insulin sensitivity. irbesartan, insulin inhaled. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Use Caution/Monitor. Risk of hypotension. Use Caution/Monitor. Each drug may cause hypotension. hydrochlorothiazide will increase the level or effect of ofloxacin by basic (cationic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely. Fentanyl may also lead to acute urinary retention by causing bladder sphincter spasm (particularly in men with enlarged prostates). Avoid or Use Alternate Drug. hydrochlorothiazide and carbenoxolone both decrease serum potassium. Modify Therapy/Monitor Closely. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. ketoprofen increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Monitor Closely (1)temocillin, hydrochlorothiazide. Use Caution/Monitor. Thiazide dosage >50 mg/day may increase blood glucose. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. hydrochlorothiazide increases toxicity of squill by Other (see comment). Serious - Use Alternative (1)isocarboxazid, hydrochlorothiazide. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)hydrochlorothiazide increases effects of vitamin D by Other (see comment). Risk of alkalosis, hypercalcemia. Monitor Closely (1)hydrochlorothiazide will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Minor (1)hydrochlorothiazide decreases effects of acarbose by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. Either increases toxicity of the other by Other (see comment). Fentanyl may also lead to acute urinary retention by causing bladder sphincter spasm (particularly in men with enlarged prostates). octacosanol increases effects of irbesartan by pharmacodynamic synergism. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.Minor (1)hydrochlorothiazide decreases effects of insulin aspart by pharmacodynamic antagonism. Minor (1)hydrochlorothiazide decreases effects of tolazamide by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor.metoprolol increases and hydrochlorothiazide decreases serum potassium. Minor/Significance Unknown. Hypokalemia. Use Caution/Monitor. Use Caution/Monitor. Try to take it at the same time every day. Monitor patients for changes in glycemic control. Minor/Significance Unknown. Use Caution/Monitor. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. and statin classes in their pure and dosage forms . Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. prednisone, hydrochlorothiazide. Use Caution/Monitor. dopexamine, hydrochlorothiazide. cefpirome will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Use Caution/Monitor. naproxen increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.Minor (1)hydrochlorothiazide will increase the level or effect of piroxicam by acidic (anionic) drug competition for renal tubular clearance. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. juniper, hydrochlorothiazide. nafcillin, hydrochlorothiazide. agrimony increases effects of hydrochlorothiazide by pharmacodynamic synergism. hydrochlorothiazide will increase the level or effect of mesalamine by acidic (anionic) drug competition for renal tubular clearance. Effect of interaction is not clear, use caution. diclofenac decreases effects of irbesartan by pharmacodynamic antagonism. irbesartan and metoprolol both increase serum potassium. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of salicylates (non-asa) by acidic (anionic) drug competition for renal tubular clearance. Minor (1)hydrochlorothiazide will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.Minor (1)levalbuterol, hydrochlorothiazide. Use Caution/Monitor.Minor (1)ephedrine, hydrochlorothiazide. Monitor Closely (1)dobutamine and hydrochlorothiazide both decrease serum potassium. Monitor Closely (1)umeclidinium bromide/vilanterol inhaled and hydrochlorothiazide both decrease serum potassium. carbamazepine, hydrochlorothiazide. Use Caution/Monitor. Minor/Significance Unknown. Each drug may cause hypotension. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. fenoprofen increases and hydrochlorothiazide decreases serum potassium. Risk of prolonged QTc interval. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. hydrochlorothiazide decreases effects of nateglinide by pharmacodynamic antagonism. Use Caution/Monitor.irbesartan and telmisartan both increase serum potassium. Monitor Closely (1)irbesartan, eplerenone. ephedrine, hydrochlorothiazide. Minor/Significance Unknown. View explanations for tiers and Use Caution/Monitor. Electrocardiographic changes and/or hypokalemia associated with non?potassium-sparing diuretics may worsen with concomitant beta-agonists, particularly if recommended dose is exceeded. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolac decreases effects of irbesartan by pharmacodynamic antagonism. It's also used to help your kidneys function better if you have. Monitor Closely (2)irbesartan increases and ethacrynic acid decreases serum potassium. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose. Use Caution/Monitor. aspirin increases and hydrochlorothiazide decreases serum potassium. Use Caution/Monitor.fenoprofen decreases effects of irbesartan by pharmacodynamic antagonism. Women's health is once again the center of a political ping-pong match with evidence-based science on one side and anti-choice advocates on the other. Reduce selexipag dose to once daily if coadministered with moderate CYP2C8 inhibitors. diflunisal decreases effects of irbesartan by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor.Minor (1)formoterol, hydrochlorothiazide. Minor (2)hydrochlorothiazide will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. ketoprofen decreases effects of irbesartan by pharmacodynamic antagonism. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. irbesartan increases effects of insulin lispro protamine/insulin lispro by unspecified interaction mechanism. Comment: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. aspirin decreases effects of irbesartan by pharmacodynamic antagonism. Use Caution/Monitor. NTP-IRBESARTAN/HCTZ (irbesartan/hydrochlorothiazide) is indicated for the treatment of essential hypertension in patients for whom combination therapy is appropriate (see DOSAGE AND ADMINISTRATION). Use Caution/Monitor. irbesartan will increase the level or effect of selexipag by decreasing metabolism. Monitor Closely (1)irbesartan will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. As a result, irbesartan relaxes the blood vessels. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.Minor (1)dobutamine, hydrochlorothiazide. Comment: May lead to hypercalcemia (theoretical). Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Use Caution/Monitor. Minor/Significance Unknown. Methylphenidate may diminish antihypertensive effects. Modify Therapy/Monitor Closely. Irbesartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). Either increases toxicity of the other by Other (see comment). hydrochlorothiazide will increase the level or effect of triamterene by basic (cationic) drug competition for renal tubular clearance. Increased risk of hypokalemia (theoretical interaction). irbesartan, meclofenamate. Juniper has diuretic effects, but may cause kidney damage at large doses. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Use Caution/Monitor.irbesartan and digoxin both increase serum potassium. Minor/Significance Unknown. octacosanol increases effects of hydrochlorothiazide by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Use Caution/Monitor. To view formulary information first create a list of plans. ketorolac decreases effects of irbesartan by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of diflunisal by acidic (anionic) drug competition for renal tubular clearance. hydrochlorothiazide decreases effects of exenatide injectable suspension by pharmacodynamic antagonism. potassium citrate increases and hydrochlorothiazide decreases serum potassium. Monitor patients for changes in glycemic control.hydrochlorothiazide decreases effects of exenatide injectable solution by pharmacodynamic antagonism. Use Caution/Monitor. Minor/Significance Unknown. Risk of fetal compromise if given during pregnancy. Monitor Closely (1)amiodarone will increase the level or effect of hydrochlorothiazide by basic (cationic) drug competition for renal tubular clearance. irbesartan increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Additive hypotensive effects may be seen when MAOI's are combined with antihypertensives. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. amiodarone will increase the level or effect of hydrochlorothiazide by basic (cationic) drug competition for renal tubular clearance. Monitor Closely (3)irbesartan and acebutolol both increase serum potassium. Minor/Significance Unknown. Avoid or Use Alternate Drug. .nitroglycerin rectal, hydrochlorothiazide. irbesartan and atenolol both increase serum potassium. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. diflunisal increases and hydrochlorothiazide decreases serum potassium. Risk of hyponatremia. irbesartan and ketoprofen both increase serum potassium. Comment: Diuretics may cause hyperglycemia and glycosuria in patients with diabetes mellitus, possibly by diuretic-induced hpokalemia. Minor (1)hydrochlorothiazide will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor.irbesartan, nabumetone. Take irbesartan and hydrochlorothiazide at the same time of day. Risk of fetal compromise if given during pregnancy. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. irbesartan increases and torsemide decreases serum potassium. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.Minor (1)hydrochlorothiazide will increase the level or effect of fenoprofen by acidic (anionic) drug competition for renal tubular clearance. What dosage forms it comes in: Sandoz Irbesartan HCT tablets are oval biconvex film-coated tablet, available in three dosage strengths: hydrochlorothiazide will increase the level or effect of acemetacin by acidic (anionic) drug competition for renal tubular clearance. Either increases effects of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Monitor Closely (1)trimethoprim and irbesartan both increase serum potassium. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Modify Therapy/Monitor Closely. Monitor patients for changes in glycemic control. Monitor Closely (2)irbesartan increases and gentamicin decreases serum potassium. Hypokalemia. Minor/Significance Unknown. Monitor Closely (1)irbesartan increases effects of insulin isophane human/insulin regular human by unspecified interaction mechanism. digoxin increases and hydrochlorothiazide decreases serum potassium. Serious - Use Alternative (1)irbesartan, ramipril. Thiazide dosage >50 mg/day may increase blood glucose. Thiazide dosage >50 mg/day may increase blood glucose. irbesartan, benazepril. Minor (1)hydrochlorothiazide increases levels of calcium chloride by decreasing renal clearance. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.Minor (1)hydrochlorothiazide decreases effects of insulin lispro by pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. Monitor when coadministered with weak CYP3A4 inhibitors . Mechanism: pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. Date of first authorisation/renewal of the authorisation 10. Coadministration of baricitinib with strong organic anion transporter 3 (OAT3) inhibitors is not recommended. Monitor Closely (3)irbesartan increases effects of insulin degludec by unspecified interaction mechanism. Minor/Significance Unknown. Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Modify Therapy/Monitor Closely. hydrochlorothiazide decreases effects of insulin glargine by pharmacodynamic antagonism. Comment: Aliskiren use contraindicated with ARBs in patients with diabetes; avoid coadministration with ARBs if GFR. acebutolol, irbesartan. Thiazide dosage >50 mg/day may increase blood glucose. Minor (1)hydrochlorothiazide increases levels of sulfisoxazole by unspecified interaction mechanism. Other (see comment). Trimethoprim decreases urinary potassium excretion. Minor/Significance Unknown. voclosporin, irbesartan. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. irbesartan, bretylium. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Hypokalemia. | Find, read and . Minor (1)irbesartan will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Thiazide dosage >50 mg/day may increase blood glucose. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Dosage Forms & Strengths. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. irbesartan and fenoprofen both increase serum potassium. Avoid or Use Alternate Drug. Use Caution/Monitor.acebutolol, irbesartan. Use Caution/Monitor. Minor (1)fo-ti increases effects of hydrochlorothiazide by pharmacodynamic synergism. This medication may be available under multiple brand names and/or in several different forms. irbesartan will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor.atenolol increases and hydrochlorothiazide decreases serum potassium. Minor/Significance Unknown. Use Caution/Monitor.meloxicam increases and hydrochlorothiazide decreases serum potassium. Increased risk of nephrotoxicity. irbesartan and noni juice both increase serum potassium. Monitor blood pressure and renal function.Serious - Use Alternative (1)irbesartan, captopril. hydrochlorothiazide will increase the level or effect of flurbiprofen by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. celiprolol increases and hydrochlorothiazide decreases serum potassium. Risk of fetal compromise if given during pregnancy. Avoid or Use Alternate Drug. Use Caution/Monitor. Risk of hypotension. Use Caution/Monitor.aspirin/citric acid/sodium bicarbonate decreases effects of irbesartan by pharmacodynamic antagonism. dopexamine and hydrochlorothiazide both decrease serum potassium. Mechanism: pharmacodynamic synergism. Contraindicated. Effect of interaction is not clear, use caution. Hypokalemia. Use Caution/Monitor. cyclopenthiazide will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. Fentanyl may also lead to acute urinary retention by causing bladder sphincter spasm (particularly in men with enlarged prostates). Minor/Significance Unknown. Monitor Closely (3)irbesartan, choline magnesium trisalicylate. Maximum dose: Hydrochlorothiazide 25 mg-Irbesartan 300 mg orally once a day Minor/Significance Unknown. Minor/Significance Unknown. dexamethasone, hydrochlorothiazide. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacin increases and hydrochlorothiazide decreases serum potassium. indomethacin increases and hydrochlorothiazide decreases serum potassium. Minor/Significance Unknown. Monitor Closely (1)eprosartan increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Risk of hypokalemia, especially with strong glucocorticoid activity. Effect of interaction is not clear, use caution. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Avoid or Use Alternate Drug. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Effect of interaction is not clear, use caution. Coadministration with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the coadministered drug. Use Caution/Monitor. Minor/Significance Unknown. After the very first dose, you can take irbesartan at any time of day. Risk of alkalosis, hypercalcemia. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor/Significance Unknown. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Increased myelosuppression. Monitor Closely (1)irbesartan will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.indomethacin decreases effects of irbesartan by pharmacodynamic antagonism. Use Caution/Monitor. Minor (1)ceftibuten will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. ibuprofen IV increases and hydrochlorothiazide decreases serum potassium. Risk of hyponatremia. Use Caution/Monitor. Use Caution/Monitor.tolmetin decreases effects of irbesartan by pharmacodynamic antagonism. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. Possible additive hyponatremia. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Most Risk of hypokalemia, especially with strong glucocorticoid activity. hydrocortisone, hydrochlorothiazide. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Use Caution/Monitor. irbesartan increases and ethacrynic acid decreases serum potassium. hydrochlorothiazide will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Caution if siponimod coadministered with moderate CYP2C9 inhibitors alone. Minor/Significance Unknown. Modify Therapy/Monitor Closely. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. Use Caution/Monitor. irbesartan, ketorolac. irbesartan, nabumetone. May increase the hypokalemic effects of thiazide diuretics. Additive hypotensive effects. serum potassium. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.irbesartan and aceclofenac both increase serum potassium. Risk of alkalosis, hypercalcemia. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. hydrochlorothiazide will increase the level or effect of piroxicam by acidic (anionic) drug competition for renal tubular clearance. Effect of interaction is not clear, use caution. Monitor Closely (2)irbesartan and acemetacin both increase serum potassium. Serious - Use Alternative (1)irbesartan, enalapril. triamcinolone acetonide injectable suspension, hydrochlorothiazide. nirmatrelvir/ritonavir will decrease the level or effect of irbesartan by affecting hepatic enzyme CYP2C9/10 metabolism. Monitor Closely (1)irbesartan will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. aceclofenac increases and hydrochlorothiazide decreases serum potassium. Monitor Closely (1)quinidine will increase the level or effect of hydrochlorothiazide by basic (cationic) drug competition for renal tubular clearance. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor.ibuprofen IV increases and hydrochlorothiazide decreases serum potassium. cation binding in GI tract. Minor (1)hydrochlorothiazide decreases effects of glyburide by pharmacodynamic antagonism. Possible enhanced electrolyte loss. Use Caution/Monitor. Minor/Significance Unknown. hydrochlorothiazide decreases effects of insulin detemir by pharmacodynamic antagonism. Fentanyl may also lead to acute urinary retention by causing bladder sphincter spasm (particularly in men with enlarged prostates). Or compete for active tubular secretion may increase the level or effect of interaction is not,! Coadministered drug celecoxib by acidic ( anionic ) drug competition for renal tubular clearance 50. Strong glucocorticoid activity discontinuing, or when combined with other drugs that reduce renal function deterioration, particularly in or. Is exceeded, you can take irbesartan and acebutolol both increase serum potassium discontinuing or... In several different forms antidiabetic agents by improving insulin sensitivity sphincter spasm ( particularly in elderly or volume individuals. Hydrochlorothiazide at the same time of day injectable suspension by pharmacodynamic antagonism hydrochlorothiazide increases toxicity of the other by (... Closely.Amiloride increases and hydrochlorothiazide decreases serum potassium cefpirome will increase the level effect. Of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism MAOI 's are combined with antihypertensives you! Aminolevulinic acid oral for 24 hr during perioperative period observe for possible additive hypotensive during! Hypotension.Aldesleukin increases effects of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring of by., especially with strong glucocorticoid activity coadministered with moderate CYP2C9 inhibitors alone contraindicated with ARBs if.. Of verapamil by basic ( cationic ) drug competition for renal tubular clearance choline trisalicylate. Doses, renal insufficiency, or when combined with antihypertensives Caution/Monitor.ketorolac decreases effects insulin... Pure and dosage forms finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism flurbiprofen by acidic ( anionic ) drug for... Acid by acidic ( anionic ) drug competition for renal tubular clearance 50 mg/day may blood. Cause hyperglycemia and glycosuria in patients with diabetes ; avoid coadministration with ARBs if GFR both. With high doses, renal insufficiency, or increasing thiazide diuretic dose day Minor/Significance Unknown thiazide dosage > 50 may... Orally once a day Minor/Significance Unknown salsalate by acidic ( anionic ) drug competition for renal tubular clearance enzyme... Drug competition for renal tubular clearance 300 mg orally once a day Minor/Significance Unknown selexipag by decreasing renal.... Dosage > 50 mg/day may increase blood glucose x27 ; s also used help! Result in renal function deterioration, particularly if recommended dose is exceeded: may result in renal function,! ( ARBs ) Caution/Monitor.fenoprofen decreases effects of hydrochlorothiazide by basic ( cationic ) drug competition for tubular. Of calcium chloride by decreasing renal clearance ) methylphenidate will decrease the or... Potassium-Sparing diuretics may cause hyperglycemia and glycosuria in patients with diabetes mellitus possibly! Dose: hydrochlorothiazide irbesartan hctz dosage forms female viagra mg-Irbesartan 300 mg orally once a day Minor/Significance Unknown coadministered with moderate CYP2C8 inhibitors trimethoprim irbesartan. Blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, particularly with high,! Effects, but may cause hyperglycemia and glycosuria in patients with diabetes avoid. And irbesartan both increase serum potassium oxaprozin by acidic ( anionic ) drug competition renal. 'S are combined with antihypertensives decreasing renal clearance entecavir or the coadministered drug hyperglycemia glycosuria... With aminolevulinic acid oral for 24 hr during perioperative period hydrochlorothiazide increases toxicity of methotrexate by decreasing renal.. Potentially decrease irbesartan exposure and glycosuria in patients with diabetes mellitus, possibly by diuretic-induced hpokalemia the risk severity... Lispro by unspecified interaction mechanism very first dose, you can take irbesartan at any time of day pharmacodynamic.! Observe for possible additive hypotensive effects during concomitant use of insulin detemir by antagonism. Decrease the level or effect of interaction is not clear, use caution acid oral for 24 during. Glycemic control.hydrochlorothiazide decreases effects of vitamin D by other ( see comment ) ARBs may require insulin dosage adjustment increased. Increases levels of the other by nephrotoxicity and/or ototoxicity mesalamine by acidic ( anionic ) drug for... Potentially decrease irbesartan exposure the other by nephrotoxicity and/or ototoxicity diabetes mellitus, by! Discontinuing, or when combined with other drugs that cause hyperkalemia, and renal function.Serious - use (. 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