Dextromethorphan has serotonergic activity. Linezolid is an antibiotic that is also a non-selective monoamine oxidase (MAO) inhibitor. 10 mg/kg/dose IV every 8 hours. The patient should be monitored for serotonin syndrome for 21 days or until 24 hours after the last dose of linezolid, whichever comes first. Linezolid is a reversible, non-selective inhibitor of MAO. Fluticasone; Salmeterol: (Moderate) Linezolid may enhance the hypertensive effect of beta-agonists. Linezolid is in a class of antibacterials called oxazolidinones. Norgestimate; Ethinyl Estradiol: (Moderate) It would be prudent to recommend alternative or additional contraception when oral contraceptives (OCs) are used in conjunction with antibiotics. The AUC and Cmax of linezolid were decreased when coadministered with another strong CYP450 inducer, rifampin. Linezolid is an antibiotic that is also a non-selective monoamine oxidase (MAO) inhibitor. In cases where the outcome is known, when linezolid was discontinued, the affected hematologic parameters have risen toward pretreatment concentrations. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. 10 mg/kg/dose (Max: 400 mg/dose) PO every 8 hours as part of combination therapy for 3 to 7 days as an alternative. Similar severe adverse events have occurred after combining other MAOIs. Since monoamine oxidase type A deaminates serotonin, administration of a non-selective MAO inhibitor concurrently with fluvoxamine can lead to serious reactions including serotonin syndrome or neuroleptic malignant syndrome-like reactions. If urgent psychiatric treatment is required, interventions other than trazodone (e.g., alternative medication, hospitalization) should be considered. The patient should be monitored for symptoms of serotonin syndrome for 2 weeks or until 24 hours after the last dose of linezolid, whichever comes first. ZYVOX I.V. Linezolid is an antibiotic that is also a weak, reversible nonselective inhibitor of monoamine oxidase (MAO). Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. Such drugs should be avoided during and for up to 2 weeks following the discontinuation of linezolid. Therefore, linezolid has the potential for interaction with adrenergic agents, such as the beta-agonists. Atropine; Difenoxin: (Moderate) Linezolid may enhance the hypertensive effect of diphenoxylate. . Linezolid is an antibiotic that is also a reversible, non-selective MAO inhibitor. Acetaminophen; Caffeine; Dihydrocodeine: (Contraindicated) Dihydrocodeine use in patients taking linezolid or within 14 days of stopping such treatment is contraindicated due to the risk of serotonin syndrome or opioid toxicity. Guidelines suggest linezolid as an option in patients with MRSA or VRE. The clinical significance of this interaction is unknown and the mechanism is not fully understood, but it may be related to the induction of hepatic enzymes. relationships of a spouse or life partner, that could create a conflict of interest. Linezolid is an antibiotic that is also a weak, reversible nonselective inhibitor of monoamine oxidase (MAO). These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. Discontinue all serotonergic agents and initiate symptomatic treatment if serotonin syndrome occurs. 10 mg/kg/dose IV every 8 hours for 5 to 14 days. 10 mg/kg/dose PO every 12 hours for 5 to 14 days. The patient should be monitored for serotonin syndrome for two weeks or until 24 hours after the last dose of linezolid, whichever comes first. 10 mg/kg/dose (Max: 600 mg/dose) PO every 8 to 12 hours for 5 to 14 days. Inform patients taking this combination of the possible increased risk and monitor for the emergence of serotonin syndrome, particularly after a dose increase or the addition of other serotonergic medications to an existing regimen. Vilazodone may be re-initiated 24 hours after the last dose of linezolid. Diabetic patients should be monitored for potential hypoglycemic reactions while on linezolid. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. The patient should be monitored for serotonin syndrome for two weeks or until 24 hours after the last dose of linezolid, whichever comes first. For systemic infection without CNS involvement, treatment should continue for at least 14 days or until clinical criteria for improvement are met. Current guidelines do not provide a linezolid dose and recommend infectious disease consultation as the standard of care for pediatric patients with enterococcal endocarditis. Linezolid is a reversible, nonselective MAO inhibitor and other MAO inhibitors have been associated with hypoglycemic episodes in diabetic patients receiving insulin or oral hypoglycemic agents. The recommended duration of treatment is 2 weeks for meningitis and 4 to 6 weeks for brain abscess, subdural empyema, spinal epidural abscess, and septic thrombosis of the cavernous or dural venous sinus. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. Codeine; Guaifenesin; Pseudoephedrine: (Contraindicated) Codeine use in patients taking linezolid or within 14 days of stopping such treatment is contraindicated due to the risk of serotonin syndrome or opioid toxicity. (Minor) In a study of healthy volunteers (n=16), coadministration of rifampin (600 mg daily administered for 8 days) with oral linezolid (600 mg twice daily administered for 5 days) resulted in a 21% decrease in linezolid Cmax (90% CI, 15-27%) and a 32% decrease in linezolid AUC (90% CI, 27-37%). being able to get an erection, but not having it last long enough for sex. Trazodone may be resumed 24 hours after the last dose of linezolid. No serotonin syndrome effects (confusion, delirium, restlessness, tremors, blushing, diaphoresis, hyperpyrexia) have been observed in normal subjects receiving linezolid and dextromethorphan. Serotonin syndrome has been reported in patients receiving either citalopram, escitalopram, fluoxetine, or paroxetine in combination with linezolid. Bradycardia may be worsened when MAO-inhibitors are co-administered to patients receiving beta-blockers. Closely monitor for increased blood pressure during coadministration. Additonally, phentermine has a weak ability to dose-dependently raise serotonin levels. It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in enterohepatic circulation via changes in GI flora. Closely monitor for increased blood pressure during coadministration. Linezolid is a reversible, nonselective MAO inhibitor and other MAO inhibitors have been associated with hypoglycemic episodes in diabetic patients receiving insulin or oral hypoglycemic agents. Therefore, linezolid has the potential for interaction with adrenergic agents, such as pseudoephedrine. Diabetic patients should be monitored for potential hypoglycemic reactions while on linezolid. Atomoxetine, a selective norepinephrine reuptake inhibitor, is contraindicated with the use of any MAOI due to the potential for serious reactions. If acceptable alternatives to linezolid are not available and the potential benefits of linezolid are determined to outweigh the risks of serotonin syndrome in an individual patient, levomilnacipran should be stopped promptly, and linezolid can be administered. Therefore, linezolid has the potential for interaction with adrenergic agents, such as pseudoephedrine. A longer course (i.e., 4 to 6 weeks or longer) may be needed for severe or complicated infections. Closely monitor for increased blood pressure during coadministration. Linezolid is an antibiotic that is also a reversible, non-selective MAO inhibitor and has potential to interact with serotonergic agents. 10 mg/kg/dose IV every 12 hours for 5 to 14 days. Linezolid is a reversible, nonselective MAO inhibitor and other MAO inhibitors have been associated with hypoglycemic episodes in diabetic patients receiving insulin or oral hypoglycemic agents. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. Betaxolol: (Moderate) Linezolid is an antibiotic that is also a reversible, non-selective MAO inhibitor. Desipramine: (Contraindicated) Treatment with tricyclic antidepressants (TCAs) is contraindicated in patients currently receiving linezolid due to an increased risk of serotonin syndrome. Subjects were administered dextromethorphan (two 20-mg doses given 4 hours apart) with or without linezolid. If hypoglycemia occurs, discontinue or decrease the dose of the antidiabetic agent or discontinue the linezolid therapy. If urgent psychiatric treatment is required, interventions other than mirtazapine (e.g., alternative medication, hospitalization) should be considered. Therefore, linezolid has the potential for interaction with adrenergic agents, such as phenylephrine. Conversely, in patients receiving clomipramine and requiring urgent treatment with linezolid, clomipramine should be discontinued immediately and linezolid therapy initiated only if acceptable alternatives are not available and the potential benefits of linezolid outweigh the risks. Linezolid is an antibiotic that is also a weak, reversible nonselective inhibitor of monoamine oxidase (MAO). Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. Available for Android and iOS devices. It works by killing bacteria or preventing their growth. Diabetic patients should be monitored for potential hypoglycemic reactions while on linezolid. 600 mg PO every 12 hours plus rifampin followed by long-term oral therapy. Therefore, linezolid has the potential for interaction with adrenergic agents, such as phenylephrine. Closely monitor for increased blood pressure during coadministration. Pioglitazone: (Moderate) Hypoglycemia, including symptomatic episodes, has been noted in post-marketing reports with linezolid in patients with diabetes mellitus receiving therapy with antidiabetic agents, such as insulin and oral hypoglycemic agents. Chlorpheniramine; Dextromethorphan: (Moderate) Because of the potential risk and severity of serotonin syndrome, caution should be observed when administering linezolid with dextromethorphan. Prophylaxis to complete an antimicrobial course of up to 60 days will be required in both cases. Coadministration may increase the risk for serotonin syndrome. 10 mg/kg/dose IV every 8 hours in combination with appropriate antimicrobial therapy. This content is intended for U.S. Healthcare Professionals. The MICs are defined for Staphylococcus sp. resistant to penicillin, aminoglycosides, and vancomycin. Linezolid is an antibiotic that is also a weak, reversible nonselective inhibitor of monoamine oxidase (MAO). Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Monoamine oxidase and catechol-O-methyltransferase (COMT) are the two major enzymes involved in the metabolism of catecholamines. Serotonin syndrome is characterized by rapid development of hyperthermia, hypertension, myoclonus, rigidity, autonomic instability, mental status changes (e.g., delirium or coma), and in rare cases, death. The AUC and Cmax of linezolid were decreased when coadministered with another strong CYP450 inducer, rifampin. 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